Ionic Actions On Vascular Smooth Muscle

Author : E. Betz
Publisher : Springer Science & Business Media
Page : 285 pages
File Size : 45,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642664274

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Ionic Actions on Vascular Smooth Muscle by E. Betz Pdf

This book contains the contributions and discussions of the second symposium on vascular smooth muscles held in Ttibingen in February, 1976. It provides an up-to-date review of the role of ions in the trans mission of signals from the perivascular space to the contractile ele ments of the smooth muscle cells. The various aspects are mainly discussed from a functional point of view and only few contributions concern the morphologic variations of cells .during varying ion activity. Special emphasis was placed on the significance of ion variations in the cerebral tissue and their rela tion to metabolic and nervous control of the brain vessels. It could be seen in this symposium that new techniques enabled the in vestigators to make considerable progress in the understanding of the actions and the interactions of ions on the membranes and on the inter nal structures of the smooth muscle cells if one compares the findings with the results of the previous symposium held in Ttibingen in 1972. It became evident that the insight into ionic actions enables the de velopment of powerful tools to be utilized in future therapy of dis turbances of local blood flow regulation. The participants of the symposium render thanks to the Dr. Thiemann GmbH in Ltinen, which supported the symposium and this publication in a generous way. Finally it is a pleasure of the Editor to thank the members of the Physiological Institute of Ttibingen for their encouragement in the ar rangement of the meeting.

Author : M.F. III Crass
Publisher : Elsevier
Page : 220 pages
File Size : 44,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323159876

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Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms by M.F. III Crass Pdf

Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms addresses the vascular smooth muscle function by describing plasma lipoprotein structure, synthesis, and transport in relation to the concepts of altered vascular smooth muscle lipid metabolism leading to the genesis of atherosclerotic disease. This book is organized into six chapters and begins with an introduction to the complexities of energy metabolism and how metabolic events can be correlated with a simultaneous quantitative assessment of smooth muscle mechanics and the contractile machinery at the molecular level. The next two chapters offer the reader a view of smooth muscle membrane properties in terms of the distribution, transport, and metabolic control of electrolytes and specific aspects of ion conductance and electrical activity. This text also explains how smooth muscle cells regulate their contractile activity through regulation of calcium ion fluxes and the interaction, at the molecular level, of calcium ions with regulatory proteins associated with the contractile apparatus. Reference is made to the relation of possible anomalies in cellular or subcellular smooth muscle metabolic and/or ionic events to the bases of certain types of vascular disease. A chapter that examines the events leading to vascular pathology in the form of atherogenesis concludes the book. This book is intended for researchers and clinicians engaged in the study of smooth muscle and related areas.

Author : Anonim
Publisher : Unknown
Page : 786 pages
File Size : 50,8 Mb
Release : 1977
Category : Medicine
ISBN : OSU:32436001304581

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Cumulated Index Medicus by Anonim Pdf

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 40,6 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

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The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 50,7 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

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Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : Yuansheng Gao
Publisher : Springer
Page : 286 pages
File Size : 54,8 Mb
Release : 2017-06-14
Category : Medical
ISBN : 9789811048104

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Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation by Yuansheng Gao Pdf

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on recently identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.

Author : G. B. Weiss
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468433548

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Calcium in Drug Action by G. B. Weiss Pdf

Anyone surveying physiological and pharmacological journals can readily see that the biological actions of calcium ion are of increasingly widespread current interest. The scope of investi gated actions and reactions in which a role for calcium ion is of some importance is so numerous as to convey the impression that calcium ion is everywhere and interacts with everything. This being so, the challenge in contemporary research is to focus on investigation of those actions of calcium ion which, in some manner, influence either significant physiological parameters or the manner in which pharmacological agents act. This multi-authored book originated from a more limited Symposium on "Importance of Calcium as a Primary Locus of Drug Action" co-chaired by myself and Dr. Frank R. Goodman at the April, 1977 FASEB meeting in Chicago. This Symposium was organized in response to a perceived need for increased communication among 2 workers in different areas of Ca +-related research. In the pro cess of selecting the maximum of six areas for presentation within the format provided, it soon became apparent that this would result in only a limited sampling of current research efforts. Expansion of the number of areas to fourteen within a book format appeared to be the most logical mechanism to provide a more coherent inter disciplinary approach to consideration of various aspects of the 2 roles of Ca + in drug action. This is not to imply that all rele 2 vant Ca +-related areas are surveyed within this volume.

Author : Katherine Elliott,Maeve O'Connor
Publisher : John Wiley & Sons
Page : 192 pages
File Size : 46,5 Mb
Release : 2009-09-16
Category : Science
ISBN : 9780470718063

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Cerebral Vascular Smooth Muscle and its Control by Katherine Elliott,Maeve O'Connor Pdf

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Author : E. Kenneth Weir,Joseph R. Hume,John T. Reeves
Publisher : Springer Science & Business Media
Page : 345 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461523970

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Ion Flux in Pulmonary Vascular Control by E. Kenneth Weir,Joseph R. Hume,John T. Reeves Pdf

6 Ions can pass through a single membrane channel at a rate of 10 ions/second. Over the last decade the ability to measure ion flux so precisely and to document the opening and closing of individual ion channels has provided a powerful tool to those working on smooth muscle physiology and vascular reactivity. The use of potassium channel blockers by Tom Lloyd in the 1960s and calcium channel blockers by Ivan McMurtry in the 1970s indicated the importance of ion flux in regulating pulmonary vascular tone. Recent advances in technology. principally the patch-clamp technique and fluorescent ion-sensitive dyes. now permit a more detailed description of physiologic mechanisms. This volume arises from the Sixth Grover Conference on the Pulmonary Circulation. a NATO Advanced Research Workshop. held in Colorado in October 1992. A group of international sCientists who are leaders in the field of ion flux focused their attention on the problems of the pulmonary vasculature. The chapters in this book describe the present state of knowledge of the movement and storage of ions in vascular endothelial and smooth muscle cells. Those who are not familiar with the techniques of patch clamping and calcium imaging will find an introduction to these methods in the chapters by Leblanc and Wan and Archer et al. The role of potassium channels in oxygen sensing illustrates the rapid progress which the study of ion currents has made possible.

