Inhalation Toxicology The Design And Interpretation Of Inhalation Studies And Their Use In Risk Assessment

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Inhalation Toxicology

Ulrich Mohr,Donald L. Dungworth,Georg Kimmerle,James Lewkowski,Roger O. McClellan,Werner Stöber
Inhalation Toxicology Book PDF

Author : Ulrich Mohr,Donald L. Dungworth,Georg Kimmerle,James Lewkowski,Roger O. McClellan,Werner Stöber
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 54,7 Mb
Release : 2013-03-07
Category : Medical
ISBN : 9783642613555

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Inhalation Toxicology by Ulrich Mohr,Donald L. Dungworth,Georg Kimmerle,James Lewkowski,Roger O. McClellan,Werner Stöber Pdf

The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi Part I. Approaches to Assessing the Toxicity of Airborne Toxicants Chapter 1. Standard-Setting as an Integrative Exercise: Alchemy, Juggling, or Science? . . . . . . . . . . . . . . . . . . . . . . . 1 D. v. Bates Chapter 2. Species Differences in Inhalation Toxicology: Variations in Exposure-Dose Relationships and Macrophage Function. . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 J. D. Brain Chapter 3. Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology . . . . . . . . . . . . . . . . . . . . . . . . 25 e. G. Plopper, A. Mir, J. St. George, N. Tyler, A. Mariassy, D. Wilson, S. Nishio, D. Cranz, J. Heidsiek, and D. Hyde Chapter 4. Comparative Metabolic Basis for the Disposition and Toxic Effects of Inhaled Materials . . . . . . . . . . . . . . . . . 41 A. R. Dahl Part II. Methodological Issues in Designing and Conducting Studies with Laboratory Animals Chapter 5. Exposure Facilities and Aerosol Generation and Characterization for Inhalation Experiments. . . . . . . . . .

Inhalation Toxicology; the Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment

U MOHR (Ed)
Inhalation Toxicology the Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment Book PDF

Author : U MOHR (Ed)
Publisher : Unknown
Page : 128 pages
File Size : 51,7 Mb
Release : 1988
Category : Electronic
ISBN : OCLC:985818351

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Inhalation Toxicology; the Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment by U MOHR (Ed) Pdf

APPROACHES TO ASSESSING THE TOXICITY OF AIRBORNE TOXICANTS; STANDARD-SETTING AS AN INTEGRATIVE EXERCISE: ALCHEMY, JUGGLING, OR SCIENCE; SPECIES DIFFERENCES IN INHALATION TOXICOLOGY: VARIATIONS IN EXPOSURE-DOSE RELATIONSHIPS AND MACROPHAGE FUNCTION; CELL POPULATIONS OF THE RESPIRATORY SYSTEM: INTERSPECIES DIVERSITY IN COMPOSITION, DISTRIBUTION AND MORPHOLOGY; COMPARATIVE METABOLIC BASIS FOR THE DISPOSITION AND TOXIC EFFECTS OF INHALED MATERIALS; METHODOLOGICAL ISSUES IN DESIGNING AND CONDUCTING STUDIES WITH LABORATORY ANIMALS; EXPOSURE FACILITIES AND AEROSOL GENERATION AND CHARACTERIZATION FOR INHALATION EXPERIMENTS; DIFFERENT METHODS USED IN ACUTE AND SUBCHRONIC INHALATION STUDIES OF POTENTIAL LUNG IRRITANTS, WITH PARTICULAR ATTENTION TO LUNG FUNCTION; CHRONIC INHALATION TOXICITY STUDIES: PROTOCOLS AND PITFALLS; CARCINOGENICITY PROTOCOLS.

Assessment of Inhalation Hazards

David V. Bates,Donald L. Dungworth,Peter N. Lee,Roger O. McClellan,Francis J.C. Roe
Assessment of Inhalation Hazards Book PDF

Author : David V. Bates,Donald L. Dungworth,Peter N. Lee,Roger O. McClellan,Francis J.C. Roe
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642746062

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Assessment of Inhalation Hazards by David V. Bates,Donald L. Dungworth,Peter N. Lee,Roger O. McClellan,Francis J.C. Roe Pdf

The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . xiii . . . . . . . . . . . . . Part I. Integrative Approach to Assessing Human Health Risk: Two Contemporary Problems Chapter 1. Integrating Diverse Data Sets to Assess the Risks of Airborne Pollutants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 R.o. McClellan, R.G. Cuddihy, w.e. Griffith, and J. L. Mauderly Chapter 2. Risk Assessment for Radon Inhalation Based on Animal Exposure Data and Human Epidemiology . . . . . . . 23 . F. Steinhausler Part II. Types of Evidence: General Strengths and Weaknesses Section 1. Epidemiological Chapter 3. Inhalation Hazards: The Interpretation of Epidemiologic Evidence. . . . . . . . . . . . . . . . . . . . 39 . . . . . . . J.e. Bailar Chapter 4. Problems in Interpreting Epidemiological Data 49 P.N. Lee Section 2. Animal Chapter 5. Rodent Carcinogenicity Studies: Their Value and Limitations. . . . . . . . . . . . . . . . . . . . . . . . . . 61 . . . . . . . . . .

