Insect Cell Culture Engineering

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Insect Cell Culture Engineering

Mattheus F. A. Goosen
Insect Cell Culture Engineering Book PDF

Author : Mattheus F. A. Goosen
Publisher : CRC Press
Page : 260 pages
File Size : 53,5 Mb
Release : 2020-07-24
Category : Science
ISBN : 9781000105667

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Insect Cell Culture Engineering by Mattheus F. A. Goosen Pdf

Consolidating and expanding current, fundamental notions of virology and animal cell cultivation, this practical reference examines the development of insect cell culture techniques for the production of recombinant proteins and insect pathogenic viruses.;Resolving on-the-job problems such as sparging cell damage and reduced infectivity cells, Insect Cell Culture Engineering: includes special introductory material as well as background information on insect pathogenic viruses, the molecular biology of baculoviruses and bioreactor design; offers advice on how to save time when deciding which insect cell line, bioreactor and medium to exploit; discusses the preparation of mathematical modelling in animal cell culture; addresses the concerns associated with insect cell immobilization and the use of serum-free culture media; provides insights into the protective effects of polymer additives and insect cell gene expression in pharmaceutical research; and analyzes process scale-up and reactor design.;Bridging the gap between laboratory research and pilot plant scale insect culture/baculovirus technology, Insect Cell Culture Engineering is designed as a reference for biochemical and bioprocess engineers, bioprocess technologists, biochemists, molecular and cell biologists, microbiologists, and upper-level undergraduate and graduate students in these disciplines.

Insect Cell Cultures

Just M. Vlak,Cornelis D. de Gooijer,Johannes Tramper,Herbert G. Miltenburger
Insect Cell Cultures Book PDF

Author : Just M. Vlak,Cornelis D. de Gooijer,Johannes Tramper,Herbert G. Miltenburger
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 48,6 Mb
Release : 2006-04-11
Category : Science
ISBN : 9780306468506

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Insect Cell Cultures by Just M. Vlak,Cornelis D. de Gooijer,Johannes Tramper,Herbert G. Miltenburger Pdf

A comprehensive reference work covering the key issues in insect cell cultures, this text includes 30 review papers on such topics as: cell lines (development, characterisation, physiology, cultivation and medium design); viruses (virus-cell interactions, replication, recombinant construction, infection kinetics, post-translational modification and passage effects); engineering (shear, bioreactors including perfusion, immobilisation, scale-up and modelling, downstream processing); applications; and economics and regulatory aspects.; This text should be useful for cell biologists, biochemists, molecular biologists, virologists, immunologists and other basic and applied disciplines related to cell culture engineering, both academic and industrial.

Cell Culture Engineering

Wei-Shu Hu
Cell Culture Engineering Book PDF

Author : Wei-Shu Hu
Publisher : Springer
Page : 0 pages
File Size : 54,6 Mb
Release : 2010-11-18
Category : Science
ISBN : 3642070515

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Cell Culture Engineering by Wei-Shu Hu Pdf

Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.

Cell Culture Engineering

Gyun Min Lee,Helene Faustrup Kildegaard
Cell Culture Engineering Book PDF

Author : Gyun Min Lee,Helene Faustrup Kildegaard
Publisher : John Wiley & Sons
Page : 436 pages
File Size : 49,8 Mb
Release : 2020-01-13
Category : Science
ISBN : 9783527343348

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Cell Culture Engineering by Gyun Min Lee,Helene Faustrup Kildegaard Pdf

Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e.g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned "Advanced Biotechnology" book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.

Cell Culture Engineering IV

B.C. Buckland
Cell Culture Engineering IV Book PDF

Author : B.C. Buckland
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 46,9 Mb
Release : 2013-06-29
Category : Science
ISBN : 9789401102575

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Cell Culture Engineering IV by B.C. Buckland Pdf

Cell Culture Engineering IV, Improvements of Human Health covers the latest approaches to improving the cell host through improved understanding of the molecular biology, the development of novel vaccines, approaches to bioreactor design and operation, monitoring techniques in process control and quality related topics. The work was carefully put together as one result of the Cell Culture Engineering IV Meeting held in San Diego, U.S.A. in 1994, however, the book may not be perceived as a proceedings volume - the criteria of the book series apply. For cell biologists, biochemists, molecular biologists, immunologists and other disciplines related to cell culture engineering, working in the academic environment, as well as in (biotechnology or pharmaceutical) industry.

