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Author : Franklin Bretschneider
Publisher : Unknown
Page : 156 pages
File Size : 48,7 Mb
Release : 1995
Category : Electronic
ISBN : 9074005020
Author : Franklin Bretschneider,Jan R. de Weille
Publisher : Academic Press
Page : 370 pages
File Size : 40,7 Mb
Release : 2018-11-13
Category : Science
ISBN : 9780128142110
Introduction to Electrophysiological Methods and Instrumentation, Second Edition covers all topics of interest to electrophysiologists, neuroscientists and neurophysiologists, from the reliable penetration of cells and the behavior and function of the equipment, to the mathematical tools available for analyzing data. It discusses the pros and cons of techniques and methods used in electrophysiology and how to avoid pitfalls. Although the basics of electrophysiological techniques remain the principal purpose of this second edition, it now integrates several current developments, including, amongst others, automated recording for high throughput screening and multimodal recordings to correlate electrical activity with other physiological parameters collected by optical means. This book provides the electrophysiologist with the tools needed to understand his or her equipment and how to acquire and analyze low-voltage biological signals. Introduces possibilities and solutions, along with the problems, pitfalls, and artefacts of equipment and electrodes Discusses the particulars of recording from brain tissue slices, oocytes and planar bilayers Describes optical methods pertinent to electrophysiological practice Presents the fundamentals of signal processing of analogue signals, spike trains and single channel recordings, along with procedures for signal recording and processing Includes appendices on electrical safety and foundations of useful mathematical tools
Author : George Camougis
Publisher : Springer Science & Business Media
Page : 81 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468413694
For centuries man knew about the lightning of the sky (atmospheric or physical electricity) and the numbing effects from contact with powerful electric fishes (animal electricity). Then, after proper experimentation and a synthetic ration ale, it began to appear that physical and animal electricity were related in fundamental respects. This realization was made at the end of the eighteenth century, since when the pages of history have been replete with exciting dis coveries and developments in electricity and magnetism, electrochemistry, and electrophysiology. It is hoped that this manual will enable some students to relive some of that excitement. The author remembers vividly the excitement when, as an undergraduate, he saw his first action potential. This book is not intended for any particular group of students; it should prove to be of some value to students in secondary schools, colleges, and gradu ate schools. Based on personal experience, the author feels that many teachers will also find it of use. Nor is the manual intended solely as a laboratory manual for an introductory course in neurophysiology. Some of the experiments might be introduced into the formallaboratory schedule of general or animal physiology courses. Alternatively, the various experiments might provide the bases for the beginning of special projects lasting for a full semester or even longer.
Author : Ellen Covey,Matt Carter
Publisher : Oxford University Press, USA
Page : 241 pages
File Size : 52,7 Mb
Release : 2015
Category : Medical
ISBN : 9780199939800
A broad, concise, and no-nonsense guide to contemporary electrophysiological techniques, covering intracellular and extracellular recording through recording of population activity, neuropharmacology, dye imaging, voltammetry, and optogenetics.
Author : Jay L. Nadeau
Publisher : CRC Press
Page : 658 pages
File Size : 44,9 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781439897409
Increasing numbers of physicists, chemists, and mathematicians are moving into biology, reading literature across disciplines, and mastering novel biochemical concepts. To succeed in this transition, researchers must understand on a practical level what is experimentally feasible. The number of experimental techniques in biology is vast and often s
Author : Pollnow, Stefan
Publisher : KIT Scientific Publishing
Page : 296 pages
File Size : 51,6 Mb
Release : 2019-04-23
Category : Electronic
ISBN : 9783731508861
Author : Joseph Tranquillo
Publisher : Springer Nature
Page : 144 pages
File Size : 42,9 Mb
Release : 2022-06-01
Category : Technology & Engineering
ISBN : 9783031016288
Quantitative Neurophysiology is supplementary text for a junior or senior level course in neuroengineering. It may also serve as an quick-start for graduate students in engineering, physics or neuroscience as well as for faculty interested in becoming familiar with the basics of quantitative neuroscience. The first chapter is a review of the structure of the neuron and anatomy of the brain. Chapters 2-6 derive the theory of active and passive membranes, electrical propagation in axons and dendrites and the dynamics of the synapse. Chapter 7 is an introduction to modeling networks of neurons and artificial neural networks. Chapter 8 and 9 address the recording and decoding of extracellular potentials. The final chapter has descriptions of a number of more advanced or new topics in neuroengineering. Throughout the text, vocabulary is introduced which will enable students to read more advanced literature and communicate with other scientists and engineers working in the neurosciences. Numerical methods are outlined so students with programming knowledge can implement the models presented in the text. Analogies are used to clarify topics and reinforce key concepts. Finally, homework and simulation problems are available at the end of each chapter. Table of Contents: Preface / Neural Anatomy / Passive Membranes / Active Membranes / Propagation / Neural Branches / Synapses / Networks of Neurons / Extracellular Recording and Stimulation / The Neural Code / Applications / Biography / Index
Author : Jianghui Hou
Publisher : Academic Press
Page : 422 pages
File Size : 43,7 Mb
Release : 2020-04-24
Category : Science
ISBN : 9780128226438
A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. Provides consistent and detailed research methods Covers various cell, tissue and animal models Includes step-by-step guidance from beginner to sophisticated levels
Author : Keller, Matthias
Publisher : KIT Scientific Publishing
Page : 266 pages
File Size : 43,8 Mb
Release : 2014-09-09
Category : Electronic
ISBN : 9783731502289
Author : Jonathan Wolpaw,Elizabeth Winter Wolpaw
Publisher : OUP USA
Page : 419 pages
File Size : 51,7 Mb
Release : 2012-01-24
Category : Medical
ISBN : 9780195388855
In the last 15 years, a recognizable surge in the field of Brain Computer Interface (BCI) research and development has emerged. This emergence has sprung from a variety of factors. For one, inexpensive computer hardware and software is now available and can support the complex high-speed analyses of brain activity that is essential is BCI. Another factor is the greater understanding of the central nervous system including the abundance of new information on the nature and functional correlates of brain signals and improved methods for recording these signals in both the short-term and long-term. And the third, and perhaps most significant factor, is the new recognition of the needs and abilities of people disabled by disorders such as cerebral palsy, spinal cord injury, stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, and muscular dystrophies. The severely disabled are now able to live for many years and even those with severely limited voluntary muscle control can now be given the most basic means of communication and control because of the recent advances in the technology, research, and applications of BCI. This book is intended to provide an introduction to and summary of essentially all major aspects of BCI research and development. Its goal is to be a comprehensive, balanced, and coordinated presentation of the field's key principles, current practice, and future prospects.
