Ion Channels Channel Production And Optical Methods

Author : Anonim
Publisher : Academic Press
Page : 422 pages
File Size : 42,8 Mb
Release : 2021-06-05
Category : Science
ISBN : 9780323853774

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Ion Channels: Channel Production and Optical Methods by Anonim Pdf

Ion Channels Part B, Volume 652 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including NMDAR, Pannexin, and CALHM, Making NaV1.4 and NaV1.7, TRPVs, Purification native nAChRs, GABAR Radu Aricescu, TRPV5/2, NaV1.5, KATP, TRPA1, TREK-1, SARS-CoV-2 3a ion channel, Ion channel conformational dynamics by encoded unnatural amino acid, Fluorescence lifetime measurement of absolute membrane potential, Fluorescent Toxins as Activity Sensors, FRET Analyses of Ion Channel Protein-Protein Interactions, Control of Ion Channel Gating with Photo-Switchable Tweezers, and Counting Subunits in Kv Channel Complexes. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Author : Anonim
Publisher : Academic Press
Page : 358 pages
File Size : 42,5 Mb
Release : 2021-05-29
Category : Science
ISBN : 9780323853750

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Ion Channels: Channel Biochemistry, Reconstitution, and Function by Anonim Pdf

Ion Channels Part A, Volume 651 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of new developments on the topic. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Author : Anonim
Publisher : Academic Press
Page : 454 pages
File Size : 40,9 Mb
Release : 2021-06-12
Category : Science
ISBN : 9780128239254

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Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function by Anonim Pdf

Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more. Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Author : Srdjan D. Antic,Bradley James Baker,Marco Canepari
Publisher : Frontiers Media SA
Page : 193 pages
File Size : 51,6 Mb
Release : 2020-01-06
Category : Electronic
ISBN : 9782889632671

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New Insights on Neuron and Astrocyte Function from Cutting-Edge Optical Techniques by Srdjan D. Antic,Bradley James Baker,Marco Canepari Pdf

Author : Ian Stolerman
Publisher : Springer Science & Business Media
Page : 1433 pages
File Size : 48,7 Mb
Release : 2010-07-31
Category : Medical
ISBN : 9783540686989

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Encyclopedia of Psychopharmacology by Ian Stolerman Pdf

Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.

Author : Toshio Yanagida,Yoshiharu Ishii
Publisher : John Wiley & Sons
Page : 347 pages
File Size : 42,5 Mb
Release : 2008-11-24
Category : Science
ISBN : 9783527312887

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Single Molecule Dynamics in Life Science by Toshio Yanagida,Yoshiharu Ishii Pdf

In this first comprehensive resource to cover the application of single molecule techniques to biological measurements, the pioneers in the field show how to both set up and interpret a single molecule experiment. Following an introduction to single molecule measurements and enzymology, the expert authors consider molecular motors and mechanical properties before moving on to the applications themselves. Detailed discussions of studies on protein enzymes, ribozymes and nucleic acids are also included.

Author : Anonim
Publisher : Academic Press
Page : 534 pages
File Size : 55,9 Mb
Release : 2008-12-11
Category : Science
ISBN : 9780080949109

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Methods in Nano Cell Biology by Anonim Pdf

Understanding live cells at the single molecule level is the most important and single major challenge facing biology and medicine today. Nanobiology focuses on the properties and structure of complex assemblies of biomolecules—biochips and molecular motors, for example—in conjunction with distinctive surfaces, rods, dots, and materials of nanoscience. Nano Cell Biology will describe the current applications of nanobiology to the study of the structure, function, and metabolic processes of cells. Provides historical background on this newly emerging field Covers the latest application of new instrumentation in the field Detailed protocols in the study of live cells at the nanometer level Discusses future technologies and their applications in the study of living cells

Author : David J. Triggle,Murali Gopalakrishnan,David Rampe,Wei Zheng
Publisher : John Wiley & Sons
Page : 492 pages
File Size : 47,5 Mb
Release : 2006-08-21
Category : Science
ISBN : 9783527607747

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Voltage-Gated Ion Channels as Drug Targets by David J. Triggle,Murali Gopalakrishnan,David Rampe,Wei Zheng Pdf

Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.

Author : Andrea Becchetti,Annarosa Arcangeli
Publisher : Springer Science & Business Media
Page : 138 pages
File Size : 53,7 Mb
Release : 2010-12-28
Category : Medical
ISBN : 9781441960665

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Integrins and Ion Channels by Andrea Becchetti,Annarosa Arcangeli Pdf

Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.

Author : Louis W. Chang,William Slikker Jr.
Publisher : Elsevier
Page : 875 pages
File Size : 47,6 Mb
Release : 1995-04-20
Category : Science
ISBN : 9780080537474

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Neurotoxicology by Louis W. Chang,William Slikker Jr. Pdf

Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity. Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market. Discusses neurobehavioral testing methods for assessment of neural dysfunctions Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems Discusses In Vitro methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity Presents step-by-step procedures for many methods Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation

Author : Jie Zheng,Matthew C. Trudeau
Publisher : CRC Press
Page : 682 pages
File Size : 55,7 Mb
Release : 2015-02-25
Category : Medical
ISBN : 9781466551428

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Handbook of Ion Channels by Jie Zheng,Matthew C. Trudeau Pdf

The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Author : Fabio Benfenati,Enzo Di Fabrizio,Vincent Torre
Publisher : Springer
Page : 227 pages
File Size : 51,8 Mb
Release : 2014-06-26
Category : Science
ISBN : 9783662433676

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Novel Approaches for Single Molecule Activation and Detection by Fabio Benfenati,Enzo Di Fabrizio,Vincent Torre Pdf

How can we obtain tools able to process and exchange information at the molecular scale? In order to do this, it is necessary to activate and detect single molecules under controlled conditions. This book focuses on the generation of biologically-inspired molecular devices. These devices are based on the developments of new photonic tools able to activate and stimulate single molecule machines. Additionally, new light sensitive molecules can be selectively activated by photonic tools. These technological innovations will provide a way to control activation of single light-sensitive molecules, allowing the investigation of molecular computation in a biological environment.

Author : A. Ménez
Publisher : John Wiley & Sons
Page : 540 pages
File Size : 50,6 Mb
Release : 2002-05-17
Category : Science
ISBN : 0471495034

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Perspectives in Molecular Toxinology by A. Ménez Pdf

Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins. Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites. In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.

Author : Sanjeev Saksena,A. John Camm
Publisher : Elsevier Health Sciences
Page : 1726 pages
File Size : 47,9 Mb
Release : 2011-12-12
Category : Medical
ISBN : 9781437709711

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Electrophysiological Disorders of the Heart E-Book by Sanjeev Saksena,A. John Camm Pdf

The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient problems. Stay current with the latest molecular and technical advances as well as new treatment options implemented over the last few years. Use the latest technologies and devices to accurately diagnose and manage heart rhythm disorders. Consult new and expanded coverage of regenerative therapies, echo-guided procedures, cardiac pacing, and CRT, as well as a new section on pediatric electrophysiology and imaging. Enjoy improved visual guidance with many new full-color images. Log on to www.expertconsult.com to easily search the complete contents online and access a downloadable image library.

Author : Shin-Ho Chung,Olaf S. Anderson,Vikram V. Krishnamurthy
Publisher : Springer Science & Business Media
Page : 657 pages
File Size : 53,8 Mb
Release : 2007-11-13
Category : Science
ISBN : 9780387689197

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Biological Membrane Ion Channels by Shin-Ho Chung,Olaf S. Anderson,Vikram V. Krishnamurthy Pdf

This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.