Links Between Recombination And Replication

Author : Proceedings of the National Academy of Sciences
Publisher : National Academies Press
Page : 303 pages
File Size : 52,8 Mb
Release : 2002-09-18
Category : Science
ISBN : 9780309074247

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Links Between Recombination and Replication by Proceedings of the National Academy of Sciences Pdf

There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.

Author : Anonim
Publisher : Unknown
Page : 303 pages
File Size : 40,8 Mb
Release : 2000
Category : Genetic recombination
ISBN : OCLC:895779303

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Colloquium on Links Between Recombination and Replication by Anonim Pdf

Author : Andrés Aguilera,Rodney Rothstein
Publisher : Springer Science & Business Media
Page : 524 pages
File Size : 45,5 Mb
Release : 2007-04-24
Category : Science
ISBN : 9783540710219

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Molecular Genetics of Recombination by Andrés Aguilera,Rodney Rothstein Pdf

This work offers a fascinating insight into a crucial genetic process. Recombination is, quite simply, one of the most important topics in contemporary biology. This book is a totally comprehensive treatment of the subject, summarizing all existing views on the topic and at the same time putting them into context. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 52,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 1048 pages
File Size : 40,6 Mb
Release : 1980
Category : Science
ISBN : UOM:39015000888522

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Mechanistic Studies of DNA Replication and Genetic Recombination by Bruce Alberts Pdf

Mechanistic Studies of DNA Replication and Genetic Recombination emerged from a symposium on DNA replication and genetic recombination held from March 16-21, 1980 in Keystone, Colorado. The event featured 30 plenary session talks, 13 workshop discussion groups, and the 210 poster sessions. The studies described in this book are paving the way for the elucidation of other basic genetic mechanisms, including """"new"""" areas in molecular genetics such as those of eukaryotic gene expression and the transposition of mobile genetic elements. This book is divided into 10 parts: summaries of worksho ...

Author : Fumio Hanaoka,Kaoru Sugasawa
Publisher : Springer
Page : 555 pages
File Size : 55,6 Mb
Release : 2016-01-22
Category : Science
ISBN : 9784431558736

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DNA Replication, Recombination, and Repair by Fumio Hanaoka,Kaoru Sugasawa Pdf

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

Author : Anonim
Publisher : Academic Press
Page : 610 pages
File Size : 52,5 Mb
Release : 2018-02-17
Category : Science
ISBN : 9780128144305

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Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination by Anonim Pdf

Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts. Contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability Documents cutting edge methods

Author : Gajanan V. Sherbet
Publisher : Elsevier
Page : 264 pages
File Size : 53,8 Mb
Release : 2003-07-24
Category : Medical
ISBN : 0080521908

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Genetic Recombination in Cancer by Gajanan V. Sherbet Pdf

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers

Author : Roger J. A. Grand,John J. Reynolds
Publisher : Garland Science
Page : 368 pages
File Size : 50,5 Mb
Release : 2018-09-03
Category : Science
ISBN : 9780429876547

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DNA Repair and Replication by Roger J. A. Grand,John J. Reynolds Pdf

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

Author : Wiesława Widłak
Publisher : Springer
Page : 153 pages
File Size : 40,8 Mb
Release : 2013-12-05
Category : Computers
ISBN : 9783642453618

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Molecular Biology - Not Only for Bioinformaticians by Wiesława Widłak Pdf

Bioinformatics, which can be defined as the application of computer science and information technology to the field of biology and medicine, has been rapidly developing over the past few decades. It generates new knowledge as well as the computational tools to create that knowledge. Understanding the basic processes in living organisms is therefore indispensable for bioinformaticians. This book addresses beginners in molecular biology, especially computer scientists who would like to work as bioinformaticians. It presents basic processes in living organisms in a condensed manner. Additionally, principles of several high-throughput technologies in molecular biology, which need the assistance of bioinformaticians, are explained from a biological point of view. It is structured in the following 9 chapters: cells and viruses; protein structure and function; nucleic acids; DNA replication, mutations, and repair; transcription and posttranscriptional processes; synthesis and posttranslational modifications of proteins; cell division; cell signaling pathways; and high-throughput technologies in molecular biology.

Author : Paul James Smith,Christopher John Jones
Publisher : Oxford University Press, USA
Page : 260 pages
File Size : 45,8 Mb
Release : 1999
Category : Medical
ISBN : WISC:89065112831

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DNA Recombination and Repair by Paul James Smith,Christopher John Jones Pdf

The processes of DNA recombination and repair are vital to cell integrity - an error can lead to disease such as cancer. It is therefore a large and exciting area of research and is also taught on postgraduate and undergraduate courses. This book is not a comprehensive view of the field, but a selection of the issues currently at the forefront of knowledge.

Author : Anonim
Publisher : Ardent Media
Page : 8 pages
File Size : 47,9 Mb
Release : 1953
Category : DNA.
ISBN : 8210379456XXX

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Molecular Structure of Nucleic Acids by Anonim Pdf

Author : Robert Landick,Terence Strick,Jue Wang
Publisher : Royal Society of Chemistry
Page : 295 pages
File Size : 44,8 Mb
Release : 2021-11-23
Category : Science
ISBN : 9781839160660

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RNA Polymerases as Molecular Motors by Robert Landick,Terence Strick,Jue Wang Pdf

To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.

Author : Anonim
Publisher : Academic Press
Page : 454 pages
File Size : 44,9 Mb
Release : 2021-11-12
Category : Science
ISBN : 9780323907347

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The DNA Replication-Repair Interface by Anonim Pdf

Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Includes the latest information on replication-coupled repair

Author : Samantha Fowler,Rebecca Roush,James Wise
Publisher : Unknown
Page : 618 pages
File Size : 47,9 Mb
Release : 2018-01-07
Category : Science
ISBN : 9888407457

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Concepts of Biology by Samantha Fowler,Rebecca Roush,James Wise Pdf

Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.