Methods in Inhalation Toxicology

Robert F. Phalen
Methods in Inhalation Toxicology Book PDF

Author : Robert F. Phalen
Publisher : CRC Press
Page : 174 pages
File Size : 46,7 Mb
Release : 1996-11-06
Category : Medical
ISBN : 0849333431

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Methods in Inhalation Toxicology by Robert F. Phalen Pdf

Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research. The book covers techniques needed to: provide suitable clean air for experiments correctly generate the particles and gases being studied select the proper exposure system monitor the exposure prepare tissues for study ensure that animals do not have confounding lung disease The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.

Inhalation Toxicology

Harry Salem,Sidney A. Katz
Inhalation Toxicology Book PDF

Author : Harry Salem,Sidney A. Katz
Publisher : CRC Press
Page : 1055 pages
File Size : 50,8 Mb
Release : 2005-12-22
Category : Medical
ISBN : 9781420037302

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Inhalation Toxicology by Harry Salem,Sidney A. Katz Pdf

Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances

Concepts In Inhalation Toxicology

Roger O. McClellan
Concepts In Inhalation Toxicology Book PDF

Author : Roger O. McClellan
Publisher : CRC Press
Page : 678 pages
File Size : 55,5 Mb
Release : 1995-09-25
Category : Medical
ISBN : 1439805571

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Concepts In Inhalation Toxicology by Roger O. McClellan Pdf

Recent developments have provided new data on the subject of inhalation toxicology, requiring an update of the previous edition of this popular text. Like the first, this second edition explains the basic concepts and quantitative approaches in inhalation toxicology, and it gives a comprehensive treatment of evaluations of respiratory responses to inhaled particles and gases. The author here explores new understanding of the role of cytokines in pulmonary inflammation and risk assessment. Immunologists, oncologists, respiratory specialists and students in those fields will find Concepts In Inhalation Toxicology to be essential to their practice.

How Tobacco Smoke Causes Disease

Anonim
How Tobacco Smoke Causes Disease Book PDF

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 48,9 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Drinking Water and Health,

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Toxicology and Environmental Health Hazards,Safe Drinking Water Committee
Drinking Water and Health Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Toxicology and Environmental Health Hazards,Safe Drinking Water Committee
Publisher : National Academies Press
Page : 476 pages
File Size : 48,9 Mb
Release : 1986-02-01
Category : Nature
ISBN : 9780309036870

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Drinking Water and Health, by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Toxicology and Environmental Health Hazards,Safe Drinking Water Committee Pdf

The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.

Methods in Inhalation Toxicology

Robert F. Phalen
Methods in Inhalation Toxicology Book PDF

Author : Robert F. Phalen
Publisher : CRC Press
Page : 174 pages
File Size : 45,6 Mb
Release : 2020-04-30
Category : Medical
ISBN : 9781000674606

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Methods in Inhalation Toxicology by Robert F. Phalen Pdf

This book focuses on an important aspect of the methods in laboratory animal inhalation toxicology. It is targeted to students in toxicology programs and scientists contemplating performing inhalation studies.

Toxicology of the Lung

Donald E. Gardner,James D Crapo,Roger O. McClellan
Toxicology of the Lung Book PDF

Author : Donald E. Gardner,James D Crapo,Roger O. McClellan
Publisher : CRC Press
Page : 684 pages
File Size : 55,5 Mb
Release : 2000-01-20
Category : Medical
ISBN : 1560328010

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Toxicology of the Lung by Donald E. Gardner,James D Crapo,Roger O. McClellan Pdf

Thoroughly revised and updated, the third edition of Toxicology of the Lung brings together the latest accomplishments and advancements in concepts, approaches, and procedures now used to evaluate the risks associated with airborne contaminants. With chapters from leading authorities, including nine new chapters and a number of new topic areas, this edition describes how and why the lung and respiratory system respond as they do to toxicants and provides a clear understanding of human health risks associated with chemical exposure. This one-of-a-kind reference on inhalation toxicology will be invaluable to all professionals in academia, industry, clinics, research laboratories, and government agencies.

