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Presents an overview of the disease, discussing its history, symptoms, the prognosis of people who have contracted it, and how they are treated, along with current efforts to improve prevention measures and develop a vaccine.
During World War II malaria was one of the most powerful enemies of the Australian troops in the South West Pacific. In 1943 the Australian Army formed a special research team to tackle the problem. This book documents the Australian search for a cure, and the scientific breakthroughs.
Treatment and Prevention of Malaria by Henry M. Staines,Sanjeev Krishna Pdf
Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
Malaria is one of the leading killers in the world today. Though drugs against malaria have a long history, attempts to develop novel therapeutics spanned the twentieth century and continue today. In this historical study, Leo B. Slater shows the roots and branches of an enormous drug development project during World War II. Fighting around the globe, American soldiers were at high risk for contracting malaria, yet quinine–a natural cure–became harder to acquire. A U.S. government-funded antimalarial program, initiated by the National Research Council, brought together diverse laboratories and specialists to provide the best drugs to the nation's military. This wartime research would deliver chloroquinine–long the drug of choice for prevention and treatment of malaria–and a host of other chemotherapeutic insights. A massive undertaking, the antimalarial program was to biomedical research what the Manhattan Project was to the physical sciences. A volume in the Critical Issues in Health and Medicine series, edited by Rima D. Apple and Janet Golden.
The Malaria Genome Projects by Irwin W. Sherman Pdf
The year 2012 marks the tenth anniversary of the announcement of the genome sequence of the human malaria parasite Plasmodium falciparum and that of its mosquito vector Anopheles. The genome sequences were a result of the Plasmodium falciparum Genome Project. This book covers in detail the biology of malaria parasites and the mosquitoes that transmit the disease, how the Genome Project came into being, the people who created it, and the cadre of scientists who are attempting to see the promise of the Project realized. The promise was: a more complete understanding of the genes of the parasite (and its vector) would provide a rational basis for the development of antimalarial drugs and vaccines, allow a better understanding of the regulation of the complex life cycle in the red blood and liver cells of the human, identify the genes the parasite uses to thwart the host immune response and the ways in which the parasite evades cure by drug treatments, as well as leading to more effective measures of control transmission. The hope was that cracking the genetic code of Plasmodium and Anopheles would reveal the biochemical Achilles heel of the parasite and its vector, leading to the development of novel drugs and better methods of control, and by finding the targets of protective immunity could result in the manufacture of effective vaccines. Through a historic approach, this book will allow for those new to the field, or those with insufficient background in the sciences, to have an easier entry point. Even scientists already working in the field may better appreciate how discoveries made in the past can impact the direction of future research.
A fascinating and shocking historical exposé, The Malaria Project is the story of America's secret mission to combat malaria during World War II—a campaign modeled after a German project which tested experimental drugs on men gone mad from syphilis. American war planners, foreseeing the tactical need for a malaria drug, recreated the German model, then grew it tenfold. Quickly becoming the biggest and most important medical initiative of the war, the project tasked dozens of the country’s top research scientists and university labs to find a treatment to remedy half a million U.S. troops incapacitated by malaria. Spearheading the new U.S. effort was Dr. Lowell T. Coggeshall, the son of a poor Indiana farmer whose persistent drive and curiosity led him to become one of the most innovative thinkers in solving the malaria problem. He recruited private corporations, such as today's Squibb and Eli Lilly, and the nation’s best chemists out of Harvard and Johns Hopkins to make novel compounds that skilled technicians tested on birds. Giants in the field of clinical research, including the future NIH director James Shannon, then tested the drugs on mental health patients and convicted criminals—including infamous murderer Nathan Leopold. By 1943, a dozen strains of malaria brought home in the veins of sick soldiers were injected into these human guinea pigs for drug studies. After hundreds of trials and many deaths, they found their “magic bullet,” but not in a U.S. laboratory. America 's best weapon against malaria, still used today, was captured in battle from the Nazis. Called chloroquine, it went on to save more lives than any other drug in history. Karen M. Masterson, a journalist turned malaria researcher, uncovers the complete story behind this dark tale of science, medicine and war. Illuminating, riveting and surprising, The Malaria Project captures the ethical perils of seeking treatments for disease while ignoring the human condition.
