Lynch Syndrome

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Lynch Syndrome

Naohiro Tomita
Lynch Syndrome Book PDF

Author : Naohiro Tomita
Publisher : Springer Nature
Page : 143 pages
File Size : 50,7 Mb
Release : 2020-08-24
Category : Medical
ISBN : 9789811568916

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Lynch Syndrome by Naohiro Tomita Pdf

This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition. Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease’s manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome. Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.

DNA Alterations in Lynch Syndrome

Matjaž Vogelsang
DNA Alterations in Lynch Syndrome Book PDF

Author : Matjaž Vogelsang
Publisher : Springer
Page : 0 pages
File Size : 40,7 Mb
Release : 2013-05-25
Category : Medical
ISBN : 9400765967

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DNA Alterations in Lynch Syndrome by Matjaž Vogelsang Pdf

Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.

Daughter of Family G

Ami McKay
Daughter of Family G Book PDF

Author : Ami McKay
Publisher : Knopf Canada
Page : 322 pages
File Size : 51,5 Mb
Release : 2019-09-24
Category : Biography & Autobiography
ISBN : 9780345809469

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Daughter of Family G by Ami McKay Pdf

Weaving together family history, genetic discovery, and scenes from her life, Ami McKay tells the compelling, true-science story of her own family's unsettling legacy of hereditary cancer while exploring the challenges that come from carrying the mutation that not only killed many people you loved, but might also kill you. The story of Ami McKay's connection to a genetic disorder called Lynch syndrome begins over seventy years before she was born and long before scientists discovered DNA. In 1895 her great-great aunt, Pauline Gross, a seamstress in Ann Arbor, Michigan, confided to a pathology professor at the local university that she expected to die young, like so many others in her family. Rather than dismiss her fears, the pathologist chose to enlist Pauline in the careful tracking of those in her family tree who had died of cancer. Pauline's premonition proved true--she died at 46--but because of her efforts, her family (who the pathologist dubbed 'Family G') would become the longest and most detailed cancer genealogy ever studied in the world. A century after Pauline's confession, researchers would identify the genetic mutation responsible for the family's woes. Now known as Lynch syndrome, the genetic condition predisposes its carriers to several types of cancer, including colorectal, endometrial, ovarian and pancreatic. In 2001, as a young mother with two sons and a keen interest in survival, Ami McKay was among the first to be tested for Lynch syndrome. She had a feeling she'd test positive: her mother's side of the family was riddled with early deaths and her own mother was being treated for the disease. When the test proved her fears true, she began living in "an unsettling state between wellness and cancer," and she's been there ever since. Intimate, candid, and probing, her genetic memoir tells a fascinating story, teasing out the many ways to live with the hand you are dealt.

A Guide to Genetic Counseling

Wendy R. Uhlmann,Jane L. Schuette,Beverly Yashar
A Guide to Genetic Counseling Book PDF

Author : Wendy R. Uhlmann,Jane L. Schuette,Beverly Yashar
Publisher : John Wiley & Sons
Page : 644 pages
File Size : 48,8 Mb
Release : 2011-09-20
Category : Medical
ISBN : 9781118210536

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A Guide to Genetic Counseling by Wendy R. Uhlmann,Jane L. Schuette,Beverly Yashar Pdf

The first book devoted exclusively to the principles and practice of genetic counseling—now in a new edition First published in 1998, A Guide to Genetic Counseling quickly became a bestselling and widely recognized text, used nationally and internationally in genetic counseling training programs. Now in its eagerly anticipated Second Edition, it provides a thoroughly revised and comprehensive overview of genetic counseling, focusing on the components, theoretical framework, and unique approach to patient care that are the basis of this profession. The book defines the core competencies and covers the genetic counseling process from case initiation to completion—in addition to addressing global professional issues—with an emphasis on describing fundamental principles and practices. Chapters are written by leaders in the field of genetic counseling and are organized to facilitate academic instruction and skill attainment. They provide the most up-to-date coverage of: The history and practice of genetic counseling Family history Interviewing Case preparation and management Psychosocial counseling Patient education Risk communication and decision-making Medical genetics evaluation Understanding genetic testing Medical documentation Multicultural counseling Ethical and legal issues Student supervision Genetic counseling research Professional development Genetics education and outreach Evolving roles and expanding opportunities Case examples A Guide to Genetic Counseling, Second Edition belongs on the syllabi of all medical and human genetics and genetic counseling training programs. It is an indispensable reference for both students and healthcare professionals working with patients who have or are at risk for genetic conditions.

