Economic Evaluation Of Cancer Drugs

Author : Iftekhar Khan,Ralph Crott,Zahid Bashir
Publisher : CRC Press
Page : 334 pages
File Size : 48,6 Mb
Release : 2019-06-14
Category : Mathematics
ISBN : 9780429531842

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Economic Evaluation of Cancer Drugs by Iftekhar Khan,Ralph Crott,Zahid Bashir Pdf

Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems. With advances in the diagnosis and treatment, more people are diagnosed early and receive treatments for a disease where few treatments options were previously available. As a result, the survival of patients with cancer has steadily improved and, in most cases, patients who are not cured may receive multiple lines of treatment, often with financial consequences for the patients, insurers and healthcare systems. Although many books exist that address economic evaluation, Economic Evaluation of Cancer Drugs using Clinical Trial and Real World Data is the first unified text that specifically addresses the economic evaluation of cancer drugs. The authors discuss how to perform cost-effectiveness analyses while emphasising the strategic importance of designing cost-effectiveness into cancer trials and building robust economic evaluation models that have a higher chance of reimbursement if truly cost-effective. They cover the use of real-world data using cancer registries and discuss how such data can support or complement clinical trials with limited follow up. Lessons learned from failed reimbursement attempts, factors predictive of successful reimbursement and the different payer requirements across major countries including US, Australia, Canada, UK, Germany, France and Italy are also discussed. The book includes many detailed practical examples, case studies and thought-provoking exercises for use in classroom and seminar discussions. Iftekhar Khan is a medical statistician and health economist and a lead statistician at Oxford Unviersity’s Center for Statistics in Medicine. Professor Khan is also a Senior Research Fellow in Health Economics at University of Warwick and is a Senior Statistical Assessor within the Licensing Division of the UK Medicine and Health Regulation Agency. Ralph Crott is a former professor in Pharmacoeconomics at the University of Montreal in Quebec, Canada and former head of the EORTC Health Economics Unit and former senior health economist at the Belgian HTA organization. Zahid Bashir has over twelve years experience working in the pharmaceutical industry in medical affairs and oncology drug development where he is involved in the design and execution of oncology clinical trials and development of reimbursement dossiers for HTA submission.

Author : Iftekhar Khan (Statistician),Ralph Crott,Zahid Bashir
Publisher : Chapman & Hall/CRC
Page : 416 pages
File Size : 46,9 Mb
Release : 2019-06-14
Category : HEALTH & FITNESS
ISBN : 0429546548

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Economic Evaluation of Cancer Drugs by Iftekhar Khan (Statistician),Ralph Crott,Zahid Bashir Pdf

Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems. With advances in the diagnosis and treatment, more people are diagnosed early and receive treatments for a disease where few treatments options were previously available. As a result, the survival of patients with cancer has steadily improved and, in most cases, patients who are not cured may receive multiple lines of treatment, often with financial consequences for the patients, insurers and healthcare systems. Although many books exist that address economic evaluation, Economic Evaluation of Cancer Drugs using Clinical Trial and Real World Data is the first unified text that specifically addresses the economic evaluation of cancer drugs. The authors discuss how to perform cost-effectiveness analyses while emphasising the strategic importance of designing cost-effectiveness into cancer trials and building robust economic evaluation models that have a higher chance of reimbursement if truly cost-effective. They cover the use of real-world data using cancer registries and discuss how such data can support or complement clinical trials with limited follow up. Lessons learned from failed reimbursement attempts, factors predictive of successful reimbursement and the different payer requirements across major countries including US, Australia, Canada, UK, Germany, France and Italy are also discussed. The book includes many detailed practical examples, case studies and thought-provoking exercises for use in classroom and seminar discussions. Iftekhar Khan is a medical statistician and health economist and a lead statistician at Oxford Unviersity's Center for Statistics in Medicine. Professor Khan is also a Senior Research Fellow in Health Economics at University of Warwick and is a Senior Statistical Assessor within the Licensing Division of the UK Medicine and Health Regulation Agency. Ralph Crott is a former professor in Pharmacoeconomics? at the University of Montreal in Quebec, Canada and former head of the EORTC Health Economics Unit and former senior health economist at the Belgian HTA organization. Zahid Bashir has over twelve years experience working in the pharmaceutical industry in medical affairs and oncology drug development where he is involved in the design and execution of oncology clinical trials and development of reimbursement dossiers for HTA submission.

