Imaging And Monitoring Astrocytes In Health And Disease

Author : Carole Escartin, Keith Murai
Publisher : Frontiers Media SA
Page : 190 pages
File Size : 49,7 Mb
Release : 2014-11-25
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889193936

Get Book

Imaging and monitoring astrocytes in health and disease by Carole Escartin, Keith Murai Pdf

Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the functional impact of astrocyte reactivity is still unclear. During the last decades, the development of innovative approaches to study astrocytes has significantly improved our understanding of their prominent role in brain function and their contribution to disease states. In particular, new genetic tools, molecular probes, and imaging techniques that achieve high spatial and temporal resolution have revealed new insight into astrocyte functions in situ. This Research Topic provides a collection of cutting-edge techniques, approaches and models to study astrocytes in health and disease. It also suggests new directions to achieve discoveries on these fascinating cells.

Author : Eric Boué-Grabot,David Blum,Stefania Ceruti
Publisher : Frontiers Media SA
Page : 330 pages
File Size : 48,7 Mb
Release : 2020-03-13
Category : Electronic
ISBN : 9782889635566

Get Book

Purinergic Signaling in Health and Disease by Eric Boué-Grabot,David Blum,Stefania Ceruti Pdf

Author : Katerina Dorovini-Zis
Publisher : CRC Press
Page : 394 pages
File Size : 43,5 Mb
Release : 2015-10-21
Category : Medical
ISBN : 9781498727099

Get Book

The Blood-Brain Barrier in Health and Disease, Volume Two by Katerina Dorovini-Zis Pdf

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Author : Stuart J. McDougall,Heike Münzberg, Andrei V. Derbenev, Andrea Zsombok
Publisher : Frontiers Media SA
Page : 94 pages
File Size : 54,8 Mb
Release : 2015-06-30
Category : Disease control
ISBN : 9782889194759

Get Book

Central control of autonomic functions in health and disease by Stuart J. McDougall,Heike Münzberg, Andrei V. Derbenev, Andrea Zsombok Pdf

The field of autonomic neuroscience research concentrates on those neural pathways and processes that ultimately modulate parasympathetic and sympathetic output to alter peripheral organ function. In the following ebook, laboratories from across the field have contributed reviews and original research to summarize current views on the role of the brain in tuning peripheral organ performance to regulate body temperature, glucose homeostasis and blood pressure.

Author : Margaret S. Ho,Alexei Verkhratsky,Shumin Duan,Vladimir Parpura
Publisher : Frontiers Media SA
Page : 385 pages
File Size : 50,7 Mb
Release : 2019-08-16
Category : Electronic
ISBN : 9782889458509

Get Book

Glia in Health and Disease by Margaret S. Ho,Alexei Verkhratsky,Shumin Duan,Vladimir Parpura Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Firas H. Kobeissy
Publisher : CRC Press
Page : 718 pages
File Size : 55,7 Mb
Release : 2015-02-25
Category : Medical
ISBN : 9781466565999

Get Book

Brain Neurotrauma by Firas H. Kobeissy Pdf

With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.

Author : Tania Spohr
Publisher : BoD – Books on Demand
Page : 164 pages
File Size : 46,5 Mb
Release : 2020-05-20
Category : Science
ISBN : 9781789852530

Get Book

Glia in Health and Disease by Tania Spohr Pdf

The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.

