Calcium In Drug Action

Author : G. B. Weiss
Publisher : Springer Science & Business Media
Page : 366 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468433548

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Calcium in Drug Action by G. B. Weiss Pdf

Anyone surveying physiological and pharmacological journals can readily see that the biological actions of calcium ion are of increasingly widespread current interest. The scope of investi gated actions and reactions in which a role for calcium ion is of some importance is so numerous as to convey the impression that calcium ion is everywhere and interacts with everything. This being so, the challenge in contemporary research is to focus on investigation of those actions of calcium ion which, in some manner, influence either significant physiological parameters or the manner in which pharmacological agents act. This multi-authored book originated from a more limited Symposium on "Importance of Calcium as a Primary Locus of Drug Action" co-chaired by myself and Dr. Frank R. Goodman at the April, 1977 FASEB meeting in Chicago. This Symposium was organized in response to a perceived need for increased communication among 2 workers in different areas of Ca +-related research. In the pro cess of selecting the maximum of six areas for presentation within the format provided, it soon became apparent that this would result in only a limited sampling of current research efforts. Expansion of the number of areas to fourteen within a book format appeared to be the most logical mechanism to provide a more coherent inter disciplinary approach to consideration of various aspects of the 2 roles of Ca + in drug action. This is not to imply that all rele 2 vant Ca +-related areas are surveyed within this volume.

Author : Peter F. Baker
Publisher : Springer Science & Business Media
Page : 579 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642718069

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Calcium in Drug Actions by Peter F. Baker Pdf

The Editorial Board and the Publishers of the Handbook of Experimental Pharmacology wish to express their profound grief at the untimely death of Professor Peter Baker. Aware of his international recognition as an expert on the ubiquitous role of calcium in physiological processes and their pharma cological control, the Board was gratified when Professor Baker accepted its invitation to edit a new Handbook volume on "Calcium in Drug Actions". He went about this task with his usual energy and effectiveness so that, in the few months before his unexpected death, Professor Baker had mustered his distinguished contributors, got them to provide their manuscripts, and seen almost the entire material into the press. This achievement is all the more remarkable when one bears in mind the extraordinary number of his other commitments during the same time; they are mentioned in Sir Alan Hodgkin's preface to this volume. With so many other professional and personal responsibilities upon him, the Board of the Handbook wishes to record its grateful appreciation for the admirable way in which Professor Baker took on and carried out the additional work of bringing this fine book into existence; and the Board wishes it to be dedicated to the memory of Professor Peter Frederick Baker. The Editorial Board: G. V. R. BORN, P. CUATRECASAS, H. HERKEN, A.

Author : Michael Denborough
Publisher : Pergamon
Page : 208 pages
File Size : 49,6 Mb
Release : 1987
Category : Medical
ISBN : UOM:39015012458801

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The Role of Calcium in Drug Action by Michael Denborough Pdf

The role of the calcium ion is central to many homeostatic processes and as a result any perturbation in the concentration can cause profound metabolic effects. Disorders of red blood cells, platelets, the heart, bone, hypertension and asthma are all linked by this common factor and this book describes the effects of the drugs currently used in the control of calcium concentration. In describing the actions of these drugs on calcium metabolism, this volume of the International Encyclopedia of Pharmacology & Therapeutics will provide a greater understanding of the processes at work, and will undoubtedly lead to greater, more effective control of calcium concentration. It should thus be invaluable reading for those dealing with both the clinical and experimental control of calcium metabolism.

Author : Christopher J. Coulson
Publisher : CRC Press
Page : 318 pages
File Size : 55,9 Mb
Release : 1994-02-03
Category : Medical
ISBN : 0748400680

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Molecular Mechanisms Of Drug Action by Christopher J. Coulson Pdf

In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme inhibition and receptor binding by drugs. The next seven chapters deal with drugs that modulate biochemical pathways, both of synthesis and breakdown, while the last four chapters are concerned with organizational structures of the cell.; The book brings together the state of knowledge with respect to drug action and emphasizes mechanistic aspects of drug action. It encompasses the modes of action of drugs for infectious disease and those for endogenous conditions. There is a listing of reviews and essay questions are provided for each chapter.

Author : Biological Council. Co-ordinating Committee for Symposia on Drug Action
Publisher : Raven Press (ID)
Page : 416 pages
File Size : 49,6 Mb
Release : 1985
Category : Medical
ISBN : UCAL:B4494614

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Control and Manipulation of Calcium Movement by Biological Council. Co-ordinating Committee for Symposia on Drug Action Pdf

Author : R. Pochet,Rosario Donato,J. Haiech,Claus W. Heizmann,Volker Gerke
Publisher : Springer Science & Business Media
Page : 746 pages
File Size : 53,9 Mb
Release : 2011-06-28
Category : Medical
ISBN : 9789401006880

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Calcium: The molecular basis of calcium action in biology and medicine by R. Pochet,Rosario Donato,J. Haiech,Claus W. Heizmann,Volker Gerke Pdf

The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

Author : Alan William Cuthbert,Biological Council. Co-ordinating Committee for Symposia on Drug Action
Publisher : MacMillan Publishing Company
Page : 328 pages
File Size : 46,9 Mb
Release : 1970
Category : Medical
ISBN : CORNELL:31924003214123

