Immuno Systems Biology

Author : Kumar Selvarajoo
Publisher : Springer Science & Business Media
Page : 153 pages
File Size : 42,5 Mb
Release : 2013-10-01
Category : Medical
ISBN : 9781461476900

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Immuno Systems Biology by Kumar Selvarajoo Pdf

Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches. The book links complex immunological processes with computational analysis and emphasizes the importance of immunology to the mammalian system.

Author : Jim Wang
Publisher : Hayle Medical
Page : 0 pages
File Size : 45,6 Mb
Release : 2023-09-26
Category : Medical
ISBN : 1646475712

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Immuno Systems Biology by Jim Wang Pdf

The immune system refers to the network of biological processes that protect an organism from diseases. It recognizes and reacts to a wide range of pathogens including cancer cells, viruses and parasitic worms. The immune system is divided into two main subsystems, namely, the adaptive immune system and the innate immune system. The adaptive immune system recognizes the unique components of individual pathogens, whereas innate immune system recognizes the components shared by all pathogens. Antigens are the type of substances that are identified by the immune system and can subsequently trigger an immune response. A dysfunctional immune system can lead to cancer, autoimmune diseases, and inflammatory diseases. Immunodeficiency is caused when the immune system is not active, which leads to persistent and potentially fatal infections. This book is compiled in such a manner, that it will provide in-depth knowledge about immuno systems biology. It will prove to be immensely beneficial to students and researchers in this area of study.

Author : Jayajit Das,Ciriyam Jayaprakash
Publisher : CRC Press
Page : 405 pages
File Size : 42,9 Mb
Release : 2018-09-03
Category : Science
ISBN : 9781351646147

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Systems Immunology by Jayajit Das,Ciriyam Jayaprakash Pdf

"Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 50,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Lars Kaderali,Fabian Theis,Esteban A. Hernandez-Vargas,Vitaly V. Ganusov,Stanca M. Ciupe,Ramit Mehr,Ruy Ribeiro
Publisher : Frontiers Media SA
Page : 290 pages
File Size : 46,6 Mb
Release : 2019-04-09
Category : Electronic
ISBN : 9782889458011

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Integrative Computational Systems Biology Approaches in Immunology and Medicine by Lars Kaderali,Fabian Theis,Esteban A. Hernandez-Vargas,Vitaly V. Ganusov,Stanca M. Ciupe,Ramit Mehr,Ruy Ribeiro Pdf

Author : Katie Murphy
Publisher : States Academic Press
Page : 0 pages
File Size : 49,5 Mb
Release : 2023-09-26
Category : Medical
ISBN : 1639897801

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Immunology: A Systems Biology Perspective by Katie Murphy Pdf

The branch of biology and medicine that focuses on the study of immune systems in all organisms is termed as immunology. The basic purpose of studying the immune systems is to chart, measure and describing the functioning of the immune system in the state of health and disease. The study of immunology has a wide range of applications in different fields of medicine such as bacteriology, parasitology, psychiatry, oncology and organ transplantation. Immunological disorders can lead to immunodeficiency and autoimmune diseases. Immunodeficiency is a condition in which the organism's ability to fight infectious diseases and cancer is absent or is highly compromised. Autoimmune diseases are a result of abnormal immune response to a functioning part of the body. This book contains some path-breaking studies in the field of immunology. From theories to research to practical applications, case studies related to all contemporary topics of relevance to this field have been included herein. The book aims to serve as a resource guide for students and experts alike and contribute to the growth of the discipline.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 55,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Mahbuba Rahman
Publisher : Bentham Science Publishers
Page : 167 pages
File Size : 53,7 Mb
Release : 2016-06-07
Category : Medical
ISBN : 9781681083070

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Systems Biology in Cancer Immunotherapy by Mahbuba Rahman Pdf

Over the past decades, systems biology approaches have been applied in different areas of life science research including oncology. Researchers now understand the hallmarks of cancer cells such as abnormal cell growth, inflammation, dysregulated metabolic pathways and drug resistance properties at a molecular level. Systems biology approaches have enabled researchers to investigate cancer immunology by identifying cancer related biomarkers on immune cells, and to study the effect of different therapies in tissue cultures and mouse models. Systems Biology in Cancer Immunotherapy explains the scope of systems biology in understanding the immune response to neoplasms. The book introduces readers to the concepts crucial to cancer immunology before delving into the applied systems biology topics such as the metabolic pathways in cancer cells, the biomolecular roles of signal transduction molecules and their respective biochemical pathways ad cancer immunotherapy. A brief conclusion at the end also provides some information from a clinical and commercial perspective on cancer immunotherapy. This volume is intended as an introductory reference for life science and medical students, researchers and academics interested in the application of systems biology to the immune system in oncology research and chemotherapy practice.