King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Publisher : World Bank Publications Page : 506 pages File Size : 51,7 Mb Release : 2017-11-06 Category : Medical ISBN : 9781464805257
Disease Control Priorities, Third Edition (Volume 6) by King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Pdf
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Malaria is not only the greatest killer of humankind, the disease has been the relentless scourge of armies throughout history. Malaria thwarted the efforts of Alexander the Great to conquer India in the fourth century BC. Malaria frustrated the ambitions of Attila the Hun and Genghis Khan to rule all Europe in the fourth and thirteenth centuries AD; and malaria stymied Napoleon Bonaparte’s plan to conquer Syria at the end of the eighteenth century. Malaria has also been the Australian Army’s continuing implacable foe in almost all its overseas deployments formation of the Australian Army in 1901. On at least three occasions malaria has halted Australian Army operations, bringing it to a standstill and threatening its defeat. The first time was in Syria in 1918, when a malaria epidemic cut a swathe through the Australian-led Desert Mounted Corps. The second time was in Papua New Guinea in 1942–43, when the Army was fighting malaria as well as the Japanese. The third time was in Vietnam in 1968, when malaria caused more casualties than did enemy action. Indeed the Australian Army has been fighting ‘an unending war’ against malaria ever since the Boer War at the end of the nineteenth century. The struggle against the disease continues 115 years later because virtually all Army’s overseas deployments are to malarious regions. Fortunately for Australian troops serving in nations where malaria is endemic, the Australian Army Malaria Institute undertakes the scientific research necessary to protect our service personnel against the disease. Ian Howie-Willis, in this very readable book, tells the dramatic story of the Army’s long and continuing struggle against malaria. It breaks new ground by showing how just one disease, malaria, is as much the serving soldier’s foe as any enemy force.
Tropical Medicine in the Twentieth Century by Helen J. Power Pdf
First published in 1998. Despite the upsurge of interest in the history of tropical medicine, international public health and the provision of health care in colonial and post-colonial tropical countries, no major text discusses the history of the academic discipline in the twentieth century. In Britain, the two Schools of Tropical Medicine opened within six months of each other in the final year of the nineteenth century. They have played a pivotal role in developing tropical medicine, as an academic discipline in postgraduate medicine with an active research profile. The Schools also affected the development of health care in the tropical colonies. They trained the Medical Officers of the Colonial Medical Service and the indigenous doctors whose training failed to include infectious endemic diseases and lacked an emphasis on community health. The Schools also contributed to a body of knowledge applied by the colonial powers, international agencies and independent nation states as part of their health care programmes. Ultimately the Schools helped the developing world to establish its own priorities for health. This volume charts the history of the Liverpool School of Tropical Medicine from1898 to1990.
Author : World Health Organization Publisher : World Health Organization Page : 356 pages File Size : 41,7 Mb Release : 2023-11-30 Category : Medical ISBN : 9789240086173
Historically, prolonged campaigns have been frequently lost or won because of the greater fitness of one of the combatant armies. In the twentieth century, infection was still a major problem, leading to withdrawal from Gallipoli, and the near defeat of the Allies due to malaria early in the Second World War’s Pacific campaign. Malaria emerged again as a major problem in the Vietnam War. The Australian Army Medical Corps, founded in 1901, learned from past medical experience. However, errors leading to significant morbidity did occur mainly in relation to malaria. These errors included lack of instruction of doctors sent to New Guinea with the Australian Force in the Great War, inadequate prophylactic measures against malaria in New Guinea early in World War Two, failure to perceive the threat of emerging resistant strains of malaria in the 1960s, and military commanders not fully implementing the recommendations of their medical advisers. Many Australian campaigns have taken place in tropical locations; a substantial amount of scientific work to prevent and manage tropical diseases has therefore been conducted by the Army Medical Corps’ medical researchers—particularly in the Land Headquarters Medical Research Unit and the Army Malaria Institute. Their work extends well beyond the military, greatly improving health outcomes throughout the world. This book recognises the efforts of both.
Four Brothers in the Pacific War by Chris Pratt Pdf
Dave, Ray, Morris and Alex Rohrlach were Australian Lutherans of German descent who served in the Australian Army and Navy in the Pacific during World War Two. In a fascinating biography of the brothers, Chris Pratt chronicles the events of their lives before, during, and in the aftermath of war. Dave, a Lutheran missionary in New Guinea, captained his mission schooner to rescue defeated Australian soldiers from New Britain in the opening months of the war. Ray served in a motorised infantry unit before enduring a year in an isolated malarial outpost in Dutch New Guinea. Morris struggled through two amphibious landings in Japanese occupied Borneo. Alex survived kamikaze attacks and a battle with a Japanese fleet in the Philippines to witness from an Australian heavy cruiser the signing of the Japanese surrender in Tokyo Bay. Included are historical maps and photographs provided by the family.
Major-General `Ginger' Burston led the Army Medical Service throughout the Pacific campaigns. This pivotal book explains how Burston and his medical team kept Allied troops healthy in primitive and hostile conditions and during the greatest medical emergency of World War II - the struggle against malaria. By keeping the soldiers healthy, and particularly by reducing malaria infection rates from 100 to less than one case per 1000 troops per week, the Army Medical Service assured an Allied victory over Japan. A Medical Emergency tells this remarkable story for the first time. In engrossing detail and using contemporary accounts, veteran historian Ian Howie-Willis brings to life the struggle of `Ginger' Burston and his Medical Service to fight a deadly opponent that decimated the ranks of friend and foe alike. Their victory was key to the ultimate Allied success.