Author : William L. Nastuk
Publisher : Academic Press
Page : 478 pages
File Size : 51,6 Mb
Release : 2017-01-31
Category : Science
ISBN : 9781483191799
Electrophysiological Methods presents a compilation of essays relating to the field of electricity. One topic is the introduction and analysis of electrical stimulation. Other types of stimulation are thermal stimulation, light stimulation, touch stimulation, and auditory stimulation. Microelectrodes act as links by which small regions in biological tissues are electrically joined to amplifying and recording devices. This topic is explored more thoroughly in the book. The physiological activity of cells in nerves, muscles, secretory organs, and other biological structures is accompanied by electrical changes which appear across the cell membrane. This occurrence is another topic in the text. Intracellular techniques employed to record transmembrane potentials and to stimulate cells are likewise presented. A section of the book presents microelectrophoresis which is a method wherein electrical flow is employed to manipulate the ejection of chemical substances from fine microelectrodes or micropipettes. The book will provide useful information to neurologist, cytologist, doctors, students, and researchers in the field of medicine.
Author : Areles Molleman
Publisher : John Wiley & Sons
Page : 186 pages
File Size : 50,5 Mb
Release : 2003-06-13
Category : Science
ISBN : 9780470856512
Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells. Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results. This book will explain the basic principles and practical application of patch clamp electrophysiology Written in a non-technical style to ensure its broad appeal to novice users Takes a practical approach This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns
Author : Clifford Ferris
Publisher : Springer
Page : 243 pages
File Size : 44,6 Mb
Release : 2013-02-01
Category : Technology & Engineering
ISBN : 146842078X
This book is the outgrowth of several courses that the author has taught during the last decade at three universities. Most recently, it has served as the principal text for a course offered in the Bioengineering Graduate Program at the University of Wyoming. The book is designed to fill two needs. For the casual reader who just wants to know something about electrodes, it provides a general overview of the types of electrodes available for different uses. For the student, clinician, and researcher, theories are discussed and practical methods are described. Both fabrication methods and techniques for use are presented for a variety of electrodes, as well as electrode systems and configurations. The discussion applies to electrodes in both the stimulating and recording modes. In addition to fabrication and use techniques, there is extensive dis cussion of various problems associated with electrodes. Attention is directed to electrode polarization (both alternating-and direct-current phenomena), electrical noise, and requirements for backup instrumentation such as electronic amplifiers. A brief treatment of signal analysis and filtering tech niques is included to complement the chapter dealing with amplifiers and the discussions of noise.
Author : Mark Dallas,Damian Bell
Publisher : Humana
Page : 333 pages
File Size : 52,5 Mb
Release : 2021-11-13
Category : Medical
ISBN : 1071608207
This volume describes a range of standard and novel methodological approaches used to probe ion channel function across different modalities. Chapters guide readers through methods and protocols from an introduction to the decades old patch clamp method for the ion channel neophyte to more complex, recent protocol advances, such as optogenetics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Patch Clamp Electrophysiology: Methods and Protocols aims to be a reference guide for current and future ion channel physiologists.
Author : Louis J. DeFelice
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 40,7 Mb
Release : 2013-06-29
Category : Nature
ISBN : 9781489902481
DeFelice presents this intricate subject in an easy-to-follow, stepwise fashion: he reviews the fundamentals of electricity; transfers those principles to a biological context; and expands the discussion to encompass the subject's practical dimensions. Clear definitions and intuitive descriptions characterize the presentation, which is complemented by over 150 drawings and graphs. Mathematics is kept to the minimum necessary. The text covers both excitable and non-excitable membranes and includes the plasma membrane as well as intracellular membranes. A unique, `electronics-made-simple' appendix, designed specifically for biologists, treats the operational amplifiers used in patch clamp, and other appendices offer solutions to equations and examples that illustrate principles.