Introduction To Skin Toxicology

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Principles and Practice of Skin Toxicology

Robert Chilcott,Shirley Price
Principles and Practice of Skin Toxicology Book PDF

Author : Robert Chilcott,Shirley Price
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 49,9 Mb
Release : 2008-07-31
Category : Science
ISBN : 9780470773086

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Principles and Practice of Skin Toxicology by Robert Chilcott,Shirley Price Pdf

Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.

Introduction to Skin Toxicology

Sharon Hotchkiss
Introduction to Skin Toxicology Book PDF

Author : Sharon Hotchkiss
Publisher : Unknown
Page : 350 pages
File Size : 50,6 Mb
Release : 1998-09
Category : Medical
ISBN : 074840662X

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Introduction to Skin Toxicology by Sharon Hotchkiss Pdf

A comprehensive introduction to skin toxicology, which covers the general structure and function of the skin, pathology, toxicants, absorption, and metabolism of chemicals, corrosion, irritation, sensitation, phototoxicity and skin cancer. Case studies include carbaryl in head lice shampoos, skin cancer in sun creams, chemical warfare agents, nickel in jewellery, organophosphates in sheep dips, reproductive toxins in retinoid anti-acne, psoriasis and ageing drugs. There is also a short section on techniques.

Toxicology of Skin

Howard I. Maibach
Toxicology of Skin Book PDF

Author : Howard I. Maibach
Publisher : CRC Press
Page : 573 pages
File Size : 45,6 Mb
Release : 2001-03-15
Category : Medical
ISBN : 9781420022728

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Toxicology of Skin by Howard I. Maibach Pdf

Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th

Advances in Dermatological Sciences

Keith R Brain,Robert P Chilcott
Advances in Dermatological Sciences Book PDF

Author : Keith R Brain,Robert P Chilcott
Publisher : Royal Society of Chemistry
Page : 476 pages
File Size : 47,7 Mb
Release : 2013
Category : Medical
ISBN : 9781849733984

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Advances in Dermatological Sciences by Keith R Brain,Robert P Chilcott Pdf

Readily accessible, yet detailed, this book presents cutting-edge advances in the field of dermatological sciences.

Skin Pharmacology and Toxicology

Corrado L. Galli,Christopher N. Hensby,Marina Marinovich
Skin Pharmacology and Toxicology Book PDF

Author : Corrado L. Galli,Christopher N. Hensby,Marina Marinovich
Publisher : Springer
Page : 338 pages
File Size : 52,5 Mb
Release : 1990
Category : Medical
ISBN : UCAL:B5040149

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Skin Pharmacology and Toxicology by Corrado L. Galli,Christopher N. Hensby,Marina Marinovich Pdf

Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent from their gainful employment for either medical consultation or treatment. Given that in all NATO countries the average age of the population is continually increasing, these chronic skin diseases will increase in importance in the coming years. Furthermore, as the average population age increases, additional disease processes such as skin photodamage and carcinogenicity risk becoming major areas of therapeutic concern. This book reviews in detail the major scientific areas of interest for research and clinical scientists working in skin pharmacology and toxicology. The basic principles relating to an understanding of how drugs and chemicals may influence either the skin or the body as a whole are discussed in detail by recognized international scientific experts.

Toxicology of the Skin

Nancy A. Monteiro-Riviere
Toxicology of the Skin Book PDF

Author : Nancy A. Monteiro-Riviere
Publisher : CRC Press
Page : 0 pages
File Size : 47,5 Mb
Release : 2010-02-17
Category : Medical
ISBN : 1420079174

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Toxicology of the Skin by Nancy A. Monteiro-Riviere Pdf

This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barrier may result in damage to the skin or may alter absorption. With contributions from over 40 international experts in the field of skin biology, the book presents the central role of the skin barrier to health and disease reviewing; The skin’s anatomy and physiology, with focus on the stratum corneum as a barrier to foreign substances. Dermal absorption, cutaneous metabolism, and epidermal transporters. Altered barriers, racial skin types, aged skin, photoaged skin, cosmetics and skin sensitization. Modern approaches to drug delivery across the skin barrier, including liposomes, microneedle technology, active and passive transdermal delivery. Examples and case studies of chemical toxicity after topical exposures ranging from arsenic, metal working fluids, bromine, jet fuel, sulfur mustard and including the emerging area of nanomaterial penetration. Toxicology of the Skin is essential reading for drug delivery pharmacologist, formulation scientists, dermatologists, toxicologists, molecular biologists, engineers, surgeons, students and anyone interested in skin irritation and skin absorption.

Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds

Kenji Sugibayashi
Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds Book PDF

Author : Kenji Sugibayashi
Publisher : Springer
Page : 428 pages
File Size : 42,6 Mb
Release : 2017-11-28
Category : Medical
ISBN : 9784431565260

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Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds by Kenji Sugibayashi Pdf

This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.

A Framework to Guide Selection of Chemical Alternatives

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions
A Framework to Guide Selection of Chemical Alternatives Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions
Publisher : National Academies Press
Page : 280 pages
File Size : 54,5 Mb
Release : 2014-10-29
Category : Science
ISBN : 9780309310161

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A Framework to Guide Selection of Chemical Alternatives by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions Pdf

Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.

How Tobacco Smoke Causes Disease

Anonim
How Tobacco Smoke Causes Disease Book PDF

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 49,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Applied Dermatotoxicology

Howard I. Maibach,Golara Honari
Applied Dermatotoxicology Book PDF

Author : Howard I. Maibach,Golara Honari
Publisher : Academic Press
Page : 150 pages
File Size : 48,6 Mb
Release : 2014-06-24
Category : Science
ISBN : 9780124201996

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Applied Dermatotoxicology by Howard I. Maibach,Golara Honari Pdf

Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents. A concise, yet inclusive review of effects of chemical exposure Includes background on basic skin biology Provides vital clinical reference for toxicologists in non-clinical settings

Modern Poisons

Alan Kolok
Modern Poisons Book PDF

Author : Alan Kolok
Publisher : Island Press
Page : 224 pages
File Size : 41,7 Mb
Release : 2016-05-05
Category : Health & Fitness
ISBN : 9781610913829

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Modern Poisons by Alan Kolok Pdf

Modern Poisons bridges the gap between traditional toxicology textbooks and journal articles on cutting-edge science. This accessible book explains basic principles in plain language while illuminating the most important issues in contemporary toxicology. Kolok begins by exploring age-old precepts such as the dose-response relationship and goes on to show exactly how chemicals enter the body and elicit their toxic effect. Kolok then traces toxicology's development, from studies of endocrine-disrupting chemicals in toiletries to the emerging science on prions and epigenetics. Whether studying toxicology itself, public health, or environmental science, readers will develop a core understanding of--and curiosity about--this fast-changing field.

Dermal Absorption and Toxicity Assessment

Michael S. Roberts
Dermal Absorption and Toxicity Assessment Book PDF

Author : Michael S. Roberts
Publisher : CRC Press
Page : 704 pages
File Size : 54,5 Mb
Release : 2007-12-14
Category : Medical
ISBN : 9780849375927

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Dermal Absorption and Toxicity Assessment by Michael S. Roberts Pdf

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Toxicology and Risk Assessment

Helmut Greim,Robert Snyder
Toxicology and Risk Assessment Book PDF

Author : Helmut Greim,Robert Snyder
Publisher : John Wiley & Sons
Page : 840 pages
File Size : 51,8 Mb
Release : 2018-08-10
Category : Science
ISBN : 9781119135920

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Toxicology and Risk Assessment by Helmut Greim,Robert Snyder Pdf

Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Essentials of Toxicology for Health Protection

David Baker,Lakshman Karalliedde,Virginia Murray,Robert Maynard,Norman HT Parkinson
Essentials of Toxicology for Health Protection Book PDF

Author : David Baker,Lakshman Karalliedde,Virginia Murray,Robert Maynard,Norman HT Parkinson
Publisher : Oxford University Press
Page : 128 pages
File Size : 48,5 Mb
Release : 2012-03-15
Category : Medical
ISBN : 9780191646218

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Essentials of Toxicology for Health Protection by David Baker,Lakshman Karalliedde,Virginia Murray,Robert Maynard,Norman HT Parkinson Pdf

Essentials of Toxicology for Health Protection is ideal as both a course book for students and a handbook for field professionals involved in responding to chemical incidents and local environmental concerns. Produced by Health Protection England, it offers a comprehensive and structured approach to dealing with toxicological problems worldwide. The text covers both the basics of toxicology and its application to issues of topical concern such as contaminated land, food additives, and water and air pollution. Each chapter is written by an expert in the field, making Essentials of Toxicology for Health Protection essential reading for all professionals in environmental public health, including: health protection consultants, specialists and trainees; public health practitioners; environmental health practitioners; environmental scientists; and staff of the emergency services, the water and waste industries, and other industrial and regulatory bodies.

An Introduction to Interdisciplinary Toxicology

Carey N. Pope,Jing Liu
An Introduction to Interdisciplinary Toxicology Book PDF

Author : Carey N. Pope,Jing Liu
Publisher : Academic Press
Page : 644 pages
File Size : 55,5 Mb
Release : 2020-03-06
Category : Medical
ISBN : 9780128136027

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An Introduction to Interdisciplinary Toxicology by Carey N. Pope,Jing Liu Pdf

An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology. Covers major topics and newer areas in toxicology, including nanotoxicology, Tox21, epigenetic toxicology, and organ-specific toxicity Includes a variety of perspectives to give a complete understanding of toxicology Written by specialists within each subject area, e.g., a chemical engineer, to ensure concepts are clearly explained