Inflammation And The Microcirculation

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Inflammation and the Microcirculation

D. Neil Granger,Elena Senchenkova
Inflammation and the Microcirculation Book PDF

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 46,5 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

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Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Molecular Basis for Microcirculatory Disorders

Geert W. Schmid-Schönbein,D.Neil Granger
Molecular Basis for Microcirculatory Disorders Book PDF

Author : Geert W. Schmid-Schönbein,D.Neil Granger
Publisher : Springer Science & Business Media
Page : 610 pages
File Size : 43,9 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9782817807614

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Molecular Basis for Microcirculatory Disorders by Geert W. Schmid-Schönbein,D.Neil Granger Pdf

A large number of cardiovascular diseases are accompanied by inflammation. This volume on the molecular basis of microcirculatory disorders gives a comprehensive summary of key steps in the inflammatory cascade. Leading investigators present a state-of-the-art analysis of the molecular determinants of leukocyte-endothelial cell adhesion, mechanotransduction in endothelial and inflammatory cells, mechanisms of cell activation, microvascular apoptosis with applications to ischemia-reperfusion in the brain, the heart and in venous disease, diabetes and hypertension. The book provides the latest thinking in these important cardiovascular problems, with the most contemporary literature and a look at the increasingly complex events during inflammation. Molecular biology tools, microvascular and modern bioengineering analysis are seamlessly integrated into the analysis of clinical problems. The book helps not only newcomers to gain entry into the interesting problems associated with microvascular disorders, but lays the foundation for the design of new therapeutic interventions.

Microcirculation

Ronald F. Tuma,Walter N. Duran,Klaus Ley
Microcirculation Book PDF

Author : Ronald F. Tuma,Walter N. Duran,Klaus Ley
Publisher : Academic Press
Page : 1000 pages
File Size : 43,9 Mb
Release : 2011-04-28
Category : Science
ISBN : 0080569935

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Microcirculation by Ronald F. Tuma,Walter N. Duran,Klaus Ley Pdf

This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume

Vascular Responses to Pathogens

Felicity N.E. Gavins,Karen Y. Stokes
Vascular Responses to Pathogens Book PDF

Author : Felicity N.E. Gavins,Karen Y. Stokes
Publisher : Academic Press
Page : 252 pages
File Size : 53,9 Mb
Release : 2015-10-31
Category : Medical
ISBN : 9780128013250

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Vascular Responses to Pathogens by Felicity N.E. Gavins,Karen Y. Stokes Pdf

Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease. Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs

Inflammation, 4 Volume Set

Jean-Marc Cavaillon,Mervyn Singer
Inflammation 4 Volume Set Book PDF

Author : Jean-Marc Cavaillon,Mervyn Singer
Publisher : John Wiley & Sons
Page : 1818 pages
File Size : 49,7 Mb
Release : 2018-02-20
Category : Medical
ISBN : 9783527338993

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Inflammation, 4 Volume Set by Jean-Marc Cavaillon,Mervyn Singer Pdf

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Coronary Microvascular Dysfunction

Filippo Crea,Gaetano A. Lanza,Paolo G. Camici
Coronary Microvascular Dysfunction Book PDF

Author : Filippo Crea,Gaetano A. Lanza,Paolo G. Camici
Publisher : Springer Science & Business Media
Page : 257 pages
File Size : 46,6 Mb
Release : 2013-08-15
Category : Medical
ISBN : 9788847053670

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Coronary Microvascular Dysfunction by Filippo Crea,Gaetano A. Lanza,Paolo G. Camici Pdf

In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.

