Interrelations Between Essential Metal Ions And Human Diseases

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Interrelations between Essential Metal Ions and Human Diseases

Astrid Sigel,Helmut Sigel,Roland K.O. Sigel
Interrelations between Essential Metal Ions and Human Diseases Book PDF

Author : Astrid Sigel,Helmut Sigel,Roland K.O. Sigel
Publisher : Springer Science & Business Media
Page : 603 pages
File Size : 46,7 Mb
Release : 2014-01-27
Category : Science
ISBN : 9789400775008

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Interrelations between Essential Metal Ions and Human Diseases by Astrid Sigel,Helmut Sigel,Roland K.O. Sigel Pdf

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Peggy L. Carver
Essential Metals in Medicine Therapeutic Use and Toxicity of Metal Ions in the Clinic Book PDF

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 455 pages
File Size : 45,7 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110527872

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Metal Ions in Biological Systems

Astrid Sigel
Metal Ions in Biological Systems Book PDF

Author : Astrid Sigel
Publisher : Routledge
Page : 848 pages
File Size : 47,6 Mb
Release : 2018-05-04
Category : Science
ISBN : 9781351432146

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Metal Ions in Biological Systems by Astrid Sigel Pdf

Continues the tradition of excellence established in previous volumes in this acclaimed series. Volume 36 focuses on the vibrant research area concerning the interrelation between free radicals and metal ions and their resulting effects on life processes; it offers an authoritative and timely account of this fascinating area of research in 21 chapters.

Trace Metals and Infectious Diseases

Jerome O. Nriagu,Eric P. Skaar
Trace Metals and Infectious Diseases Book PDF

Author : Jerome O. Nriagu,Eric P. Skaar
Publisher : MIT Press
Page : 501 pages
File Size : 53,5 Mb
Release : 2024-06-11
Category : Medical
ISBN : 9780262552486

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Trace Metals and Infectious Diseases by Jerome O. Nriagu,Eric P. Skaar Pdf

Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Peggy L. Carver
Essential Metals in Medicine Therapeutic Use and Toxicity of Metal Ions in the Clinic Book PDF

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 640 pages
File Size : 48,9 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110526981

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Diet and Health

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
Diet and Health Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
Publisher : National Academies Press
Page : 765 pages
File Size : 47,8 Mb
Release : 1989-01-01
Category : Medical
ISBN : 9780309039949

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Diet and Health by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health Pdf

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

The Alkali Metal Ions: Their Role for Life

Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
The Alkali Metal Ions Their Role for Life Book PDF

Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
Publisher : Springer
Page : 628 pages
File Size : 48,5 Mb
Release : 2016-02-09
Category : Science
ISBN : 9783319217567

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The Alkali Metal Ions: Their Role for Life by Astrid Sigel,Helmut Sigel,Roland K. O. Sigel Pdf

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment

Peter M.H. Kroneck,Martha E. Sosa Torres
The Metal Driven Biogeochemistry of Gaseous Compounds in the Environment Book PDF

Author : Peter M.H. Kroneck,Martha E. Sosa Torres
Publisher : Springer
Page : 363 pages
File Size : 51,7 Mb
Release : 2014-11-22
Category : Science
ISBN : 9789401792691

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The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment by Peter M.H. Kroneck,Martha E. Sosa Torres Pdf

MILS-14 provides a most up-to-date view of the exciting biogeochemistry of gases in our environment as driven mostly by microorganisms. These employ a machinery of sophisticated metalloenzymes, where especially transition metals (such as Fe, Ni, Cu, Mo, W) play a fundamental role, that is, in the activation, transformation and syntheses of gases like dihydrogen, methane, carbon monoxide, acetylene and those of the biological nitrogen and sulfur cycles. The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment is a vibrant research area based mainly on structural and microbial biology, inorganic biological chemistry and environmental biochemistry. All this is covered in an authoritative manner in 11 stimulating chapters, written by 26 internationally recognized experts and supported by nearly 1200 references, informative tables and about 100 illustrations (two thirds in color). MILS-14 also provides excellent information for teaching. Peter M. H. Kroneck is a bioinorganic chemist who is exploring the role of transition metals in biology, with a focus on functional and structural aspects of microbial iron, copper and molybdenum enzymes and their impact on the biogeochemical cycles of nitrogen and sulfur. Martha E. Sosa Torres is an inorganic chemist, with special interests in magnetic properties of newly synthesized transition metal complexes and their reactivity towards molecular oxygen, applying kinetic, electrochemical and spectroscopic techniques.

Metal Ions in Biological Systems

Helmut Sigel
Metal Ions in Biological Systems Book PDF

Author : Helmut Sigel
Publisher : CRC Press
Page : 416 pages
File Size : 53,9 Mb
Release : 1986-02-21
Category : Science
ISBN : 0824775406

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Metal Ions in Biological Systems by Helmut Sigel Pdf

Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 21 describes the underlying theories of nuclear magnetic resonance (NMR), promoting a wider use of NMR in studies of paramagnetic species. In six concise chapters by leading international authorities, Applications of Nuclear Magnetic Resonance to Paramagnetic Species outlines the most recent developments regarding the use of nuclear relaxation as a source for structural information ... examines studies of magnetically coupled metalloproteins and metal-porphyrin induced dipolar shifts for conformational analysis ... and evaluates the potential of paramagnetic ions as agents for enhancing NMR image contrast. With over 500 references that facilitate further research, Applications of Nuclear Magnetic Resonance to Paramagnetic Species is an essential resource for scientists and students in such disciplines as biophysics; bioinorganic, inorganic, and coordination chemistry; biochemistry; molecular biology; and enzymology. Book jacket.