Toxicology

Hans Marquardt,Siegfried G. Schäfer,Roger O. McClellan,Frank Welsch
Toxicology Book PDF

Author : Hans Marquardt,Siegfried G. Schäfer,Roger O. McClellan,Frank Welsch
Publisher : Academic Press
Page : 1355 pages
File Size : 41,6 Mb
Release : 1999-10-05
Category : Medical
ISBN : 9780080543116

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Toxicology by Hans Marquardt,Siegfried G. Schäfer,Roger O. McClellan,Frank Welsch Pdf

Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments. Key Features * Comprehensive text, covering all aspects of the field of toxicology * Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects * Identifies the various classes of chemical compounds responsible for the toxic effects * Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention * Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables

The Particulate Air Pollution Controversy

Robert F. Phalen
The Particulate Air Pollution Controversy Book PDF

Author : Robert F. Phalen
Publisher : Springer Science & Business Media
Page : 128 pages
File Size : 54,5 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306482083

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The Particulate Air Pollution Controversy by Robert F. Phalen Pdf

Small invisible particles in the urban air, especially those produced by human activities, have recently stimulated intense scrutiny, debate, regulation, and legal proceedings. The stakes are high, both with respect to health impacts and economic costs, and the methods used previously to resolve similar issues are no longer adequate. Everyone on earth inhales thousands to millions of particles in each breath, so if urban particulate air pollution—particulate matter (PM)—is significantly hazardous, the negative impact on health could be staggering. Yet the activities that generate PM, such as farming, manufacturing, mining, transportation, and generating electricity, are themselves essential to human health and welfare. Scientists, regulators, legislators, activists, judges, lawyers, journalists, and representatives of the business community are actively involved in addressing the question of what should be done. This complex issue presents opportunities for critically assessing the relevant knowledge and for adopting more rigorous approaches to this and similar problems. What is the PM controversy, and why is it a good case study for how science and public policy might better interface? The PM controversy is the sum of the frequently heated debates related to the potential health risks from urban PM.

Advances in Controlled Clinical Inhalation Studies

D.V. Bates,H. Fabel,M.J. Utell
Advances in Controlled Clinical Inhalation Studies Book PDF

Author : D.V. Bates,H. Fabel,M.J. Utell
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642771767

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Advances in Controlled Clinical Inhalation Studies by D.V. Bates,H. Fabel,M.J. Utell Pdf

Advances in Controlled Clinical Inhalation Studies represents scientific work presented at the 3rd International Inhalation Symposium held 1991 in Hannover, FRG. The symposium covered the new developments in this field of research. The main pollutants of interest were acid aerosols, fog, and indoor pollutants, while with regard to biological effects, an emphasis was placed on immunotoxicological and biochemical parameters. Tests on high risk groups were also considered. Initial chapters describe the outdoor environment as well as indoor air, measurement and quality - both at home and in the workplace. Besides methods for clinical inhalation and assessing personal exposure, new methodologies are particularly presented. Further chapters focus on the relevance of clinical data for regulatory decisions.

Comprehensive Toxicology

Anonim
Comprehensive Toxicology Book PDF

Author : Anonim
Publisher : Elsevier
Page : 6448 pages
File Size : 52,5 Mb
Release : 2010-06-01
Category : Medical
ISBN : 9780080468846

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Comprehensive Toxicology by Anonim Pdf

An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version

Bioavailability in Environmental Risk Assessment

Weiping Chen,Steve E. Hrudey,Colin Rousseaux
Bioavailability in Environmental Risk Assessment Book PDF

Author : Weiping Chen,Steve E. Hrudey,Colin Rousseaux
Publisher : CRC Press
Page : 322 pages
File Size : 41,6 Mb
Release : 1995-11-10
Category : Technology & Engineering
ISBN : 1566701864

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Bioavailability in Environmental Risk Assessment by Weiping Chen,Steve E. Hrudey,Colin Rousseaux Pdf

Since bioavailability can alter health risk estimates by a factor of 10, 100 or more, its importance in risk assessment cannot be underestimated. Presenting the basic principles that govern bioavailability and how it is measured, this very unique and timely book fills a void in the existing literature on toxicology and toxicokinetics. It contains clear and concise discussions on the behavior of environmental contaminants and how they reach the bloodstream in living organisms. It also presents an exhaustive review of measured bioavailability factors for environmental contaminants most frequently encountered at contaminated sites.