Immunoconjugates

Author : Tak W. Mak,Mary E. Saunders
Publisher : Academic Press
Page : 464 pages
File Size : 55,6 Mb
Release : 2011-01-26
Category : Medical
ISBN : 9780123848888

Get Book

Primer to the Immune Response by Tak W. Mak,Mary E. Saunders Pdf

Primer to the Immune Response effectively presents complex immunological concepts. The book is divided into two parts, which cover basic immunology and clinical immunology. Part I presents the history and nature of immune response, and it describes the general features of the innate and adaptive immune responses. This part also explores the components of the immune system such as the cells and tissues. It also illustrates the intracellular communication through signal induction, intercellular communication through cytokines, and the cellular movement in the immune system. Furthermore, this part discusses proteins and genes, the development, activation and effector functions of both B cells and T cells. Part II focuses on clinical immunology and covers immunity to infection caused by extracellular and intracellular bacteria, viruses, parasites and fungi. This part also describes different kinds of diseases, such as the Acquired Immunodeficiency Syndrome caused by the Human Immunodeficiency virus, tumors, autoimmune diseases, and hematopoietic cancers. This part also includes discussions on vaccination, transplantation, and different types of immune hypersensitivity. Color illustrations enhance key topics and concepts

Author : Carl-Wilhelm Vogel
Publisher : Oxford University Press, USA
Page : 330 pages
File Size : 47,5 Mb
Release : 1987
Category : Medical
ISBN : UOM:39015012457548

Get Book

Immunoconjugates by Carl-Wilhelm Vogel Pdf

Immunoconjugate research aims to develop improved methods of cancer detection and more effective, efficient drugs to combat cancer. This book contains contributions from virtually all established research groups in the immunotoxin field and offers a comprehensive discussion of current and potential applications of immunoconjugates, covering all pertinent topics from chemical synthesis to clinical trial.

Author : Robert William Baldwin,Vera S. Byers,Ronald David Mann
Publisher : Parthenon Publishing
Page : 232 pages
File Size : 54,9 Mb
Release : 1990
Category : Antibody-drug conjugates
ISBN : UOM:39015019559700

Get Book

Monoclonal Antibodies and Immunoconjugates by Robert William Baldwin,Vera S. Byers,Ronald David Mann Pdf

Author : Elizabeth Garrett-Mayer,Manuel Hidalgo,S. Gail Eckhardt,Neil J. Clendeninn
Publisher : Springer Science & Business Media
Page : 673 pages
File Size : 55,6 Mb
Release : 2010-12-29
Category : Medical
ISBN : 9781441973580

Get Book

Principles of Anticancer Drug Development by Elizabeth Garrett-Mayer,Manuel Hidalgo,S. Gail Eckhardt,Neil J. Clendeninn Pdf

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Author : Michael Magerstadt
Publisher : CRC Press
Page : 246 pages
File Size : 47,7 Mb
Release : 1991-01-03
Category : Medical
ISBN : 0849360897

Get Book

Conjugates and Malignant Disease by Michael Magerstadt Pdf

This book provides a comprehensive overview of antibody conjugates for in vivo applications. It discusses each of the major classes of antibody conjugates used in cancer diagnosis and therapy, as well as the major chemical and biological aspects of antibody selection, conjugate preparation, characterization, and application. The book is designed to close the information gap that exists regarding these compounds between such diverse disciplines as radiochemists, immunochemists, oncologists, clinicians and immunologists. It also provides a thorough overview for newcomers to the field.

Author : Gail Lewis Phillips
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 44,6 Mb
Release : 2012-12-13
Category : Medical
ISBN : 9781461454564

Get Book

Antibody-Drug Conjugates and Immunotoxins by Gail Lewis Phillips Pdf

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

Author : Mark David Savellano
Publisher : Unknown
Page : 732 pages
File Size : 52,8 Mb
Release : 2000
Category : Electronic
ISBN : UOM:39015050182941

Get Book

Photodynamic Targeting with Photosensitizer Immunoconjugates by Mark David Savellano Pdf

Author : Steven T. Rosen,Timothy M. Kuzel
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530763

Get Book

Immunoconjugate Therapy of Hematologic Malignancies by Steven T. Rosen,Timothy M. Kuzel Pdf

The hybridoma technique for producing monoclonal antibodies, developed by Drs. Kohler and Millstein in 1975, revolutionized the field of tumor immunology. It is now clear that there are antigens associated with or restricted to human neoplasms that have biologic significance. Monoclonal antibodies have already been demonstrated to have great immunodiagnostic value and it is anticipated that they will become a component of our therapeutic armamentarium. Most investigators in the field, however, feel that the true potential of monoclonal antibodies in cancer therapy remains to be determined. Clearly the most encouraging results have been witnessed in the treatment of hematologic malignancies. This volume of CANCER TREATMENT AND RESEARCH explores the current state of the art of immunoconjugate therapy of hematologic malignancies. Immunoconjugate Therapy of Hematologic Malignancies provides an update of a rapidly advancing field. The preliminary experience of a number of investigators suggests a role for targeted therapy in the treatment of hematologic malignancies. At the present time, immunoconjugates have, in most instances, been reserved for patients with advanced refractory disease. However, it is anticipated in the future that these reagents will be utilized as a complement to traditional therapy or as post-remission consolidation in patients with minimal residual disease. The obstacles have been defined; solutions will require further research and creative imagination.