Author : Victor R. Preedy
Publisher : Springer Science & Business Media
Page : 3113 pages
File Size : 52,8 Mb
Release : 2011-12-02
Category : Medical
ISBN : 9781441917942

Get Book

Handbook of Growth and Growth Monitoring in Health and Disease by Victor R. Preedy Pdf

Growth is one of the human body’s most intricate processes: each body part or region has its own unique growth patterns. Yet at the individual and population levels, growth patterns are sensitive to adverse conditions, genetic predispositions, and environmental changes. And despite the body’s capacity to compensate for these developmental setbacks, the effects may be far-reaching, even life-long. The Handbook of Growth and Growth Monitoring in Health and Disease brings this significant and complex field together in one comprehensive volume: impact of adverse variables on growth patterns; issues at different stages of prenatal development, childhood, and adolescence; aspects of catch-up growth, endocrine regulation, and sexual maturation; screening and assessment methods; and international perspectives. Tables and diagrams, applications to other areas of health and disease, and summary points help make the information easier to retain. Together, these 140 self-contained chapters in 15 sections [ok?] cover every area of human growth, including: Intrauterine growth retardation. Postnatal growth in normal and abnormal situations. Cells and growth of tissues. Sensory growth and development. Effects of disease on growth. Methods and standards for assessment of growth, and more. The Handbook of Growth and Growth Monitoring in Health and Disease is an invaluable addition to the reference libraries of a wide range of health professionals, among them health scientists, physicians, physiologists, nutritionists, dieticians, nurses, public health researchers, epidemiologists, exercise physiologists, and physical therapists. It is also useful to college-level students and faculty in the health disciplines, and to policymakers and health economists.

Author : Anonim
Publisher : Academic Press
Page : 308 pages
File Size : 49,6 Mb
Release : 2021-07-09
Category : Science
ISBN : 9780128240359

Get Book

Inter-Organellar Ca2+ Signaling in Health and Disease - Part A by Anonim Pdf

Inter-Organellar Ca2+ Signaling in Health and Disease - Part A, Volume 362, the latest release in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Cell and Molecular Biology series Updated release includes the latest information on the topic of Inter-Organellar Ca2+ Signaling in Health and Disease - Part A

Author : Baoman Li,Vladimir Parpura,Alexei Verkhratsky,Caterina Scuderi
Publisher : Springer Nature
Page : 368 pages
File Size : 47,5 Mb
Release : 2021-12-09
Category : Medical
ISBN : 9783030773755

Get Book

Astrocytes in Psychiatric Disorders by Baoman Li,Vladimir Parpura,Alexei Verkhratsky,Caterina Scuderi Pdf

This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.

Author : Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess
Publisher : Springer Nature
Page : 252 pages
File Size : 51,5 Mb
Release : 2020-02-14
Category : Medical
ISBN : 9783030384906

Get Book

Diseases of the Brain, Head and Neck, Spine 2020–2023 by Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess Pdf

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Author : Vladimir Parpura,Philip G. Haydon
Publisher : Springer Science & Business Media
Page : 701 pages
File Size : 53,5 Mb
Release : 2008-12-11
Category : Medical
ISBN : 9780387794921

Get Book

Astrocytes in (Patho)Physiology of the Nervous System by Vladimir Parpura,Philip G. Haydon Pdf

Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.

Author : Jeffrey G. Tasker,Jaideep S. Bains,Julie A. Chowen
Publisher : Springer
Page : 0 pages
File Size : 44,8 Mb
Release : 2022-04-02
Category : Medical
ISBN : 3030623858

Get Book

Glial-Neuronal Signaling in Neuroendocrine Systems by Jeffrey G. Tasker,Jaideep S. Bains,Julie A. Chowen Pdf

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Marie-Ève Tremblay,Amanda Sierra
Publisher : Springer
Page : 490 pages
File Size : 52,8 Mb
Release : 2014-09-22
Category : Medical
ISBN : 9781493914296

Get Book

Microglia in Health and Disease by Marie-Ève Tremblay,Amanda Sierra Pdf

These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Author : C. Laura Sayas,Monica Mendes Sousa,Jesus Avila
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 42,7 Mb
Release : 2020-03-25
Category : Electronic
ISBN : 9782889635528

Get Book

Shaping the Brain by Neuronal Cytoskeleton: from Development to Disease and Regeneration by C. Laura Sayas,Monica Mendes Sousa,Jesus Avila Pdf