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A Symposium on Calcium and Cellular Function by Alan William Cuthbert,Biological Council. Co-ordinating Committee for Symposia on Drug Action Pdf

Author : Institute of Medicine,Division of Health Care Services,VA Pharmacy Formulary Analysis Committee
Publisher : National Academies Press
Page : 280 pages
File Size : 42,9 Mb
Release : 2000-10-03
Category : Medical
ISBN : 9780309183536

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Description and Analysis of the VA National Formulary by Institute of Medicine,Division of Health Care Services,VA Pharmacy Formulary Analysis Committee Pdf

The VA National Formulary generated controversy, which motivated congressional scrutiny and a directive to the VA to commission this report reviewing the experience with the National Formulary and formulary system. This Institute of Medicine committee was pleased to assist the Congress with this review, in part because the committee saw in the VHA example an opportunity to understand and anticipate problems that all publicly funded programs are likely to encounter in this new age of pharmaceuticals. The Congress asked the committee to review the restrictiveness of the National Formulary, its impact on the costs and quality of care in the VHA, and how it compared to formularies and drug management practices in the private sector and in other public programs, especially Medicaid. Detailed in the pages that follow, the committee's findings and conclusions on these questions are, the committee believes, highly instructive, though not always in the ways that we anticipated.

Author : Anonim
Publisher : Academic Press
Page : 307 pages
File Size : 48,5 Mb
Release : 2013-07-24
Category : Science
ISBN : 9780124079380

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Store-Operated Calcium Channels by Anonim Pdf

Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Author : Mutschler,Hartmut Derendorf
Publisher : CRC Press
Page : 830 pages
File Size : 55,9 Mb
Release : 1995
Category : Medical
ISBN : 0849377749

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Drug Actions by Mutschler,Hartmut Derendorf Pdf

The most highly acclaimed pharmacology and toxicology text/reference used in Europe is now available in English. This excellent translation of Mutschler's Arzneimittelwirkungen combines a clear, informative narrative with 255 figures, 261 diagrams, and 198 tables to appeal to both new students and experts in pharmacy, pharmacology, and therapeutics. Drug structure and activity relationships are emphasized as an important dimension that is sometimes lacking in other pharmacology texts. Drug Actions is organized into three major sections covering general drug action and dosing principles, specific drug therapeutics, and toxicology. The first section provides an integrated overview of basic principles in pharmacology with chapters addressing pharmacokinetics, pharmacodynamics, drug side effects, drug interactions, chronopharmacology, rational and irrational drug combinations as well as drug developments and drug trials. The second section systematically describes specific drug actions with pharmacology, clinical indications, standard doses side effects, and contraindications described for each approved drug category. The third section addresses toxicology where specific drug toxicities are identified and treatment options for accidental and drug associated poisoning are presented. Topics covered include environmental, occupational, and nutritional exposure to toxins.

Author : Alex S. Evers,Mervyn Maze,Evan D. Kharasch
Publisher : Cambridge University Press
Page : 2902 pages
File Size : 45,5 Mb
Release : 2011-03-10
Category : Medical
ISBN : 9781139497022

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Anesthetic Pharmacology by Alex S. Evers,Mervyn Maze,Evan D. Kharasch Pdf

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Author : Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 172 pages
File Size : 40,9 Mb
Release : 2002-01-07
Category : Medical
ISBN : 9780309082587

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Caffeine for the Sustainment of Mental Task Performance by Institute of Medicine,Food and Nutrition Board,Committee on Military Nutrition Research Pdf

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Author : Francesco Clementi,Guido Fumagalli
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 42,7 Mb
Release : 2015-07-01
Category : Medical
ISBN : 9781118768594

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General and Molecular Pharmacology by Francesco Clementi,Guido Fumagalli Pdf

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

Author : G.N. Woodruff
Publisher : Springer
Page : 264 pages
File Size : 46,7 Mb
Release : 1986-06-18
Category : Medical
ISBN : 9781349080267

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Mechanisms of Drug Action by G.N. Woodruff Pdf

Author : Lionel H. Opie
Publisher : Springer
Page : 0 pages
File Size : 49,5 Mb
Release : 2011-10-18
Category : Medical
ISBN : 146128208X

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Clinical Use of Calcium Channel Antagonist Drugs by Lionel H. Opie Pdf

Calcium antagonists are now regarded as the most important advance in cardiac drug therapy since the advent of beta-adrenergic blocking agents. Acting ba sically as vasodilators-though with many other com plex mechanisms especially in the case of the anti arrhythmic calcium antagonists, these agents have grown in importance to become among the therapeutic agents of first choice for angina pectoris and hyper tension. The major aim of the present book is to present the clinician with the information needed for the practical use of calcium antagonists. What do all the numerous and often conflicting trials say? Do these agents really work? If so, which agent and in what dose? How do the three front runners, verapamil, nifedipine and diltia zem compare in the efficacy and side-effects with each other? How do the new second generation agents, now entering the North American market, slot in and com pare with the three first-liners? When the gloss is taken away from the advertisements, what is really left? The strong clinical bias of the present book should be complimented by further reading of books slanted towards fundamentals. One of the most important and recent of these is that by Dr Winifred Nayler (Calcium Antagonists, Academic Press, 1988). That book should be basic for essential background knowledge in the area of calcium antagonists. The important basic contribu tions of Fleckenstein deserve emphasis.