Rna Polymerases As Molecular Motors

Author : Robert Landick,Terence Strick,Jue Wang
Publisher : Royal Society of Chemistry
Page : 295 pages
File Size : 54,8 Mb
Release : 2021-11-23
Category : Science
ISBN : 9781839160660

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RNA Polymerases as Molecular Motors by Robert Landick,Terence Strick,Jue Wang Pdf

To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.

Author : Henri C. Buc,Terence Strick
Publisher : Royal Society of Chemistry
Page : 353 pages
File Size : 44,5 Mb
Release : 2009-04-16
Category : Science
ISBN : 9780854041343

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RNA Polymerases as Molecular Motors by Henri C. Buc,Terence Strick Pdf

This book, written by expert scientists in the field, analyses how these diverse fields of research interact on a specific example - RNA polymerase. The book concentrates on RNA polymerases because they play a central role among all the other machines operating in the cell and are the target of a wide range of regulatory mechanisms. They have also been the subject of spectacular advances in their structural understanding in recent years, as testified by the attribution of the Nobel prize in chemistry in 2006 to Roger Kornberg. The book focuses on two aspects of the transcription cycle that have been more intensively studied thanks to this increased scientific cooperation - the recognition of the promoter by the enzyme, and the achievement of consecutive translocation steps during elongation of the RNA product. Each of these two topics is introduced by an overview, and is then presented by worldwide experts in the field, taking the viewpoint of their specialty. The overview chapters focus on the mechanism-structure interface and the structure-machine interface while the individual chapters within each section concentrate more specifically on particular processes-kinetic analysis, single-molecule spectroscopy, and termination of transcription, amongst others. Specific attention has been paid to the newcomers in the field, with careful descriptions of new emerging techniques and the constitution of an atlas of three-dimensional pictures of the enzymes involved.

Author : Christopher P. Toseland,Natalia Fili
Publisher : Springer
Page : 298 pages
File Size : 55,9 Mb
Release : 2014-08-05
Category : Science
ISBN : 9783034808569

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Fluorescent Methods for Molecular Motors by Christopher P. Toseland,Natalia Fili Pdf

This book focuses on the application of fluorescence to study motor proteins (myosins, kinesins, DNA helicases and RNA polymerases). It is intended for a large community of biochemists, biophysicists and cell biologists who study a diverse collection of motor proteins. It can be used by researchers to gain an insight into their first experiments, or by experienced researchers who are looking to expand their research to new areas. Each chapter provides valuable advice for executing the experiments, along with detailed background knowledge in order to develop own experiments.

Author : Manfred Schliwa
Publisher : John Wiley & Sons
Page : 604 pages
File Size : 50,6 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605651

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Molecular Motors by Manfred Schliwa Pdf

The latest knowledge on molecular motors is vital for the understanding of a wide range of biological and medical topics: cell motility, organelle movement, virus transport, developmental asymmetry, myopathies, and sensory defects are all related to the function or malfunction of these minute molecular machines. Since there is a vast amount of information on motor mechanisms and potential biomedical and nanobiotechnological applications, this handbook fulfills the need for a collection of current research results on the functionality, regulation, and interactions of cytoskeletal, DNA, and rotary motors. Here, leading experts present a concise insight, ranging from atomic structure, biochemistry, and biophysics to cell biology, developmental biology and pathology. Basic principles and applications make this book a valuable reference tool for researchers, professionals, and clinicians alike - all set to become a "classic" in the years to come.

Author : Christopher P. Toseland,Natalia Fili
Publisher : Unknown
Page : 310 pages
File Size : 52,5 Mb
Release : 2014-08-31
Category : Electronic
ISBN : 3034808577

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Fluorescent Methods for Molecular Motors by Christopher P. Toseland,Natalia Fili Pdf

Author : Christophe Lavelle
Publisher : Humana
Page : 452 pages
File Size : 44,9 Mb
Release : 2019-07-18
Category : Science
ISBN : 1493993240

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Molecular Motors by Christophe Lavelle Pdf

This volume expands on the previous edition with a more extensive look at molecular motors and their roles in muscle contractions, vesicle transport, flagellar beating, chromosome segregation, and DNA replication and repair. The chapters in this book are divided into three parts: Part One looks at membrane motors, such as the bacterial flagellar rotary motor; Part Two discusses cytoskeletal motors, such as kinesin and myosin; and Part Three talks about nucleic acid motors, such as DNA polymerases, helicases, and nucleosome remodelers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Molecular Motors: Methods and Protocols, Second Edition is a valuable resource for (bio)physicists and molecular/cellular biologists whose research delves into the mechanisms at work in cells and the motors which power them.

Author : Anatoly B. Kolomeisky
Publisher : CRC Press
Page : 222 pages
File Size : 45,5 Mb
Release : 2015-05-21
Category : Medical
ISBN : 9781482224764

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Motor Proteins and Molecular Motors by Anatoly B. Kolomeisky Pdf

