Lipid Oxidation In Health And Disease

Author : Corinne M. Spickett,Henry Jay Forman
Publisher : CRC Press
Page : 440 pages
File Size : 42,9 Mb
Release : 2015-03-03
Category : Medical
ISBN : 9781482202861

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Lipid Oxidation in Health and Disease by Corinne M. Spickett,Henry Jay Forman Pdf

Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Covering the diverse topics that contribute to research in this important field, this book explores: The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

Author : Corinne M. Spickett,Henry Jay Forman
Publisher : CRC Press
Page : 0 pages
File Size : 51,7 Mb
Release : 2015-03-03
Category : Medical
ISBN : 1482202859

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Lipid Oxidation in Health and Disease by Corinne M. Spickett,Henry Jay Forman Pdf

Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Covering the diverse topics that contribute to research in this important field, this book explores: The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

Author : Andres Trostchansky,Homero Rubbo
Publisher : Springer
Page : 198 pages
File Size : 41,5 Mb
Release : 2019-05-28
Category : Medical
ISBN : 9783030114886

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Bioactive Lipids in Health and Disease by Andres Trostchansky,Homero Rubbo Pdf

The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology

Author : Lawrence J. Berliner,Narasimham L. Parinandi
Publisher : Springer Nature
Page : 237 pages
File Size : 45,8 Mb
Release : 2020-08-08
Category : Science
ISBN : 9783030473181

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Measuring Oxidants and Oxidative Stress in Biological Systems by Lawrence J. Berliner,Narasimham L. Parinandi Pdf

This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.

Author : Alex Sevanian
Publisher : The American Oil Chemists Society
Page : 272 pages
File Size : 43,8 Mb
Release : 1988
Category : Science
ISBN : 0935315187

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Lipid Peroxidation in Biological Systems by Alex Sevanian Pdf

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
Publisher : National Academies Press
Page : 765 pages
File Size : 54,8 Mb
Release : 1989-01-01
Category : Medical
ISBN : 9780309039949

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Diet and Health by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health Pdf

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Author : Michael Breitenbach,S. Michal Jazwinski,Peter Laun
Publisher : Springer Science & Business Media
Page : 373 pages
File Size : 50,8 Mb
Release : 2011-11-19
Category : Science
ISBN : 9789400725614

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Aging Research in Yeast by Michael Breitenbach,S. Michal Jazwinski,Peter Laun Pdf

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Author : Angel Catalá
Publisher : Nova Science Publishers
Page : 376 pages
File Size : 49,6 Mb
Release : 2017
Category : Science
ISBN : 1536105309

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Lipid Peroxidation by Angel Catalá Pdf

This book presents an overview of lipid peroxidation: inhibition, effects and mechanisms. The topics analyzed, cover a broad spectrum of functions played by lipid peroxidation and presents new information in this area of research. The topics analyzed include: progress in the knowledge of lipid peroxidation, from the first evidences issued by Nicolas Theodore de Saussure in Paris 1804; fighting against lipid peroxidation: the unique story of docosahexaenoic acid in the brain; protective effects of melatonin and structurally-related molecules in reducing membrane rigidity due to lipid peroxidation; synergistic effects of antioxidant compositions during inhibited lipid autoxidation; lipid peroxidation and animal longevity; free radicals in health and disease; lipid peroxidation in autoimmune diseases; aldehydes derived from lipid peroxidation in cancer and autoimmunity; the role of reactive oxygen species and lipid peroxidation in the neurodegenerative process after spinal cord injury; kinetics and mechanisms of inhibited lipid autoxidation in presence of 4-substituted-coumarins; hypoxia and oxidative stress: cell signaling mechanisms and protective role of vitamin C and cilnidipine; characterization of oxidative stress and antioxidant potency; paying attention to time and location; lipid peroxidation in aquatic organisms: ontogenetic, phylogenetic and ecological aspects; chemistry of lipid oxidation in edible oils; and menopause progression and oxidative stress: associated mechanisms and the importance of physical exercise.

Author : Pınar Atukeren
Publisher : BoD – Books on Demand
Page : 160 pages
File Size : 46,7 Mb
Release : 2021-12-08
Category : Science
ISBN : 9781839688256

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Accenting Lipid Peroxidation by Pınar Atukeren Pdf

Lipid peroxidation can occur via either enzymatic or nonenzymatic reactions due to excess production of free radical molecules. This process culminates in cellular damage causing various diseases. This book examines lipid peroxidation as a current and future biomarker of oxidative stress.

Author : Edwin N. Frankel
Publisher : Elsevier
Page : 488 pages
File Size : 55,7 Mb
Release : 2014-01-23
Category : Science
ISBN : 9780857097927

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Lipid Oxidation by Edwin N. Frankel Pdf

In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 49,6 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781838801250

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Glutathione System and Oxidative Stress in Health and Disease by Anonim Pdf

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

Author : Allen J. St. Angelo
Publisher : Unknown
Page : 386 pages
File Size : 49,7 Mb
Release : 1992
Category : TECHNOLOGY & ENGINEERING
ISBN : UOM:39015028427881

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Lipid Oxidation in Food by Allen J. St. Angelo Pdf