Author : Niels Neymark
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642721236

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Assessing the Economic Value of Anticancer Therapies by Niels Neymark Pdf

With ever increasing demands on the constrained resources available for health care services, no one involved in decision making in health care can continue to ignore the economic costs of the services provided or the relative value for money offered by the available treatments. Economic evaluation has therefore become an important and indispensable tool for medical deci sion making, alongside the well-known methods for clinical eval uation. This is also true for cancer, despite the aura of sanctity often of surrounding this dreaded disease and the apparent willingness the general population to spend large sums in this area and do "everything possible" for the patients. In recent years, articles dealing with assessing the costs and benefits of various cancer treatments have begun to appear in scientific medical and eco nomic journals. This book provides a comprehensive survey and assessment of the current state of the art of economic evaluations and cost ana lyses in cancer. It gives an introduction to the methods available for economic evaluations, before surveying and assessing the available publications. Separate chapters are devoted to the most prevalent cancers, and in each chapter the current clinical prac tice and research problems are summarized in order to provide a background for the economic analyses. At the end, a summary assessment of the literature is provided along with some sugges tions for a future research agenda.

Author : Evelyn Walter
Publisher : Springer
Page : 205 pages
File Size : 48,7 Mb
Release : 2018-12-13
Category : Medical
ISBN : 9783030012076

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Regulatory and Economic Aspects in Oncology by Evelyn Walter Pdf

This book explores topics of importance to all who have an interest in economic methods for assessment of the efficacy and effectiveness of new cancer treatments and in regulatory measures relating to their marketing authorization and pricing. Targeted therapies and modern immunotherapy are placing a substantial strain on health care budgets. Regulation and economic methods to assess the parameters for establishing efficacy and effectiveness are therefore of prime importance. Payer authorities have to determine whether the use of these novel therapies yields clinical benefits that justify their increasing cost. In the simplest terms, cost-effectiveness analyses quantify the ratio between the extent to which an intervention raises healthcare costs and the extent to which it improves health outcomes. Rigorous cost-effectiveness analyses translate all health outcomes into quality-adjusted life years. On the other hand, in order to sustain innovation, price regulations must be coupled with efforts to ensure that drug companies are still able to recoup their investments in high-risk and high-costs research programs. Ultimately, decisions regarding health care expenditures are also a question of society’s willingness to pay.

Author : Cornelia Aaltje Groot
Publisher : Unknown
Page : 233 pages
File Size : 54,9 Mb
Release : 1995
Category : Electronic
ISBN : 9090085289

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Economic Evaluation of Cancer Treatments by Cornelia Aaltje Groot Pdf

Author : Olivier Ethgen,Ulf Staginnus
Publisher : Taylor & Francis
Page : 284 pages
File Size : 54,6 Mb
Release : 2016-10-14
Category : Business & Economics
ISBN : 9781317031123

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The Future of Health Economics by Olivier Ethgen,Ulf Staginnus Pdf

The pharmaceutical industry faces a well-documented perfect storm: on the one hand, the patent cliff; the lack of new blockbusters and, on the other, economic pressure on pricing from markets with growing expectations and shrinking budgets. In the face of such pressure, traditional health economics models no longer seem appropriate and yet what do we have to replace them? The growing focus on 'value' and 'cost effectiveness' are evidence of new emerging thinking although, even here, with the shift from medicine as cure to medicine as palliative, as a treatment for chronic illness and with the growing emphasis on preventative approaches, the landscape is complex and challenging. The Future of Health Economics offers a window into some of the most influential emerging issues in pharmacoeconomics; issues such as risk-sharing and alternative pricing models or the potential impact of radical new approaches such as personalized medicine; as well as exploring the changing role of government and regulators. Ulf Staginnus and Olivier Ethgen, themselves two of the most well-regarded practitioners in this field, have brought together some leading-edge thinkers from industry and academia around the world to provide the industry, policy-makers, regulators, health practitioners and academics with the raw material for their future scenarios.

