Low Level Radiation And Immune System Damage

Author : Joseph J. Mangano
Publisher : CRC Press
Page : 239 pages
File Size : 52,8 Mb
Release : 2018-01-31
Category : Science
ISBN : 9781351091107

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Low-Level Radiation and Immune System Damage by Joseph J. Mangano Pdf

Atomic weapons and nuclear power plants: they promised to ensure world peace and provide efficient energy to Americans during the 1940s and 1950s. Meanwhile, the post war prosperity led to the most dramatic population explosion ever witnessed in the United States: the "baby boomer" generation.Times and politics may change, but many baby boomers-as well as their descendants-now live with an unforeseen result of the nuclear age. Rates of immune-related diseases have risen steadily throughout the past few decades, from allergies to cancer. While advances in medical care have kept death rates relatively low, the increased prevalence of certain diseases cannot be ignored.Low Level Radiation and Immune System Damage: An Atomic Era Legacy establishes an undeniable connection between the nuclear build up of the past and the widespread health problems seen today. While baby boomers were growing up in the 40s and 50s, above-ground atomic bomb tests and start ups of civilian nuclear power plants were carried out without fear of public exposure to radioactive emissions.Although the consequences of low-level radiation are still hotly debated, Mangano's research findings emphasize a direct link between nuclear exposure and immune system deficiency. In addition to substantial data on immune disease trends among Americans born between the mid-1940s and mid-1960s, Mangano also examines similar issues concerning baby boomer children and grandchildren. Health professionals, environmentalists, historians and students alike will find much to learn from these pages.As America and the world come to terms with the post-Cold War era, there are still many lessons to recognize, consider, and learn from the still-recent past. Low Level Radiation and Immune System Damage: An Atomic Era Legacy explores a relentless trend that will not soon be over-with potential repercussions into the 21st century.

Author : Katalin Lumniczky,Serge M. Candéias,Udo S. Gaipl,Benjamin Frey
Publisher : Frontiers Media SA
Page : 283 pages
File Size : 45,9 Mb
Release : 2018-05-03
Category : Electronic
ISBN : 9782889454747

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Radiation and the Immune System: Current Knowledge and Future Perspectives by Katalin Lumniczky,Serge M. Candéias,Udo S. Gaipl,Benjamin Frey Pdf

For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in the tumor microenvironment, and at systemic level. These observations paved the way for studies exploring optimal combinations of radiotherapy and immunotherapy in order to achieve a synergistic effect to eradicate tumors. However, not all interactions between radiation and the immune system are beneficial, as it was recognized that many of radiation-induced late side effects are also of immune and inflammatory nature. Currently perhaps the most studied field of research in radiation biology is focused around the biological effects of low doses, where many of the observed pathophysiological endpoints are due to mechanisms other than direct radiation-induced cell killing and are immune-related. Finally, it must not be forgotten that the interactions between the ionizing radiations and the immune system are bi-directional, and activation of the immune system also influences the outcome of radiation exposure. This Research Topic brings together 23 articles and aims to give an overview of the complex and very often contradictory nature of the interactions between ionizing radiation and the immune system. Due to its increasing penetrance in the population both through medical diagnostic or environmental sources or during cosmic travel low dose ionizing radiation exposure is becoming a major epidemiological concern world-wide. Several of the articles within the Research Topic specifically address potential long-term health consequences and the underlying mechanisms of low dose radiation exposure. A major intention of the Editors was also to draw the attention of the non-radiobiological scientific community on the fact that ionizing radiation is by far more than purely an immune suppressing agent.