Essential and Toxic Trace Elements and Vitamins in Human Health

George J. Brewer,Ananda S. Prasad
Essential and Toxic Trace Elements and Vitamins in Human Health Book PDF

Author : George J. Brewer,Ananda S. Prasad
Publisher : Academic Press
Page : 328 pages
File Size : 47,7 Mb
Release : 2020-06-14
Category : Medical
ISBN : 9780128093016

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Essential and Toxic Trace Elements and Vitamins in Human Health by George J. Brewer,Ananda S. Prasad Pdf

Essential and Toxic Trace Elements and Vitamins in Human Health is a comprehensive guide to the wide variety of micronutrients that affect human health, including fat-soluble and water-soluble vitamins that support diverse biochemical functions, trace elements with established and suggested links to health maintenance, and elements with known human toxicity such as arsenic, cadmium, and lead. An essential reference text for nutritionists working in academia and functional food and supplement industries, dieticians, and clinicians, Essential and Toxic Trace Elements and Vitamins in Human Health provides an in-depth look at toxic trace elements and essential vitamins and minerals and their direct influence on the body’s overall health with expert research from renowned scientists. Presents a balanced scientific view of essential and nonessential micronutrients with an in-depth analysis of the biochemical functions each plays in human health Examines particular micronutrients in detail with coverage of clinical aspects, interaction with other micronutrients, immunological effects, cognitive functions and epigenetics Focuses on effective management of micronutrient deficiencies and on toxicity implications of overexposure

Sustaining Life on Planet Earth: Metalloenzymes Mastering Dioxygen and Other Chewy Gases

Peter M. H Kroneck,Martha E. Sosa Torres
Sustaining Life on Planet Earth Metalloenzymes Mastering Dioxygen and Other Chewy Gases Book PDF

Author : Peter M. H Kroneck,Martha E. Sosa Torres
Publisher : Springer
Page : 329 pages
File Size : 52,8 Mb
Release : 2015-02-23
Category : Medical
ISBN : 9783319124155

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Sustaining Life on Planet Earth: Metalloenzymes Mastering Dioxygen and Other Chewy Gases by Peter M. H Kroneck,Martha E. Sosa Torres Pdf

MILS-15 provides an up-to-date review of the metalloenzymes involved in the activation, production, and conversion of molecular oxygen as well as the functionalization of the chemically inert gases methane and ammonia. Found either in aerobes (humans, animals, plants, microorganisms) or in anaerobes (so-called “impossible bacteria”) these enzymes employ preferentially iron and copper at their active sites, in order to conserve energy by redox-driven proton pumps, to convert methane to methanol, or ammonia to hydroxylamine or other compounds. When it comes to the light-driven production of molecular oxygen, the tetranuclear manganese cluster of photosystem II must be regarded as the key player. However, dioxygen can also be produced in the dark, by heme iron-dependent dismutation of oxyanions. Metalloenzymes Mastering Dioxygen and Other Chewy Gases is a vibrant research area based mainly on structural and microbial biology, inorganic biological chemistry, and environmental biochemistry. All this is covered in an authoritative manner in 7 stimulating chapters, written by 21 internationally recognized experts, and supported by nearly 1100 references, informative tables, and over 140 illustrations (many in color). MILS-15 provides excellent information for teaching; it is also closely related to MILS-14, The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment. Peter M. H. Kroneck is a bioinorganic chemist who is exploring the role of transition metals in biology, with a focus on functional and structural aspects of microbial iron, copper, and molybdenum enzymes and their impact on the biogeochemical cyles of nitrogen and sulfur. Martha E. Sosa Torres is an inorganic chemist, with special interests in magnetic properties of newly synthesized transition metal complexes and their reactivity towards molecular oxygen, applying kinetic, electrochemical, and spectroscopic techniques.

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology

Seth Kwabena Amponsah,Yashwant V. Pathak
Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Book PDF

Author : Seth Kwabena Amponsah,Yashwant V. Pathak
Publisher : Springer Nature
Page : 384 pages
File Size : 53,5 Mb
Release : 2022-10-25
Category : Medical
ISBN : 9783031123986

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology by Seth Kwabena Amponsah,Yashwant V. Pathak Pdf

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Transition Metals and Sulfur – A Strong Relationship for Life

Martha Sosa Torres,Peter Kroneck
Transition Metals and Sulfur A Strong Relationship for Life Book PDF

Author : Martha Sosa Torres,Peter Kroneck
Publisher : Walter de Gruyter GmbH & Co KG
Page : 610 pages
File Size : 46,9 Mb
Release : 2020-04-06
Category : Science
ISBN : 9783110588941

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Transition Metals and Sulfur – A Strong Relationship for Life by Martha Sosa Torres,Peter Kroneck Pdf

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes; in fact, it is an old wisdom that metals are indispensable for life. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in numerous interconnecting research fields.

Trace Metals and Infectious Diseases

Joseph Lemire
Trace Metals and Infectious Diseases Book PDF

Author : Joseph Lemire
Publisher : MIT Press
Page : 501 pages
File Size : 44,6 Mb
Release : 2015-05-22
Category : Medical
ISBN : 9780262029193

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Trace Metals and Infectious Diseases by Joseph Lemire Pdf

Experts explore the influence of trace metals on the pathogenesis of infectious diseases.

Cadmium: From Toxicity to Essentiality

Astrid Sigel,Helmut Sigel,Roland KO Sigel
Cadmium From Toxicity to Essentiality Book PDF

Author : Astrid Sigel,Helmut Sigel,Roland KO Sigel
Publisher : Springer Science & Business Media
Page : 590 pages
File Size : 47,7 Mb
Release : 2013-02-26
Category : Science
ISBN : 9789400751798

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Cadmium: From Toxicity to Essentiality by Astrid Sigel,Helmut Sigel,Roland KO Sigel Pdf

Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.