Immunology A Systems Biology Perspective

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Immunology: A Systems Biology Perspective

Katie Murphy
Immunology A Systems Biology Perspective Book PDF

Author : Katie Murphy
Publisher : States Academic Press
Page : 0 pages
File Size : 47,6 Mb
Release : 2023-09-26
Category : Medical
ISBN : 1639897801

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Immunology: A Systems Biology Perspective by Katie Murphy Pdf

The branch of biology and medicine that focuses on the study of immune systems in all organisms is termed as immunology. The basic purpose of studying the immune systems is to chart, measure and describing the functioning of the immune system in the state of health and disease. The study of immunology has a wide range of applications in different fields of medicine such as bacteriology, parasitology, psychiatry, oncology and organ transplantation. Immunological disorders can lead to immunodeficiency and autoimmune diseases. Immunodeficiency is a condition in which the organism's ability to fight infectious diseases and cancer is absent or is highly compromised. Autoimmune diseases are a result of abnormal immune response to a functioning part of the body. This book contains some path-breaking studies in the field of immunology. From theories to research to practical applications, case studies related to all contemporary topics of relevance to this field have been included herein. The book aims to serve as a resource guide for students and experts alike and contribute to the growth of the discipline.

Immuno Systems Biology

Kumar Selvarajoo
Immuno Systems Biology Book PDF

Author : Kumar Selvarajoo
Publisher : Springer Science & Business Media
Page : 153 pages
File Size : 54,5 Mb
Release : 2013-10-01
Category : Medical
ISBN : 9781461476900

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Immuno Systems Biology by Kumar Selvarajoo Pdf

Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches. The book links complex immunological processes with computational analysis and emphasizes the importance of immunology to the mammalian system.

The Science and Applications of Synthetic and Systems Biology

Institute of Medicine,Board on Global Health,Forum on Microbial Threats
The Science and Applications of Synthetic and Systems Biology Book PDF

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 52,5 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

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The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Systems Immunology

Jayajit Das,Ciriyam Jayaprakash
Systems Immunology Book PDF

Author : Jayajit Das,Ciriyam Jayaprakash
Publisher : CRC Press
Page : 405 pages
File Size : 52,6 Mb
Release : 2018-09-03
Category : Science
ISBN : 9781351646147

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Systems Immunology by Jayajit Das,Ciriyam Jayaprakash Pdf

"Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

Systems Biology

Michael G. Katze
Systems Biology Book PDF

Author : Michael G. Katze
Publisher : Springer Science & Business Media
Page : 278 pages
File Size : 53,5 Mb
Release : 2013-01-04
Category : Medical
ISBN : 9783642330995

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Systems Biology by Michael G. Katze Pdf

First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.

Osteoimmunopathology

Francesco Chiappelli
Osteoimmunopathology Book PDF

Author : Francesco Chiappelli
Publisher : Springer Science & Business Media
Page : 147 pages
File Size : 52,8 Mb
Release : 2011-05-30
Category : Medical
ISBN : 9781441994950

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Osteoimmunopathology by Francesco Chiappelli Pdf

Osteoimmunology pertains to the study of the relationship between the bones, particularly the bone marrow, and the immune system. This monograph pursues the best available evidence, by means of research synthesis, for the characterization of the physiological relevance and pathological implications of the inter-connectedness between the skeletal and the immune system. Research will be discussed that highlights the associated role of the circulatory, nervous and endocrine systems, as well as proteomic and genomic pathways and signatures. Emphasis is given that domain of medicine that relates to the oral cavity, its diseases and their systemic sequelae. This monograph arises from observations that have suggested that the skeletal system and the immune system are intimately intertwined. Chronic inflammatory reactions subsequent to an excessive immune reaction can damage the bones, as in rheumatoid arthritis (RA), osteoporosis, patients seropositive for the human immunodeficiency virus (HIV)-1 and with signs and symptoms of the acquired immune deficiency syndrome (AIDS), and bone cancer. Bones – in particular the bone marrow – are one of the primary locations in which cells of the immune system mature. In brief, this monograph begins to answer a range of questions, such as, what is osteoimmunology all about?, does the immune system and its components affect bone development?, how do stress hormones impact upon the pathophysiology of bone-immune interactions?, can the scientific process of research synthesis, obtain the best available evidence for treatment of diseases involving the bone-immune entity (i.e., osteo immunopathologies) means of evidence-based clinical decision-making directed at the treatment of osteoimmune pathologies?

Systems Biology in Cancer Immunotherapy

Mahbuba Rahman
Systems Biology in Cancer Immunotherapy Book PDF

Author : Mahbuba Rahman
Publisher : Bentham Science Publishers
Page : 167 pages
File Size : 52,9 Mb
Release : 2016-06-07
Category : Medical
ISBN : 9781681083070

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Systems Biology in Cancer Immunotherapy by Mahbuba Rahman Pdf

Over the past decades, systems biology approaches have been applied in different areas of life science research including oncology. Researchers now understand the hallmarks of cancer cells such as abnormal cell growth, inflammation, dysregulated metabolic pathways and drug resistance properties at a molecular level. Systems biology approaches have enabled researchers to investigate cancer immunology by identifying cancer related biomarkers on immune cells, and to study the effect of different therapies in tissue cultures and mouse models. Systems Biology in Cancer Immunotherapy explains the scope of systems biology in understanding the immune response to neoplasms. The book introduces readers to the concepts crucial to cancer immunology before delving into the applied systems biology topics such as the metabolic pathways in cancer cells, the biomolecular roles of signal transduction molecules and their respective biochemical pathways ad cancer immunotherapy. A brief conclusion at the end also provides some information from a clinical and commercial perspective on cancer immunotherapy. This volume is intended as an introductory reference for life science and medical students, researchers and academics interested in the application of systems biology to the immune system in oncology research and chemotherapy practice.