The Value of Genetic and Genomic Technologies

Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
The Value of Genetic and Genomic Technologies Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
Publisher : National Academies Press
Page : 109 pages
File Size : 55,5 Mb
Release : 2010-11-29
Category : Medical
ISBN : 9780309184991

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The Value of Genetic and Genomic Technologies by Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health Pdf

Knowing one's genetic disposition to a variety of diseases, including common chronic diseases, can benefit both the individual and society at large. The IOM's Roundtable on Translating Genomic-Based Research for Health held a workshop on March 22, 2010, to bring together diverse perspectives on the value of genetic testing, and to discuss its use in clinical practice.

Cancer Family

C. Richard Boland, MD
Cancer Family Book PDF

Author : C. Richard Boland, MD
Publisher : AuthorHouse
Page : 330 pages
File Size : 48,5 Mb
Release : 2015-08-30
Category : Biography & Autobiography
ISBN : 9781504928670

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Cancer Family by C. Richard Boland, MD Pdf

It is 1946, and a young man stares out his third-story apartment window. He has returned from the war with metastatic cancer and assumes he will die, leaving his wife and infant daughter behind. Instead, he lives another twenty-four years, raising a family of four children, before he succumbs to a second colon cancer. His son, the author, recognizes that there is a hereditary cancer syndrome in the family and resolves to solve the problem as a medical researcher. Eventually, hereditary colorectal cancer is recognized as a medical entity, and multiple genes responsible for this hereditary condition are isolated. However, the mutation responsible in the author’s family escaped detection. In 2001, his laboratory identifies the mutation responsible for the problem and develops a specific test for the family. This permits the mutation carriers to obtain life-saving care, altering the natural history of the disease for his family and others.

Hereditary Colorectal Cancer

Laura Valle,Stephen B. Gruber,Gabriel Capellá
Hereditary Colorectal Cancer Book PDF

Author : Laura Valle,Stephen B. Gruber,Gabriel Capellá
Publisher : Springer
Page : 505 pages
File Size : 45,8 Mb
Release : 2018-05-04
Category : Medical
ISBN : 9783319742595

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Hereditary Colorectal Cancer by Laura Valle,Stephen B. Gruber,Gabriel Capellá Pdf

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

Hereditary Colorectal Cancer

Joji Utsunomiya,Henry T. Lynch
Hereditary Colorectal Cancer Book PDF

Author : Joji Utsunomiya,Henry T. Lynch
Publisher : Springer Science & Business Media
Page : 564 pages
File Size : 50,7 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9784431683377

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Hereditary Colorectal Cancer by Joji Utsunomiya,Henry T. Lynch Pdf

Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.

Mommy Has Lynch Syndrome & Here's What That Means

Dr Kelsey M Finn
Mommy Has Lynch Syndrome Here s What That Means Book PDF

Author : Dr Kelsey M Finn
Publisher : Unknown
Page : 28 pages
File Size : 42,8 Mb
Release : 2020-09-16
Category : Electronic
ISBN : 9798686990944

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Mommy Has Lynch Syndrome & Here's What That Means by Dr Kelsey M Finn Pdf

This book tells the story of a mother who has Lynch Syndrome, a hereditary cancer condition, from the perspective of her two children. Lynch Syndrome affects 1 in every 279 people in the United States, and in turn, it affects many families. This book is intended to serve as a way to communicate with children about Lynch Syndrome, and help children understand what it means for both themselves and someone they know who is affected by Lynch Syndrome. This book also contains a section for parents of tips on how to talk with your child about Lynch Syndrome. This section is based on empirical, peer-reviewed research.

