Isolation And Structure Elucidation Of Bioactive Secondary Metabolites From Microbial Sources

Author : Kate J. Graham
Publisher : Unknown
Page : 256 pages
File Size : 42,8 Mb
Release : 1994
Category : Electronic
ISBN : CORNELL:31924074509773

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Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Microbial Sources by Kate J. Graham Pdf

Microbial organisms often produce biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay- guided fractionations were employed on a variety of natural products sources. Active compounds were characterized by spectroscopic analysis and X-ray diffraction methods. As a result of these studies, six projects were completed, resulting in the purification of a diverse range of compounds containing activity in a variety of assays. A coumarin and parahydroxyphenylethanol were determined to possess phytotoxic activity from fungal pathogens. Two novel C-glycosidic compounds from a bacterial plant pathogen were found to be the first low molecular weight elicitors of the hypersensitive response in plants. A verticillin of the epi-polythiodiketopiperazine class isolated from a soil fungus was discovered to be responsible for inhibition of ras farnesylation transferase. Leafcutter ants were found to be deterred by the presence of a novel sesqualterpenoid in epiphylls. Finally, inhibitors of the PDGF receptor were isolated and characterized from a lichen.

Author : Ling Liu,Dewu Zhang,Fushuang Li,Kalindi Morgan
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 55,6 Mb
Release : 2023-08-30
Category : Science
ISBN : 9782832532751

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The discovery of bioactive natural products: The isolation and structural elucidation, genome mining, OSMAC strategy, and biotransformation by Ling Liu,Dewu Zhang,Fushuang Li,Kalindi Morgan Pdf

Author : Muhammad Ilias,Charles L. Cantrell
Publisher : MDPI
Page : 276 pages
File Size : 40,8 Mb
Release : 2019-04-11
Category : Medical
ISBN : 9783038977803

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Isolation and Structure Elucidation of Bioactive Compounds (Dedicated to the memory of the late Professor Charles D. Hufford) by Muhammad Ilias,Charles L. Cantrell Pdf

We are very pleased to introduce the Book Version of our Special Issue in Molecules dedicated to the memory of the late Professor Dr. Charles D. Hufford. The issue has been a huge success, with 22 full-length peer-reviewed papers and a tribute by Professor Alice M.Clark. Authors, reviewers, and collaborators from many countries across the worldhave contributed to this endeavour, and we are truly grateful to all. This Special Issue isrepresentative of the broad impact that “Charlie” had on the field of bioactive naturalproducts. This Special Issue comprises papers from Professor Hufford’s former students,colleagues, and collaborators throughout the world who have utilized a wide array ofstate-of-the-art techniques to examine diverse natural sources to isolate and identify avariety of natural products with a wide spectrum of biological activities, including somenew microbial transformations and insights into bioactive molecules. Many new bioactive compounds are described and reported here for the first time. Bioactivities reportedinclude cytotoxicity, antimicrobial activity, anti-inflammatory activity, antileishmanialactivity, antitrypanosomal activity, antimalarial activity, analgesic activity, and beneficialliver activities, just to name a few. This Special Issue will undoubtedly have a lasting impact on the field of bioactive natural products, as exemplified by the career of Dr. Hufford. Lastly, without the timely and outstanding contributions from all of you, this Special Issue would not have been possible. We thank you all very much for your contributions and your time devoted to this Special Issue in memory of a special person. Finally, we express ourgratitude and thanks to the journal Molecules and their excellent team of expert reviewers for giving us the support and opportunity to make this Special Issue a huge success!

Author : Ramasamy Vijayakumar,Suresh S.S. Raja
Publisher : BoD – Books on Demand
Page : 149 pages
File Size : 51,8 Mb
Release : 2018-09-05
Category : Science
ISBN : 9781789236422

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Secondary Metabolites by Ramasamy Vijayakumar,Suresh S.S. Raja Pdf

This book consists of an introductory overview of secondary metabolites, which are classified into four main sections: microbial secondary metabolites, plant secondary metabolites, secondary metabolites through tissue culture technique, and regulation of secondary metabolite production. This book provides a comprehensive account on the secondary metabolites of microorganisms, plants, and the production of secondary metabolites through biotechnological approach like the plant tissue culture method. The regulatory mechanisms of secondary metabolite production in plants and the pharmaceutical and other applications of various secondary metabolites are also highlighted. This book is considered as necessary reading for microbiologists, biotechnologists, biochemists, pharmacologists, and botanists who are doing research in secondary metabolites. It should also be useful to MSc students, MPhil and PhD scholars, scientists, and faculty members of various science disciplines.

