Investigating The Human Genome

Author : Moyra Smith
Publisher : FT Press
Page : 243 pages
File Size : 41,7 Mb
Release : 2011-06-08
Category : Medical
ISBN : 9780132172844

Get Book

Investigating the Human Genome by Moyra Smith Pdf

Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome. This book addresses into a wide spectrum of topics associated with human genetics and genomics, including: Human origins; migrations and human population diversity gained though genomic analyses. The complexities of psychiatric diseases that are influenced by genetics. The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS. Key aspects of protein misfolding. Gene-environment interactions in DNA damage and repair and DNA instability. Micro RNAs and mRNA translation. Epigenetics. New functions for old enzymes in cancer.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 46,8 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409

Get Book

Mapping and Sequencing the Human Genome by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome Pdf

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Author : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations
Publisher : Unknown
Page : 142 pages
File Size : 51,7 Mb
Release : 1988
Category : Gene mapping
ISBN : UOM:39015019770737

Get Book

OTA Report on the Human Genome Project by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations Pdf

Author : Bertrand Jordan
Publisher : John Libbey Eurotext
Page : 210 pages
File Size : 44,7 Mb
Release : 1993
Category : Gene mapping
ISBN : 2855985722

Get Book

Travelling Around the Human Genome by Bertrand Jordan Pdf

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Human Genome Diversity
Publisher : National Academies Press
Page : 101 pages
File Size : 54,6 Mb
Release : 1998-01-19
Category : Science
ISBN : 9780309184748

Get Book

Evaluating Human Genetic Diversity by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Human Genome Diversity Pdf

This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.

Author : Kevin Davies
Publisher : JHU Press
Page : 358 pages
File Size : 53,8 Mb
Release : 2002-10
Category : Medical
ISBN : 0801871409

Get Book

Cracking the Genome by Kevin Davies Pdf

This newly updated edition sheds light on the secrets of the sequence, highlighting the myriad ways in which genomics will impact human health for generations to come.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 54,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 51,9 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

Get Book

Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 55,9 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

Get Book

Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Author : John Parrington
Publisher : OUP Oxford
Page : 288 pages
File Size : 51,9 Mb
Release : 2015-05-28
Category : Science
ISBN : 9780191002472

Get Book

The Deeper Genome by John Parrington Pdf

Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

Author : Ozren Polasek,Harry Campbell,Alan Wright
Publisher : Unknown
Page : 197 pages
File Size : 44,7 Mb
Release : 2009
Category : Electronic
ISBN : OCLC:708357357

Get Book

Investigating the Role of Human Genome-wide Heterozygosity as a Health Risk Factor by Ozren Polasek,Harry Campbell,Alan Wright Pdf

Aim The aim of this study was to investigate the most commonly used approaches to measure individual genome-wide heterozygosity (IGWH) and to investigate whether IGWH can be considered as a health risk factor or a protective factor in humans. Methods This study was based on two samples from isolated communities of Croatian Adriatic islands, with a total of 1,930 adult examinees from Islands of Vis (N=986) and Korcula (N=944). Examinees were genotyped with a total of 302,662 single nucleotide polymorphisms. Heterozygosity was estimated using five commonly calculated methods. Results Correlation coefficients between different heterozygosity methods were generally in the range of 0.7-0.8. A worsening in some phenotypic traits, including cholesterol and triglycerides as well as increased odds for osteoporosis and metabolic syndrome was recorded in cases of IGWH reduction. Nevertheless, in these cases heterozygosity explained a relatively low amount of variance, generally in range of 0.4-0.6% of total trait variance. Conclusion However, these results were significant in Vis Island sample, while in the replication sample, Korcula Island, most of the associations were not significant, possibly due to the overall lower amount of inbreeding and higher heterozygosity in Korcula Island sample. The results warrant further research in order to provide more information on the extent and importance of individual genome-wide heterozygosity, which might have an important role in communities which experience consanguinity on a greater scale. Two main shortcomings of the study include possible lack of power to detect inbreeding depression and the need to replicate the results in other populations.

Author : Trevor Day
Publisher : The Rosen Publishing Group, Inc
Page : 50 pages
File Size : 43,5 Mb
Release : 2012-07-15
Category : Juvenile Nonfiction
ISBN : 9781448872084

Get Book

Genetics by Trevor Day Pdf

In the 1800s, an Australian monk named Gregor Mendel was experimenting on pea plants as he tried to learn how a single cell could grow into an entire human. Today we can see the results of his work in almost every aspect of modern medicine. This book explores genetics through its long and controversial history to how its discoveries have shaped modern society.

Author : John C. Avise
Publisher : Oxford University Press on Demand
Page : 237 pages
File Size : 40,9 Mb
Release : 2010-02-12
Category : Science
ISBN : 9780195393439

Get Book

Inside the Human Genome by John C. Avise Pdf

How do you explain flaw in a world engineered by God? Avise extends this age-old question to the most basic aspect of humanity's physical evidence-- our genes-- and provides the evolutionary answers.

Author : Jan Christian Heller
Publisher : Fordham University Press
Page : 179 pages
File Size : 49,5 Mb
Release : 1996
Category : Religion
ISBN : 1881871207

Get Book

Human Genome Research and the Challenge of Contingent Future Persons by Jan Christian Heller Pdf

Human Genome Research and the Challenge of Contingent Future Persons is an investigation into how the Human Genome Project is likely to affect future generations. It explores the implications these effects hold for evaluating genetic research, particularly from a theological perspective. Examining the economic, political, and philosophical issues underlying genetic research, Heller finds that some future people may bear an inordinate share of certain social costs stemming from the Project's biomedical applications. Further, the existence, numbers, and identities of those people will be contingent on decisions made based on this research. Heller investigates the theological implications of this problem, arriving at an "impersonal theocentric" approach to value in this detailed, thoughtful, and original contribution to the literature.

Author : Ira H. Carmen
Publisher : Univ of Wisconsin Press
Page : 368 pages
File Size : 46,5 Mb
Release : 2004
Category : Genomics
ISBN : 0299202100

Get Book

Politics in the Laboratory by Ira H. Carmen Pdf

Ira Carmen seeks a fusion of experimental biological research and political science research as he explores the important and controversial realm of human genomics. Politics in the Laboratory takes a close look at the ethical, legal, social, constitutional, and political implications of modern biological research. It addresses both biopolicy issues and basic science--including cloning, embryonic stem cell investigations, and experimentation involving the human germline--from the perspective of a political scientist.