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Author : World Health Organization Publisher : World Health Organization Page : 110 pages File Size : 55,6 Mb Release : 2024-06-21 Category : Medical ISBN : 9789240095113
Laboratory biosecurity guidance by World Health Organization Pdf
The Laboratory biosecurity guidance is a revision of the first edition of the WHO Biorisk management - Laboratory biosecurity guidance, 2006. As introduced in the 4th edition of the Laboratory biosafety manual (LBM4), the novel risk- and evidence-based approach is applied for biosecurity in this guidance. The guidance is intended to help researchers, biosafety/biosecurity officers and other laboratory personnel properly assess and manage risks inherent to high-consequence research. Furthermore, it contains a template for biosecurity risk assessment in the laboratory to prevent theft, misuse and unauthorized access to biological material, and also includes a two-tier approach for national oversight of biological risk management as well as a hybrid approach with risk- and list-based elements to regulate high-consequence material.
Laboratory Biorisk Management by Reynolds M. Salerno,Jennifer Gaudioso Pdf
Over the past two decades bioscience facilities worldwide have experienced multiple safety and security incidents, including many notable incidents at so-called "sophisticated facilities" in North America and Western Europe. This demonstrates that a system based solely on biosafety levels and security regulations may not be sufficient. Setting the stage for a substantively different approach for managing the risks of working with biological agents in laboratories, Laboratory Biorisk Management: Biosafety and Biosecurity introduces the concept of biorisk management—a new paradigm that encompasses both laboratory biosafety and biosecurity. The book also provides laboratory managers and directors with the information and technical tools needed for its implementation. The basis for this new paradigm is a three-pronged, multi-disciplinary model of assessment, mitigation, and performance (the AMP model). The application of the methodologies, criteria, and guidance outlined in the book helps to reduce the risk of laboratories becoming the sources of infectious disease outbreaks. This is a valuable resource for those seeking to embrace and implement biorisk management systems in their facilities and operations, including the biological research, clinical diagnostic, and production/manufacturing communities.
The Laboratory Biosafety Guidelines by Canada. Health Canada,Centre for Emergency Preparedness and Response (Canada) Pdf
These guidelines were developed to guide government, industry, university, hospital, and other public health and microbiological laboratories in their development of biosafety policies and programs. They also provide information and recommendations on the design, construction, and commissioning of containment facilities. The guidelines are intended to reduce the incidence of infection and mortality among laboratory workers, as well as to prevent secondary transmission of disease to the public.
Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Committee on Hazardous Biological Substances in the Laboratory,National Research Council
Author : Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Committee on Hazardous Biological Substances in the Laboratory,National Research Council Publisher : National Academies Press Page : 237 pages File Size : 49,6 Mb Release : 1989-01-01 Category : Science ISBN : 9780309039758
Biosafety in the Laboratory by Division on Engineering and Physical Sciences,Commission on Physical Sciences, Mathematics, and Applications,Committee on Hazardous Biological Substances in the Laboratory,National Research Council Pdf
Biosafety in the Laboratory is a concise set of practical guidelines for handling and disposing of biohazardous material. The consensus of top experts in laboratory safety, this volume provides the information needed for immediate improvement of safety practices. It discusses high- and low-risk biological agents (including the highest-risk materials handled in labs today), presents the "seven basic rules of biosafety," addresses special issues such as the shipping of dangerous materials, covers waste disposal in detail, offers a checklist for administering laboratory safetyâ€"and more.
Laboratory Biosecurity Handbook by Reynolds M. Salerno,Jennifer Gaudioso,Benjamin H. Brodsky Pdf
By achieving a delicate balance between systems and practices, proper laboratory biosecurity reduces the risk of legitimate bioscience facilities becoming sources of pathogens and toxins for malicious use. Effective design and implementation of laboratory biosecurity depends on cooperation among individuals from diverse communities, including scien
Author : World Health Organization Publisher : World Health Organization Page : 196 pages File Size : 53,9 Mb Release : 2004-12-28 Category : Medical ISBN : 9241546506
Laboratory Biosafety Manual by World Health Organization Pdf
This is the third edition of this manual which contains updated practical guidance on biosafety techniques in laboratories at all levels. It is organised into nine sections and issues covered include: microbiological risk assessment; lab design and facilities; biosecurity concepts; safety equipment; contingency planning; disinfection and sterilisation; the transport of infectious substances; biosafety and the safe use of recombinant DNA technology; chemical, fire and electrical safety aspects; safety organisation and training programmes; and the safety checklist.
