Lung Cancer And Personalized Medicine Novel Therapies And Clinical Management

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Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management

Aamir Ahmad,Shirish M. Gadgeel
Lung Cancer and Personalized Medicine Novel Therapies and Clinical Management Book PDF

Author : Aamir Ahmad,Shirish M. Gadgeel
Publisher : Springer
Page : 231 pages
File Size : 46,9 Mb
Release : 2015-12-24
Category : Medical
ISBN : 9783319249322

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Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management by Aamir Ahmad,Shirish M. Gadgeel Pdf

This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality.

Lung Cancer and Personalized Medicine

Anonim
Lung Cancer and Personalized Medicine Book PDF

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 51,9 Mb
Release : 2016
Category : Lungs
ISBN : 3319249339

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Lung Cancer and Personalized Medicine by Anonim Pdf

This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality.

Lung Cancer and Personalized Medicine

Aamir Ahmad,Shirish Gadgeel
Lung Cancer and Personalized Medicine Book PDF

Author : Aamir Ahmad,Shirish Gadgeel
Publisher : Springer
Page : 228 pages
File Size : 55,9 Mb
Release : 2015-12-14
Category : Medical
ISBN : 9783319242231

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Lung Cancer and Personalized Medicine by Aamir Ahmad,Shirish Gadgeel Pdf

This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.

Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners

Marianne Davies,Beth Eaby-Sandy
Targeted Therapies in Lung Cancer Management Strategies for Nurses and Practitioners Book PDF

Author : Marianne Davies,Beth Eaby-Sandy
Publisher : Springer
Page : 120 pages
File Size : 49,9 Mb
Release : 2019-07-16
Category : Medical
ISBN : 9783030165505

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Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners by Marianne Davies,Beth Eaby-Sandy Pdf

This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Lung Cancer

Henry S. Park
Lung Cancer Book PDF

Author : Henry S. Park
Publisher : BoD – Books on Demand
Page : 226 pages
File Size : 41,7 Mb
Release : 2021-06-02
Category : Medical
ISBN : 9781789855753

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Lung Cancer by Henry S. Park Pdf

Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts.

Advancing Healthcare Through Personalized Medicine

Priya Hays
Advancing Healthcare Through Personalized Medicine Book PDF

Author : Priya Hays
Publisher : Springer Nature
Page : 755 pages
File Size : 45,8 Mb
Release : 2021-09-27
Category : Medical
ISBN : 9783030801007

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Advancing Healthcare Through Personalized Medicine by Priya Hays Pdf

This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients.

Lung Cancer E-Book

Erin Alexis Gillaspie,Leora Horn,Amanda S. Cass
Lung Cancer E Book Book PDF

Author : Erin Alexis Gillaspie,Leora Horn,Amanda S. Cass
Publisher : Elsevier Health Sciences
Page : 355 pages
File Size : 44,5 Mb
Release : 2023-08-24
Category : Medical
ISBN : 9780323695749

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Lung Cancer E-Book by Erin Alexis Gillaspie,Leora Horn,Amanda S. Cass Pdf

Care of the lung cancer patient—screening, diagnosis, and treatment—has undergone recent dramatic changes due to technologic and research-driven advances. Lung Cancer: An Evidence-Based Approach to Multidisciplinary Management covers every aspect of this fast-changing field, including new screening guidelines, new practice standards, and new treatment advances that have led to higher survival rates. This practical, clinically oriented resource provides thorough, evidence-based coverage from experts in the field, including the increasingly important precision medicine approach in lung cancer planning and management. Discusses key topics such as small cell and non-small cell lung cancers; immunotherapy, molecular cohorts including ROS1, BRAF, HER2, Met, and NTRK; oligometastatic disease; and more. Covers individualized treatment plans for chemotherapy, radiotherapy, targeted biomarker-derived therapies, and new and emerging immunotherapies. Provides excellent visual guidance throughout, including algorithms, pathology specimens, anatomic drawings, and PET/CT and CT imaging for diagnosis and treatment planning. Features “Top 5 Clinical Pearls at the beginning of each chapter. Shares the experience and knowledge of medical oncologists, radiation oncologists, surgical oncologists, and thoracic radiologists for a real-world tumor board perspective.

