Skin Pharmacology And Toxicology

Author : Corrado L. Galli,Christopher N. Hensby,Marina Marinovich
Publisher : Springer Science & Business Media
Page : 310 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468479027

Get Book

Skin Pharmacology and Toxicology by Corrado L. Galli,Christopher N. Hensby,Marina Marinovich Pdf

Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent from their gainful employment for either medical consultation or treatment. Given that in all NATO countries the average age of the population is continually increasing, these chronic skin diseases will increase in importance in the coming years. Furthermore, as the average population age increases, additional disease processes such as skin photodamage and carcinogenicity risk becoming major areas of therapeutic concern. This book reviews in detail the major scientific areas of interest for research and clinical scientists working in skin pharmacology and toxicology. The basic principles relating to an understanding of how drugs and chemicals may influence either the skin or the body as a whole are discussed in detail by recognized international scientific experts.

Author : Robert Chilcott,Shirley Price
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 49,6 Mb
Release : 2008-07-31
Category : Science
ISBN : 9780470773086

Get Book

Principles and Practice of Skin Toxicology by Robert Chilcott,Shirley Price Pdf

Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.

Author : Anonim
Publisher : Springer Science & Business Media
Page : 602 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642740541

Get Book

Pharmacology of the Skin II by Anonim Pdf

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.

Author : Nancy A. Monteiro-Riviere
Publisher : CRC Press
Page : 452 pages
File Size : 49,8 Mb
Release : 2010-02-17
Category : Medical
ISBN : 9781420079180

Get Book

Toxicology of the Skin by Nancy A. Monteiro-Riviere Pdf

This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr

Author : Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1232 pages
File Size : 49,9 Mb
Release : 2004-02-25
Category : Medical
ISBN : 9780203426272

Get Book

Dermatotoxicology by Hongbo Zhai,Howard I. Maibach Pdf

For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, De

Author : Hasan Mukhtar
Publisher : Springer
Page : 456 pages
File Size : 41,6 Mb
Release : 1991-12-07
Category : Medical
ISBN : UOM:39015039092351

Get Book

Pharmacology of the Skin by Hasan Mukhtar Pdf

This book presents a balanced, state-of-the-art summary of pharmacology as it relates to the skin. Topics discussed include structure of the skin and its barrier function; model systems for research in skin pharmacology; the drug metabolizing capability of the skin, skin pharmacology in health and disease; the role of oxidants and antioxidants in the skin; immunopharmacology of the skin; signal transduction, protein kinase C and the role of the eicosanoid receptors in skin; and cutaneous chemical- and photo-carcinogenesis. Pharmacology of the Skin provides essential information for investigators working in cutaneous biology, investigative and clinical dermatologists, pharmacologists, pharmacists, biochemists, and workers in the pharmaceutical industry engaged in drug development.

Author : Keith R Brain,Robert P Chilcott
Publisher : Royal Society of Chemistry
Page : 476 pages
File Size : 41,8 Mb
Release : 2013
Category : Medical
ISBN : 9781849733984

Get Book

Advances in Dermatological Sciences by Keith R Brain,Robert P Chilcott Pdf

Readily accessible, yet detailed, this book presents cutting-edge advances in the field of dermatological sciences.

Author : Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 0 pages
File Size : 52,7 Mb
Release : 2012-09-27
Category : Medical
ISBN : 1841848557

Get Book

Dermatotoxicology, Eighth Edition by Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach Pdf

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances. This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Author : Howard I. Maibach
Publisher : CRC Press
Page : 573 pages
File Size : 40,8 Mb
Release : 2001-03-15
Category : Medical
ISBN : 9781420022728

Get Book

Toxicology of Skin by Howard I. Maibach Pdf

Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th

Author : Anonim
Publisher : Springer
Page : 510 pages
File Size : 53,6 Mb
Release : 2011-12-21
Category : Medical
ISBN : 3642737986

Get Book

Pharmacology of the Skin I by Anonim Pdf

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.

