Hyaluronan In Cancer Biology

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Hyaluronan in Cancer Biology

Robert Stern
Hyaluronan in Cancer Biology Book PDF

Author : Robert Stern
Publisher : Academic Press
Page : 468 pages
File Size : 51,5 Mb
Release : 2009-03-07
Category : Medical
ISBN : 0080921086

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Hyaluronan in Cancer Biology by Robert Stern Pdf

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. * Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer * Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination * Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Hyaluronan Signaling and Turnover

Melanie Simpson,Paraskevi Heldin
Hyaluronan Signaling and Turnover Book PDF

Author : Melanie Simpson,Paraskevi Heldin
Publisher : Academic Press
Page : 418 pages
File Size : 52,6 Mb
Release : 2014-07-26
Category : Medical
ISBN : 9780128003930

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Hyaluronan Signaling and Turnover by Melanie Simpson,Paraskevi Heldin Pdf

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students

Hyaluronan

Alberto Passi
Hyaluronan Book PDF

Author : Alberto Passi
Publisher : Springer Nature
Page : 220 pages
File Size : 45,7 Mb
Release : 2023-06-22
Category : Science
ISBN : 9783031303005

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Hyaluronan by Alberto Passi Pdf

This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA). The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored. This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Chemistry and Biology of Hyaluronan

Hari G. Garg,Charles A. Hales
Chemistry and Biology of Hyaluronan Book PDF

Author : Hari G. Garg,Charles A. Hales
Publisher : Elsevier
Page : 625 pages
File Size : 46,6 Mb
Release : 2004-07-14
Category : Science
ISBN : 9780080472225

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Chemistry and Biology of Hyaluronan by Hari G. Garg,Charles A. Hales Pdf

It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow. Expertly written by leading scientists in the field, this book provides readers with a broad, yet detailed review of the chemistry of hyaluronan, and the role it plays in human biology and pathology. Twenty-seven chapters present a sequence leading from the chemistry and biochemistry of hyaluronan, followed by its role in various pathological conditions, to modified hylauronans as potential therapeutic agents and finally to the functional, structural and biological properties of hyaluronidases. Chemistry and Biology of Hyaluronan covers the many interesting facets of this fascinating molecule, and all chapters are intended to reach the wider research community. Comprehensive look at the chemistry and biology of hyaluronans Essential to Chemists, Biochemists and Medical researchers Broad yet detailed review of this rapidly growing research area

The Biology of Hyaluronan

David Evered,Julie Whelan
The Biology of Hyaluronan Book PDF

Author : David Evered,Julie Whelan
Publisher : John Wiley & Sons
Page : 308 pages
File Size : 53,8 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470513781

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The Biology of Hyaluronan by David Evered,Julie Whelan Pdf

Presents state-of-the-art applications in hyaluronan research, from hyaluronan's physicochemical properties to its clinical role as a connective tissue marker and its surgical implications, particularly in ear, eye and orthopaedic surgery. Covers hyaluronan's synthesis and catabolism, its role in cells, its interactions with specific binding proteins, and its role in the embryonic nervous system.

Hyaluronic Acid

V. N. Khabarov,P. Y. Boykov,M. A. Selyanin
Hyaluronic Acid Book PDF

Author : V. N. Khabarov,P. Y. Boykov,M. A. Selyanin
Publisher : John Wiley & Sons
Page : 228 pages
File Size : 42,5 Mb
Release : 2015-03-16
Category : Science
ISBN : 9781118633793

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Hyaluronic Acid by V. N. Khabarov,P. Y. Boykov,M. A. Selyanin Pdf

Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical–chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.

The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives

T. C. Laurent
The Chemistry Biology and Medical Applications of Hyaluronan and Its Derivatives Book PDF

Author : T. C. Laurent
Publisher : Portland Press, London
Page : 368 pages
File Size : 44,8 Mb
Release : 1998
Category : Hyaluronic acid
ISBN : CORNELL:31924081103859

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The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives by T. C. Laurent Pdf

The aim of this book is to collect within one volume information on hyaluronan. This polysaccharide has received rapid attention for two reasons: it has important regulative functions within cell biology; and it has become a commercially important product because of its use in ophthalmic surgery and treatment of joint diease. A number of other practical applications are also discussed. The book covers various aspects of hyaluronan from the structure and chemistry of the polymer to its metabolism, cell biological interactions, behaviour in pathological processes, and potentially new medical applications.

Extracellular Matrix in Tumor Biology

Rolf A. Brekken,Dwayne Stupack
Extracellular Matrix in Tumor Biology Book PDF

Author : Rolf A. Brekken,Dwayne Stupack
Publisher : Springer
Page : 115 pages
File Size : 46,9 Mb
Release : 2017-08-04
Category : Medical
ISBN : 9783319609072

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Extracellular Matrix in Tumor Biology by Rolf A. Brekken,Dwayne Stupack Pdf

This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.