Author : Joseph J. Mangano
Publisher : CRC Press
Page : 239 pages
File Size : 40,6 Mb
Release : 2018-01-31
Category : Science
ISBN : 9781351082655

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Low-Level Radiation and Immune System Damage by Joseph J. Mangano Pdf

Atomic weapons and nuclear power plants: they promised to ensure world peace and provide efficient energy to Americans during the 1940s and 1950s. Meanwhile, the post war prosperity led to the most dramatic population explosion ever witnessed in the United States: the "baby boomer" generation.Times and politics may change, but many baby boomers-as well as their descendants-now live with an unforeseen result of the nuclear age. Rates of immune-related diseases have risen steadily throughout the past few decades, from allergies to cancer. While advances in medical care have kept death rates relatively low, the increased prevalence of certain diseases cannot be ignored.Low Level Radiation and Immune System Damage: An Atomic Era Legacy establishes an undeniable connection between the nuclear build up of the past and the widespread health problems seen today. While baby boomers were growing up in the 40s and 50s, above-ground atomic bomb tests and start ups of civilian nuclear power plants were carried out without fear of public exposure to radioactive emissions.Although the consequences of low-level radiation are still hotly debated, Mangano's research findings emphasize a direct link between nuclear exposure and immune system deficiency. In addition to substantial data on immune disease trends among Americans born between the mid-1940s and mid-1960s, Mangano also examines similar issues concerning baby boomer children and grandchildren. Health professionals, environmentalists, historians and students alike will find much to learn from these pages.As America and the world come to terms with the post-Cold War era, there are still many lessons to recognize, consider, and learn from the still-recent past. Low Level Radiation and Immune System Damage: An Atomic Era Legacy explores a relentless trend that will not soon be over-with potential repercussions into the 21st century.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V)
Publisher : National Academies
Page : 436 pages
File Size : 41,7 Mb
Release : 1990-02-01
Category : Science
ISBN : 9780309039956

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Health Effects of Exposure to Low Levels of Ionizing Radiation by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Pdf

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council
Publisher : National Academies Press
Page : 422 pages
File Size : 43,6 Mb
Release : 2006-03-23
Category : Science
ISBN : 9780309133340

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Health Risks from Exposure to Low Levels of Ionizing Radiation by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council Pdf

This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Author : Sōhei Kondō
Publisher : Unknown
Page : 0 pages
File Size : 47,6 Mb
Release : 1993
Category : Ionizing radiation
ISBN : 4906434010

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Health Effects of Low-level Radiation by Sōhei Kondō Pdf

Author : National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I
Publisher : National Academies Press
Page : 424 pages
File Size : 48,5 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780309255714

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Analysis of Cancer Risks in Populations Near Nuclear Facilities by National Research Council,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilitiesâ¬"Phase I Pdf

In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

Author : Denis Tack,Mannudeep K. Kalra,Pierre Alain Gevenois
Publisher : Springer Science & Business Media
Page : 642 pages
File Size : 41,7 Mb
Release : 2012-06-05
Category : Medical
ISBN : 9783642245350

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Radiation Dose from Multidetector CT by Denis Tack,Mannudeep K. Kalra,Pierre Alain Gevenois Pdf

Computed tomography (CT) is a powerful technique providing precise and confident diagnoses. The burgeoning use of CT has resulted in an exponential increase in collective radiation dose to the population. Despite investigations supporting the use of lower radiation doses, surveys highlight the lack of proper understanding of CT parameters that affect radiation dose. Dynamic advances in CT technology also make it important to explain the latest dose-saving strategies in an easy-to-comprehend manner. This book aims to review all aspects of the radiation dose from CT and to provide simple rules and tricks for radiologists and radiographers that will assist in the appropriate use of CT technique. The second edition includes a number of new chapters on the most up-to-date strategies and technologies for radiation dose reduction while updating the outstanding contents of the first edition. Vendor perspectives are included, and an online image gallery will also be available to readers.

Author : Institute of Medicine
Publisher : National Academies Press
Page : 78 pages
File Size : 40,5 Mb
Release : 1997-10-28
Category : Science
ISBN : 9780309058957

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An Evaluation of Radiation Exposure Guidance for Military Operations by Institute of Medicine Pdf

Author : Alexander Choukèr
Publisher : Springer Nature
Page : 756 pages
File Size : 55,9 Mb
Release : 2019-11-27
Category : Medical
ISBN : 9783030169961

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Stress Challenges and Immunity in Space by Alexander Choukèr Pdf

This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Harry Henderson
Publisher : Bloomsbury Publishing USA
Page : 248 pages
File Size : 43,7 Mb
Release : 2014-05-12
Category : Science
ISBN : 9798216124054

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Nuclear Power by Harry Henderson Pdf

Provides timely and up-to-date facts, context, perspectives, and tools to make informed decisions about nuclear energy. In the 21st century, nuclear power has been identified as a viable alternative to traditional energy sources to stem global climate change, and condemned as risky to human health and environmentally irresponsible. Do the advantages of nuclear energy outweigh the risks, especially in light of the meltdown at the Fukushima plant in 2011? This guide provides both a comprehensive overview of this critical and controversial technology, presenting reference tools that include important facts and statistics, biographical profiles, a chronology, and a glossary. It covers major controversies and proposed solutions in detail and contains contributions by experts and important stakeholders that provide invaluable perspective on the topic.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Nuclear and Radiation Studies Board
Publisher : National Academies Press
Page : 143 pages
File Size : 40,7 Mb
Release : 2020-01-13
Category : Medical
ISBN : 9780309497718

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The Future of Low Dose Radiation Research in the United States by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Nuclear and Radiation Studies Board Pdf

Exposures at low doses of radiation, generally taken to mean doses below 100 millisieverts, are of primary interest for setting standards for protecting individuals against the adverse effects of ionizing radiation. However, there are considerable uncertainties associated with current best estimates of risks and gaps in knowledge on critical scientific issues that relate to low dose radiation. The Nuclear and Radiation Studies Board of the National Academies hosted the symposium on The Future of Low Dose Radiation Research in the United States on May 8 and 9, 2019. The goal of the symposium was to provide an open forum for a national discussion on the need for a long-term strategy to guide a low dose radiation research program in the United States. The symposium featured presentations on low dose radiation programs around the world, panel discussions with representatives from governmental and nongovernmental organizations about the need for a low dose radiation research program, reviews of low dose radiation research in epidemiology and radiation biology including new directions, and lessons to be learned from setting up large research programs in non-radiation research fields. This publication summarizes the presentation and discussion of the symposium.

Author : D. Tack,Pierre Alain Gevenois
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 45,8 Mb
Release : 2007-12-31
Category : Medical
ISBN : 9783540685753

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Radiation Dose from Adult and Pediatric Multidetector Computed Tomography by D. Tack,Pierre Alain Gevenois Pdf

This book considers in depth all the factors that influence the radiation dose and the risk associated with MDCT in children and adults. Only a small proportion of referring clinicians, radiologists, and technologists are aware of both the radiation risks and their underlying mechanisms. The book proposes detailed guidelines for optimization of the radiation dose when using MDCT. It is written by experts of international standing.

Author : Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 43,5 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642256042

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Stereotactic Body Radiation Therapy by Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter Pdf

Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Author : M. A. Hayat
Publisher : Academic Press
Page : 655 pages
File Size : 48,8 Mb
Release : 2007-10-25
Category : Medical
ISBN : 9780080553658

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Cancer Imaging by M. A. Hayat Pdf

With cancer-related deaths projected to rise to 10.3 million people by 2020, the need to prevent, diagnose, and cure cancer is greater than ever. Cancer Imaging presents readers with the most up-to-date imaging instrumentation, general and diagnostic applications for various cancers, with an emphasis on lung and breast carcinomas--the two major worldwide malignancy types. This book discusses the various imaging techniques used to locate and diagnose tumors, including ultrasound, X-ray, color Doppler sonography, PET, CT, PET/CT, MRI, SPECT, diffusion tensor imaging, dynamic infrared imaging, and magnetic resonance spectroscopy. It also details strategies for imaging cancer, emphasizing the importance of the use of this technology for clinical diagnosis. Imaging techniques that predict the malignant potential of cancers, response to chemotherapy and other treatments, recurrence, and prognosis are also detailed. Concentrates on the application of imaging technology to the diagnosis and prognosis of lung and breast carcinomas, the two major worldwide malignancies Addresses the relationship between radiation dose and image quality Discusses the role of molecular imaging in identifying changes for the emergence and progression of cancer at the cellular and/or molecular levels