Inflammatory Reaction

H. Z. Movat
Inflammatory Reaction Book PDF

Author : H. Z. Movat
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642673115

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Inflammatory Reaction by H. Z. Movat Pdf

With contributions by numerous experts

Microcirculation in Cardiovascular Diseases

Enrico Agabiti-Rosei,Anthony M. Heagerty,Damiano Rizzoni
Microcirculation in Cardiovascular Diseases Book PDF

Author : Enrico Agabiti-Rosei,Anthony M. Heagerty,Damiano Rizzoni
Publisher : Springer Nature
Page : 215 pages
File Size : 46,7 Mb
Release : 2020-10-03
Category : Medical
ISBN : 9783030478018

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Microcirculation in Cardiovascular Diseases by Enrico Agabiti-Rosei,Anthony M. Heagerty,Damiano Rizzoni Pdf

This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.

Fundamentals of Inflammation

Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Fundamentals of Inflammation Book PDF

Author : Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Publisher : Cambridge University Press
Page : 489 pages
File Size : 46,8 Mb
Release : 2010-04-26
Category : Medical
ISBN : 9780521887298

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Fundamentals of Inflammation by Charles N. Serhan,Peter A. Ward,Derek W. Gilroy Pdf

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Molecular Basis of Health and Disease

Undurti N. Das
Molecular Basis of Health and Disease Book PDF

Author : Undurti N. Das
Publisher : Springer Science & Business Media
Page : 591 pages
File Size : 50,8 Mb
Release : 2011-04-02
Category : Medical
ISBN : 9789400704954

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Molecular Basis of Health and Disease by Undurti N. Das Pdf

The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

Encyclopedia of Inflammatory Diseases

Anonim
Encyclopedia of Inflammatory Diseases Book PDF

Author : Anonim
Publisher : Birkhäuser
Page : 0 pages
File Size : 53,6 Mb
Release : 2016-09-15
Category : Medical
ISBN : 3764385308

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Encyclopedia of Inflammatory Diseases by Anonim Pdf

Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.

Microcirculation Revisited

Helena Lenasi
Microcirculation Revisited Book PDF

Author : Helena Lenasi
Publisher : BoD – Books on Demand
Page : 288 pages
File Size : 40,5 Mb
Release : 2016-10-26
Category : Medical
ISBN : 9789535127307

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Microcirculation Revisited by Helena Lenasi Pdf

The book provides a comprehensive overview of selected topics in microcirculation, from physiology to pathophysiology including molecular mechanisms and clinical aspects. It contains 10 chapters written by reputed authors, which comprehensively sum up the current knowledge and some interesting new insights in the field of microcirculation. It will be useful to a broad range of audience, from students to highly profiled experts, helping them to expand their knowledge on microcirculation and opening up additional questions for further investigation.

Inflammation and Angiogenesis

Domenico Ribatti
Inflammation and Angiogenesis Book PDF

Author : Domenico Ribatti
Publisher : Springer
Page : 111 pages
File Size : 43,9 Mb
Release : 2017-11-08
Category : Medical
ISBN : 9783319684482

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Inflammation and Angiogenesis by Domenico Ribatti Pdf

This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.

Angiogenesis

William D. Figg,Judah Folkman
Angiogenesis Book PDF

Author : William D. Figg,Judah Folkman
Publisher : Springer Science & Business Media
Page : 592 pages
File Size : 45,9 Mb
Release : 2008-05-24
Category : Medical
ISBN : 9780387715186

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Angiogenesis by William D. Figg,Judah Folkman Pdf

Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.

Coronary Microvascular Obstruction in Acute Myocardial Infarction

Giampaolo Niccoli,Ingo Eitel
Coronary Microvascular Obstruction in Acute Myocardial Infarction Book PDF

Author : Giampaolo Niccoli,Ingo Eitel
Publisher : Academic Press
Page : 400 pages
File Size : 51,5 Mb
Release : 2018-07-20
Category : Medical
ISBN : 9780128133613

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Coronary Microvascular Obstruction in Acute Myocardial Infarction by Giampaolo Niccoli,Ingo Eitel Pdf

Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment Includes the most up-to-date information on CMVO as presented from top experts around the word Provides access to a companion website with extra material, including tables, additional references and instructional videos Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon