Hyaluronic Acid

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Hyaluronic Acid

V. N. Khabarov,P. Y. Boykov,M. A. Selyanin
Hyaluronic Acid Book PDF

Author : V. N. Khabarov,P. Y. Boykov,M. A. Selyanin
Publisher : John Wiley & Sons
Page : 228 pages
File Size : 48,5 Mb
Release : 2015-03-16
Category : Science
ISBN : 9781118633793

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Hyaluronic Acid by V. N. Khabarov,P. Y. Boykov,M. A. Selyanin Pdf

Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical–chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.

Interaction between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer

David Naor
Interaction between Hyaluronic Acid and Its Receptors CD44 RHAMM Regulates the Activity of Inflammation and Cancer Book PDF

Author : David Naor
Publisher : Frontiers Media SA
Page : 220 pages
File Size : 48,6 Mb
Release : 2016-07-18
Category : Immunologic diseases. Allergy
ISBN : 9782889199136

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Interaction between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer by David Naor Pdf

The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat with cell surface CD44, in contrast to the interaction of short tissue HA (less than 3000 kDa) with the mouse CD44, makes the difference. More specifically, this communication shows that the interaction of short HA with fibroblasts’ CD44 imposes on them susceptibility for malignant transformation, whereas the corresponding interaction with long HA imposes on the fibroblasts a resistance to malignant transformation. The article does not explain the mechanism that underlines these findings. However, the articles, that will be published in the proposed Research Topic in the Inflammation section of Frontiers in Immunology, can bridge not only this gap, but also may explain why interaction between short HA and cell surface CD44 (or RHAMM, an additional HA receptor) enhances the development of inflammatory and malignant diseases. Furthermore, the articles included in the proposed Frontiers Research Topic will show that cancer cells and inflammatory cells share several properties related to the interaction between short HA and cell surface CD44 and/or RHAMM. These shared properties include: 1. Support of cell migration, which allows tumor metastasis and accumulation of inflammatory cells at the inflammation site; 2. Delivery of intracellular signaling, which leads to cell survival of either cancer cells or inflammatory cells; 3. Delivery of intracellular signaling, which activates cell replication and population expansion of either cancer cells or inflammatory cells; and 4. Binding of growth factors to cell surface CD44 of cancer cells or inflammatory cells (i.e., the growth factors) and their presentation to cells with cognate receptors (endothelial cells, fibroblasts), leading to pro-malignant or pro-inflammatory activities. Going back to the naked mole rat story, we may conclude from the proposed articles of this Frontiers Research Topic that the long HA, which displays anti-malignant effect, interferes with the above described pro-malignant potential of the short HA (perhaps by competing on the same CD44 receptor). Extrapolating this concept to Inflammation, the same mechanism (competition?) may be valid for inflammatory (and autoimmune) activities. If this is the case, long HA may be used for therapy of both malignant and inflammatory diseases. Moreover, targeting the interaction between short HA and CD44 (e.g. by anti-CD44 blocking antibodies) may display also a therapeutic effect on both malignant and inflammatory diseases, an issue that encourages not only fruitful exchange of views, but also practical experimental collaboration.

Hyaluronic Acid

Riia Rautiola
Hyaluronic Acid Book PDF

Author : Riia Rautiola
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2020-03
Category : Hyaluronic acid
ISBN : 1536170593

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Hyaluronic Acid by Riia Rautiola Pdf

Hyaluronic acid, or hyaluronan, is a water soluble, anionic extracellular matrix glycosaminoglycan polymer with variable molecular weight that determines its physiological role, rheological properties and applications. Since its discovery in the early 1930s, there has been an increased awareness concerning the biology of hyaluronic acid, its signaling pathways and its role in the biomedical and cosmeceutical industry. Being an endogenous molecule, hyaluronic acid is biocompatible, biodegradable, and has strong mucoadhesive, viscoelastic properties. The authors provide chemical modification approaches to hyaluronic acid, as well as address the magnitude of applications of hyaluronic acid-based targeted drug vectors and patents. The closing study discusses glycosaminoglycans, a specialized group of unbranched, anionic disaccharide polymers attached by a covalent linkage to the membrane proteins via sulphate groups in their sugar moieties.