Author : C.L. Bennett,Tammy Stinson
Publisher : Springer
Page : 188 pages
File Size : 51,7 Mb
Release : 2007-08-20
Category : Medical
ISBN : 9780585304984

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Cancer Policy: Research and Methods by C.L. Bennett,Tammy Stinson Pdf

Policy and outcome studies represent a new area of research in oncology. Understanding the factors that affect quality of life, costs of care, patterns of care, and outcomes in oncology is important to providing comprehensive care. Health services is meant to be both a productive area of research as well as a discipline that improves patient decision making. In sum, Cancer Policy highlights some of the important areas of health services research in oncology.

Author : Martin Brown,National Cancer Institute (U.S.)
Publisher : Unknown
Page : 42 pages
File Size : 45,7 Mb
Release : 1998
Category : Cancer
ISBN : UCSD:31822024222606

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Integrating Economic Analysis Into Cancer Clinical Trials by Martin Brown,National Cancer Institute (U.S.) Pdf

Clinical economics is a new and evolving discipline that addresses the economic implications of changes in medical practice. As applied to cancer care, clinical economics assesses the costs and effectiveness of new cancer interventions and can be a valuable endpoint in selected clinical trials. Through the integration of economics into clinical evaluations, information can be developed that contributes to the decisions of patients, clinicians, health care managers, and policymakers as to the most effective allocation of cancer care resources.

Author : Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Page : 165 pages
File Size : 43,7 Mb
Release : 2009-10-30
Category : Medical
ISBN : 9780309147330

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Assessing and Improving Value in Cancer Care by Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum Pdf

Unlike many other areas in health care, the practice of oncology presents unique challenges that make assessing and improving value especially complex. First, patients and professionals feel a well-justified sense of urgency to treat for cure, and if cure is not possible, to extend life and reduce the burden of disease. Second, treatments are often both life sparing and highly toxic. Third, distinctive payment structures for cancer medicines are intertwined with practice. Fourth, providers often face tremendous pressure to apply the newest technologies to patients who fail to respond to established treatments, even when the evidence supporting those technologies is incomplete or uncertain, and providers may be reluctant to stop toxic treatments and move to palliation, even at the end of life. Finally, the newest and most novel treatments in oncology are among the most costly in medicine. This volume summarizes the results of a workshop that addressed these issues from multiple perspectives, including those of patients and patient advocates, providers, insurers, health care researchers, federal agencies, and industry. Its broad goal was to describe value in oncology in a complete and nuanced way, to better inform decisions regarding developing, evaluating, prescribing, and paying for cancer therapeutics.

Author : Henry A. Glick,Jalpa A. Doshi,Seema S. Sonnad,Daniel Polsky
Publisher : OUP Oxford
Page : 288 pages
File Size : 54,9 Mb
Release : 2014-10-02
Category : Medical
ISBN : 9780191508066

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Economic Evaluation in Clinical Trials by Henry A. Glick,Jalpa A. Doshi,Seema S. Sonnad,Daniel Polsky Pdf

It is becoming increasingly important to examine the relationship between the outcomes of a clinical trial and the costs of the medical therapy under study. The results of such analysis can affect reimbursement decisions for new medical technologies, drugs, devices or diagnostics. It can aid companies seeking to make claims about the cost-effectiveness of their product, as well as allowing early consideration of the economic value of therapies which may be important to improving initial adoption decisions. It is also vital for addressing the requirements of regulatory bodies. Economic Evaluation in Clinical Trials provides practical advice on how to conduct cost-effectiveness analyses in controlled trials of medical therapies. This new edition has been extensively rewritten and revised; topics discussed range from design issues such as the types of services that should be measured and price weights, to assessment of quality-adjusted life years. Illustrative materials, case histories and worked examples are included to encourage the reader to apply the methods discussed. These exercises are supported with datasets, programmes and solutions made available online.