Author : Xiangdong Wang
Publisher : Springer
Page : 177 pages
File Size : 43,8 Mb
Release : 2015-03-27
Category : Medical
ISBN : 9789401797535

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Single Cell Sequencing and Systems Immunology by Xiangdong Wang Pdf

The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

Author : Ole Lund,Morten Nielsen,Claus Lundegaard,Can Kesmir,Søren Brunak
Publisher : MIT Press
Page : 335 pages
File Size : 47,8 Mb
Release : 2024-02-06
Category : Computers
ISBN : 9780262551120

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Immunological Bioinformatics by Ole Lund,Morten Nielsen,Claus Lundegaard,Can Kesmir,Søren Brunak Pdf

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms. Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes. This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.

Author : Shailza Singh
Publisher : Springer
Page : 0 pages
File Size : 53,9 Mb
Release : 2021-04-25
Category : Medical
ISBN : 9811533520

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Systems and Synthetic Immunology by Shailza Singh Pdf

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.

Author : Dominik Wodarz
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 47,8 Mb
Release : 2007-04-05
Category : Mathematics
ISBN : 9780387687339

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Killer Cell Dynamics by Dominik Wodarz Pdf

This book reviews how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates, in a writing style that exemplifies the point, that such mathematical and computational approaches are most valuable when coupled with experimental work through interdisciplinary collaborations. Designed to be useful to immunoligists and viroligists without extensive computational background, the book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.

Author : Davide Malagoli
Publisher : Academic Press
Page : 384 pages
File Size : 46,6 Mb
Release : 2016-07-21
Category : Medical
ISBN : 9780128020135

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The Evolution of the Immune System by Davide Malagoli Pdf

The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors. Helps the reader gain a modern idea of the evolution of the immune systems in pluricellular organisms Provides a complete overview of the most studied and hot topics in comparative and evolutionary immunology Reflects the organisation of the immune system (cell-based, humoral [innate], humoral [adaptive]) without introducing further and misleading levels of organization Brings concepts and ideas on the evolution of the immune system to a wide readership

Author : Mahbuba Rahman
Publisher : Frontiers in Cancer Immunology
Page : 166 pages
File Size : 42,8 Mb
Release : 2016-06-07
Category : Medical
ISBN : 1681083086

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Frontiers in Cancer Immunology; Systems Biology in Cancer Immunotherapy by Mahbuba Rahman Pdf

Over the past decades, systems biology approaches have been applied in different areas of life science research including oncology. Researchers now understand the hallmarks of cancer cells such as abnormal cell growth, inflammation, dysregulated metabolic pathways and drug resistance properties at a molecular level. Systems biology approaches have enabled researchers to investigate cancer immunology by identifying cancer related biomarkers on immune cells, and to study the effect of different therapies in tissue cultures and mouse models. Systems Biology in Cancer Immunotherapy explains the scope of systems biology in understanding the immune response to neoplasms. The book introduces readers to the concepts crucial to cancer immunology before delving into the applied systems biology topics such as the metabolic pathways in cancer cells, the biomolecular roles of signal transduction molecules and immunotherapy. A brief conclusion at the end also provides some information from a clinical and commercial perspective on cancer immunotherapy. This volume is intended as an introductory reference for life science and medical students, researchers and academics interested in the application of systems biology to the immune system in cancer patients.

Author : Shailza Singh
Publisher : Springer Nature
Page : 273 pages
File Size : 48,9 Mb
Release : 2020-04-24
Category : Medical
ISBN : 9789811533501

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Systems and Synthetic Immunology by Shailza Singh Pdf

Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.