Hyaluronic Acid for Biomedical and Pharmaceutical Applications

Maurice N Collins
Hyaluronic Acid for Biomedical and Pharmaceutical Applications Book PDF

Author : Maurice N Collins
Publisher : Smithers Rapra
Page : 238 pages
File Size : 53,6 Mb
Release : 2014-10-09
Category : Medical
ISBN : 9781909030787

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Hyaluronic Acid for Biomedical and Pharmaceutical Applications by Maurice N Collins Pdf

Hyaluronic acid (HA) is found in extracellular tissue in many parts of the body. It is a material of increasing importance to biomaterials science and is finding applications in diverse areas ranging from tissue culture scaffolds to cosmetic materials. Its properties, both physical and biochemical, in solution or hydrogel form, are extremely attractive for various technologies concerned with body repair. This book considers the materials science behind some of the important biomedical and therapeutic applications that are emerging for HA. Key characteristics such as its mechanical properties, biological function and degradation are discussed. The latest technologies in chemical modification and crosslinking strategies are analysed and emerging applications in soft and hard tissue repair are highlighted. The first objective of the book, which consists of a collection of chapters from leading researchers across the globe, is to highlight the role of HA based hydrogels as scaffolds in sustaining stem cells for transplantation and regrowth. The second objective is to detail the significant influence of HA derived materials in the latest advances in cancer therapy, general therapeutics and cosmetics. The third objective is to link the structure-property relationships of HA to medical function and application while reflecting on current clinical and market trends. The book will be of interest to those involved in HA research for medical device and therapeutic applications. Graduate and undergraduate students engaged in the fields of biomedical engineering, materials science, chemistry, medical science, pharmaceutical science and polymer science will find this book of particular interest.

The Hyaluronic Acid Miracle

Dr. Chris Meletis,David Rousett
The Hyaluronic Acid Miracle Book PDF

Author : Dr. Chris Meletis,David Rousett
Publisher : SCB Distributors
Page : 200 pages
File Size : 42,8 Mb
Release : 2012-05-24
Category : Health & Fitness
ISBN : 9781893910874

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The Hyaluronic Acid Miracle by Dr. Chris Meletis,David Rousett Pdf

Now for the first time the anti-aging secrets of the world’s most exciting rejuvenation molecule are revealed by two of the leading experts. For healthy eyes, heart, joints and more, bio-identical, high molecular weight hyaluronic acid should be a key part of your dietary supplement program. When used topically,women across America have found the natural alternative to Botox. Learn how this true anti-aging miracle can... •Give anyone an instant facelift •Replace Botox injections •Offer full plump lips and skin •Thicken your hair •Improve your vision and eliminate floaters •Provide the cushioning fluid your joints need to move free •Improve your heart and circulatory health

Tissue Engineering

John P. Fisher
Tissue Engineering Book PDF

Author : John P. Fisher
Publisher : Springer Science & Business Media
Page : 465 pages
File Size : 54,8 Mb
Release : 2007-12-31
Category : Technology & Engineering
ISBN : 9780387341330

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Tissue Engineering by John P. Fisher Pdf

This special issue of the Advances in Experimental Medicine and Biology presents much of the research described at the recent 2nd International Tissue Engineering Conference held in Crete in May 2005. The conference brought together over 150 researchers from around the world to examine the emerging and most advanced aspects of their particular field. The chapters reflect a diverse group of authors, including both clinicians and academicians.

Developmental and Cellular Skeletal Biology

Brian K. Hall
Developmental and Cellular Skeletal Biology Book PDF

Author : Brian K. Hall
Publisher : Academic Press
Page : 315 pages
File Size : 44,8 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483267210

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Developmental and Cellular Skeletal Biology by Brian K. Hall Pdf

Developmental and Cellular Skeletal Biology reviews the development, growth, and cell biology of the skeleton. The monograph provides a comprehensive overview of the aspects of skeletal biology, focusing mainly on the cellular level. It covers topics on the types of skeletal tissues, its evolution, and origin; location of the skeleton within the embryo; initiation of centers of skeletogenesis; and the initiation of skeletal growth. The book will be of great use to physiologists, cell biologists, hematologists, pathologists, orthopedic surgeons, and others whose professions are concerned with the study of the skeletal system.