Developed from a symposium at the 202nd National Meeting of the ACS, New York City, August 1991, this volume contains 20 papers in the areas of mechanisms of free-radical processes, prevention of lipid oxidation, methodologies for assessing lipid oxidation products, and processing effects on lipid oxidation. Commodities covered include beef, pork, fresh and saltwater fish, peanuts, vegetable oils, and baby foods. Annotation copyright by Book News, Inc., Portland, OR

Author : Augustine S. H. Ong,Etsuo Niki,Lester Packer
Publisher : The American Oil Chemists Society
Page : 396 pages
File Size : 41,9 Mb
Release : 1995
Category : Antioxidants
ISBN : 0935315640

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Nutrition, Lipids, Health, and Disease by Augustine S. H. Ong,Etsuo Niki,Lester Packer Pdf

Antioxidant activities of phenolic compounds in solutions membranes, and lipoprotein. Nutrition and biochemistry of the lipophilic antioxidants vitamin E and Carotenoids. Biokinetics of human plasma vitamin E concentrations. Free-radical regulatory and immunomodulatory effects of bio-normalizer. Effect of dietary factors on the metabolism of essential fatty acids-focusing on the components of spices. Studies on green tea polyphenols antiocidadtive and protctive effects on biomembranes. Phenolic antioxidant components of evening primrose. Tocotrienols and cholesterol metabolism. Tocotrienols-A dose-dependent inhibitor for HMG CoA reductase. The cholesterol-and tumor suppressive actions of palm oil isoprenoids. Anti-cancer properties of tocotrienols from palm oil. the ubiquinones of palm oil. Effects of soybean oil supplement im palm oil dieta on weight gain and tissue lipids of rats. Effects of pal oil as a dietary supplement on Eel culture.Role of n-3 fatty acids in cultured cardiomyocyte. Enhancement of PG12 formation by eicosapentaenoic acid in rat vascular smooth muscle cells. Inhibition of DNA-biosynthesis by B-Carotene in the P-388 lymphocytic leukemia cell. the relation between serum lipids and lipoprotein levels. Uses of lipophore system for lipoprotein electrophresis of human lipemic plasma. Effect of low-fat and low-protein diets on cholesterol metabolism in the aortas, livers, and small intestine of male albino rats. Effects of a decrease in linoleic acid intake on indices of cardiovascular risk and lipid perocidation. Conjugated diene fatty acids in human and animal tissues. Deficiency of n-3 polyunsaturated fatty acids in the retina brains, and liver of chow-fed ghinea pigs. Fat-modified eggs. Palm oil comsumption effects on urinary excretions of phytoestrogens and estrogenic steroids. Calories, fat and cancer. Antioxidants in the prevention of oral cancer. Role of antioxidants in healing gastric ulcers. role of different types of dietary fat in experimetal alcoholic liver disease. use of natural antioxidants as a prophylactic for neurological disordes. Dietary implications for parasitc and viral infectious disease. Vitamin C metabolism in malaria. Nutrition in populations.

Author : Carlos Bravo-Diaz
Publisher : Springer Nature
Page : 477 pages
File Size : 45,9 Mb
Release : 2022-02-06
Category : Technology & Engineering
ISBN : 9783030872229

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Lipid Oxidation in Food and Biological Systems by Carlos Bravo-Diaz Pdf

This book offers a new physical chemistry perspective on the control of lipid oxidation reactions by antioxidants, and it further explores the application of several oxidation inhibition strategies on food and biological systems. Divided in 3 parts, the book reviews the latest methods to control lipid oxidation, it examines lipid oxidation and inhibition in different food systems, and it finishes with an overview of the biological, health and nutritional effects of lipid oxidation. Chapters from expert contributors cover topics such as the use of magnetic methods to monitor lipid and protein oxidation, the kinetics and mechanisms of lipid oxidation and antioxidant inhibition reactions, interfacial chemistry, oxidative stress and its impact in human health, nutritional, sensory and physiological aspects of lipid oxidation, and new applications of plant and marine antioxidants. While focused on lipid peroxidation in food and biological systems, the chemistry elucidated in this book is applicable also to toxicology, medicine, plant physiology and pathology, and cosmetic industry. The book will therefore appeal to researchers in the lipid oxidation field covering food, biological and medical areas.

Author : Glen D. Lawrence
Publisher : Rutgers University Press
Page : 297 pages
File Size : 44,6 Mb
Release : 2013-02-26
Category : Medical
ISBN : 9780813554235

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The Fats of Life by Glen D. Lawrence Pdf

Omega-3s, trans-fats, polyunsaturated fatty acids, linoleic acidùresearch facts about fatty acids and their relationship to heart disease and atherosclerosis, obesity, cancer, and neurological disorders abound. Chemical names appear on every nutrition label. But, just what do these terms mean in health and disease? The Fats of Life delineates the importance of essential fatty acids, with a focus on distinctions between omega-3 and omega-6 fatty acid variants. The chemical and biochemical characteristics of these fatty acids and their metabolism to a vast array of potent bioactive messengers are described in the context of their potential effects on general health and impact on various diseases and neurological disorders. Glen D. Lawrence addresses in detail the capacity for polyunsaturated fatty acids to influence asthma, atherosclerosis, heart disease, inflammation, cancer, and immunity. Lawrence makes clear that our understanding of the biochemical and physiological effects of dietary fats has advanced tremendously as a result of careful research, but he also stresses that this knowledge has not easily translated into sound dietary recommendations.