Toxicology Of The Skin

Author : Robert Chilcott,Shirley Price
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 54,6 Mb
Release : 2008-07-31
Category : Science
ISBN : 9780470773086

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Principles and Practice of Skin Toxicology by Robert Chilcott,Shirley Price Pdf

Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.

Author : Howard I. Maibach
Publisher : CRC Press
Page : 573 pages
File Size : 43,6 Mb
Release : 2001-03-15
Category : Medical
ISBN : 9781420022728

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Toxicology of Skin by Howard I. Maibach Pdf

Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th

Author : Nancy A. Monteiro-Riviere
Publisher : CRC Press
Page : 452 pages
File Size : 48,6 Mb
Release : 2010-02-17
Category : Medical
ISBN : 9781420079180

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Toxicology of the Skin by Nancy A. Monteiro-Riviere Pdf

This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr

Author : Howard I. Maibach
Publisher : CRC Press
Page : 377 pages
File Size : 45,9 Mb
Release : 2000-12-21
Category : Medical
ISBN : 1135465703

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Toxicology of Skin by Howard I. Maibach Pdf

Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. This benchmark volume provides the latest findings in skin toxicology in one definitive source. Toxicology of the Skin is part of the highly acclaimed Target Organ Toxicology Series-a leading series of reviews by internationally renowned experts in their respective fields. Dermatologists and toxicology specialists will find this text indispensable.

Author : Corrado L. Galli,Christopher N. Hensby,Marina Marinovich
Publisher : Springer Science & Business Media
Page : 310 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468479027

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Skin Pharmacology and Toxicology by Corrado L. Galli,Christopher N. Hensby,Marina Marinovich Pdf

Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent from their gainful employment for either medical consultation or treatment. Given that in all NATO countries the average age of the population is continually increasing, these chronic skin diseases will increase in importance in the coming years. Furthermore, as the average population age increases, additional disease processes such as skin photodamage and carcinogenicity risk becoming major areas of therapeutic concern. This book reviews in detail the major scientific areas of interest for research and clinical scientists working in skin pharmacology and toxicology. The basic principles relating to an understanding of how drugs and chemicals may influence either the skin or the body as a whole are discussed in detail by recognized international scientific experts.

Author : Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 518 pages
File Size : 44,9 Mb
Release : 2012-09-27
Category : Medical
ISBN : 9781841848570

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Dermatotoxicology, Eighth Edition by Klaus Peter Wilhelm,Hongbo Zhai,Howard I. Maibach Pdf

The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international experts, this continues the tradition of providing unsurpassed theoretical and practical guidance for all those working on research aspects, on practical clinical issues, and on the regulatory aspects of exposure to toxic substances. This new edition contains updates to each chapter and contributions from leading international experts, provides an in-depth summary of research and regulatory applications related to dermal toxicology and pharmacology, presents many new chapters that describe the latest advances in dermatotoxicology, and addresses various levels of expertise regarding the development and use of dermal exposure data. New chapters include those on safety terminology, pharmacogenetics and dermatology, ethnic differences in skin properties, and the principles and practice of percutaneous absorption.

Author : Keith R Brain,Robert P Chilcott
Publisher : Royal Society of Chemistry
Page : 476 pages
File Size : 48,8 Mb
Release : 2013
Category : Medical
ISBN : 9781849733984

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Advances in Dermatological Sciences by Keith R Brain,Robert P Chilcott Pdf

Readily accessible, yet detailed, this book presents cutting-edge advances in the field of dermatological sciences.

Author : Michael S. Roberts,Kenneth A. Walters
Publisher : CRC Press
Page : 714 pages
File Size : 50,7 Mb
Release : 2008
Category : Health & Fitness
ISBN : UOM:39015074220701

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Dermal Absorption and Toxicity Assessment, Second Edition by Michael S. Roberts,Kenneth A. Walters Pdf

The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies

Author : Hongbo Zhai,Howard I. Maibach
Publisher : CRC Press
Page : 1232 pages
File Size : 55,8 Mb
Release : 2004-02-25
Category : Medical
ISBN : 9780203426272

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Dermatotoxicology by Hongbo Zhai,Howard I. Maibach Pdf

For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, De

Author : World Health Organization,International Program on Chemical Safety
Publisher : World Health Organization
Page : 91 pages
File Size : 49,5 Mb
Release : 2008
Category : Business & Economics
ISBN : 9789241563604

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Skin Sensitization in Chemical Risk Assessment by World Health Organization,International Program on Chemical Safety Pdf

This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information. This book will be useful to toxicologists, researchers, regulatory authorities and industry.

Author : Victor Alexander Drill,Paul Lazar
Publisher : Toxicology-Sci
Page : 296 pages
File Size : 52,8 Mb
Release : 1984
Category : Contact dermatitis
ISBN : UCAL:B4526746

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Cutaneous Toxicity by Victor Alexander Drill,Paul Lazar Pdf

Author : Sharon Hotchkiss
Publisher : Unknown
Page : 350 pages
File Size : 52,9 Mb
Release : 1998-09
Category : Medical
ISBN : 074840662X

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Introduction to Skin Toxicology by Sharon Hotchkiss Pdf

A comprehensive introduction to skin toxicology, which covers the general structure and function of the skin, pathology, toxicants, absorption, and metabolism of chemicals, corrosion, irritation, sensitation, phototoxicity and skin cancer. Case studies include carbaryl in head lice shampoos, skin cancer in sun creams, chemical warfare agents, nickel in jewellery, organophosphates in sheep dips, reproductive toxins in retinoid anti-acne, psoriasis and ageing drugs. There is also a short section on techniques.

Author : Phillip L. Williams,Robert C. James,Stephen M. Roberts
Publisher : John Wiley & Sons
Page : 625 pages
File Size : 42,6 Mb
Release : 2003-10-10
Category : Science
ISBN : 9780471459231

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Principles of Toxicology by Phillip L. Williams,Robert C. James,Stephen M. Roberts Pdf

A fully updated and expanded edition of the bestselling guide on toxicology and its practical application The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Through contributions from leading experts in diverse fields, Principles of Toxicology, Second Edition features: Clear explanations of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems Coverage of occupational medicine and epidemiological issues The manifestation of toxic agents such as metals, pesticides, organic solvents, and natural toxins Special emphasis on the evaluation and control of toxic hazards Specific case histories on applying risk assessment methods in the modern workplace Ample figures, references, and a comprehensive glossary of toxicological terms

Author : CURTIS. WATKINS KLAASSEN (JOHN.)
Publisher : Unknown
Page : 524 pages
File Size : 52,5 Mb
Release : 2015-09-16
Category : Poisons
ISBN : 1259255352

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Casarett & Doull's Essentials of Toxicology by CURTIS. WATKINS KLAASSEN (JOHN.) Pdf

Author : Francis N. Marzulli,Howard I. Maibach
Publisher : CRC Press
Page : 390 pages
File Size : 46,5 Mb
Release : 2019-05-07
Category : Medical
ISBN : 9781439805879

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Dermatotoxicology Methods by Francis N. Marzulli,Howard I. Maibach Pdf

This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.