Glycoconjugate Research

John Gregory
Glycoconjugate Research Book PDF

Author : John Gregory
Publisher : Elsevier
Page : 622 pages
File Size : 46,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323140935

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Glycoconjugate Research by John Gregory Pdf

Glycoconjugate Research, Volume I contains the proceedings of the Fourth International Symposium on Glycoconjugates, held in Woods Hole, Massachusetts, in September 1977. Contributors focus on the state of knowledge in the field of glycoconjugates ranging from polysaccharides and glycoproteins to glycolipids, proteoglycans, and all their varieties in plants, animals, and microorganisms. This text is organized into three sections and consists of 87 chapters. After an introductory chapter where the use of glycosidases for the structural analysis of complex carbohydrates is described, the discussion turns to other methods used for elucidating the structure of complex carbohydrates. The chapters that follow focus on the primary structure and conformation of glycans that are N-glycosically linked to peptide chains; isolation of monofuco-disialoganglioside from human and bovine brains; and partial chemical characterization of activated peptides isolated from a single cell suspension of rat colonic secretory cells. The last two sections explore cartilage proteoglycans and the structure-function relationships of glycoconjugates, touching on topics such as link proteins; the biochemical aspects of malignancy in human chondrosarcomas; defensive response of plants to a microbial oligosaccharide with a pheromone-like activity; and the interaction of saccharides with ricin. This book is intended for students and practitioners of chemistry and biochemistry; biology and microbiology; and physiology.

The Hyaluronic Acid Miracle

Chris D. Meletis,Dr Chris Meletis, Dr,David Rousett
The Hyaluronic Acid Miracle Book PDF

Author : Chris D. Meletis,Dr Chris Meletis, Dr,David Rousett
Publisher : Unknown
Page : 0 pages
File Size : 55,8 Mb
Release : 2010-09
Category : Aging
ISBN : 1893910695

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The Hyaluronic Acid Miracle by Chris D. Meletis,Dr Chris Meletis, Dr,David Rousett Pdf

A complete guide to the world's most exciting anti-aging compound for flexible joints, vibrant skin and a healthy heart. Now, for the first time, the anti-aging secrets of hyaluronic acid are revealed by two of the leading experts. Learn how hyaluronic acid can: *Give anyone an instant facelift *Replace a Botox injection *Offer full, plump lips and skin *Thicken your hair *Improve your vision and eliminate floaters *Provide the cushioning fluid your joints need to move freely *Improve your heart and circulatory health

Minimally Invasive Aesthetic Procedures

Adilson Da Costa
Minimally Invasive Aesthetic Procedures Book PDF

Author : Adilson Da Costa
Publisher : Springer Nature
Page : 817 pages
File Size : 44,8 Mb
Release : 2020-02-24
Category : Medical
ISBN : 9783319782652

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Minimally Invasive Aesthetic Procedures by Adilson Da Costa Pdf

Minimally invasive aesthetic procedures are an important part of dermatologists’ day-to-day clinical routine. However, plastic surgeons are also becoming more willing to explore them, and minimally invasive cosmetic and aesthetic procedures are now an established interdisciplinary topic. Minimally Invasive Aesthetic Procedures - A Guide for Dermatologists and Plastic Surgeons addresses the needs of both these specialties. It provides a comprehensive overview of the most relevant and widely used minimally invasive procedures, presented in a practical and straightforward style. Rather than a broad overview of the literature, it offers a step-by-step guide to clinical procedures. Each chapter explores a single clinical procedure, discussing the theoretical basis; the materials needed; the methods and techniques; clinical follow-up; before-and-after illustrations; as well as the side effects and complications and their management. It also includes a summary of tips and relevant references. With more than a hundred procedures presented and discussed in a clinically applicable format, Minimally Invasive Aesthetic Procedures - A Guide for Dermatologists and Plastic Surgeons is a practical manual for all dermatology and plastic surgery practitioners who are interested in aesthetic medicine.

