Inhibiting Parp As A Strategic Target In Cancer

Author : Christina Annunziata,Kristin Zorn
Publisher : Frontiers Media SA
Page : 99 pages
File Size : 51,5 Mb
Release : 2016-08-05
Category : Medicine (General)
ISBN : 9782889199556

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Inhibiting PARP as a Strategic Target in Cancer by Christina Annunziata,Kristin Zorn Pdf

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 46,5 Mb
Release : 2016
Category : Electronic
ISBN : OCLC:1368430801

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Inhibiting PARP as a Strategic Target in Cancer by Anonim Pdf

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell's ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.

Author : Nicola J. Curtin,Ricky A. Sharma
Publisher : Humana Press
Page : 591 pages
File Size : 54,5 Mb
Release : 2015-06-13
Category : Medical
ISBN : 9783319141510

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PARP Inhibitors for Cancer Therapy by Nicola J. Curtin,Ricky A. Sharma Pdf

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

Author : Csaba Szabo
Publisher : CRC Press
Page : 354 pages
File Size : 42,7 Mb
Release : 2000-06-22
Category : Medical
ISBN : 9781420038897

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Cell Death by Csaba Szabo Pdf

Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e

Author : Alexander Bürkle
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 41,6 Mb
Release : 2008-01-11
Category : Medical
ISBN : 9780387360058

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Poly(ADP-Ribosyl)ation by Alexander Bürkle Pdf

This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 44,7 Mb
Release : 1985
Category : Small cell lung cancer
ISBN : OCLC:260164712

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Small Cell Lung Cancer by Anonim Pdf

Author : Lixiang Xue,Zhengquan Yu,Ke-Wu Zeng,Fei Chen,Na Li
Publisher : Frontiers Media SA
Page : 152 pages
File Size : 44,9 Mb
Release : 2023-07-05
Category : Science
ISBN : 9782832528952

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New anti-cancer strategies targeting epigenetic modifications and associated metabolism reprogramming by Lixiang Xue,Zhengquan Yu,Ke-Wu Zeng,Fei Chen,Na Li Pdf

Author : Mark D. Evans,Marcus S. Cooke
Publisher : Springer Science & Business Media
Page : 228 pages
File Size : 48,8 Mb
Release : 2009-06-11
Category : Science
ISBN : 9780387729749

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Oxidative Damage to Nucleic Acids by Mark D. Evans,Marcus S. Cooke Pdf

This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.

Author : Mark R. Kelley,Melissa L. Fishel
Publisher : Academic Press
Page : 464 pages
File Size : 46,8 Mb
Release : 2016-06-07
Category : Medical
ISBN : 9780128035993

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DNA Repair in Cancer Therapy by Mark R. Kelley,Melissa L. Fishel Pdf

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Author : Anonim
Publisher : Academic Press
Page : 308 pages
File Size : 49,6 Mb
Release : 2018-03-28
Category : Medical
ISBN : 9780128137543

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Targeting Cell Survival Pathways to Enhance Response to Chemotherapy by Anonim Pdf

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials

Author : Stephen Neidle
Publisher : Elsevier
Page : 496 pages
File Size : 41,7 Mb
Release : 2011-04-28
Category : Medical
ISBN : 0080554954

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Cancer Drug Design and Discovery by Stephen Neidle Pdf

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories

Author : Lucy Andrews,Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Page : 197 pages
File Size : 52,9 Mb
Release : 2007-11-29
Category : Medical
ISBN : 9781588296832

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Telomerase Inhibition by Lucy Andrews,Trygve O. Tollefsbol Pdf

This volume presents a compendium of the most recent and advanced methods applied to the rapidly expanding field of telomerase inhibition. The techniques described provide the researcher with a diverse and comprehensive set of tools for the study of telomerase inhibition. The volume is aimed at biochemists, molecular biologists, cancer researchers, and geneticists.

Author : Gw Sledge,George W. Sledge (Jr.)
Publisher : Clinical Pub
Page : 0 pages
File Size : 50,9 Mb
Release : 2012-06
Category : Breast
ISBN : 1846920663

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Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Author : Timothy A. Yap,Geoffrey I. Shapiro
Publisher : Springer Nature
Page : 333 pages
File Size : 40,8 Mb
Release : 2023-12-19
Category : Medical
ISBN : 9783031300653

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Targeting the DNA Damage Response for Cancer Therapy by Timothy A. Yap,Geoffrey I. Shapiro Pdf

This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.

Author : Shankar Suman
Publisher : Bentham Science Publishers
Page : 287 pages
File Size : 50,9 Mb
Release : 2022-07-18
Category : Medical
ISBN : 9781681089539

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Breast Cancer: Current Trends in Molecular Research by Shankar Suman Pdf

Breast cancer is one of the most common cancer types worldwide, and is a leading cause of cancer related deaths in women. In this book, medical experts review our current understanding of the molecular biology and characteristics of breast cancer. The topics covered in this book provide comprehensive knowledge of mechanisms underlying breast carcinogenesis, and are intended for a wide audience including scientists, teachers, and students. 11 chapters present information about several topics on breast cancer, including the role of cell growth and proliferation pathways, androgen and cytokine signaling, germline mutations in breast cancer susceptibility genes, and molecular factors causing invasive and metastatic breast cancer. In addition, the editors discuss the recent advancements in multi-omics data analysis based on inter-and intra-tumor molecular profiles. The reference highlights how the knowledge and understanding of the biological behavior of breast neoplasms have facilitated ongoing investigations into dietary polyphenolic compounds with antioxidant properties, making them function as cancer chemopreventive agents. Along with this, the current development of treatment strategies such as targeted molecular therapy, and radiation therapy is brought to the fore to update readers.