Leucocyte Trafficking

Author : Alf Hamann,Britta Engelhardt
Publisher : John Wiley & Sons
Page : 557 pages
File Size : 41,8 Mb
Release : 2006-05-12
Category : Medical
ISBN : 9783527607013

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Leukocyte Trafficking by Alf Hamann,Britta Engelhardt Pdf

Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.

Author : Joaquin Teixidó,Andres Hidalgo,Susanna Carola Fagerholm
Publisher : Frontiers Media SA
Page : 153 pages
File Size : 42,6 Mb
Release : 2019-12-30
Category : Electronic
ISBN : 9782889632961

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Leukocyte Trafficking in Homeostasis and Disease by Joaquin Teixidó,Andres Hidalgo,Susanna Carola Fagerholm Pdf

Author : A. Hamann,Khusru Asadullah,A. Schottelius
Publisher : Springer Science & Business Media
Page : 258 pages
File Size : 47,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662053973

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Leucocyte Trafficking by A. Hamann,Khusru Asadullah,A. Schottelius Pdf

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

Author : Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 49,8 Mb
Release : 2022-02-04
Category : Medical
ISBN : 9782889742851

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Targeting Leukocyte Trafficking: Insights and Future Directions by Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin Pdf

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 47,5 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

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Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Author : Larry W. Moreland
Publisher : Springer Science & Business Media
Page : 933 pages
File Size : 41,5 Mb
Release : 2004-07-20
Category : Medical
ISBN : 9783540206255

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Rheumatology and Immunology Therapy by Larry W. Moreland Pdf

Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

Author : Klaus Ley
Publisher : Academic Press
Page : 300 pages
File Size : 53,7 Mb
Release : 2009-11-09
Category : Science
ISBN : 008095698X

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Leucocyte Adhesion by Klaus Ley Pdf

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. This volume provides a review of the latest developments in leukocyte adhesion. Regulation of cell adhesion is important for immune system function. Contributions from leading experts in the field Reviews the latest developments

Author : Beth A. Jirón Tamburini,Amanda W. Lund,Timothy P. Padera
Publisher : Frontiers Media SA
Page : 205 pages
File Size : 53,6 Mb
Release : 2020-01-22
Category : Electronic
ISBN : 9782889633258

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Regulation of Immune Function by the Lymphatic Vasculature by Beth A. Jirón Tamburini,Amanda W. Lund,Timothy P. Padera Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 837 pages
File Size : 43,5 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781464992643

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Mononuclear Leukocytes—Advances in Research and Application: 2012 Edition by Anonim Pdf

Mononuclear Leukocytes—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Mononuclear Leukocytes. The editors have built Mononuclear Leukocytes—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mononuclear Leukocytes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Mononuclear Leukocytes—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Federica M. Marelli-Berg,Sussan Nourshargh
Publisher : Humana Press
Page : 290 pages
File Size : 44,8 Mb
Release : 2011-03-04
Category : Medical
ISBN : 1607614642

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T-Cell Trafficking by Federica M. Marelli-Berg,Sussan Nourshargh Pdf

In the last decade, a large number of major discoveries have shed light on the molecular mechanisms of lymphocyte migration and the anatomy of immune responses. In T-Cell Trafficking: Methods and Protocols, expert researchers explore how the development of novel and cutting-edge techniques, particularly in the field of real-time imaging and genetic manipulation, have led to an increased understanding of lymphocyte trafficking. Written by internationally recognized experts in their respective fields, chapters provide state-of-the-art protocols to study lymphocyte migration and T-cell: endothelial cell interactions in vitro, address various approaches used for direct visualization of the development of the lymphoid system, lymphocyte recirculation, and effector responses in experimental models in vivo, and explore lymphocyte migration and inflammation in the human system. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Innovative and highly practical, T-Cell Trafficking: Methods and Protocols is an essential manual for newcomers in this ever-expanding and exciting area of research, as well as a valuable addition to more specialized laboratories.

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 54,7 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

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The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Author : Bruno A. Bernard,B. Shroot
Publisher : Karger Medical and Scientific Publishers
Page : 214 pages
File Size : 42,6 Mb
Release : 1993-01-01
Category : Science
ISBN : 3805557760

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From Molecular Biology to Therapeutics by Bruno A. Bernard,B. Shroot Pdf

Author : Salvador Moncada,Annie Higgs
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 49,6 Mb
Release : 2006-10-14
Category : Medical
ISBN : 9783540360285

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The Vascular Endothelium II by Salvador Moncada,Annie Higgs Pdf

This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.

Author : Adam S. Cheifetz,Joseph D. Feuerstein
Publisher : Springer
Page : 335 pages
File Size : 43,8 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9783319602769

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Treatment of Inflammatory Bowel Disease with Biologics by Adam S. Cheifetz,Joseph D. Feuerstein Pdf

This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.

Author : Anonim
Publisher : Unknown
Page : 1488 pages
File Size : 42,5 Mb
Release : 1995
Category : Medicine
ISBN : UIUC:30112005408940

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Cumulated Index Medicus by Anonim Pdf