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Immunology in the Twentieth Century by Domenico Ribatti Pdf
Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology. Provides a concise overhead of the history of immunology and its applications in medicine Includes a discussion of the scientists who were pioneers in landmark discoveries in immunology Summarizes the clinical applications of major discoveries
Immunology in the Twentieth Century by Domenico Ribatti Pdf
Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology.
A History of Modern Immunology by Zoltan A. Nagy Pdf
A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider details Gives an insight into personal aspects of the players in the history of immunology Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author
Immunity is as old as illness itself, yet historians have only just begun to take up the challenge of reconstructing the modern transformation of attempts to protect against disease. Crafting Immunity assembles in one volume the most recent efforts of an international group of scholars to place the diverse practices of immunity in their historical contexts. It is this diversity that provides the book with its greatest source of strength. Collectively, the papers in this volume suggest that it was the craft-like, small-scale, and local conditions of clinical medicine that turned the immunity of individuals and populations into biomedical objects. That is to say, the modern conception of immunity was at least as much the product of the work of healing as it was the systematic result of discoveries about the immune system. Working outside the narrow confines of laboratory histories, Crafting Immunity is the first attempt to set the problems of immunity into a variety of social, technological, institutional and intellectual contexts. It will appeal not only to historians and sociologists of health, but also to social and cultural historians interested in the biomedical creation of modern health regimens.
A History of Medical Bacteriology and Immunology by W. D. Foster Pdf
A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.
A Historical Perspective on Evidence-Based Immunology by Edward J. Moticka Pdf
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
A History of Transplantation Immunology by Leslie Brent Pdf
Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. Describes landmarks in immunology and places them in historical context Beautifully written by one of the founding fathers of the field Portrays the surprising history of events in a colorful and readable manner Contains biographical sketches of some of the pioneers Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation Foreword by Ray Owen
History of the Basel Institute for Immunology by Ivan Lefkovits Pdf
Lectures, Parties, and Nobel Prizes: living and researching at the Basel Institute for Immunology By the early seventies of the 20th century, the Basel Institute for Immunology had become one of the largest - and certainly the most prominent - immunology institutes in the world. Its lean structure was highly successful, and the quality of the research and its reputation remained outstandingly high throughout the three decades it existed. This book describes the institute's history from its conception and the laying of the foundation stone in 1969 by the pharmaceutical company Roche to the triumph of three Nobel Prizes (1984 and 1987) for Niels K. Jerne, Georges K�hler and Susumu Tonegawa. Can all this be portrayed to make the layman understand it and the scientist relish it? Indeed, the book succeeds in tuning in to what fascinates students, advanced researchers and scientists, historians, policy makers and philanthropists alike. The narrative reveals many aspects of the institute's life and also describes all its research and achievements. Immunologists at every level, from beginners to old hands, will find something of interest to them in this history, and some readers will even make use of the huge database (documents, pictures and films) linked to the book by hundreds of QR codes.
Basics and Fundamentals of Immunology by Manzoor Ahmad Mir Pdf
Immunology is a distinctive subject that rose in the mid-20th century. The subject developed as scientists started to unravel the mysteries about the defense system against pathogens. Researchers started to understand the mechanisms employed by the innate and the adaptive immune system in defense against pathogens. During the last decade, the subject of immunology has been in sharp focus as the immunotherapies against diseases like cancer and AIDS seems last hope. Employing the body's own defense system against diseases like cancer and AIDS by activating specific cells of the immune system looks promising, and therapies like CAR-T cell therapy have been approved. In the first edition of the book "The Fundamentals of Immunology" we have explained the basics of the defense system of our body. The book is organised into four volumes. The first volume comprises of ten chapters and it describes the rise, history and scope of immunology and the building blocks of the immune system viz., cells, molecules and organs of the immune system. The second chapter describes the cells of the innate and the adaptive immune system and how the granulocytes and macrophages employ defense mechanisms to protect the body against pathogenic invasions. In the third chapter of this book, we have described the organs of the immune systems and how different organs are involved in the differentiation and maturation of immune cells. The chapter also focused on the structure of lymph nodes and their function in concentrating the antigens. In chapter four of this book, we have described the terms like antigens, immunogens, antigenicity, immunogenicity and how immunogenicity of an antigen is affected and how antigenicity of an immunogens is related to the immune response. The innate and adaptive immune systems and the different types of cells and molecules employed by the two branches of immunity have been described in a separate chapter. The structure and biology of immunoglobulins, their types and function in antigen binding and antibody dependent cellular cytotoxicity (ADCC) have been described well in chapter six. Focus has been laid on the distinction between an antibody and an immunoglobulin. The structure and function and major histocompatibility complex (MHC) has been described. The education of cells about self and non-self during their maturation and the processing and presentation of antigens by MHC bearing cells and how MHC coordinates both humoral and cell-mediated immune responses has been explained well throughout the book. The book has explained the complement system and its components, mechanisms and functions in a separate chapter. At the end of the book, we have given an insight about the vaccines, their history, development and how they are useful and helpful in the defense against diseases. The book also discusses the immune disfunction and diseases associated with the dysregulation of immune responses.
Viruses, Pandemics, and Immunity by Arup K. Chakraborty,Andrey Shaw Pdf
How viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work. Throughout history, humans have contended with pandemics. History is replete with references to plagues, pestilence, and contagion, but the devastation wrought by pandemics had been largely forgotten by the twenty-first century. Now, the enormous human and economic toll of the rapidly spreading COVID-19 disease offers a vivid reminder that infectious disease pandemics are one of the greatest existential threats to humanity. This book provides an accessible explanation of how viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work-- concepts that are a foundation for our public health policies.
Institute of Medicine,Committee on Military Nutrition Research
Author : Institute of Medicine,Committee on Military Nutrition Research Publisher : National Academies Press Page : 723 pages File Size : 53,6 Mb Release : 1999-06-13 Category : Medical ISBN : 9780309063456
Military Strategies for Sustainment of Nutrition and Immune Function in the Field by Institute of Medicine,Committee on Military Nutrition Research Pdf
Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Author : Steven A. Frank Publisher : Princeton University Press Page : 364 pages File Size : 50,6 Mb Release : 2002-07-21 Category : Medical ISBN : 0691095957
Computational Immunology by Josep Bassaganya-Riera Pdf
Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. Offers case studies with different levels of complexity Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting