Introduction To Cancer Metastasis

Author : Aamir Ahmad
Publisher : Academic Press
Page : 416 pages
File Size : 42,9 Mb
Release : 2016-11-14
Category : Science
ISBN : 9780128040331

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Introduction to Cancer Metastasis by Aamir Ahmad Pdf

Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe

Author : Aamir Ahmad
Publisher : Academic Press
Page : 416 pages
File Size : 42,5 Mb
Release : 2016-12-30
Category : Electronic
ISBN : 0128040033

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Introduction to Cancer Metastasis by Aamir Ahmad Pdf

Introduction to Cancer Metastasis provides an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis all in one place. Through specific chapters on individual primary cancers and their metastasis, along with chapters on common metastatic site, this volume comprehensively informs readers on the broader knowledge so far obtained on cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, so as to increase understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe

Author : Venkateshwar Keshamouni,Douglas Arenberg,Gregory Kalemkerian
Publisher : Springer Science & Business Media
Page : 409 pages
File Size : 42,7 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9781441907721

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Lung Cancer Metastasis by Venkateshwar Keshamouni,Douglas Arenberg,Gregory Kalemkerian Pdf

Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

Author : Momna Hejmadi
Publisher : Bookboon
Page : 46 pages
File Size : 54,6 Mb
Release : 2014*
Category : Cancer
ISBN : 9788776814786

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Introduction to Cancer Biology by Momna Hejmadi Pdf

"Introduction to Cancer Biology is a short primer on how cancers develop and grow. The aim of this book is to provide a gentle exploration of the fundamental concepts in a easy-to-understand format, using examples and key figures for illustration. It is written in a style to help the reader understand the six basic principles that inform our current understanding of cancer, at the molecular, cellular and physiological level. The text can be used either as a first step towards a deeper understanding of the mechanisms of cancer progression or it can be used as a quick revision guide. It would be suitable for anyone, with or without a background in biology."--Website.

Author : R.E. Mansel,Oystein Fodstad,Wen G. Jiang
Publisher : Springer Science & Business Media
Page : 439 pages
File Size : 40,7 Mb
Release : 2007-06-17
Category : Medical
ISBN : 9781402058677

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Metastasis of Breast Cancer by R.E. Mansel,Oystein Fodstad,Wen G. Jiang Pdf

Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.

Author : Anastasia Malek
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 41,7 Mb
Release : 2013-12-02
Category : Medical
ISBN : 9789400778351

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Experimental Metastasis: Modeling and Analysis by Anastasia Malek Pdf

Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.

Author : Leonard Weiss,Harvey A. Gilbert
Publisher : Macmillan Reference USA
Page : 362 pages
File Size : 42,5 Mb
Release : 1978
Category : Medical
ISBN : UOM:39015003796250

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Pulmonary Metastasis by Leonard Weiss,Harvey A. Gilbert Pdf

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 40,5 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Yasemin Basbinar,Gizem Calibasi Kocal
Publisher : BoD – Books on Demand
Page : 154 pages
File Size : 50,6 Mb
Release : 2018-12-05
Category : Medical
ISBN : 9781789846324

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Cancer Metastasis by Yasemin Basbinar,Gizem Calibasi Kocal Pdf

Metastasis of cancer cells from primary tumor site to secondary locations is considered a late event in multistep tumorigenesis, and causes most cancer-related mortality. The process from the spreading of cancer cells to the seeding of newly formed tumor colonizations is governed by sequential events, including local invasion, intravasation into stroma and blood vessels, survival in circulation, extravasation, and colonization at secondary tumor sites. Cancer research provides information on the fate of metastatic cancer cells in each sequential movement or heterogeneous tumor microenvironment. However, the complexity of this mechanism remains the most stringent concept of cancer management. This book provides information for cancer researchers on metastatic phenotypes of cancer cells, and diverse promoting factors and molecular mechanisms of metastasis.

Author : Gajanan V. Sherbet,M. S. Lakshmi
Publisher : Academic Press
Page : 338 pages
File Size : 52,5 Mb
Release : 1997-06-22
Category : Medical
ISBN : 0080542484

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The Genetics of Cancer by Gajanan V. Sherbet,M. S. Lakshmi Pdf

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes

Author : J.M. Debois
Publisher : Springer Science & Business Media
Page : 757 pages
File Size : 49,8 Mb
Release : 2006-05-08
Category : Medical
ISBN : 9780306476785

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TxNxM1 by J.M. Debois Pdf

Although distant metastases are the most dreaded situation in the evolution of cancer of every organ, the medical literature has surprisingly given little attention to the anatomical relationship between the primary tumor and metastasic sites. Only risk factors, treatment possibilities, and survival results are extensively examined. Stimulated by the occurrence in his practice of some puzzling and unexpected metastases, the author reviewed more than 12,000 references. He looked for anatomical relationships highlighting the relation between the location of the primary tumors and the particular patterns of metastasis observed. It would seem that the `pathways and flows' are apparently a more decisive factor in the implantation of the metastases than the `seed and soil' properties of the cancer cells and the metastatic site. Aided by his colleague Dr. T. Geukens, M.D., the author includes original anatomical drawings, illustrating the sometimes unexpected pathways the cancer cells follow in order to reach the organs where they will become lodged and give rise to metastatic tumors. The subject has apparently not been exhausted in the literature and several ideas are given for further research.

Author : Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi
Publisher : Academic Press
Page : 342 pages
File Size : 45,6 Mb
Release : 2022-05-14
Category : Science
ISBN : 9780128217900

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Unraveling the Complexities of Metastasis by Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi Pdf

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis. Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and newcomers in the field of cancer metastasis

Author : Venkateshwar Keshamouni,Douglas Arenberg,Gregory Kalemkerian
Publisher : Springer
Page : 409 pages
File Size : 54,5 Mb
Release : 2009-10-29
Category : Medical
ISBN : 1441907718

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Lung Cancer Metastasis by Venkateshwar Keshamouni,Douglas Arenberg,Gregory Kalemkerian Pdf

Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

Author : Rahul Jandial
Publisher : CRC Press
Page : 312 pages
File Size : 45,9 Mb
Release : 2013-08-08
Category : Medical
ISBN : 1587066599

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Metastatic Cancer: Clinical and Biological Perspectives by Rahul Jandial Pdf

Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Author : Wen G. Jiang,R.E. Mansel
Publisher : Springer Science & Business Media
Page : 434 pages
File Size : 41,5 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306483882

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Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention by Wen G. Jiang,R.E. Mansel Pdf

This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.