Author : Sergey Ilyin
Publisher : CRC Press
Page : 160 pages
File Size : 53,5 Mb
Release : 2007-08-27
Category : Medical
ISBN : 1420015680

Get Book

Functional Informatics in Drug Discovery by Sergey Ilyin Pdf

Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical

Author : Yashwant V. Pathak,Simon Benita
Publisher : John Wiley & Sons
Page : 542 pages
File Size : 54,7 Mb
Release : 2012-05-15
Category : Science
ISBN : 9780470612811

Get Book

Antibody-Mediated Drug Delivery Systems by Yashwant V. Pathak,Simon Benita Pdf

This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.

Author : Marc Damelin
Publisher : Springer
Page : 357 pages
File Size : 41,5 Mb
Release : 2018-05-29
Category : Medical
ISBN : 9783319781549

Get Book

Innovations for Next-Generation Antibody-Drug Conjugates by Marc Damelin Pdf

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Author : Shan S. Wong,David M. Jameson
Publisher : CRC Press
Page : 624 pages
File Size : 53,5 Mb
Release : 2011-10-10
Category : Medical
ISBN : 9780849374913

Get Book

Chemistry of Protein and Nucleic Acid Cross-Linking and Conjugation, Second Edition by Shan S. Wong,David M. Jameson Pdf

Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross-linking reagents, and advances have also been made in the area of biosensors and microarray biochips for the detection and analysis of genes, proteins, and carbohydrates. In addition, developments in physical techniques with unprecedented sensitivity and resolution have facilitated the analysis of cross-linked products. Updated to reflect the advances of the 21st century, this book offers: An overview of the chemical principles underlying the processes of cross-linking and conjugation A thorough list of cross-linking reagents published in the literature since the first edition, covering monofunctional, homobifunctional, heterobifunctional, multifunctional, and zero-length cross-linkers Reviews of the use of these reagents in studying protein tertiary structures, geometric arrangements of subunits within complex proteins and nucleic acids, near-neighbor analysis, protein-to-protein or ligand–receptor interactions, and conformational changes of biomolecules Discusses the application of immunoconjugation for immunoassays, immunotoxins for targeted therapy, microarray technology for analysis of various biomolecules, and solid state chemistry for immobilizations

Author : Roberto L. Ceriani
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461524434

Get Book

Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment by Roberto L. Ceriani Pdf

Today, advances in the area of immunology and breast cancer are made at an increasing rate, yielding an amount of information that can become unwieldy. The opportunity for scientists in this area of research to gather together to exchange results and working hypotheses represents, in my belief, a very attractive proposition. With this in mind, these workshops have been convened with two year intervals for the last ten years. In each of them, selected topics have been highlighted. The present workshop underscores the large advancements made in the molecular biology of both breast cancer associated antigens and their corresponding antibodies. Understanding the genetic information for the expression of these antigens has been recently advanced leading to preparation of molecularly engineered reagents for use in vaccination, serum assays, and immunizations for novel antibody production. In the anti-breast cancer antibody field the availability of molecular engineering approaches to humanize murine antibodies has induced intense interest in the creation of less immunogenic antibody forms that are now available for clinical testing. Clinical studies using anti-breast murine antibody continue to be carried out and are presented at this meeting establishing a base line for safety and efficaciousness in imaging and immunotherapy that it is hoped will be superseded by the humanized forms. Basic immunology and immunochemistry studies in breast cancer are also included in this workshop that demonstrate the fast pace at which this research is advancing in many laboratories worldwide.

Author : Shrikaant Kulkarni
Publisher : Springer Nature
Page : 376 pages
File Size : 55,7 Mb
Release : 2024-07-01
Category : Electronic
ISBN : 9789819725960

Get Book

Biosystems, Biomedical & Drug Delivery Systems by Shrikaant Kulkarni Pdf

Author : J. Gordon McVie,W. Bakker,Sj.Sc. Wagenaar,D. Carney
Publisher : Springer Science & Business Media
Page : 189 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400950368

Get Book

Clinical and Experimental Pathology of Lung Cancer by J. Gordon McVie,W. Bakker,Sj.Sc. Wagenaar,D. Carney Pdf

J. G. MCVIE The impact of therapy on one subset of lung cancer, the "small cell" type has been significant and lasting. The reality of cure for even a fraction of patients with this disease has caused reverberations in the pathology lab where the responsibili. '~y and challenge of diagnosis of this vital sub group lies. No less dramatic has been the discovery that the cell types of lung cancer have recognisable growth characteristics in serum free culture, they are recognisable by patterns of markers and some produce growth factors which autoregulate their eventual fate. Many of the discoveries from the biological studies have impacted on the pathologist in the form of disturbing evidence for a single stem cell origin for all the cell types of lung cancer and in the shape of new facilitation in diagnosis by appli cation of immunoperoxidase techniques. Monoclonal antibodies raised against oncogene products, growth factor receptor sites, "bystander" cell membrane proteins can all be applied to cytology specimens and frozen or paraffin fixed tissue sections to aid diagnosis and some can be used in sequential serum assay to monitor therapy and predict prognosis. Adding to these extraordinary tools, the sophistication of electron micro scopy and immuno-electrcn microscopy, new techniques for preparation of tissue and novel methods for studying vital cells in "kinesis", you sense the flavour of the future of lung cancer which is captured in this book.