Metals In Medicine

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Metals in Medicine

James C. Dabrowiak
Metals in Medicine Book PDF

Author : James C. Dabrowiak
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 52,7 Mb
Release : 2017-05-02
Category : Science
ISBN : 9781119191346

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Metals in Medicine by James C. Dabrowiak Pdf

Working from basic chemical principles, Metals in Medicine 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer’s, Wilson’s and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Peggy L. Carver
Essential Metals in Medicine Therapeutic Use and Toxicity of Metal Ions in the Clinic Book PDF

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 640 pages
File Size : 46,8 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110526981

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Metallotherapeutic Drugs and Metal-Based Diagnostic Agents

Marcel Gielen,Edward R. T. Tiekink
Metallotherapeutic Drugs and Metal Based Diagnostic Agents Book PDF

Author : Marcel Gielen,Edward R. T. Tiekink
Publisher : John Wiley & Sons
Page : 638 pages
File Size : 49,9 Mb
Release : 2005-09-01
Category : Science
ISBN : 9780470864043

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Metallotherapeutic Drugs and Metal-Based Diagnostic Agents by Marcel Gielen,Edward R. T. Tiekink Pdf

There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.

Metal Chelation in Medicine

Robert R Crichton,Roberta J Ward,Robert C Hider
Metal Chelation in Medicine Book PDF

Author : Robert R Crichton,Roberta J Ward,Robert C Hider
Publisher : Royal Society of Chemistry
Page : 322 pages
File Size : 41,6 Mb
Release : 2016-10-18
Category : Science
ISBN : 9781782623892

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Metal Chelation in Medicine by Robert R Crichton,Roberta J Ward,Robert C Hider Pdf

Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Precious Metals for Biomedical Applications

Niklaus Baltzer,Thierry Copponnex
Precious Metals for Biomedical Applications Book PDF

Author : Niklaus Baltzer,Thierry Copponnex
Publisher : Elsevier
Page : 236 pages
File Size : 45,8 Mb
Release : 2014-05-07
Category : Technology & Engineering
ISBN : 9780857099051

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Precious Metals for Biomedical Applications by Niklaus Baltzer,Thierry Copponnex Pdf

Precious metals and semi-precious metals are used for an increasing number of medical applications due to the properties of these metals and their alloys. Precious Metals for Biomedical Applications reviews the properties of precious metals and their resulting applications in medicine. Part one outlines the fundamentals of precious metals for biomedical applications, discussing their useful properties, such as biocompatibility and corrosion resistance. Part two goes on to provide an overview of the applications of precious metals in biomedicine, including dental, therapeutic, tissue engineering, and bioimaging applications. It discusses the advantages of the structure and properties of precious metals for these applications. Precious Metals for Biomedical Applications is a key reference for material scientists and academics concerned with the properties and uses of these metals. Provides a useful review of this group of materials’ unique properties and applications Examines the fundamentals of precious metals for biomedical applications, before looking at a wide range of applications of precious metals in medicine

Advances in Metallodrugs

Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Advances in Metallodrugs Book PDF

Author : Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 51,7 Mb
Release : 2020-07-08
Category : Science
ISBN : 9781119640424

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Advances in Metallodrugs by Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan Pdf

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Uses of Inorganic Chemistry in Medicine

Nicholas P Farrell
Uses of Inorganic Chemistry in Medicine Book PDF

Author : Nicholas P Farrell
Publisher : Royal Society of Chemistry
Page : 174 pages
File Size : 50,5 Mb
Release : 2007-10-31
Category : Medical
ISBN : 9781847552242

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Uses of Inorganic Chemistry in Medicine by Nicholas P Farrell Pdf

Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine. Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging. The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses. This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.

Medicinal Applications of Coordination Chemistry

Chris J Jones,John R Thornback
Medicinal Applications of Coordination Chemistry Book PDF

Author : Chris J Jones,John R Thornback
Publisher : Royal Society of Chemistry
Page : 366 pages
File Size : 54,5 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847557759

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Medicinal Applications of Coordination Chemistry by Chris J Jones,John R Thornback Pdf

Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.