Role of Cancer Stem Cells in Cancer Biology and Therapy

Thomas Dittmar,Kurt S. Zänker
Role of Cancer Stem Cells in Cancer Biology and Therapy Book PDF

Author : Thomas Dittmar,Kurt S. Zänker
Publisher : CRC Press
Page : 334 pages
File Size : 55,6 Mb
Release : 2013-03-01
Category : Medical
ISBN : 9781466577350

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Role of Cancer Stem Cells in Cancer Biology and Therapy by Thomas Dittmar,Kurt S. Zänker Pdf

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.

Essentials of Glycobiology

Ajit Varki,Maarten J. Chrispeels
Essentials of Glycobiology Book PDF

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 46,5 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Tumor Microenvironment

Alexander Birbrair
Tumor Microenvironment Book PDF

Author : Alexander Birbrair
Publisher : Springer
Page : 181 pages
File Size : 46,5 Mb
Release : 2020-05-24
Category : Medical
ISBN : 3030401456

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Tumor Microenvironment by Alexander Birbrair Pdf

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Molecular Regulation of Endocytosis

Brian Ceresa
Molecular Regulation of Endocytosis Book PDF

Author : Brian Ceresa
Publisher : BoD – Books on Demand
Page : 470 pages
File Size : 48,9 Mb
Release : 2012-07-06
Category : Science
ISBN : 9789535106623

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Molecular Regulation of Endocytosis by Brian Ceresa Pdf

Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.

Cancer

Gary S. Stein,Kimberly P. Luebbers
Cancer Book PDF

Author : Gary S. Stein,Kimberly P. Luebbers
Publisher : John Wiley & Sons
Page : 708 pages
File Size : 45,6 Mb
Release : 2019-09-18
Category : Science
ISBN : 9781118962886

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Cancer by Gary S. Stein,Kimberly P. Luebbers Pdf

A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.

Nanomaterials for Cancer Therapy

Challa S. S. R. Kumar
Nanomaterials for Cancer Therapy Book PDF

Author : Challa S. S. R. Kumar
Publisher : Wiley-VCH
Page : 448 pages
File Size : 54,5 Mb
Release : 2006-07-24
Category : Medical
ISBN : UOM:39015064903340

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Nanomaterials for Cancer Therapy by Challa S. S. R. Kumar Pdf

This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.

Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer

Anonim
Interaction Between Hyaluronic Acid and Its Receptors CD44 RHAMM Regulates the Activity of Inflammation and Cancer Book PDF

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 44,6 Mb
Release : 2016
Category : Electronic
ISBN : OCLC:1368423593

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Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer by Anonim Pdf

The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat with cell surface CD44, in contrast to the interaction of short tissue HA (less than 3000 kDa) with the mouse CD44, makes the difference. More specifically, this communication shows that the interaction of short HA with fibroblasts' CD44 imposes on them susceptibility for malignant transformation, whereas the corresponding interaction with long HA imposes on the fibroblasts a resistance to malignant transformation. The article does not explain the mechanism that underlines these findings. However, the articles, that will be published in the proposed Research Topic in the Inflammation section of Frontiers in Immunology, can bridge not only this gap, but also may explain why interaction between short HA and cell surface CD44 (or RHAMM, an additional HA receptor) enhances the development of inflammatory and malignant diseases. Furthermore, the articles included in the proposed Frontiers Research Topic will show that cancer cells and inflammatory cells share several properties related to the interaction between short HA and cell surface CD44 and/or RHAMM. These shared properties include: 1. Support of cell migration, which allows tumor metastasis and accumulation of inflammatory cells at the inflammation site; 2. Delivery of intracellular signaling, which leads to cell survival of either cancer cells or inflammatory cells; 3. Delivery of intracellular signaling, which activates cell replication and population expansion of either cancer cells or inflammatory cells; and 4. Binding of growth factors to cell surface CD44 of cancer cells or inflammatory cells (i.e., the growth factors) and their presentation to cells with cognate receptors (endothelial cells, fibroblasts), leading to pro-malignant or pro-inflammatory activities. Going back to the naked mole rat story, we may conclude from the proposed articles of this Frontiers Research Topic that the long HA, which displays anti-malignant effect, interferes with the above described pro-malignant potential of the short HA (perhaps by competing on the same CD44 receptor). Extrapolating this concept to Inflammation, the same mechanism (competition?) may be valid for inflammatory (and autoimmune) activities. If this is the case, long HA may be used for therapy of both malignant and inflammatory diseases. Moreover, targeting the interaction between short HA and CD44 (e.g. by anti-CD44 blocking antibodies) may display also a therapeutic effect on both malignant and inflammatory diseases, an issue that encourages not only fruitful exchange of views, but also practical experimental collaboration.