Author : Corrado Tringali
Publisher : CRC Press
Page : 704 pages
File Size : 51,5 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203212318

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Bioactive Compounds from Natural Sources by Corrado Tringali Pdf

Interest in obtaining biologically active compounds from natural sources has recently spiked due to their low toxicity, complete biodegradability, availability from renewable sources, and in most cases, low cost. Taking an interdisciplinary approach, Bioactive Compounds from Natural Sources: Isolation, Characterization, and Biological Properties covers general methods and main topics in the research field of bioactive natural products. The book describes general screening methods, modern HPLC hyphenated techniques, and NMR methods in the structural elucidation of compounds and devotes individual chapters to specific topics of research. Surveys on compounds displaying important pharmacological activities are presented in chapters devoted to Mexican medicinal plants, anti-tumor drugs of natural origin, cancer chemopreventive flavonoids, and metabolites displaying anti-HIV, antioxidative, antimalarial, and anti-inflammatory activity. The final chapters are devoted to representative examples of research into marine metabolites: immunomodulating marine glycolipids and surveys of bioactive compounds from marine opisthobranchs and Japanese soft corals. With its focus on modern approaches to the isolation of biologically active natural products, this book encourages interdisciplinary work among chemists, pharmacologists, biologists, botanists, and agronomists with an interest in bioactive natural products.

Author : Jaroslava Švarc-Gajić
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 41,6 Mb
Release : 2013
Category : Biochemistry
ISBN : 1628089261

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Biological Activity of Natural Products by Jaroslava Švarc-Gajić Pdf

Many thousands of years ago, humans were introduced to the toxicants of minerals and plants of microbial origin, and since that time, natural bioactive compounds have been used in traditional medicine for treating different health conditions, but also as aphrodisiacs and as a means of suicide or murder. Modern medicine acknowledges natural bioactive compounds as valuable medicinal sources for both diagnostic and curative purposes. Natural compounds serve as templates for the production of new drugs with improved pharmacological properties. This book explains the term bioactivity and deals with the bioactive compounds of plants, animals, microbial and marine origin. Their use by traditional medicinal approach, as well as by modern medicine is further elaborated. Both beneficial and toxic properties of different chemical classes, including alkaloids, peptides, terpenoids, bioactive amines etc., are described. Their isolation at the industrial scale is presented through several technological processes which are explained in detail for several compound classes. The research explains how natural sources can be exploited my modern and traditional medicine, and presents the risks and benefits associated with their use. In addition, a new approach to studying bioactivity, that includes computational modelling and softwares for in silico description and prediction, is explained. A chemometric approach to studying bioactivity is demonstrated through several models given for some natural bioactive compounds and their derivatives.

Author : Dewan S. Bhakuni,D.S. Rawat
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 47,7 Mb
Release : 2006-06-30
Category : Science
ISBN : 9781402034848

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Bioactive Marine Natural Products by Dewan S. Bhakuni,D.S. Rawat Pdf

Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.

Author : Xiachang Wang,Khaled A. Shaaban,Guojun Wang,Javier Echeverria,Xuekui Xia,Yuanyuan Lu
Publisher : Frontiers Media SA
Page : 134 pages
File Size : 42,8 Mb
Release : 2022-04-11
Category : Science
ISBN : 9782889749072

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Bioactive Natural Products From Microbes: Isolation, Characterization, Biosynthesis and Structure Modification by Xiachang Wang,Khaled A. Shaaban,Guojun Wang,Javier Echeverria,Xuekui Xia,Yuanyuan Lu Pdf

Author : Nobuhiro Fusetani,Anthony S. Clare
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 47,6 Mb
Release : 2006-10-11
Category : Science
ISBN : 9783540300168

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Antifouling Compounds by Nobuhiro Fusetani,Anthony S. Clare Pdf

Awareness of the dangers of toxic components in antifouling coatings has raised interest in the potential for nontoxic alternatives. Marine organisms from bacteria to invertebrates and plants use chemicals to communicate and defend themselves. This book explores natural based antifoulants, their ecological functions, methods of characterisation and possible uses in antifouling. The text takes on the challenge of identifying such compounds, designing sustainable production and incorporating them into antifouling coatings.

Author : Joginder Singh,Ajar Nath Yadav
Publisher : Springer Nature
Page : 307 pages
File Size : 44,8 Mb
Release : 2020-05-11
Category : Medical
ISBN : 9789811530241

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Natural Bioactive Products in Sustainable Agriculture by Joginder Singh,Ajar Nath Yadav Pdf

This book discusses various aspects of bioactive natural products employed in the agrochemical and agriculture sectors. It covers the use of plants, microorganisms, and microbial metabolites as eco-friendly, cost-effective, and sustainable alternatives to chemicals in the field of agriculture. Written by active researchers and academics, the book highlights state-of-art products in the field, as well as the gaps, challenges, and obstacles associated with the use of plants, microbes and their products. Given its scope, it is a valuable resource for the scientific community and professionals in enterprises wanting insights into the latest developments and advances in the context of biological products, including their applications, traditional uses, modern practices, and strategies to harness their full potential.