Author : Zaheer-Ud-Din Babar
Publisher : Academic Press
Page : 238 pages
File Size : 40,7 Mb
Release : 2018-02-27
Category : Business & Economics
ISBN : 9780128119624

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Equitable Access to High-Cost Pharmaceuticals by Zaheer-Ud-Din Babar Pdf

Equitable Access to High-Cost Pharmaceuticals seeks to aid the development and implementation of equitable public health policies by pharmaco-economics professionals, health economists, and policymakers. With detailed country-by country analysis of policy and regulation, the Work compares and contrasts national healthcare systems to support researchers and practitioners identify optimal healthcare policy solutions. The Work incorporates chapters on global regulatory changes, health technology assessment guidelines, and competitive effectiveness research recommendations from international bodies such as the OECD or the EU. Novel policies such as horizon scanning, managed-entry agreement and post-launch monitoring are considered in detail. The Work also thoroughly reviews novel pharmaceuticals with particular research interest, including cancer drugs, orphan medicines, Hep C, and personalized medicines. Evaluates impact and efficacy of current access policies and pricing regulation of high-cost drugs Incorporates existing guidelines and recommendations by international organizations Compares and contrasts how different countries fund and police high-cost drug access Explores novel and emergent policies, including managed entry agreement, analysis of real world data and differential pricing Reviews novel pharmaceuticals of current research interest

Author : William G. Newman
Publisher : Springer Science & Business Media
Page : 186 pages
File Size : 43,7 Mb
Release : 2010-07-20
Category : Medical
ISBN : 9789048186181

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Pharmacogenetics: Making cancer treatment safer and more effective by William G. Newman Pdf

Chemotherapy has made a dramatic difference to improved survival in patients with cancer. However, not all patients respond and some experience serious side effects. "Pharmacogenetics: Making cancer treatment safer and more effective" is an up to date summary of the exciting new field of how genetic testing can tailor more effective prescription in oncology. It is targeted at oncologists and professionals involved in the treatment of patients with cancer. It provides a core background in genetics and pharmacological principles before providing chapters from acknowledged experts in the field on genetic tests in specific cancer types, including breast, bowel and lung cancer. Clinical cases are used to illustrate the practical application of this knowledge. Chapters on ethics, health economics and the industry aspects of pharmacogenetics set out the challenges and opportunities afforded by this new science.

Author : Anonim
Publisher : Unknown
Page : 96 pages
File Size : 48,8 Mb
Release : 1995
Category : Cancer
ISBN : MINN:31951D01191101B

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National Cancer Institute Economic Conference, the Integration of Economic Outcome Measures Into NCI-Sponsored Therapeutic Trials by Anonim Pdf

Author : Iftekhar Khan
Publisher : CRC Press
Page : 339 pages
File Size : 51,9 Mb
Release : 2015-11-11
Category : Mathematics
ISBN : 9781466505483

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Design & Analysis of Clinical Trials for Economic Evaluation & Reimbursement by Iftekhar Khan Pdf

Economic evaluation has become an essential component of clinical trial design to show that new treatments and technologies offer value to payers in various healthcare systems. Although many books exist that address the theoretical or practical aspects of cost-effectiveness analysis, this book differentiates itself from the competition by detailing

Author : Karen Rascati
Publisher : Lippincott Williams & Wilkins
Page : 313 pages
File Size : 42,7 Mb
Release : 2013-11-14
Category : Medical
ISBN : 9781469841861

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Essentials of Pharmacoeconomics by Karen Rascati Pdf

"This new text is designed for a student or practitioner who is unfamiliar with "pharmacoeconomics." It provides a straightforward explanation of the essential pharmacoeconomics topics outlined by The Accreditation Council for Pharmacy Education (ACPE). It defines terminology used in research and covers the application of economic-based evaluation methods for pharmaceutical products and services. Users will find examples of how pharmacoeconomic evaluations relate to decisions that affect patient care and health-related quality of life"--Provided by publisher.