Lung Cancer: A Practical Approach to Evidence-Based Clinical Evaluation and Management

Lynn T. Tanoue,Frank C Detterbeck
Lung Cancer A Practical Approach to Evidence Based Clinical Evaluation and Management Book PDF

Author : Lynn T. Tanoue,Frank C Detterbeck
Publisher : Elsevier Health Sciences
Page : 350 pages
File Size : 45,9 Mb
Release : 2018-05-30
Category : Medical
ISBN : 9780323496063

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Lung Cancer: A Practical Approach to Evidence-Based Clinical Evaluation and Management by Lynn T. Tanoue,Frank C Detterbeck Pdf

Get a quick, expert overview of the many key facets of lung cancer evaluation and management with this concise, practical resource by Drs. Lynn T. Tanoue and Frank Detterbeck. This easy-to-read reference presents a summary of today’s best evidence-based approaches to diagnosis and management in this critical area. Covers diagnosis and evaluation, treatment considerations, and comprehensive care options for patients with lung cancer. Provides insight on evidence for today’s best practices, as well as future directions in the field. Consolidates today’s evidence-based information on the clinical aspects of lung cancer into one convenient resource.

Lung Cancer Metastasis

Venkateshwar Keshamouni,Douglas Arenberg,Gregory Kalemkerian
Lung Cancer Metastasis Book PDF

Author : Venkateshwar Keshamouni,Douglas Arenberg,Gregory Kalemkerian
Publisher : Springer Science & Business Media
Page : 409 pages
File Size : 43,9 Mb
Release : 2009-09-18
Category : Medical
ISBN : 9781441907721

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Lung Cancer Metastasis by Venkateshwar Keshamouni,Douglas Arenberg,Gregory Kalemkerian Pdf

Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

Lung Cancer Unveiled: From Research to Personalized Care

Dr. Spineanu Eugenia
Lung Cancer Unveiled From Research to Personalized Care Book PDF

Author : Dr. Spineanu Eugenia
Publisher : Dr. Spineanu Eugenia
Page : 227 pages
File Size : 51,9 Mb
Release : 2024-03-03
Category : Medical
ISBN : 8210379456XXX

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Lung Cancer Unveiled: From Research to Personalized Care by Dr. Spineanu Eugenia Pdf

Unlock the secrets of lung cancer in "Lung Cancer Unveiled: From Research to Personalized Care." Delve into the world of cutting-edge research, revolutionary treatments, and the global efforts that are reshaping the landscape of lung cancer care. In this comprehensive treatise, you'll embark on a journey through the intricate web of lung cancer, exploring its multifaceted nature and the global collaborations that are driving progress. Discover how epidemiology and risk factors play a pivotal role in shaping the incidence of lung cancer and how early detection technologies are transforming the odds for patients. With a focus on personalized treatment approaches, this treatise unveils the power of precision medicine in lung cancer care. Explore genetic profiling, molecular biomarkers, and immunotherapy innovations that are redefining how we combat this deadly disease. Learn how personalized treatment strategies are offering patients not just hope, but real outcomes that extend survival and enhance quality of life. But "Lung Cancer Unveiled" goes beyond the science. It delves into the global efforts, advocacy, and healthcare policies that are shaping the future of lung cancer care. Gain insights into the collaborative initiatives, research advancements, and challenges that researchers, clinicians, and organizations worldwide are tackling head-on. If you seek knowledge, hope, and actionable insights into lung cancer, this treatise is your comprehensive guide. With its SEO-optimized content, it's designed not just to inform but also to reach those who need it most. Join us on this journey through the world of lung cancer research, and discover how we're unveiling a brighter future for patients and their families.