Author : Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1232 pages
File Size : 45,8 Mb
Release : 2004-02-25
Category : Medical
ISBN : 0415288622

Get Book

Dermatotoxicology, Sixth Edition by Hongbo Zhai,Howard I. Maibach Pdf

For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, Dermatotoxicology, Sixth Edition includes fundamental information on the mechanisms of action of toxic substances on the skin, as well as practical information on the various methods to evaluating dermal toxicity. It is unparalleled in its coverage, and this new edition broadens its scope to include chapters on: * Barrier Creams * Cosmetic Reactions * UV Radiation Exposure * Electron Paramagnetic Resonance * Powdered Human Stratum Corneum * Iontophoresis * Permeability of Skin for Metal Compounds * Current Trends in Skin Cancer Research * Tape Stripping Method v. Stratum Corneum * Hazardous Substances from Soil and Water * Isolated Perfused Porcine Skin Flap * Physiologically-based Pharmacokinetic Models This completely revised and reworked edition constitutes a major contribution to the field of dermatotoxicology. Presenting the most modern concepts and methods in use today, researchers and clinicians will find this an invaluable resource time and time again.

Author : Christian Surber,Peter Elsner,Andreas J. Bircher
Publisher : S Karger Ag
Page : 0 pages
File Size : 43,9 Mb
Release : 1995
Category : Medical
ISBN : 3805560621

Get Book

Exogenous Dermatology by Christian Surber,Peter Elsner,Andreas J. Bircher Pdf

This concise collection of contributions brings together researchers from many areas of dermatology, including allergology, bioengineering and pharmacology, in commemoration of the 65th birthday of Howard I. Maibach. It reflects only a small number of the fields where Professor Maibach has made a lasting impression. Highlights of this volume include a study on an allergen bank and the ideas behind it, a comprehensive presentation of textile dye contact allergens, and the clinical standardization of the TRUE Test formaldehyde patch. Contributions in bioengineering and occupational dermatology deal with quantification of biophysical properties of the skin, irritancy exposure assessment in metal workers, and the effects of surfactants on skin hydration. A large section on skin pharmacology provides the reader with solid research data and incisive commentaries from researchers and leading authorities on issues of in vitro and in vivo percutaneous absorption, skin metabolism, topical bioavailability and bioequivalency. Dermatologists, pharmacologists and toxicologists will have much to gain from having a copy of this volume close at hand.

Author : Kirsti Kauppinen,Kristiina Alanko,Matti Hannuksela,Howard Maibach
Publisher : CRC-Press
Page : 178 pages
File Size : 40,5 Mb
Release : 1998-06-01
Category : Medical
ISBN : 0849383765

Get Book

Skin Reactions to Drugs by Kirsti Kauppinen,Kristiina Alanko,Matti Hannuksela,Howard Maibach Pdf

Emphasising the mechanisms and clinical and laboratory proof of a cause-and-effect relationship between drugs and adverse reactions, this book discusses the technique of drug challenge, which has been extensively developed in Finland, but not commonly practiced in the rest of the world. 12 of the most common drug eruptions are described both clinically and histologically. It features a chapter on systemic contact dermatitis and also addresses cutaneous adverse drug reactions that appear in HIV-infected patients. 40 full-color photographs provide vivid examples of the reactions being discussed. A highly practical resource for practicing physicians and other health care workers.

Author : Jim E. Riviere,Nancy A. Monteiro-Riviere
Publisher : CRC Press
Page : 392 pages
File Size : 41,7 Mb
Release : 2005-08-24
Category : Medical
ISBN : 0203020820

Get Book

Dermal Absorption Models in Toxicology and Pharmacology by Jim E. Riviere,Nancy A. Monteiro-Riviere Pdf

Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.

Author : Howard I. Maibach,N. J. Lowe
Publisher : Unknown
Page : 390 pages
File Size : 53,9 Mb
Release : 1985
Category : Electronic
ISBN : NWU:35558000545323

Get Book

Models in Dermatology: Dermatopharmacology and toxicology by Howard I. Maibach,N. J. Lowe Pdf