Interindividual Variability In Human Drug Metabolism

Author : Gian Maria Pacifici,Olavi Pelkonen
Publisher : CRC Press
Page : 560 pages
File Size : 43,8 Mb
Release : 2001-05-24
Category : Medical
ISBN : 0748408649

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Interindividual Variability in Human Drug Metabolism by Gian Maria Pacifici,Olavi Pelkonen Pdf

The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction. Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource.

Author : Fundación Dr. Antonio Esteve. Symposium,Geoffrey T. Tucker
Publisher : Elsevier Science & Technology
Page : 328 pages
File Size : 41,8 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015043198012

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Variability in Human Drug Response by Fundación Dr. Antonio Esteve. Symposium,Geoffrey T. Tucker Pdf

Hardbound. Variability in Human Drug Response represents a comprehensive account of the information shared by the participants of the Esteve Foundation's Eight Symposium held in Sitges, Spain. The Esteve Foundation which operates independently of any pharmaceutical enterprise, organizes international multidisciplinary meetings like The Esteve Foundation Symposia whose main goal is to stimulate progress in pharmacotherapy through scientific communication and discussion. The 8th symposium provided a timely forum which took into account the many aspects of variability in human drug response. The fact that every patient is different indicates the reason why the art and science of medical diagnosis is so interesting. The diversity in treatment can be viewed both as a challenge and as an obstacle. Clinical pharmacologists have been dealing with the challenge of understanding the many sources of variability in drug responses. With the advent of mo

Author : Stephen E. Smith,Michael D. Rawlins
Publisher : Elsevier
Page : 180 pages
File Size : 51,9 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483165110

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Variability in Human Drug Response by Stephen E. Smith,Michael D. Rawlins Pdf

Variability in Human Drug Response examines why individual patients differ significantly in their response to drug administration. This book is devoted mainly to pharmacokinetics and covers topics such as drug absorption, distribution, metabolism, and excretion. The sensitivity of tissues of the body to drugs and the importance of monitoring drug therapy are also discussed. This book is comprised of 10 chapters and begins with an introduction to variability in clinical response to administration of defined drugs, as well as the importance of closely matching dosage to the individual patient's requirement to achieve an optimal response to drug administration. The chapters that follow highlight the pharmacokinetic origin of most variability in the clinical response to drugs, along with the difficulties inherent in predicting the effect of drug administration in an individual patient. The role of genetic and environmental factors, disease, and the concomitant administration of other drugs in determining an individual's response to any therapeutic maneuver is also examined. The last chapter describes two methods of monitoring drug therapy: monitoring drug effects or monitoring the plasma levels of drugs. This monograph will be of interest to practicing clinicians and senior medical students.

Author : Stephen Edward Smith,Michael David Rawlins
Publisher : Butterworth-Heinemann
Page : 172 pages
File Size : 43,6 Mb
Release : 1973
Category : Drugs
ISBN : 0407433015

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Variability in Human Drug Response by Stephen Edward Smith,Michael David Rawlins Pdf

Author : Anonim
Publisher : Academic Press
Page : 378 pages
File Size : 52,6 Mb
Release : 2019-05-24
Category : Medical
ISBN : 9780128137970

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Chromatin Signaling and Neurological Disorders by Anonim Pdf

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research. Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders

Author : Kewal K. Jain
Publisher : Humana Press
Page : 762 pages
File Size : 51,9 Mb
Release : 2015-03-17
Category : Medical
ISBN : 9781493925537

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Textbook of Personalized Medicine by Kewal K. Jain Pdf

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Author : Jennifer B. Dressman,Christos Reppas
Publisher : CRC Press
Page : 432 pages
File Size : 40,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420077346

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Oral Drug Absorption by Jennifer B. Dressman,Christos Reppas Pdf

Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Author : Corina Ionescu,Mino R. Caira
Publisher : Springer Science & Business Media
Page : 444 pages
File Size : 53,9 Mb
Release : 2006-02-28
Category : Medical
ISBN : 1402041411