Author : Anonim
Publisher : Unknown
Page : 1818 pages
File Size : 40,8 Mb
Release : 1976
Category : Medicine
ISBN : OSU:32436000861995

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Bibliography of Medical Reviews by Anonim Pdf

Author : Ronald P. Rubin,George B. Weiss,James W. Jr. Putney
Publisher : Springer Science & Business Media
Page : 697 pages
File Size : 41,7 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461323778

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Calcium in Biological Systems by Ronald P. Rubin,George B. Weiss,James W. Jr. Putney Pdf

This volume is based in part upon the proceedings of the Calcium Theme held during the 67th Annual Meeting of the Federation of American Societies for Experimental Biology, which took place in Chicago, AprillO-lS, 1983. The American Society for Pharmacology and Experimental Therapeutics had the primary responsibility for organizing the scientific program with the assistance of other member societies, including the American Physiology Society, American Association of Pathologists, and American Institute of Nutrition. The purpose of the Calcium Theme was to review progress in the diverse areas of investigation bearing on the ubiquitous role of calcium in biological systems. In addition to contributions from those participating in the Theme, this volume also includes a number of invited papers that were added to fill certain voids in topics covered. The authors were selected because they are investigators active in the mainstream of their particular research area, possessing the acumen to analyze cogently not only their own recent findings but also to relate these findings to their respective area. New information as well as reviews of current concepts generally highlight the individual contributions. Undoubtedly, some readers may argue with the emphasis made and/or the conclusions reached on individual topics. In such cases, other volumes will hopefully provide a forum for alternative points of view. Due to the broad scope of subjects covered and the large number of contributions, the papers have been arranged in three sections.

Author : J.C. Stoclet
Publisher : Elsevier
Page : 340 pages
File Size : 52,8 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483188577

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Ions-Cyclic Nucleotides-Cholinergy by J.C. Stoclet Pdf

Advances in Pharmacology and Therapeutics, Volume 3: Ions – Cyclic Nucleotides – Cholinergy covers the proceedings of the Seventh International Congress of Pharmacology, held in Paris in 1978. This book mainly focuses on studying ions, cyclic nucleotides, and cholinergy. Specifically, this text discusses the pharmacology of calcium homeostasis and presents lectures given in the symposium. The role of cyclic nucleotides in the regulation of muscular tissue functions and the evaluation of cyclic AMP and cyclic GMP are also looked into. This text presents in its latter part papers on chemical structure and cholinergic activity. This volume will be valuable to students and experts in the field of pharmacology, therapeutics, and related fields.

Author : Nicholas Sperelakis
Publisher : Springer Science & Business Media
Page : 999 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461308737

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Physiology and Pathophysiology of the Heart by Nicholas Sperelakis Pdf

The first edition of this book was quite successful. As in the first edition, the book is divided into two major sections: cardiac muscle and coronary circula Several complimentary book reviews appeared soon tion. The book is multidisciplinary and includes after the first edition was published, and written and membrane biophysics, electrophysiology, physiol oral words of praise and appreciation were given both ogy, pathophysiology, pharmacology, biochemistry, to the publisher and to me by quite a few individuals. and ultrastructure. Thus, the book attempts ro It is because of such positive comments and reactions that the publisher and I decided to embark on a integrate all relevant aspects of the factors influenc second edition of Physiology and Pathophysiology of the ing the function of the heart as a vital organ under Heart. The second edition was long in preparation, normal and various abnormal conditions. The book taking over a year to complete. All chapter contri also attempts to set the foundation for an under butors were asked to revise, improve, and update standing of the action and mechanism of action of a their articles, and all have done so with enthusiasm number of classes of cardioactive drugs.

Author : James H. Wood
Publisher : Springer Science & Business Media
Page : 771 pages
File Size : 44,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781468410396

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Neurobiology of Cerebrospinal Fluid 1 by James H. Wood Pdf

Physiologic compartmentalization effectively isolates the central nervous system from the rest of the body. This isolation not only provides protection of its delicate function from aberrant peripheral influences but also impedes its diagnostic evaluation. Cerebro spinal fluid (CSF) bathes the brain and spinal cord, is in dynamic equilibrium with its extracellular fluid, and tends to reflect the state of health and activity of the central nervous system. CSF examination is the most direct and popular method of assessing the central chemical and cellular environment in the living patient or mammal. The purpose of this multidisciplined reference text is to provide the sophisticated knowledge of CSF physiology and pathology necessary for the meaningful interpretation of data obtained by various types of CSF analysis. The methodology for reliable CSF collection, storage, preparation, and analysis is discussed with respect to individual, somatotropic, chronologic, endorcinologic, pharmacologic, and possible artifactual var iations in CSF composition. These essential aspects, which ensure the validity of CSF data, are presented to aid the investigator in clinical and experimental protocol formu lation and in elimination of possible sources of error.

Author : James Kiffin Penry
Publisher : Unknown
Page : 1376 pages
File Size : 49,5 Mb
Release : 1978
Category : Epilepsy
ISBN : MINN:31951D004182877

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Indexes to the Epilepsy Accessions of the Epilepsy Information System by James Kiffin Penry Pdf