Insect Cell Culture Engineering

Mattheus F. A. Goosen
Insect Cell Culture Engineering Book PDF

Author : Mattheus F. A. Goosen
Publisher : CRC Press
Page : 264 pages
File Size : 45,5 Mb
Release : 2020-07-24
Category : Science
ISBN : 9781000148879

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Insect Cell Culture Engineering by Mattheus F. A. Goosen Pdf

Consolidating and expanding current, fundamental notions of virology and animal cell cultivation, this practical reference examines the development of insect cell culture techniques for the production of recombinant proteins and insect pathogenic viruses.;Resolving on-the-job problems such as sparging cell damage and reduced infectivity cells, Insect Cell Culture Engineering: includes special introductory material as well as background information on insect pathogenic viruses, the molecular biology of baculoviruses and bioreactor design; offers advice on how to save time when deciding which insect cell line, bioreactor and medium to exploit; discusses the preparation of mathematical modelling in animal cell culture; addresses the concerns associated with insect cell immobilization and the use of serum-free culture media; provides insights into the protective effects of polymer additives and insect cell gene expression in pharmaceutical research; and analyzes process scale-up and reactor design.;Bridging the gap between laboratory research and pilot plant scale insect culture/baculovirus technology, Insect Cell Culture Engineering is designed as a reference for biochemical and bioprocess engineers, bioprocess technologists, biochemists, molecular and cell biologists, microbiologists, and upper-level undergraduate and graduate students in these disciplines.

Invertebrate Cell Culture

Karl Maramorosch,Jun Mitsuhashi
Invertebrate Cell Culture Book PDF

Author : Karl Maramorosch,Jun Mitsuhashi
Publisher : Unknown
Page : 318 pages
File Size : 43,6 Mb
Release : 1997
Category : Science
ISBN : STANFORD:36105019327878

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Invertebrate Cell Culture by Karl Maramorosch,Jun Mitsuhashi Pdf

This text aims to provide readers with a balanced cross-section of current developments within the research on invertebrate cell culture. Attention is focused on such topics as: the biochemistry and physiology of cultured invertebrate cells; aspects of virus infection; novel cultivation methods; assays of viruses affecting shrimp and insect cells; engineering of invertebrate cells for the production of baculovirus pesticides; application of microgravity to in vitro cell cultivation; and other aspects of biotechnology. The large body of information brings into focus the significant recent achievements in the laboratories of Africa, America, Europe and Asia.

Cell Culture Engineering VI

Michael J. Betenbaugh,Jeffrey J. Chalmers,Rob Arathoon,Frank W.R. Chaplen,Alison J. Mastrangelo
Cell Culture Engineering VI Book PDF

Author : Michael J. Betenbaugh,Jeffrey J. Chalmers,Rob Arathoon,Frank W.R. Chaplen,Alison J. Mastrangelo
Publisher : Springer Science & Business Media
Page : 229 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401147866

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Cell Culture Engineering VI by Michael J. Betenbaugh,Jeffrey J. Chalmers,Rob Arathoon,Frank W.R. Chaplen,Alison J. Mastrangelo Pdf

The latest edition in this continuing series includes the newest advances in the rapidly evolving field of animal cell culture, genetic manipulations for heterologous gene expression, cell line enhancements, improved bioreactor designs and separations, gene therapy manufacturing, tissue engineering, anti-apoptosis strategies and cell cycle research. The contents include new research articles as well as critical reviews on emerging topics such as viral and viral-like agent contamination of animal cell culture components. These papers were carefully selected from contributions by leading academic and industrial experts in the biotechnology community at the recent Cell Culture Engineering VI Meeting in San Diego, USA, 1998. However, the book is not merely a proceedings. Audience: Biochemical engineers, cell biologists, biochemists, molecular biologists, immunologists and other disciplines related to cell culture engineering, working in the academic environment and the biotechnology or pharmaceutical industry.

Animal Cell Culture

Mohamed Al-Rubeai
Animal Cell Culture Book PDF

Author : Mohamed Al-Rubeai
Publisher : Springer
Page : 766 pages
File Size : 49,5 Mb
Release : 2014-11-28
Category : Medical
ISBN : 9783319103204

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Animal Cell Culture by Mohamed Al-Rubeai Pdf

​Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a recommended volume for all biotechnology libraries.

Cell and Tissue Reaction Engineering

Regine Eibl,Dieter Eibl,Ralf Pörtner,Gerardo Catapano,Peter Czermak
Cell and Tissue Reaction Engineering Book PDF

Author : Regine Eibl,Dieter Eibl,Ralf Pörtner,Gerardo Catapano,Peter Czermak
Publisher : Springer Science & Business Media
Page : 367 pages
File Size : 51,9 Mb
Release : 2008-09-30
Category : Science
ISBN : 9783540681823

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Cell and Tissue Reaction Engineering by Regine Eibl,Dieter Eibl,Ralf Pörtner,Gerardo Catapano,Peter Czermak Pdf

The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.

