Immunotoxicology And Immunopharmacology

Author : H Dean Jack
Publisher : CRC Press
Page : 788 pages
File Size : 42,7 Mb
Release : 1994-06-30
Category : Medical
ISBN : 0781702194

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Immunotoxicology And Immunopharmacology by H Dean Jack Pdf

The second edition of this text has been revised and refocused to reflect the transformation of immunotoxicology from a subdiscipline of toxicology to an independent area of research that can best be described as "environmental immunology." New chapters discuss the role of immune mediators in liver, lung, and skin toxicity, in regulating chemical- metabolizing enzymes, and in the immunosuppression produced by ultraviolet light. More emphasis is placed on the clinical consequences of immunotoxicity, as well as the interpretation of experimental data for predicting, human health risk.; The second edition is divided into three major sections: immunosuppression, autoimmunity, and hypersensitivity. This new organization of the text allows for a more thorough treatment of these phenomena, with greater attention to test methods, theoretical considerations, and clinical implications. The book includes many chapters on specific environmental agents, therapeutic drugs, biological agents, and drugs of abuse, as well as on immune-mediated toxicity in specific organ systems.

Author : Frans P. Nijkamp,Michael J. Parnham
Publisher : Springer Science & Business Media
Page : 743 pages
File Size : 49,7 Mb
Release : 2011-09-01
Category : Medical
ISBN : 9783034601351

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Principles of Immunopharmacology by Frans P. Nijkamp,Michael J. Parnham Pdf

This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This third edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition.

Author : Emanuela Corsini,Henk Van Loveren
Publisher : John Wiley & Sons
Page : 355 pages
File Size : 41,5 Mb
Release : 2014-11-24
Category : Science
ISBN : 9783527335190

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Molecular Immunotoxicology by Emanuela Corsini,Henk Van Loveren Pdf

The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.

Author : Robert V. House,Robert Luebke,Ian Kimber
Publisher : CRC Press
Page : 672 pages
File Size : 44,8 Mb
Release : 2006-12-26
Category : Medical
ISBN : 0849337909

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Immunotoxicology and Immunopharmacology, Third Edition by Robert V. House,Robert Luebke,Ian Kimber Pdf

Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals.

Author : Robert V. House,Robert Luebke,Ian Kimber
Publisher : CRC Press
Page : 676 pages
File Size : 55,8 Mb
Release : 2006-12-26
Category : Medical
ISBN : 9781420005448

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Immunotoxicology and Immunopharmacology by Robert V. House,Robert Luebke,Ian Kimber Pdf

Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history,

Author : Anthony Dayan,R.F. Hertel,E. Heseltine,G. Kazantis,E.B. Smith
Publisher : Springer
Page : 330 pages
File Size : 47,7 Mb
Release : 2012-12-02
Category : Medical
ISBN : 1468484451

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Immunotoxicity of Metals and Immunotoxicology by Anthony Dayan,R.F. Hertel,E. Heseltine,G. Kazantis,E.B. Smith Pdf

Considerable scientific and political interest has been expressed, parallelling public concern about the effects of chemicals on the immune system and the implications of those effects for health. Coupled with speculation about the magnitude and extent of the problem is discussion of needs for predictive testing and regulatory control measures. The first international seminar on the immunological system as a target for toxic damage was held in Luxembourg in 1984. It was organized by the International Programme on Chemical Safety (United Nations Environment Programme-International Labour Office World Health Organization) and the Commission of the European Communities with the support of the US Environmental Protection Agency and the National Institute of Environmental Health Sciences (USA) and the participation of the International Society of Immunopharmacology. In view of the perceived importance of imrnunotoxicity, it was considered necessary to organize a follow-up meeting. Thus, an international workshop on the immunotoxicity of metals and immuno toxicology was held in Hanover, Federal Republic of Germany, on 6-10 November 1989.

Author : Jacques Descotes
Publisher : Elsevier
Page : 400 pages
File Size : 55,9 Mb
Release : 2004-10-14
Category : Medical
ISBN : 9780080472997

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Principles and Methods of Immunotoxicology by Jacques Descotes Pdf

This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.

Author : Anonim
Publisher : Office of Technology Assessment
Page : 108 pages
File Size : 52,7 Mb
Release : 1991
Category : Antibody-toxin conjugates
ISBN : UCR:31210024829416

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Identifying and Controlling Immunotoxic Substances by Anonim Pdf

Author : Jacques Descotes
Publisher : Academic Press
Page : 125 pages
File Size : 45,8 Mb
Release : 2017-10-01
Category : Medical
ISBN : 9780128098004

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History of Immunotoxicology by Jacques Descotes Pdf

History of Immunotoxicology offers the first book-length exploration of the development and importance of the field of immunotoxicology. Toxicology is evolving with the identification of new toxic hazards and the marketing of new chemicals. As preventive measures are implemented to reduce risks, including banning of chemicals or applications of one given chemical, current toxicologists may not be aware of the actual toxicity potential of chemicals when marketing or used in the past. Knowledge of what has occurred before can help to give context and understanding of current and future debates. Although immunotoxicology is one of the youngest areas of toxicology – its origin dates back to approximately half a century – a number of significant adverse effects and safety issues have been described, which deserve a historical perspective. History of Immunotoxicology describes the adverse health effects involving the immune system, hypersensitivity and autoimmunity. It also explores new avenues of research and immunotoxicity evaluation, as well as regulatory aspects of immunotoxicology, and the withdrawal/banning from the market of several approved drugs and chemicals due to their immunotoxic effects. Clinical manifestations of immunotoxicity, such as anaphylaxis, opportunistic infections, lymphomas, cytokine storm, and immunotherapy will be addressed. Finally, the book considers how the recent past can provide insights on the future practice of immunotoxicology. This book will be of interest to students and researchers in government, industry, and academia who have an interest in immunotoxicology. Examines the development of immunotoxicology Provides context to current debates about actual toxicity potential of chemicals Covers major developments and areas of immunotoxicology