A Unified Microscopic Approach to Analyzing Complex Processes in Molecular Motors Motor Proteins and Molecular Motors explores the mechanisms of cellular functioning associated with several specific enzymatic molecules called motor proteins. Motor proteins, also known as molecular motors, play important roles in living systems by supporting cellular transport and force generation via the transformation of chemical energy into mechanical work. The book presents established results, theoretical methods, and experimental observations related to biological molecular motors. It uses fundamental physical-chemical concepts and methods to develop a systematic theoretical framework for understanding motor protein dynamics. The author introduces the main ideas using simple arguments that avoid heavy mathematical derivations in favor of more intuitive physical understanding. Although the book assumes some rudimentary knowledge of cell biology, calculus, and basic ideas from chemistry and physics, it gives explanations and derivations for most results. Accessible to students and researchers in a wide range of scientific fields, this book provides a unified molecular picture for analyzing motor proteins. It connects major experimental facts on molecular motors to principal theoretical concepts consistent with the fundamental laws of chemistry and physics.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Didier Chatenay
Publisher : Gulf Professional Publishing
Page : 392 pages
File Size : 51,5 Mb
Release : 2005-12-19
Category : Computers
ISBN : 0444520813

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Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics by Didier Chatenay Pdf

Dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules, this book is divided into three main sections. It is intended to be a reference for advanced graduate students or young researchers to acquire an interdisciplinary understanding of the multiple aspects of DNA and RNA.

Author : Vladilen Letokhov
Publisher : OUP Oxford
Page : 328 pages
File Size : 40,7 Mb
Release : 2007-02-15
Category : Science
ISBN : 9780191523717

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Laser Control of Atoms and Molecules by Vladilen Letokhov Pdf

Rather different problems can be lumped together under the general term 'laser control of atoms and molecules'. They include the laser selection of atomic and molecular velocities for the purpose of Doppler-free spectroscopy, laser control of the position and velocity of atoms (i.e. laser trapping and cooling of atoms), and laser control of atomic and molecular processes (ionization, dissociation) with a view of detecting single atoms and molecules and particularly separating isotopes and nuclear isomers. Over the last decades the principal problems posed have been successfully solved, and many of them have evolved remarkably in the subsequent investigations of the international research community. For example, the solution of the problem of laser cooling and trapping of atoms has given birth to the new field of the physics of ultracold matter, i.e. quantum atomic and molecular gases. The laser non-coherent control of uni-molecular processes has found an interesting extension in the field of laser coherent control of molecules. The concept of laser control of position has been successfully demonstrated with microparticles (optical tweezers), concurrently with investigations into atomic control. The laser photo-ionization of molecules on surfaces has led to the development of novel techniques of laser-assisted mass spectrometry of macromolecules, and so on. The aim of this book is to review these topics from a unified or 'coherent' point of view. It will be useful for many readers in various fields of laser science and its applications.

Author : Michael G. Rossmann,Venigalla B. Rao
Publisher : Springer Science & Business Media
Page : 685 pages
File Size : 48,6 Mb
Release : 2011-12-26
Category : Medical
ISBN : 9781461409793

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Viral Molecular Machines by Michael G. Rossmann,Venigalla B. Rao Pdf

This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion. Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.

Author : Ron Milo,Rob Phillips
Publisher : Garland Science
Page : 400 pages
File Size : 41,9 Mb
Release : 2015-12-07
Category : Science
ISBN : 9781317230694

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Cell Biology by the Numbers by Ron Milo,Rob Phillips Pdf

A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Author : Burton E. Tropp
Publisher : Jones & Bartlett Publishers
Page : 1137 pages
File Size : 45,6 Mb
Release : 2012
Category : Science
ISBN : 9780763786632

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Molecular Biology by Burton E. Tropp Pdf

Newly revised and updated, the Fourth Edition is a comprehensive guide through the basic molecular processes and genetic phenomena of both prokaryotic and eukaryotic cells. Written for the undergraduate and first year graduate students, the text has been updated with the latest data in the field. It incorporates a biochemical approach as well as a discovery approach that provides historical and experimental information within the context of the narrative.

Author : Burton E. Tropp
Publisher : Jones & Bartlett Publishers
Page : 781 pages
File Size : 47,7 Mb
Release : 2012-12-14
Category : Science
ISBN : 9781449647919

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Principles of Molecular Biology by Burton E. Tropp Pdf

Includes access to the Student Companion Website with every print copy of the text.Written for the more concise course, Principles of Molecular Biology is modeled after Burton Tropp's successful Molecular Biology: Genes to Proteins and is appropriate for the sophomore level course. The author begins with an introduction to molecular biology, discussing what it is and how it relates to applications in "real life" with examples pulled from medicine and industry. An overview of protein structure and function follows, and from there the text covers the various roles of technology in elucidating the central concepts of molecular biology, from both a historical and contemporary perspective. Tropp then delves into the heart of the book with chapters focused on chromosomes, genetics, replication, DNA damage and repair, recombination, transposition, transcription, and wraps up with translation.Key Features:- Presents molecular biology from a biochemical perspective, utilizing model systems, as they best describe the processes being discussed-Special Topic boxes throughout focus on applications in medicine and technology-Presents "real world" applications of molecular biology that are necessary for students continuing on to medical school or the biotech industry-An end-of-chapter study guide includes questions for review and discussion-Difficult or complicated concepts are called-out in boxes to further explain and simplify

Author : Albert J. Courey
Publisher : John Wiley & Sons
Page : 248 pages
File Size : 41,8 Mb
Release : 2009-01-22
Category : Science
ISBN : 9781444300451

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Mechanisms in Transcriptional Regulation by Albert J. Courey Pdf

Mechanisms in Transcriptional Regulation provides a concisediscussion of the fundamental concepts in transcription and itsregulation. Covers RNA polymerases, transcriptional machinery, mechanismsof transcriptional activation, the histone code hypothesis, theepigenetic control of transcription, and combinatorial control insignaling and development Features over 80 figures available to download online Chapters include comprehensive reading lists, boxeshighlighting theoretical concepts and experimental methods andproblems designed to build and test understanding