Author : Atta-ur Rahman
Publisher : Elsevier
Page : 967 pages
File Size : 41,8 Mb
Release : 2008-07-24
Category : Science
ISBN : 9780080569840

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Studies in Natural Products Chemistry by Atta-ur Rahman Pdf

This volume presents frontier reviews of recent developments in bioactive natural products in cutting-edge areas by eminent experts in their respective fields. It is an essential addition to this important series on Natural Products Chemistry, generally acknowledged to be the leading series on this topic. • The first seven reviews cover recent developments in the field of bioactive marine natural products.• Additional coverage includes Novel Domino reactions; medicinal plants and phytochemicals; recent developments in bioactive natural peptides; the chemistry and pharmacology of natural cyclic lipopeptides; and the biological activities of Salvia .• The text includes a comprehensive review of biologically active compounds of semi-metals such as boron, silicon, arsenic, selenium and tellurium.

Author : Branislav Ranković
Publisher : Springer
Page : 260 pages
File Size : 49,7 Mb
Release : 2019-07-26
Category : Science
ISBN : 9783030168148

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Lichen Secondary Metabolites by Branislav Ranković Pdf

This revised and extended edition provides in-depth insights into the benefits and untapped potential of lichen-derived bioactive compounds. The whole spectrum of these compounds’ biological and medical functions, from antibiotic to antiviral and anti-carcinogenic properties, is presented. In addition, a new chapter discusses the anti-neurodegenerative and anti-diabetic activities of lichenic secondary metabolites. Given its scope, the book offers a valuable asset for students and researchers in this field.

Author : Didier Stien
Publisher : MDPI
Page : 146 pages
File Size : 55,8 Mb
Release : 2020-06-17
Category : Science
ISBN : 9783039361823

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Marine Microbial Diversity as a Source of Bioactive Natural Products by Didier Stien Pdf

A trillion different microbial species have been evolving for some 3.5 billion years, producing ever more complex active secondary metabolites. The sea is a cauldron of a great diversity of useful and valuable compounds. This Special Issue focused on studies of marine microbe natural products for discovering compounds useful to humankind. Papers were collected that provide up-to-date information regarding the characterization of marine microbes’ metabolic diversity and the evaluation of the therapeutic potential of marine microbes’ metabolites. Most of the articles in this book deal with marine fungi, biological and chemical diversity, and their active metabolites. This may be a sign that marine fungi have been under studied to date and are perceived by many researchers as an important source of discovery in this field. A best practices guide for the isolation of marine fungi from different matrixes and their conservation is also presented. The comparison of the phylogenetic and metabolomic profiles of microalgae from different lineages provides novel insights into the potential of chemotaxonomy in marine phytoplankton, showing a good overlap of phylogenetic and chemotaxonomic signals.

Author : Raymond Cooper
Publisher : CRC Press
Page : 206 pages
File Size : 49,8 Mb
Release : 2014-07-29
Category : Medical
ISBN : 9781466567627

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Natural Products Chemistry by Raymond Cooper Pdf

Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and

Author : Ernesto Fattorusso,William H. Gerwick,Orazio Taglialatela-Scafati
Publisher : Springer
Page : 0 pages
File Size : 43,7 Mb
Release : 2012-04-21
Category : Science
ISBN : 9048138337

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Handbook of Marine Natural Products by Ernesto Fattorusso,William H. Gerwick,Orazio Taglialatela-Scafati Pdf

"Handbook of Marine Natural Products" takes a fresh approach to describing the major themes of research in this rapidly developing field. This two volume reference work begins with a section that provides a taxonomic survey of the secondary metabolites of diverse marine life including microbes, algae, and invertebrates. This is followed by a demonstration of the techniques and strategies employed in modern structure elucidation of complex natural products. The natural roles of marine natural products are then explored in a series of focused chapters which include the topics of symbiosis, anti-predation and antifouling, chemical interactions, and defence against UV stress. Various routes which facilitate the understanding of marine natural product biosynthesis are subsequently explained and these are followed by an extensive set of chapters on the biomedical potential of marine natural products. The latter portion of this section considers the technologies and scientific disciplines necessary for advancing bioactive marine natural product lead compounds into actual pharmaceuticals. The reference work finishes with a selection of chapters describing marine toxins and their impact on public health and seafood resources. Final thoughts presented at the end of the second volume focus on the future of this field of investigation and discovery research. This publication is presented as a reference handbook and general concepts are emphasized and illustrated with numerous interesting examples, graphical information, and a comprehensive index. "Handbook of Marine Natural Products" introduces students who are at advanced undergraduate and entry graduate student levels to this fascinating multidisciplinary field. It is an ideal desk companion for courses focusing on this contemporary area.