Author : A. Berlin
Publisher : Springer
Page : 540 pages
File Size : 42,5 Mb
Release : 1987-02-28
Category : Medical
ISBN : UCAL:$B304185

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Immunotoxicology by A. Berlin Pdf

Papers presented at the International Seminar on the Immunological System as a Target for Toxic Damage - Present Status, Open Problems and Future Perspectives

Author : Helen Tryphonas,Michel Fournier,Barry R. Blakley,Judit Smits,Pauline Brousseau
Publisher : CRC Press
Page : 788 pages
File Size : 52,8 Mb
Release : 2005-01-27
Category : Medical
ISBN : 9781134393992

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Investigative Immunotoxicology by Helen Tryphonas,Michel Fournier,Barry R. Blakley,Judit Smits,Pauline Brousseau Pdf

Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discus

Author : M. A. Hayat
Publisher : Academic Press
Page : 286 pages
File Size : 53,9 Mb
Release : 2017-10-31
Category : Medical
ISBN : 9780128098974

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Immunology by M. A. Hayat Pdf

Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases. Presents the most advanced information regarding the role of autophagy and immunity Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death Edited work with chapters authored by leaders from around the globe – the broadest, most expert coverage available

Author : Jacques Descotes
Publisher : Elsevier Science Serials
Page : 400 pages
File Size : 43,6 Mb
Release : 2004
Category : Medical
ISBN : 0444510931

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Immunotoxicology of Drugs and Chemicals: Principles and methods of immunotoxicology by Jacques Descotes Pdf

This third thoroughly revised edition, written by a renowned expert in this rapidly expanding field, is a welcome and timely publication in the field of experimental and clinical immunotoxicology. Immunotoxicology is a young, but rapidly expanding area of toxicology. Since the second edition of this book was published in 1988, an increasing amount of data has resulted in the publication of many articles and reviews. This book covers the many general facets of current immunotoxicology - clinical, experimental, mechanistic and regulatory aspects, including a chapter on the immune system giving toxicologists unfamiliar with immunology the opportunity to acquire the minimal knowledge necessary to conduct and interpret immunotoxicity studies. A comprehensive chapter on adverse effects in relation to immunotoxicity is included in order to predict and understand the toxic effects of drugs and other chemicals in living beings. An effort is made to answer one of the perhaps most confusing issues confronting the student of immunotoxicology namely the identification of what constitutes an immunotoxic response and what does not. Researchers from different disciplines have shown interest in this new field, and presented results of their work on immunotoxicological issues from extremely varied perspectives. As a bridging discipline between immunology and toxicology, immunotoxicology is genuinely multidisciplinary, reflected in this excellent book.

Author : Frans P. Nijkamp,Michael Parnham
Publisher : Springer Science & Business Media
Page : 659 pages
File Size : 51,9 Mb
Release : 2006-04-04
Category : Medical
ISBN : 9783764374082

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Principles of Immunopharmacology by Frans P. Nijkamp,Michael Parnham Pdf

The rapid developments in immunology in recent immunomodulatory drugs can be distinguished years have dramatically expanded our knowledge of from their beneficial therapeutic effects. mammalian host defence mechanisms. The molecu- Currently,it is only possible to obtain an overview lar mechanisms of cellular interactions during of these various aspects of immunopharmacology immune responses have been unravelled,the intra- by reading a range of immunological,pharmacol- cellular responses involved in signal transduction ical,diagnostic and toxicological literature. Good delineated and an ever-increasing number of soluble immunological textbooks are available, while mediators of immune and inflammatory reponses immunopharmacology is covered mainly in terms of have been discovered. the inflammatory response. Principles of Immuno- The initial result of this explosion of knowledge pharmacology is intended to provide for the first time has been to provide the researcher and the clinician in a single volume a basic understanding of with an arsenal of diagnostic tools with which the immunological mechanisms,a review of important immunological bases of disease processes can be immunodiagnostic tools and a description of the investigated. This has made disease diagnosis much main pharmacological agents which modify the more precise,enabling the physician to tailor therapy immune response,together with an introduction to much more closely to the individual patient’s needs. immunotoxicology. As such we hope that it will be However,better understanding of disease processes useful as a reference text for physicians,researchers only provides a gradual improvement in therapy. This and students with a rudimentary knowledge of is because the new molecular targets that have been immunology.

Author : International Program on Chemical Safety
Publisher : Springer
Page : 344 pages
File Size : 41,5 Mb
Release : 1990-11-30
Category : Health & Fitness
ISBN : UOM:39015019579732

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Immunotoxicity of Metals and Immunotoxicology by International Program on Chemical Safety Pdf

Considerable scientific and political interest has been expressed, parallelling public concern about the effects of chemicals on the immune system and the implications of those effects for health. Coupled with speculation about the magnitude and extent of the problem is discussion of needs for predictive testing and regulatory control measures. The first international seminar on the immunological system as a target for toxic damage was held in Luxembourg in 1984. It was organized by the International Programme on Chemical Safety (United Nations Environment Programme-International Labour Office World Health Organization) and the Commission of the European Communities with the support of the US Environmental Protection Agency and the National Institute of Environmental Health Sciences (USA) and the participation of the International Society of Immunopharmacology. In view of the perceived importance of imrnunotoxicity, it was considered necessary to organize a follow-up meeting. Thus, an international workshop on the immunotoxicity of metals and immuno toxicology was held in Hanover, Federal Republic of Germany, on 6-10 November 1989.