Handbook of Lung Cancer and Other Thoracic Malignancies

Gregory P. Kalemkerian, MD,Jessica S. Donington, MD,Elizabeth M. Gore, MD,Suresh S. Ramalingam, MD
Handbook of Lung Cancer and Other Thoracic Malignancies Book PDF

Author : Gregory P. Kalemkerian, MD,Jessica S. Donington, MD,Elizabeth M. Gore, MD,Suresh S. Ramalingam, MD
Publisher : Springer Publishing Company
Page : 416 pages
File Size : 52,9 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9781617052729

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Handbook of Lung Cancer and Other Thoracic Malignancies by Gregory P. Kalemkerian, MD,Jessica S. Donington, MD,Elizabeth M. Gore, MD,Suresh S. Ramalingam, MD Pdf

In many ways, the field of lung cancer research is leading the way in personalized oncologic care, with numerous new treatment strategies moving from clinical trials to standard clinical practice within the past 10 years; and, there are no indications of bench-to-bedside innovations slowing down. Handbook of Thoracic Oncology is a practical guide to the multidisciplinary management of patients with lung cancer and other thoracic malignancies. The content highlights the applications of both conventional and novel treatment strategies to the care of real-life patients with lung cancer. Unlike many oncology textbooks that exhaustively list studies of historical or failed approaches, this handbook focuses on the application of practical, current management options to specific patient subsets and the data that specifically support these strategies. The format is open and readable with bulleted points presenting overall treatment guidelines as well as more nuanced applications of these treatments to individual patient groups. The clear focus of this book is on the question that all oncologists ask themselves every day, “How do I take care of this person sitting in front of me?” This handbook is an indispensable guide for all oncologists and practitioners who regularly care for lung cancer patients and those suffering from mesothelioma, thymic tumors, and pulmonary neuro-endocrine tumors. Features: Delivers the need-to-know points of lung cancer screening, diagnosis and staging, and appropriate multidisciplinary management for all major thoracic malignancies Provides clinical pearls and treatment recommendations for patients who don’t ‘fit’ the standard guidelines Includes specific coverage on Management of Elderly and High-Risk Patients Prepares physicians to notice and eliminate common errors in clinical practice when managing patients with lung cancer and other thoracic tumors

Lung Cancer:

David J. Stewart
Lung Cancer Book PDF

Author : David J. Stewart
Publisher : Springer Science & Business Media
Page : 544 pages
File Size : 48,9 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9781607615248

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Lung Cancer: by David J. Stewart Pdf

Defining the Lung Cancer Problem 1 Lung cancer is the leading cause of cancer death in the world. It kills almost as many Americans as cancers of the breast, prostate, colon, rectum, pancreas, and 2 kidney combined, and accounts for 28.6% of all US cancer deaths. With an increase in the 5-year relative survival rate from 13% to only 16% in the more than 2 30 years from 1974 to the present, it will take us another 840 years to eradicate lung cancer deaths if we do not improve the current rate of progress. As discussed in this text, lung cancer prevention has received substantial att- tion. The decrease in smoking in recent decades has helped, but smoking is not the only problem. Lung cancer in people who have never smoked is currently the 5th 3 leading cause of cancer death in the United States. Several factors contribute to the lethality of lung cancer, including the rapidity of tumor growth, advanced stage at diagnosis (due to nonspecificity of early sy- toms and the uncertain efficacy of screening), early development of metastases, and resistance to therapy. Several chapters in this book discuss new molecular targets that may be potentially exploitable in the future, as well as discussing our track record to date in exploiting them.

Targeted Therapies for Lung Cancer

Ravi Salgia
Targeted Therapies for Lung Cancer Book PDF

Author : Ravi Salgia
Publisher : Springer
Page : 238 pages
File Size : 43,7 Mb
Release : 2019-06-26
Category : Medical
ISBN : 9783030178321

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Targeted Therapies for Lung Cancer by Ravi Salgia Pdf

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Lung Cancer

Jack A. Roth,James D. Cox,Waun Ki Hong
Lung Cancer Book PDF

Author : Jack A. Roth,James D. Cox,Waun Ki Hong
Publisher : John Wiley & Sons
Page : 680 pages
File Size : 45,8 Mb
Release : 2011-08-26
Category : Medical
ISBN : 9781444358667

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Lung Cancer by Jack A. Roth,James D. Cox,Waun Ki Hong Pdf

Lung cancer is a major cause of cancer-related deaths in men and women. However, since the first edition of Lung Cancer was published 14 years ago, rapid progress in the biology, prevention, diagnosis, and treatment of the disease has been made.

Lung Cancer

Karen L. Reckamp
Lung Cancer Book PDF

Author : Karen L. Reckamp
Publisher : Springer
Page : 322 pages
File Size : 44,8 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9783319403892

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Lung Cancer by Karen L. Reckamp Pdf

This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.