National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Humane Transportation of Laboratory Animals
Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Humane Transportation of Laboratory Animals Publisher : National Academies Press Page : 165 pages File Size : 40,7 Mb Release : 2006-08-14 Category : Science ISBN : 9780309101103
Guidelines for the Humane Transportation of Research Animals by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Humane Transportation of Laboratory Animals Pdf
Arranging the transportation of animals at research facilities is often an ordeal. There is a confusing patchwork of local, national, and international regulations; a perceived lack of high-quality shipping services; a dearth of science-based good practices; and a lack of biosafety standards. It's a challenge â€"and an impediment to biomedical research. Guidelines for the Humane Transportation of Research Animals identifies the current problems encountered in the transportation of research animals and offers recommendations aimed at local and federal officials to rectify these problems. This book also includes a set of good practices based on the extensive body of literature on transportation of agricultural animals, universal concepts of physiology, and a scientific understanding of species-specific needs and differences. Good practices were developed by the committee to address thermal environment, space requirements, food and water requirements, social interaction, monitoring of transportation, emergency procedures, personnel training, and biosecurity. Guidelines for the Humane Transportation of Research Animals is an essential guide for all researchers, animal care technicians, facilities managers, administrators, and animal care and use committees at research institutions.
Biological Laboratory Applied Biosecurity and Biorisk Managemnet Guide by Anonim Pdf
The BIOLOGICAL LABORATORY APPLIED BIOSECURITY AND BIORISK MANAGEMENT GUIDE is a definitive and comprehensive tutorial text that, for the first time, provides a specific reference for training Biorisk and Biosecurity students or other biological community professionals. The topics included range from a clear, concise definition of Biorisk from a laboratory biosecurity perspective, biosafety/biosecurity comparisons and contracts, U.S. and WHO regulations and guidance, a unique laboratory biorisk assessment model, bio-terrorism reality, public health issues, research topics, laboratory physical security, emergency planning, export control and conducting business in foreign countries among other germane topics of interest.The cascading events in the aftermath of 9/11/2001, and the biological attacks that immediately followed have given rise to a significant proliferation of biological laboratories working with dangerous pathogens both domestically and internationally. The quest to develop effective medical countermeasures, conduct research, and provide safe and secure laboratory environments has also resulted in significant increases in funding. The expansion of this capacity has also resulted in the creation of a myriad of legislation, regulations and guidelines that are designed to protect laboratory staff, the public and ensure that these pathogens are properly secured. Ultimately, the convergence of these issues has contributed to the emergence of a new security subject matter expert category, Biological Security Professional. Currently there exists very few security management professionals specifically trained in biological security and biorisk management, to meet the needs and demand world-wide. The intent of this manual is to provide the fundamental information for new security practitioners just entering the field and the more experienced professional that is seeking to transition into the field of biological laboratory security and biorisk management. There is compelling evidence suggesting that the need for the biosecurity specialty subject matter expert will continue to grow exponentially in the near and long term, throughout the world. The ultimate goal is to assist in the proliferation of One Health world-wide and to create a professional discipline to prevent and mitigate the full spectrum of biological risks, threats and vulnerabilities
National Research Council,Institute of Medicine,Board on Health Sciences Policy,Policy and Global Affairs,Committee on Science, Technology, and Law,Division on Earth and Life Studies,Board on Life Sciences
Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Policy and Global Affairs,Committee on Science, Technology, and Law,Division on Earth and Life Studies,Board on Life Sciences Publisher : National Academies Press Page : 140 pages File Size : 48,7 Mb Release : 2015-04-13 Category : Science ISBN : 9780309367868
Potential Risks and Benefits of Gain-of-Function Research by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Policy and Global Affairs,Committee on Science, Technology, and Law,Division on Earth and Life Studies,Board on Life Sciences Pdf
On October 17, 2014, spurred by incidents at U.S. government laboratories that raised serious biosafety concerns, the United States government launched a one-year deliberative process to address the continuing controversy surrounding so-called "gain-of-function" (GOF) research on respiratory pathogens with pandemic potential. The gain of function controversy began in late 2011 with the question of whether to publish the results of two experiments involving H5N1 avian influenza and continued to focus on certain research with highly pathogenic avian influenza over the next three years. The heart of the U.S. process is an evaluation of the potential risks and benefits of certain types of GOF experiments with influenza, SARS, and MERS viruses that would inform the development and adoption of a new U.S. Government policy governing the funding and conduct of GOF research. Potential Risks and Benefits of Gain-of-Function Research is the summary of a two-day public symposia on GOF research. Convened in December 2014 by the Institute of Medicine and the National Research Council, the main focus of this event was to discuss principles important for, and key considerations in, the design of risk and benefit assessments of GOF research. Participants examined the underlying scientific and technical questions that are the source of current discussion and debate over GOF research involving pathogens with pandemic potential. This report is a record of the presentations and discussion of the meeting.
Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories,Board on Life Sciences,Committee on International Security and Arms Control,Division on Earth and Life Studies,Policy and Global Affairs,National Academy of Sciences,National Research Council
Author : Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories,Board on Life Sciences,Committee on International Security and Arms Control,Division on Earth and Life Studies,Policy and Global Affairs,National Academy of Sciences,National Research Council Publisher : National Academies Press Page : 216 pages File Size : 44,7 Mb Release : 2012-03-16 Category : Political Science ISBN : 9780309225762
Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories by Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories,Board on Life Sciences,Committee on International Security and Arms Control,Division on Earth and Life Studies,Policy and Global Affairs,National Academy of Sciences,National Research Council Pdf
During July 10-13, 2011, 68 participants from 32 countries gathered in Istanbul, Turkey for a workshop organized by the United States National Research Council on Anticipating Biosecurity Challenges of the Global Expansion of High-containment Biological Laboratories. The United States Department of State's Biosecurity Engagement Program sponsored the workshop, which was held in partnership with the Turkish Academy of Sciences. The international workshop examined biosafety and biosecurity issues related to the design, construction, maintenance, and operation of high-containment biological laboratories- equivalent to United States Centers for Disease Control and Prevention biological safety level 3 or 4 labs. Although these laboratories are needed to characterize highly dangerous human and animal pathogens, assist in disease surveillance, and produce vaccines, they are complex systems with inherent risks. Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories summarizes the workshop discussion, which included the following topics: Technological options to meet diagnostic, research, and other goals; Laboratory construction and commissioning; Operational maintenance to provide sustainable capabilities, safety, and security; and Measures for encouraging a culture of responsible conduct. Workshop attendees described the history and current challenges they face in their individual laboratories. Speakers recounted steps they were taking to improve safety and security, from running training programs to implementing a variety of personnel reliability measures. Many also spoke about physical security, access controls, and monitoring pathogen inventories. Workshop participants also identified tensions in the field and suggested possible areas for action.
Laboratory Biosecurity Handbook by Reynolds M. Salerno,Jennifer Gaudioso,Benjamin H. Brodsky Pdf
By achieving a delicate balance between systems and practices, proper laboratory biosecurity reduces the risk of legitimate bioscience facilities becoming sources of pathogens and toxins for malicious use. Effective design and implementation of laboratory biosecurity depends on cooperation among individuals from diverse communities, including scientists, technicians, policy makers, security engineers, and law enforcement officials. Providing guidance to the broad international community, Laboratory Biosecurity Handbook addresses the objectives of biosecurity and the ways in which they overlap or conflict with those of biosafety. The book describes the risks of working with dangerous pathogens and toxins in the current era of international terrorism. The authors characterize the global spread of legitimate biotechnology and relate it to the rise of transnational terrorism, emphasizing the need for biosecurity measures even in legitimate bioscience. The book discusses biosecurity risk assessment-a practical methodology that allows laboratory management and biosafety/biosecurity officers to analyze and determine the level of risk, and serves as a basis for managing those risks. The book includes questionnaires that can assist the process of collecting data for a biosecurity vulnerability assessment, example standard operating procedures and memoranda of understanding, and other useful reference material. Addressing a variety of operating environments and the particular challenges they face when designing and implementing laboratory biosecurity, this book can assist bioscience facilities ranging from the large to the small, from those that focus on diagnosis or vaccine development, to those only minimally involved with infectious diseases. The detailed recommendations help avoid a "one-size-fits-all" approach to security and save limited resources. The book shows institutions how to develop and implement a biosecurity plan, and helps ensure that all components are included in the overall system, whether existing or new.