Insect Cell Biotechnology

Gordon D. O. Maramorosch
Insect Cell Biotechnology Book PDF

Author : Gordon D. O. Maramorosch
Publisher : CRC Press
Page : 200 pages
File Size : 41,9 Mb
Release : 2018-01-18
Category : Science
ISBN : 9781351090476

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Insect Cell Biotechnology by Gordon D. O. Maramorosch Pdf

Insect Cell Biotechnology provides a lucid, up-to-date description of recent major advances in the field. A number of significant topics are addressed, including the use and production of baculoviruses in insect cells, baculovirus specificity, bacterial toxin studies in cultured insect cells, scale-up operations required in the production of recombinant protein and insect viruses propagated in insect cells, growth and nervous system interactions, and the physiological and developmental capacities of cell lines. Transfection in Drosophila cells and a chapter on the theoretical and practical implications of stress produced by x-rays, ultraviolet light, chemicals, psoralens, and heat are discussed as well.

Animal Cell Technology

Leda Castilho,Angela Moraes,Elisabeth Augusto,Mike Butler
Animal Cell Technology Book PDF

Author : Leda Castilho,Angela Moraes,Elisabeth Augusto,Mike Butler
Publisher : Taylor & Francis
Page : 752 pages
File Size : 55,9 Mb
Release : 2008-03-01
Category : Medical
ISBN : 9781134099719

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Animal Cell Technology by Leda Castilho,Angela Moraes,Elisabeth Augusto,Mike Butler Pdf

Animal Cell Technology: from Biopharmaceuticals to Gene Therapy provides a comprehensive insight into biological and engineering concepts related to mammalian and insect cell technology, as well as an overview of the applications of animal cell technology. Part 1 of the book covers the Fundamentals upon which this technology is based and covers the science underpinning the technology. Part 2 covers the Applications from the production of therapeutic proteins to gene therapy. The authors of the chapters are internationally-recognized in the field of animal cell culture research and have extensive experience in the areas covered in their respective chapters.

Cell Culture Engineering and Technology

Ralf Pörtner
Cell Culture Engineering and Technology Book PDF

Author : Ralf Pörtner
Publisher : Springer Nature
Page : 552 pages
File Size : 48,7 Mb
Release : 2022-02-20
Category : Medical
ISBN : 9783030798710

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Cell Culture Engineering and Technology by Ralf Pörtner Pdf

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Cell Engineering

Mohamed Al-Rubeai
Cell Engineering Book PDF

Author : Mohamed Al-Rubeai
Publisher : Boom Koninklijke Uitgevers
Page : 232 pages
File Size : 49,8 Mb
Release : 2000-09-30
Category : Medical
ISBN : 0792365968

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Cell Engineering by Mohamed Al-Rubeai Pdf

This volume focuses on the transient gene expression technologies for recombinant protein production and gene therapy. It provides coverage of an important issue in Cell Engineering by internationally authoritative experts. Topics covered range from the use of baculovirus, adenovirus, adeno-associated virus and alphavirus vectors in biopharmaceutical, genomics and gene delivery research, to large-scale transfection of plasmid DNA into cultured cells for bioreactor applications. This book illuminates all the scientific and technological issues involved in the research, development, production, and human use of viral and non-viral vectors for in vitro and in vivo expression of recombinant proteins, thus making it an essential reference for cell culture technologists, virologists, and scientists interested in gene therapy.

New Insights into Cell Culture Technology

Sivakumar Joghi Thatha Gowder
New Insights into Cell Culture Technology Book PDF

Author : Sivakumar Joghi Thatha Gowder
Publisher : BoD – Books on Demand
Page : 204 pages
File Size : 49,8 Mb
Release : 2017-05-10
Category : Science
ISBN : 9789535131335

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New Insights into Cell Culture Technology by Sivakumar Joghi Thatha Gowder Pdf

The book "New Insights into Cell Culture Technology" focuses on many advanced methods and techniques concerned with cell culture. The contributing authors have discussed various developments in cell culture methods, the application of insect cells for the efficient production of heterologous proteins, the expansion of human mesenchymal stromal cells for different clinical applications, the remote sensing of cell culture experiments and concepts for the development of cell culture bioprocess, continuous production of retroviral pseudotype vectors, and the production of oncolytic measles virus vectors for cancer therapy. This book is an original contribution of experts from different parts of the globe, and the in-depth information will be a significant resource for students, scientists, and physicians who are directly dealing with cells.["Culture" is essential for human life and also the life of a cell. - Sivakumar Gowder]