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Author : Anonim
Publisher : Unknown
Page : 96 pages
File Size : 53,5 Mb
Release : 1995
Category : Cancer
ISBN : MINN:31951D01191101B
Author : Henry A. Glick,Jalpa A. Doshi,Seema S. Sonnad,Daniel Polsky
Publisher : OUP Oxford
Page : 288 pages
File Size : 47,6 Mb
Release : 2014-10-02
Category : Medical
ISBN : 9780191508066
It is becoming increasingly important to examine the relationship between the outcomes of a clinical trial and the costs of the medical therapy under study. The results of such analysis can affect reimbursement decisions for new medical technologies, drugs, devices or diagnostics. It can aid companies seeking to make claims about the cost-effectiveness of their product, as well as allowing early consideration of the economic value of therapies which may be important to improving initial adoption decisions. It is also vital for addressing the requirements of regulatory bodies. Economic Evaluation in Clinical Trials provides practical advice on how to conduct cost-effectiveness analyses in controlled trials of medical therapies. This new edition has been extensively rewritten and revised; topics discussed range from design issues such as the types of services that should be measured and price weights, to assessment of quality-adjusted life years. Illustrative materials, case histories and worked examples are included to encourage the reader to apply the methods discussed. These exercises are supported with datasets, programmes and solutions made available online.
Author : Iftekhar Khan,Ralph Crott,Zahid Bashir
Publisher : CRC Press
Page : 334 pages
File Size : 43,6 Mb
Release : 2019-06-14
Category : Mathematics
ISBN : 9780429531842
Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems. With advances in the diagnosis and treatment, more people are diagnosed early and receive treatments for a disease where few treatments options were previously available. As a result, the survival of patients with cancer has steadily improved and, in most cases, patients who are not cured may receive multiple lines of treatment, often with financial consequences for the patients, insurers and healthcare systems. Although many books exist that address economic evaluation, Economic Evaluation of Cancer Drugs using Clinical Trial and Real World Data is the first unified text that specifically addresses the economic evaluation of cancer drugs. The authors discuss how to perform cost-effectiveness analyses while emphasising the strategic importance of designing cost-effectiveness into cancer trials and building robust economic evaluation models that have a higher chance of reimbursement if truly cost-effective. They cover the use of real-world data using cancer registries and discuss how such data can support or complement clinical trials with limited follow up. Lessons learned from failed reimbursement attempts, factors predictive of successful reimbursement and the different payer requirements across major countries including US, Australia, Canada, UK, Germany, France and Italy are also discussed. The book includes many detailed practical examples, case studies and thought-provoking exercises for use in classroom and seminar discussions. Iftekhar Khan is a medical statistician and health economist and a lead statistician at Oxford Unviersity’s Center for Statistics in Medicine. Professor Khan is also a Senior Research Fellow in Health Economics at University of Warwick and is a Senior Statistical Assessor within the Licensing Division of the UK Medicine and Health Regulation Agency. Ralph Crott is a former professor in Pharmacoeconomics at the University of Montreal in Quebec, Canada and former head of the EORTC Health Economics Unit and former senior health economist at the Belgian HTA organization. Zahid Bashir has over twelve years experience working in the pharmaceutical industry in medical affairs and oncology drug development where he is involved in the design and execution of oncology clinical trials and development of reimbursement dossiers for HTA submission.
Author : Martin Brown,National Cancer Institute (U.S.)
Publisher : Unknown
Page : 42 pages
File Size : 53,8 Mb
Release : 1998
Category : Cancer
ISBN : UCSD:31822024222606
Clinical economics is a new and evolving discipline that addresses the economic implications of changes in medical practice. As applied to cancer care, clinical economics assesses the costs and effectiveness of new cancer interventions and can be a valuable endpoint in selected clinical trials. Through the integration of economics into clinical evaluations, information can be developed that contributes to the decisions of patients, clinicians, health care managers, and policymakers as to the most effective allocation of cancer care resources.
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 248 pages
File Size : 40,7 Mb
Release : 2012-09-13
Category : Medical
ISBN : 9780309253185
There is growing recognition that the United States' clinical trials enterprise (CTE) faces great challenges. There is a gap between what is desired - where medical care is provided solely based on high quality evidence - and the reality - where there is limited capacity to generate timely and practical evidence for drug development and to support medical treatment decisions. With the need for transforming the CTE in the U.S. becoming more pressing, the IOM Forum on Drug Discovery, Development, and Translation held a two-day workshop in November 2011, bringing together leaders in research and health care. The workshop focused on how to transform the CTE and discussed a vision to make the enterprise more efficient, effective, and fully integrated into the health care system. Key issue areas addressed at the workshop included: the development of a robust clinical trials workforce, the alignment of cultural and financial incentives for clinical trials, and the creation of a sustainable infrastructure to support a transformed CTE. This document summarizes the workshop.
Author : Stanley P. L. Leong
Publisher : Springer Science & Business Media
Page : 326 pages
File Size : 47,5 Mb
Release : 2007-05-14
Category : Medical
ISBN : 9780387332246
Clinical trials remain the most important vehicle for improving the care of cancer patients. This text presents the fundamental components and challenges involving clinical investigations. Leading experts discuss the critical issues covering the spectrum of important topics from planning to application. The book has a foreword by Samuel A. Wells, Jr., MD, Professor of Surgery, Duke University Medical Center, Durham, NC, former Director of the American College of Surgeons and Founder of the American College of Surgeons Oncology Group.