Systems Biology for Signaling Networks

Sangdun Choi
Systems Biology for Signaling Networks Book PDF

Author : Sangdun Choi
Publisher : Springer Science & Business Media
Page : 900 pages
File Size : 53,9 Mb
Release : 2010-08-09
Category : Science
ISBN : 9781441957979

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Systems Biology for Signaling Networks by Sangdun Choi Pdf

System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.

Single Cell Sequencing and Systems Immunology

Xiangdong Wang
Single Cell Sequencing and Systems Immunology Book PDF

Author : Xiangdong Wang
Publisher : Springer
Page : 177 pages
File Size : 49,5 Mb
Release : 2015-03-27
Category : Medical
ISBN : 9789401797535

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Single Cell Sequencing and Systems Immunology by Xiangdong Wang Pdf

The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

Frontiers in Cancer Immunology; Systems Biology in Cancer Immunotherapy

Mahbuba Rahman
Frontiers in Cancer Immunology Systems Biology in Cancer Immunotherapy Book PDF

Author : Mahbuba Rahman
Publisher : Frontiers in Cancer Immunology
Page : 166 pages
File Size : 49,8 Mb
Release : 2016-06-07
Category : Medical
ISBN : 1681083086

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Frontiers in Cancer Immunology; Systems Biology in Cancer Immunotherapy by Mahbuba Rahman Pdf

Over the past decades, systems biology approaches have been applied in different areas of life science research including oncology. Researchers now understand the hallmarks of cancer cells such as abnormal cell growth, inflammation, dysregulated metabolic pathways and drug resistance properties at a molecular level. Systems biology approaches have enabled researchers to investigate cancer immunology by identifying cancer related biomarkers on immune cells, and to study the effect of different therapies in tissue cultures and mouse models. Systems Biology in Cancer Immunotherapy explains the scope of systems biology in understanding the immune response to neoplasms. The book introduces readers to the concepts crucial to cancer immunology before delving into the applied systems biology topics such as the metabolic pathways in cancer cells, the biomolecular roles of signal transduction molecules and immunotherapy. A brief conclusion at the end also provides some information from a clinical and commercial perspective on cancer immunotherapy. This volume is intended as an introductory reference for life science and medical students, researchers and academics interested in the application of systems biology to the immune system in cancer patients.

Immunological Bioinformatics

Ole Lund,Morten Nielsen,Claus Lundegaard,Can Kesmir,Søren Brunak
Immunological Bioinformatics Book PDF

Author : Ole Lund,Morten Nielsen,Claus Lundegaard,Can Kesmir,Søren Brunak
Publisher : MIT Press
Page : 342 pages
File Size : 47,9 Mb
Release : 2005-06-17
Category : Computers
ISBN : 0262122804

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Immunological Bioinformatics by Ole Lund,Morten Nielsen,Claus Lundegaard,Can Kesmir,Søren Brunak Pdf

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms. Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes. This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.

Complex Systems and Computational Biology Approaches to Acute Inflammation

Yoram Vodovotz,Gary An
Complex Systems and Computational Biology Approaches to Acute Inflammation Book PDF

Author : Yoram Vodovotz,Gary An
Publisher : Springer Nature
Page : 307 pages
File Size : 48,7 Mb
Release : 2020-11-04
Category : Medical
ISBN : 9783030565107

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Complex Systems and Computational Biology Approaches to Acute Inflammation by Yoram Vodovotz,Gary An Pdf

This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.

Handbook of Systems Biology

Marian Walhout,Marc Vidal,Job Dekker
Handbook of Systems Biology Book PDF

Author : Marian Walhout,Marc Vidal,Job Dekker
Publisher : Academic Press
Page : 553 pages
File Size : 46,5 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780123859457

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Handbook of Systems Biology by Marian Walhout,Marc Vidal,Job Dekker Pdf

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Phylogenetic Perspectives on the Vertebrate Immune System

Gregory Becker,Manickam Sugumaran,Edwin L. Cooper
Phylogenetic Perspectives on the Vertebrate Immune System Book PDF

Author : Gregory Becker,Manickam Sugumaran,Edwin L. Cooper
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461512912

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Phylogenetic Perspectives on the Vertebrate Immune System by Gregory Becker,Manickam Sugumaran,Edwin L. Cooper Pdf

This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused gathering) allowed for participation by investigators at all levels of their careers. We further agreed that we should search for a forum that would allow this meeting to continue. The FASEB Summer Research Conference was an excellent vehicle for this type of meeting. Furthermore, this year's participants decided to continue this meeting as a regularly scheduled FASEB sponsored event. This was a unique conference in the sense that it focused upon mechanisms of development and defense in protostome and deuterostome invertebrates and lower vertebrates. There was a strong emphasis on evolutionary cell biology, phylogenetic inferences and the evolution of recognition and regulatory systems.

Conceptual Modelling in Computational Immunology

Martina Husáková
Conceptual Modelling in Computational Immunology Book PDF

Author : Martina Husáková
Publisher : Tomáš Bruckner
Page : 174 pages
File Size : 52,7 Mb
Release : 2015-09-10
Category : Computers
ISBN : 9788087924020

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Conceptual Modelling in Computational Immunology by Martina Husáková Pdf

Computational immunology offers in silico strategies for understanding of complex processes occurring in the natural immune system of a living organism that are difficult to explore by traditional in vivo or in vitro techniques. The monograph introduces conceptual languages and approaches for modelling biological processes. The Agent Modelling Language is investigated for conceptualisation of immune processes. AML-based diagrams represent properties and processes occurring in a lymph node.