Dirty Genes

Ben Lynch
Dirty Genes Book PDF

Author : Ben Lynch
Publisher : HarperCollins
Page : 384 pages
File Size : 49,6 Mb
Release : 2018-01-30
Category : Health & Fitness
ISBN : 9780062698209

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Dirty Genes by Ben Lynch Pdf

Instant National Bestseller After suffering for years with unexplainable health issues, Dr. Ben Lynch discovered the root cause—“dirty” genes. Genes can be “born dirty” or merely “act dirty” in response to your environment, diet, or lifestyle—causing lifelong, life-threatening, and chronic health problems, including cardiovascular disease, autoimmune disorders, anxiety, depression, digestive issues, obesity, cancer, and diabetes. Based on his own experience and successfully helping thousands of clients, Dr. Lynch shows you how to identify and optimize both types of dirty genes by cleaning them up with targeted and personalized plans, including healthy eating, good sleep, stress relief, environmental detox, and other holistic and natural means. Many of us believe our genes doom us to the disorders that run in our families. But Dr. Lynch reveals that with the right plan in place, you can eliminate symptoms, and optimize your physical and mental health—and ultimately rewrite your genetic destiny.

The Birth House

Ami McKay
The Birth House Book PDF

Author : Ami McKay
Publisher : Vintage Canada
Page : 410 pages
File Size : 52,8 Mb
Release : 2009-04-24
Category : Fiction
ISBN : 9780307371447

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The Birth House by Ami McKay Pdf

The Birth House is the story of Dora Rare, the first daughter to be born in five generations of Rares. As a child in an isolated village in Nova Scotia, she is drawn to Miss Babineau, an outspoken Acadian midwife with a gift for healing. Dora becomes Miss B.’s apprentice, and together they help the women of Scots Bay through infertility, difficult labours, breech births, unwanted pregnancies and even unfulfilling sex lives. Filled with details as compelling as they are surprising, The Birth House is an unforgettable tale of the struggles women have faced to have control of their own bodies and to keep the best parts of tradition alive in the world of modern medicine.

The Pennsylvania Magazine Of History And Biography;

Historical Society Of Pennsylvania
The Pennsylvania Magazine Of History And Biography Book PDF

Author : Historical Society Of Pennsylvania
Publisher : Wentworth Press
Page : 562 pages
File Size : 43,6 Mb
Release : 2019-03-24
Category : History
ISBN : 1011092026

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The Pennsylvania Magazine Of History And Biography; by Historical Society Of Pennsylvania Pdf

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Syndromes: Rapid Recognition and Perioperative Implications

Bruno Bissonnette
Syndromes Rapid Recognition and Perioperative Implications Book PDF

Author : Bruno Bissonnette
Publisher : McGraw-Hill Education / Medical
Page : 988 pages
File Size : 44,5 Mb
Release : 2006-08-10
Category : Medical
ISBN : UOM:39015064795670

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Syndromes: Rapid Recognition and Perioperative Implications by Bruno Bissonnette Pdf

Essential medical facts on over 2,000 genetic syndromes. Organized alphabetically, this book provides comprehensive medical coverage for each syndrome, from genetic basis to manifestations to related medical considerations.

Hereditary Colorectal Cancer

Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen
Hereditary Colorectal Cancer Book PDF

Author : Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen
Publisher : Springer Science & Business Media
Page : 630 pages
File Size : 46,7 Mb
Release : 2010-09-10
Category : Medical
ISBN : 144196603X

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Hereditary Colorectal Cancer by Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen Pdf

Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.

Genetics of Colorectal Cancer

John D. Potter,Noralane M. Lindor
Genetics of Colorectal Cancer Book PDF

Author : John D. Potter,Noralane M. Lindor
Publisher : Springer
Page : 309 pages
File Size : 42,5 Mb
Release : 2008-12-08
Category : Medical
ISBN : 0387095675

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Genetics of Colorectal Cancer by John D. Potter,Noralane M. Lindor Pdf

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.