Biological Inorganic Chemistry

Robert R. Crichton
Biological Inorganic Chemistry Book PDF

Author : Robert R. Crichton
Publisher : Elsevier
Page : 381 pages
File Size : 49,5 Mb
Release : 2007-12-11
Category : Science
ISBN : 0080556221

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Biological Inorganic Chemistry by Robert R. Crichton Pdf

The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment. Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on. Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject. Many colour illustrations. Enables easier visualization of molecular mechanisms Written by a single author. Ensures homgeneity of style and effective cross referencing between chapters

Trace Metals and Infectious Diseases

Jerome O. Nriagu,Eric P. Skaar
Trace Metals and Infectious Diseases Book PDF

Author : Jerome O. Nriagu,Eric P. Skaar
Publisher : MIT Press
Page : 501 pages
File Size : 44,8 Mb
Release : 2024-06-11
Category : Medical
ISBN : 9780262552486

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Trace Metals and Infectious Diseases by Jerome O. Nriagu,Eric P. Skaar Pdf

Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang

High Resolution EPR

Graeme Hanson,Lawrence Berliner
High Resolution EPR Book PDF

Author : Graeme Hanson,Lawrence Berliner
Publisher : Springer Science & Business Media
Page : 666 pages
File Size : 52,5 Mb
Release : 2009-06-19
Category : Medical
ISBN : 9780387848563

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High Resolution EPR by Graeme Hanson,Lawrence Berliner Pdf

Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofactors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of high-resolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.

Biomedical Applications of Metals

Mahendra Rai,Avinash P. Ingle,Serenella Medici
Biomedical Applications of Metals Book PDF

Author : Mahendra Rai,Avinash P. Ingle,Serenella Medici
Publisher : Springer
Page : 325 pages
File Size : 53,7 Mb
Release : 2018-02-24
Category : Medical
ISBN : 9783319748146

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Biomedical Applications of Metals by Mahendra Rai,Avinash P. Ingle,Serenella Medici Pdf

Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.

Handbook on Metals in Clinical and Analytical Chemistry

Hans Seiler,Astrid Sigel,Helmut Sigel
Handbook on Metals in Clinical and Analytical Chemistry Book PDF

Author : Hans Seiler,Astrid Sigel,Helmut Sigel
Publisher : CRC Press
Page : 778 pages
File Size : 45,7 Mb
Release : 1994-01-25
Category : Science
ISBN : 0824790944

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Handbook on Metals in Clinical and Analytical Chemistry by Hans Seiler,Astrid Sigel,Helmut Sigel Pdf

Describes general aspects of metals in clinical chemistry focusing not only on the physiology of metal ions and their analytical determination in biological materials, but also on their geochemical distribution, technical uses and environmental effects.

Metals for Biomedical Devices

Mitsuo Niinomi
Metals for Biomedical Devices Book PDF

Author : Mitsuo Niinomi
Publisher : Elsevier
Page : 432 pages
File Size : 45,5 Mb
Release : 2010-03-31
Category : Technology & Engineering
ISBN : 9781845699246

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Metals for Biomedical Devices by Mitsuo Niinomi Pdf

Despite recent advances in medical devices using other materials, metallic implants are still one of the most commercially significant sectors of the industry. Given the widespread use of metals in medical devices, it is vital that the fundamentals and behaviour of this material are understood. Metals in biomedical devices reviews the latest techniques in metal processing methods and the behaviour of this important material. Initial chapters review the current status and selection of metals for biomedical devices. Chapters in part two discuss the mechanical behaviour, degradation and testing of metals with specific chapters on corrosion, wear testing and biocompatibility of biomaterials. Part three covers the processing of metals for biomedical applications with chapters on such topics as forging metals and alloys, surface treatment, coatings and sterilisation. Chapters in the final section discuss clinical applications of metals such as cardiovascular, orthopaedic and new generation biomaterials. With its distinguished editor and team of expert contributors, Metals for biomedical devices is a standard reference for materials scientists, researchers and engineers working in the medical devices industry and academia. Reviews the latest techniques in metal processing methods including surface treatment and sterilisation Examines metal selection for biomedical devices considering biocompatibility of various metals Assesses mechanical behaviour and testing of metals featuring corrosion, fatigue and wear

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Peggy L. Carver
Essential Metals in Medicine Therapeutic Use and Toxicity of Metal Ions in the Clinic Book PDF

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 455 pages
File Size : 42,9 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110527872

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.