Author : Henry Glick
Publisher : Oxford University Press
Page : 258 pages
File Size : 49,5 Mb
Release : 2007-02-15
Category : Business & Economics
ISBN : 9780198529972
The book provides a practical guide to conducting economic evaluation in ongoing clinical trials. It covers issues and techniques related to the collection of both cost and outcome data, as well as a framework for reporting and interpreting economic reports from clinical trials.
Author : Anonim
Publisher : Unknown
Page : 96 pages
File Size : 43,8 Mb
Release : 1990
Category : Cancer
ISBN : MINN:30000004649004
Author : Anonim
Publisher : Unknown
Page : 44 pages
File Size : 48,9 Mb
Release : 1998
Category : Electronic
ISBN : MINN:31951D017501836
Author : John I. Gallin
Publisher : Elsevier
Page : 490 pages
File Size : 48,8 Mb
Release : 2002-01-24
Category : Science
ISBN : 008053953X
Principles and Practice of Clinical Research is a comprehensive text which addresses the theoretical and practical issues involved in conducting clinical research. This book is divided into three parts: ethical, regulatory, and legal issues; biostatistics and epidemiology; technology transfer, protocol development and funding. It is designed to fill a void in clinical research education and provides the necessary fundamentals for clinical investigators. It should be of particular benefit to all individuals engaged in clinical research, whether as physician or dental investigators, Ph.D. basic scientists, or members of the allied health professions, as well as both students and those actively participating in clinical research. Key Features * Comprehensive review ranging from a historical perspective to the current ethical, legal and social issues and an introduction to biostatistics and epidemiology * Practical guide to writing a protocol, getting funding for clinical research, preparing images for publication and display * Cohesive and clear presentation by authors carefully selected to teach a very popular course at NIH * Excellent companion text for courses on clinical research
Author : Brian L. Strom,Stephen E. Kimmel
Publisher : John Wiley & Sons
Page : 756 pages
File Size : 40,8 Mb
Release : 2013-05-13
Category : Medical
ISBN : 9781118708002
The Textbook of Pharmacoepidemiology provides a streamlined text for evaluating the safety and effectiveness of medicines. It includes a brief introduction to pharmacoepidemiology as well as sections on data sources, methodology and applications. Each chapter includes key points, case studies and essential references. One-step resource to gain understanding of the subject of pharmacoepidemiology at an affordable price Gives a perspective on the subject from academia, pharmaceutical industry and regulatory agencies Designed for students with basic knowledge of epidemiology and public health Includes many case studies to illustrate pharmacoepidemiology in real clinical setting
Author : Joseph Lipscomb,Carolyn C. Gotay,Claire Snyder
Publisher : Cambridge University Press
Page : 682 pages
File Size : 41,9 Mb
Release : 2011-08-18
Category : Medical
ISBN : 1139442740
Cancer touches the lives of millions worldwide each year. This is reflected not only in well-publicized mortality statistics but also in the profound - though much more difficult to measure - effects of cancer on the health-related quality of life, economic status, and overall well-being of patients and their families. In 2001, the US National Cancer Institute established the Cancer Outcomes Measurement Working Group to evaluate the state of the science in measuring the important and diverse impacts of this disease on individuals and populations. The findings and recommendations of the working group's 35 internationally recognized members are reported in Outcomes Assessment in Cancer, lucidly written and accessible to both researchers and policy makers in academia, government, and industry. Originally published in 2005, this volume provides a penetrating yet practical discussion of alternative approaches for comprehensively measuring the burden of cancer and the effectiveness of preventive and therapeutic interventions.
Author : C.J. van Boxtel,B. Santoso,I.R. Edwards
Publisher : IOS Press
Page : 846 pages
File Size : 40,7 Mb
Release : 2008-08-06
Category : Medical
ISBN : 9781607503453
This updated and revised 2nd edition of Drug Benefits and Risks is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs, but in this context also highlighting the social impact which drugs have in modern societies. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases; the book gives guidance on how doctors should act so that drugs can be used effectively and safely; and it encourages the rational use of drugs in society. This publication brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.
Author : Brian L. Strom
Publisher : John Wiley & Sons
Page : 912 pages
File Size : 46,9 Mb
Release : 2006-01-04
Category : Medical
ISBN : 9780470866832
The fourth edition of Pharmacoepidemiology is an outstandingand fully comprehensive textbook, which will be an essentialresource for all interested in the field—in academia, inregulatory agencies, in industry and in the law. BrianStrom’s classic textbook continues both to reflect theincreased maturation of pharmacoepedemiology and to help shapeit’s direction. Reviews of previous editions of his celebrated textbookinclude: "The book is essential reading for anyone interested inpharmacoepidemiology." INTERNATIONAL JOURNAL OF EPIDEMIOLOGY “…an excellent textbook and a comprehensivereference which belongs in the library of everypharmaceutical manufacturer and regulator." EUROPEAN JOURNAL OF PUBLIC HEALTH
Author : Chris J. van Boxtel,Budiono Santoso,I. Ralph Edwards
Publisher : John Wiley & Sons
Page : 738 pages
File Size : 52,5 Mb
Release : 2001-11-28
Category : Medical
ISBN : 0471899275
This is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs but in this context also the social impact which drugs have in modern societies is highlighted. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book * Covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases * Gives guidance on how doctors should act so that drugs can be used effectively and safely * Encourages the rational use of drugs in society This book brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.