Ligand Design In Medicinal Inorganic Chemistry

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Ligand Design in Medicinal Inorganic Chemistry

Tim Storr
Ligand Design in Medicinal Inorganic Chemistry Book PDF

Author : Tim Storr
Publisher : John Wiley & Sons
Page : 650 pages
File Size : 52,6 Mb
Release : 2014-06-12
Category : Science
ISBN : 9781118697894

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Ligand Design in Medicinal Inorganic Chemistry by Tim Storr Pdf

Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.

Ligand Design in Metal Chemistry

Mark Stradiotto,Rylan J. Lundgren
Ligand Design in Metal Chemistry Book PDF

Author : Mark Stradiotto,Rylan J. Lundgren
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 52,5 Mb
Release : 2016-09-01
Category : Science
ISBN : 9781118839775

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Ligand Design in Metal Chemistry by Mark Stradiotto,Rylan J. Lundgren Pdf

The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales. Ligand Design in Metal Chemistry presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include: Key concepts in ligand design Redox non-innocent ligands Ligands for selective alkene metathesis Ligands in cross-coupling Ligand design in polymerization Ligand design in modern lanthanide chemistry Cooperative metal-ligand reactivity P,N Ligands for enantioselective hydrogenation Spiro-cyclic ligands in asymmetric catalysis This book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry, polymer science and materials chemistry.

Structure-based Ligand Design

Klaus Gubernator,Hans-Joachim Böhm
Structure based Ligand Design Book PDF

Author : Klaus Gubernator,Hans-Joachim Böhm
Publisher : John Wiley & Sons
Page : 167 pages
File Size : 53,5 Mb
Release : 2008-11-21
Category : Science
ISBN : 9783527612161

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Structure-based Ligand Design by Klaus Gubernator,Hans-Joachim Böhm Pdf

Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure-activity relationships. This volume presents the underlying principles of the approach and highlights real-life applications such as the discovery of HIV-protease inhibitors. It shows that structure-based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid. The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery.

Metals in Medicine

James C. Dabrowiak
Metals in Medicine Book PDF

Author : James C. Dabrowiak
Publisher : John Wiley & Sons
Page : 342 pages
File Size : 40,9 Mb
Release : 2009-10-29
Category : Science
ISBN : 0470684976

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Metals in Medicine by James C. Dabrowiak Pdf

Working from basic chemical principles, Metals in Medicine presents a complete and methodical approach to the topic. Introductory chapters discuss important bonding concepts applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background. Following this introduction, chapters focus on individual metallo-drugs and agents for treating and detecting disease, their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply. Topics covered include cisplatin; platinum anticancer drugs; ruthenium, titanium, and gallium for treating cancer; gold compounds for treating arthritis, cancer, and other diseases; vanadium, copper, and zinc in medicine; metal complexes for diagnosing disease; and metals in nanomedicine. Throughout the book, “Feature Boxes” expand on features of drugs that are not directly related to studying metals in medicine, for example discovery, medical use, specialist assays, and metals in biology. At the end of the chapters there are specifically designed problems/exercises that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in metals in medicine. Metals in Medicine distils the essence of this important topic for undergraduate and graduate students in chemistry, biochemistry, biology and the related areas of biophysics, pharmacology, and bioengineering, and for researchers in other fields interested in getting a general insight into metals in medicine.

Fragment-based Approaches in Drug Discovery

Wolfgang Jahnke,Daniel A. Erlanson
Fragment based Approaches in Drug Discovery Book PDF

Author : Wolfgang Jahnke,Daniel A. Erlanson
Publisher : John Wiley & Sons
Page : 391 pages
File Size : 43,5 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527608607

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Fragment-based Approaches in Drug Discovery by Wolfgang Jahnke,Daniel A. Erlanson Pdf

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

Advances in Metallodrugs

Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Advances in Metallodrugs Book PDF

Author : Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 46,9 Mb
Release : 2020-07-08
Category : Science
ISBN : 9781119640424

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Advances in Metallodrugs by Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan Pdf

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Medicinal Inorganic Chemistry

Jonathan L. Sessler
Medicinal Inorganic Chemistry Book PDF

Author : Jonathan L. Sessler
Publisher : Unknown
Page : 480 pages
File Size : 55,5 Mb
Release : 2005
Category : Medical
ISBN : UOM:39015062459931

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Medicinal Inorganic Chemistry by Jonathan L. Sessler Pdf

This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.

Computational and Structural Approaches to Drug Discovery

Robert M. Stroud,Janet Finer-Moore
Computational and Structural Approaches to Drug Discovery Book PDF

Author : Robert M. Stroud,Janet Finer-Moore
Publisher : Royal Society of Chemistry
Page : 171 pages
File Size : 46,8 Mb
Release : 2008
Category : Medical
ISBN : 9780854043651

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Computational and Structural Approaches to Drug Discovery by Robert M. Stroud,Janet Finer-Moore Pdf

This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.

An Introduction to Drug Design

S. N. Pandeya,J. R. Dimmock
An Introduction to Drug Design Book PDF

Author : S. N. Pandeya,J. R. Dimmock
Publisher : New Age International
Page : 228 pages
File Size : 52,5 Mb
Release : 1997
Category : Drugs
ISBN : 8122409431

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An Introduction to Drug Design by S. N. Pandeya,J. R. Dimmock Pdf

The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.

Computational Medicinal Chemistry for Drug Discovery

Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare
Computational Medicinal Chemistry for Drug Discovery Book PDF

Author : Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare
Publisher : CRC Press
Page : 1169 pages
File Size : 40,5 Mb
Release : 2003-12-17
Category : Medical
ISBN : 9780203913390

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Computational Medicinal Chemistry for Drug Discovery by Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare Pdf

Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computa

Privileged Scaffolds in Medicinal Chemistry

Stefan Bräse
Privileged Scaffolds in Medicinal Chemistry Book PDF

Author : Stefan Bräse
Publisher : Royal Society of Chemistry
Page : 486 pages
File Size : 41,7 Mb
Release : 2015-11-20
Category : Medical
ISBN : 9781782620303

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Privileged Scaffolds in Medicinal Chemistry by Stefan Bräse Pdf

This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.

Ligand Design for G Protein-coupled Receptors, Volume 30

Didier Rognan
Ligand Design for G Protein coupled Receptors Volume 30 Book PDF

Author : Didier Rognan
Publisher : John Wiley & Sons
Page : 300 pages
File Size : 50,5 Mb
Release : 2006-03-10
Category : Medical
ISBN : 3527312846

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Ligand Design for G Protein-coupled Receptors, Volume 30 by Didier Rognan Pdf

1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation of G protein-coupled receptors -- 7. Chemogenomics approaches to ligand design -- 8. Strategies for the design of pGPCR-targeted libraries -- 9. Ligand-based rational design : virtual screening -- 10. 3-D structure of G protein-coupled receptors --11. 7TM models in structure-based drug design -- 12. Receptor-based rational design : virtual screening.

Drug Design

BAREHAM BAREHAM J
Drug Design Book PDF

Author : BAREHAM BAREHAM J
Publisher : Academic Press
Page : 376 pages
File Size : 53,6 Mb
Release : 2014-11-26
Category : Medical
ISBN : 9781483294834

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Drug Design by BAREHAM BAREHAM J Pdf

Drug Design, Volume IX examines various aspects of drug design and covers topics ranging from the consequences of the Hansch paradigm for the pharmaceutical industry to the Masca model of pharmacochemistry. A physicochemical basis for the design of orally active prodrugs is also considered, along with the use of interactive graphics in medicinal chemistry. Comprised of seven chapters, this volume begins with a discussion on efforts to avoid toxicity, not only of drugs, pesticides, and food additives but also of chemicals in general. The reader is then introduced to various aspects of the development of bioactive agents, including the optimization of existing agents by the design of more efficient prodrugs. Other chapters focus on Hansch's paradigm and its application to industrial practice; the application of multivariate statistics to pharmacochemistry; a logico-structural approach to computer-assisted drug design; and spatial arrangements in bioactive molecules. This book will be of interest to pharmacologists, chemists, and those involved in drug design.

Structure-based Design of Drugs and Other Bioactive Molecules

Arun K. Ghosh,Sandra Gemma
Structure based Design of Drugs and Other Bioactive Molecules Book PDF

Author : Arun K. Ghosh,Sandra Gemma
Publisher : John Wiley & Sons
Page : 474 pages
File Size : 48,5 Mb
Release : 2014-08-11
Category : Medical
ISBN : 9783527333653

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Structure-based Design of Drugs and Other Bioactive Molecules by Arun K. Ghosh,Sandra Gemma Pdf

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.

Drug Design

E. J. Ariëns
Drug Design Book PDF

Author : E. J. Ariëns
Publisher : Elsevier
Page : 441 pages
File Size : 55,5 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483216102

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Drug Design by E. J. Ariëns Pdf

Drug Design, Volume VIII covers a critical review and new extensions of quantitative methods in drug design, the design of particular types of agents, such as synthetic sweeteners, and selective ion binding compounds. The book discusses the advances in the methodology of quantitative drug design; the application of pattern recognition to drug design; and the design of controlled drug delivery systems. The text also describes the use of receptor binding as a tool in the development of new bioactive steroids; the design of synthetic sweeteners; and the prospective assessment of environmental effects of chemicals. The design of selective ion binding macrocyclic compounds and their biological applications are also encompassed. Chemists, pharmacologists, biochemists, and people involved in drug design and manufacture will find the book invaluable.