Practical Aspects of Hyaluronan Based Medical Products

J.W. Kuo
Practical Aspects of Hyaluronan Based Medical Products Book PDF

Author : J.W. Kuo
Publisher : CRC Press
Page : 238 pages
File Size : 52,6 Mb
Release : 2005-09-23
Category : Medical
ISBN : 9781420037647

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Practical Aspects of Hyaluronan Based Medical Products by J.W. Kuo Pdf

The ballooning body of research devoted to hyaluronan (HA) reflects its enormous potential for various medical applications. There have been many successes of varying degrees in the development of medical products based on HA, but also some setbacks. While there is obviously ample information available on the chemistry and various properties of thi

Instructional Course Lectures: Volume 71

Eric Strauss,Brian Galinat
Instructional Course Lectures Volume 71 Book PDF

Author : Eric Strauss,Brian Galinat
Publisher : Lippincott Williams & Wilkins
Page : 1081 pages
File Size : 47,5 Mb
Release : 2022-01-10
Category : Medical
ISBN : 9781975189877

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Instructional Course Lectures: Volume 71 by Eric Strauss,Brian Galinat Pdf

Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Eric J. Strauss, MD, FAAOS (editor) and Brian J. Galinat, MD, MBA, FAAOS (assistant editor), Instructional Course Lectures, Volume 71 offers solutions for the most current issues and challenges faced at all stages of your career. Filled with current, clinically relevant presentations and approaches, the book broadens your treatment options with experience-based solutions from today’s most respected surgeons and specialty experts. Based on selected Instructional Course Lectures presented at the AAOS Annual Meeting 2021 in San Diego Lead innovation and raise the standard of care in your operating room with new techniques and proven practical approaches. Expand and refresh your general orthopaedic, specialty, and practice knowledge Learn new approaches and surgical techniques from thought leaders Update your action plans for rehabilitative care with expert insights Review new techniques for solving the tough challenges you encounter in your practice every day Chapters are abundantly illustrated with radiographs, drawings, and intraoperative photographs. Some chapters are enhanced with video that bring the techniques to life

Chemistry and Biology of Hyaluronan

Hari G. Garg,Charles A. Hales
Chemistry and Biology of Hyaluronan Book PDF

Author : Hari G. Garg,Charles A. Hales
Publisher : Elsevier
Page : 625 pages
File Size : 55,5 Mb
Release : 2004-07-14
Category : Science
ISBN : 9780080472225

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Chemistry and Biology of Hyaluronan by Hari G. Garg,Charles A. Hales Pdf

It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow. Expertly written by leading scientists in the field, this book provides readers with a broad, yet detailed review of the chemistry of hyaluronan, and the role it plays in human biology and pathology. Twenty-seven chapters present a sequence leading from the chemistry and biochemistry of hyaluronan, followed by its role in various pathological conditions, to modified hylauronans as potential therapeutic agents and finally to the functional, structural and biological properties of hyaluronidases. Chemistry and Biology of Hyaluronan covers the many interesting facets of this fascinating molecule, and all chapters are intended to reach the wider research community. Comprehensive look at the chemistry and biology of hyaluronans Essential to Chemists, Biochemists and Medical researchers Broad yet detailed review of this rapidly growing research area

The Biology of Hyaluronan

David Evered,Julie Whelan
The Biology of Hyaluronan Book PDF

Author : David Evered,Julie Whelan
Publisher : John Wiley & Sons
Page : 308 pages
File Size : 44,8 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470513781

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The Biology of Hyaluronan by David Evered,Julie Whelan Pdf

Presents state-of-the-art applications in hyaluronan research, from hyaluronan's physicochemical properties to its clinical role as a connective tissue marker and its surgical implications, particularly in ear, eye and orthopaedic surgery. Covers hyaluronan's synthesis and catabolism, its role in cells, its interactions with specific binding proteins, and its role in the embryonic nervous system.

Systems of Nanovesicular Drug Delivery

Amit Kumar Nayak,Md Saquib Hasnain,Tejraj M. Aminabhavi,Vladimir P. Torchilin
Systems of Nanovesicular Drug Delivery Book PDF

Author : Amit Kumar Nayak,Md Saquib Hasnain,Tejraj M. Aminabhavi,Vladimir P. Torchilin
Publisher : Academic Press
Page : 469 pages
File Size : 40,9 Mb
Release : 2022-07-16
Category : Medical
ISBN : 9780323914222

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Systems of Nanovesicular Drug Delivery by Amit Kumar Nayak,Md Saquib Hasnain,Tejraj M. Aminabhavi,Vladimir P. Torchilin Pdf

Systems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applications of various nanovesicles. This volume discusses cubosomes, proniosomes and niosomes, dendrimerosomes and other new and effective approaches for drug delivery. It will be a valuable title and resource for academics and pharmaceutical scientists, including industrial pharmacists, analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailor-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource. Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables