Ketamine For Treatment Resistant Depression

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Ketamine for Treatment-Resistant Depression

Sanjay J. Mathew,Carlos A. Zarate, Jr.
Ketamine for Treatment Resistant Depression Book PDF

Author : Sanjay J. Mathew,Carlos A. Zarate, Jr.
Publisher : Springer
Page : 155 pages
File Size : 49,6 Mb
Release : 2016-11-25
Category : Medical
ISBN : 9783319429250

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Ketamine for Treatment-Resistant Depression by Sanjay J. Mathew,Carlos A. Zarate, Jr. Pdf

This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.

Ketamine for Treatment-Resistant Depression

Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke
Ketamine for Treatment Resistant Depression Book PDF

Author : Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke
Publisher : Academic Press
Page : 170 pages
File Size : 44,6 Mb
Release : 2020-09-16
Category : Medical
ISBN : 9780128210345

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Ketamine for Treatment-Resistant Depression by Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke Pdf

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

Ketamine for Depression

Dr. Stephen J. Hyde
Ketamine for Depression Book PDF

Author : Dr. Stephen J. Hyde
Publisher : Xlibris Corporation
Page : 222 pages
File Size : 55,9 Mb
Release : 2015-09-04
Category : Health & Fitness
ISBN : 9781503509535

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Ketamine for Depression by Dr. Stephen J. Hyde Pdf

Given the unacceptably high rates of suffering, disability and premature death experienced by people with treatment-resistant depression and the surprisingly low rates of problems arising from the use of ketamine to treat the disorder, this is a therapy that all patients and their doctors should be discussing. This book summarises the research that has been carried out into ketamine for the treatment of depression over the past 15 years and, most importantly, describes different ways of using ketamine that are both practical and cost–effective. Currently most ketamine therapy is given intravenously in specialised clinics at considerable expense, but the author has successfully treated patients with low-dose sublingual ketamine and his patients have been able to safely take this at home. Profits from the sales of this book will assist further research into the use of ketamine for the treatment of depression.

Managing Treatment-Resistant Depression

Joao Quevedo,Patricio Riva-Posse,William V. Bobo
Managing Treatment Resistant Depression Book PDF

Author : Joao Quevedo,Patricio Riva-Posse,William V. Bobo
Publisher : Academic Press
Page : 614 pages
File Size : 54,8 Mb
Release : 2022-03-31
Category : Science
ISBN : 9780128240687

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Managing Treatment-Resistant Depression by Joao Quevedo,Patricio Riva-Posse,William V. Bobo Pdf

Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD. Defines Treatment-Resistant Depression and Staging Treatment Intensity Includes Treatment-Resistant Depression options for children, adolescents, geriatrics, during pregnancy, and during post-partum and menopause transitions Discusses the use of Ketamine and Esketamine for treatment-resistant depression

Treatment-resistant Mood Disorders

André Carvalho,Roger McIntyre
Treatment resistant Mood Disorders Book PDF

Author : André Carvalho,Roger McIntyre
Publisher : Oxford Psychiatry Library
Page : 175 pages
File Size : 40,8 Mb
Release : 2015
Category : Medical
ISBN : 9780198707998

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Treatment-resistant Mood Disorders by André Carvalho,Roger McIntyre Pdf

Treatment-resistant major depression and bipolar disorder are highly prevalent and disabling conditions associated with substantial morbidity and mortality. Providing a concise view of the current definitions, assessment and evidence-based management of such disorders, this work reviews novel therapeutic targets, which may enhance the future therapeutic armamentarium of clinicians.

Rapid Acting Antidepressants

Anonim
Rapid Acting Antidepressants Book PDF

Author : Anonim
Publisher : Academic Press
Page : 404 pages
File Size : 49,5 Mb
Release : 2020-06-29
Category : Medical
ISBN : 9780128201909

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Rapid Acting Antidepressants by Anonim Pdf

The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Ketamine

Kenji Hashimoto,Soichiro Ide,Kazutaka Ikeda
Ketamine Book PDF

Author : Kenji Hashimoto,Soichiro Ide,Kazutaka Ikeda
Publisher : Springer
Page : 189 pages
File Size : 47,5 Mb
Release : 2021-03-06
Category : Medical
ISBN : 9811529043

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Ketamine by Kenji Hashimoto,Soichiro Ide,Kazutaka Ikeda Pdf

This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants.

Manufacturing Depression

Gary Greenberg
Manufacturing Depression Book PDF

Author : Gary Greenberg
Publisher : Simon and Schuster
Page : 448 pages
File Size : 42,5 Mb
Release : 2010-02-02
Category : Psychology
ISBN : 141657008X

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Manufacturing Depression by Gary Greenberg Pdf

Am I depressed or just unhappy? In the last two decades, antidepressants have become staples of our medicine cabinets—doctors now write 120 million prescriptions annually, at a cost of more than 10 billion dollars. At the same time, depression rates have skyrocketed; twenty percent of Americans are now expected to suffer from it during their lives. Doctors, and drug companies, claim that this convergence is a public health triumph: the recognition and treatment of an under-diagnosed illness. Gary Greenberg, a practicing therapist and longtime depressive, raises a more disturbing possibility: that the disease has been manufactured to suit (and sell) the cure. Greenberg draws on sources ranging from the Bible to current medical journals to show how the idea that unhappiness is an illness has been packaged and sold by brilliant scientists and shrewd marketing experts—and why it has been so successful. Part memoir, part intellectual history, part exposé—including a vivid chronicle of his participation in a clinical antidepressant trial—Manufacturing Depression is an incisive look at an epidemic that has changed the way we have come to think of ourselves.

The Ketamine Papers

Phil Wolfson,Glenn Hartelius
The Ketamine Papers Book PDF

Author : Phil Wolfson,Glenn Hartelius
Publisher : Unknown
Page : 420 pages
File Size : 42,6 Mb
Release : 2016-11
Category : Body, Mind & Spirit
ISBN : 0998276502

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The Ketamine Papers by Phil Wolfson,Glenn Hartelius Pdf

The Ketamine Papers opens the door to a broad understanding of this medicine's growing use in psychiatry and its decades of history providing transformative personal experiences. Now gaining increasing recognition as a promising approach to the treatment of depression, posttraumatic stress disorder (PTSD), and other psychological conditions, ketamine therapies offer new hope for patients and clinicians alike. With multiple routes of administration and practices ranging from anesthesia to psychotherapy, ketamine medicine is a diverse and rapidly growing field. The Ketamine Papers clarifies the issues and is an inspiring introduction to this powerful tool for healing and transformation--from its early use in the 1960s to its emerging role in the treatment of depression, suicidality, and other conditions. This comprehensive volume is the ideal introduction for patients and clinicians alike, and for anyone interested in the therapeutic and transformative healing power of this revolutionary medicine.

IV Ketamine Infusion Therapy for Depression

Frank Ligons
IV Ketamine Infusion Therapy for Depression Book PDF

Author : Frank Ligons
Publisher : Unknown
Page : 118 pages
File Size : 47,7 Mb
Release : 2021-04-15
Category : Electronic
ISBN : 1736892517

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IV Ketamine Infusion Therapy for Depression by Frank Ligons Pdf

Many depressed patients are "treatment-resistant," unable to find relief. Ketamine Infusions help TWO-THIRDS of these cases.

Curing Stubborn Depression

Paul Fitzgerald
Curing Stubborn Depression Book PDF

Author : Paul Fitzgerald
Publisher : Hatherleigh Press
Page : 250 pages
File Size : 42,6 Mb
Release : 2023-11-14
Category : Self-Help
ISBN : 9781578269389

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Curing Stubborn Depression by Paul Fitzgerald Pdf

Hope and help arrives in this psychiatrist's preview of emerging and breakthrough therapies for treating more severe, treatment-resistant depression. Over 280 million individuals worldwide suffer from depression every year, with many turning to potent antidepressants and drastic lifestyle changes to help manage their condition and improve their quality of life. But what if these methods don’t work? What if, despite all efforts, an individual continues to suffer? Stubborn, treatment-resistant depression dramatically reduces a person’s quality of life while providing them with seemingly few options for relief. Curing Stubborn Depression seeks to not only explain the underlying causes of this pervasive form of depressive disorder, but to shine light on a number of non-traditional treatments, new therapies and clinical developments—including ECT, transcranial magnetic stimulation, bright light therapy, ketamine and more—offering hope to those who feel like they have none. The field of depression treatment is rapidly evolving and constantly changing, meaning it can be difficult to keep up with new therapies and clinical developments. Curing Stubborn Depression delves into these emergent treatments, many of which are transforming how this condition is managed—and offering hope to those who feel like they have none.