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Drug Metabolism by Corina Ionescu,Mino R. Caira Pdf

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Author : Dr. G. Suarez-Kurtz
Publisher : CRC Press
Page : 222 pages
File Size : 48,9 Mb
Release : 2007-08-03
Category : Science
ISBN : 9781498713795

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Pharmacogenomics in Admixed Populations by Dr. G. Suarez-Kurtz Pdf

Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 55,9 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185

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Evolution of Translational Omics by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Pdf

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Author : Mark Ashton,Paul W. Groundwater,Sophie Stocker,Adam Todd
Publisher : Elsevier
Page : 278 pages
File Size : 41,6 Mb
Release : 2024-05-13
Category : Medical
ISBN : 9780323993753

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An Integrated Guide to Human Drug Metabolism by Mark Ashton,Paul W. Groundwater,Sophie Stocker,Adam Todd Pdf

An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines and other drugs. Each of the human metabolic processes will be covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (age-related dosage adjustments, routes of administration, and personalized medicines). Appropriate for use in the classroom or for self-study, An Integrated Guide to Human Drug Metabolism is useful for students and researchers needing a reference for interdisciplinary research in drug interactions. Metabolism is at the center of personalized medicine, as it is a governing factor in the response of the patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential will be used to highlight the increasing necessity for understanding the genetic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a basis for the discussion of clinical aspects. Covers each of the human metabolic processes, employing examples drawn from known metabolic transformations of drugs used clinically Provides an integrated approach, linking together the science and practice strands of human drug metabolism Contains questions and answers to assess learning of material and real-life case studies

Author : Souzan B. Yanni
Publisher : John Wiley & Sons
Page : 353 pages
File Size : 43,9 Mb
Release : 2015-10-12
Category : Medical
ISBN : 9781118838273

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Translational ADMET for Drug Therapy by Souzan B. Yanni Pdf

Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval

Author : Jerzy Majkowski
Publisher : Cambridge University Press
Page : 530 pages
File Size : 48,6 Mb
Release : 2005-05-26
Category : Medical
ISBN : 052182219X

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Antiepileptic Drugs by Jerzy Majkowski Pdf

This book reviews the use of antiepileptic drugs focusing on the interactions between these drugs and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed supported by clinical and experimental data. The book consists of five sections covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-morbid health conditions, and concludes with a look at the future directions for this field of research. The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic patients, including epileptologists, neurologists, neuro-pediatricians, psychiatrists and general practitioners.

Author : Daniel L. Young,Seth Michelson
Publisher : John Wiley & Sons
Page : 398 pages
File Size : 50,5 Mb
Release : 2011-09-23
Category : Medical
ISBN : 9781118016428

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Systems Biology in Drug Discovery and Development by Daniel L. Young,Seth Michelson Pdf

The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

Author : Philippe Ciffroy,Alice Tediosi,Ettore Capri
Publisher : Springer
Page : 262 pages
File Size : 55,8 Mb
Release : 2017-06-30
Category : Science
ISBN : 9783319595023

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Modelling the Fate of Chemicals in the Environment and the Human Body by Philippe Ciffroy,Alice Tediosi,Ettore Capri Pdf

This volume focuses on modelling the fate of chemicals in the environment and the human body to arrive at an integrated exposure assessment. It covers five broad topics, namely: future challenges in exposure assessment; the evolution of human health and environmental risk assessment; standard documentation for exposure models; modelling different environmental components (i.e. surface waters, atmosphere, soil, groundwater, plants, aquatic organisms and mammals); and the fate of contaminants in humans. This work draws on the authors’ and editors’ extensive experience and a range of different research activities, including case studies, that have led to the development of MERLIN-Expo, a standardised software package for simulating the fate of chemicals in the main environmental systems and in the human body in an integrated manner. It will be of considerable interest to researchers and students, risk managers, and policy- and decision-makers whose work involves environmental protection and human health.