Hello I Want to Die Please Fix Me

Anna Mehler Paperny
Hello I Want to Die Please Fix Me Book PDF

Author : Anna Mehler Paperny
Publisher : Random House Canada
Page : 336 pages
File Size : 41,8 Mb
Release : 2019-08-06
Category : Biography & Autobiography
ISBN : 9780735272842

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Hello I Want to Die Please Fix Me by Anna Mehler Paperny Pdf

NATIONAL BESTSELLER SHORTLISTED FOR THE HILARY WESTON WRITERS' TRUST PRIZE FOR NONFICTION Award-winning journalist Anna Mehler Paperny's stunning memoir chronicles with courageous honesty and uncommon eloquence her experience of depression and her quest to explore what we know and don't know about this disease that afflicts almost a fifth of the population--providing an invaluable guide to a system struggling to find solutions. As fascinating as it is heartrending, as outrageously funny as it is serious, it is a must-read for anyone impacted by depression--and that's pretty much everybody. Depression is a havoc-wreaking illness that masquerades as personal failing and hijacks your life. After a major suicide attempt in her early twenties, Anna Mehler Paperny resolved to put her reporter's skills to use to get to know her enemy, setting off on a journey to understand her condition, the dizzying array of medical treatments on offer and a medical profession in search of answers. Charting the way depression wrecks so many, she maps competing schools of therapy, pharmacology, cutting-edge medicine, the pill-popping pitfalls of long-term treatment, the glaring unknowns and the institutional shortcomings that both patients and practitioners are up against. She interviews leading medical experts across Canada and the US, from psychiatrists to neurologists, brain-mapping pioneers to family practitioners, and others dabbling in strange hypotheses--and shares compassionate conversations with fellow sufferers. Hello I Want to Die Please Fix Me tracks Anna's quest for knowledge and her desire to get well. Impeccably reported, it is a profoundly compelling story about the human spirit and the myriad ways we treat (and fail to treat) the disease that accounts for more years swallowed up by disability than any other in the world.

Natural Medications for Psychiatric Disorders

David Mischoulon,Jerrold F. Rosenbaum
Natural Medications for Psychiatric Disorders Book PDF

Author : David Mischoulon,Jerrold F. Rosenbaum
Publisher : Lippincott Williams & Wilkins
Page : 386 pages
File Size : 40,6 Mb
Release : 2008
Category : Medical
ISBN : 0781767628

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Natural Medications for Psychiatric Disorders by David Mischoulon,Jerrold F. Rosenbaum Pdf

Updated for its Second Edition, this book is the only reference to focus exclusively on natural medications in psychiatry. Eminent psychiatrists from the Massachusetts General Hospital and other leading institutions examine current scientific and clinical data on the applications, effectiveness, and safety of natural psychotropics and acupuncture. Quick-reference tabular appendices list indications, contraindications, dosages, combinations, and drug-drug interactions for each remedy. This edition includes brand-new chapters on acupuncture, homeopathy, and therapies for substance dependence and weight management. The chapter on polypharmacy and side effect management addresses the growing issue of drug-drug interactions. New introductory chapters discuss complementary and alternative medicine in society and examine research limitations and quality assurance issues.

Your Brain on Food

Gary L. Wenk
Your Brain on Food Book PDF

Author : Gary L. Wenk
Publisher : Oxford University Press
Page : 288 pages
File Size : 51,6 Mb
Release : 2019-02-01
Category : Psychology
ISBN : 9780190932817

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Your Brain on Food by Gary L. Wenk Pdf

An internationally renowned neuroscientist, Dr. Wenk has been educating college and medical students about the brain and lecturing around the world for more than forty years. He has published over three hundred publications on the effects of drugs upon the brain. This essential book vividly demonstrates how a little knowledge about the foods and drugs we eat can teach us a lot about how our brain functions. The information is presented in an irreverent and non-judgmental manner that makes it highly accessible to high school teenagers, inquisitive college students and worried parents. Dr. Wenk has skillfully blended the highest scholarly standards with illuminating insights, gentle humor and welcome simplicity. The intersection between brain science, drugs, food and our cultural and religious traditions is plainly illustrated in an entirely new light. Wenk tackles fundamental questions, including: · Why do you wake up tired from a good long sleep and why does your sleepy brain crave coffee and donuts? · How can understanding a voodoo curse explain why it is so hard to stop smoking? · Why is a vegetarian or gluten-free diet not always the healthier option for the brain? · How can liposuction improve brain function? · What is the connection between nature's hallucinogens and religiosity? · Why does marijuana impair your memory now but protect your memory later in life? · Why do some foods produce nightmares? · What are the effects of diet and obesity upon the brains of infants and children? · Are some foods better to eat after traumatic brain injury?

Antidepressants

Matthew Macaluso,Sheldon H. Preskorn
Antidepressants Book PDF

Author : Matthew Macaluso,Sheldon H. Preskorn
Publisher : Springer
Page : 442 pages
File Size : 46,8 Mb
Release : 2019-05-31
Category : Medical
ISBN : 9783030109493

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Antidepressants by Matthew Macaluso,Sheldon H. Preskorn Pdf

This volume reviews the known neurobiology of depression and combines classic data on antidepressant treatments with modern theory on the physiology of depression. It also discusses novel mechanism of action drugs.