Malignant Transformation By Viruses

Author : Walter Doerfler,Petra Böhm
Publisher : Wiley-Blackwell
Page : 237 pages
File Size : 40,7 Mb
Release : 1992-09-01
Category : Science
ISBN : 3527284540

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Malignant Transformation by DNA Viruses by Walter Doerfler,Petra Böhm Pdf

An unusual compilation of experience and expertise. International experts in the field contribute chapters to this book drawn from their long-year experience in DNA tumor viruses and viral oncology. Treatment is comprehensive, covering the major groups of transforming DNA viruses: * SV40 * Polyomaviruses * Adenoviruses * Hepatitis B virus * Herpesviruses * Papillomaviruses. The authors show how viruses are pliable tools in work on cell transformation. Researchers will benefit from the realistic appraisal of the current situation and from the pragmatic analysis of the possibilities and requirements for future research. Contributing authors are: B. Biesinger (FRG), F. Cuzin (F), W. Doerfler (FRG), A.J. van der Eb (NL), E. Fanning (FRG), B. Fleckenstein (FRG), H. zur Hausen (FRG), N.C. Jones (UK), R. Koshy (UK), J.K. McDougall (USA), M. Oren (IL), A. Zantema (NL)

Author : Werner H. Kirsten
Publisher : Springer Science & Business Media
Page : 189 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642874024

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Malignant Transformation by Viruses by Werner H. Kirsten Pdf

The position of "Cancer Teaching Coordinator" at The University of Chicago has been a consistently rewarding one because of the enthusiasm and support of the faculty and the students. This volume is the result of the second of two recent intensive teach ing sessions which have been planned and implemented by the group which forms the Cancer Coordinator's Advisory Committee. The first of these teaching sessions was held in early March of 1964 and was entitled "LEUKEMIA, A Current and Forward Look. " It attracted overflow attendance from the students and staff of this medical institution augmented by members of the other medical centers in Chicago. It was a stimulating and instructive colloquium, and the only regret we heard expressed afterward was that we had not arranged for publication of the many excellent presentations. One of the events commemorating the seventy-fifth anniversary of the founding of The University of Chicago was this symposium on malignant transformations. This time the Committee advised us to plan on speedy publication, and, logically, it chose Dr. Werner Kirsten, a member of our faculty and an active and effective investigator in this general field of endeavor, to serve as editor of the volume. Again, two of the same ingredients for effective instruction were blended: an excellent group of scientists presenting their latest work and a fine, attentive audience of students and staff.

Author : Roger J. A. Grand
Publisher : Gulf Professional Publishing
Page : 540 pages
File Size : 49,6 Mb
Release : 2001-04-20
Category : Medical
ISBN : 0444504966

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Viruses, Cell Transformation, and Cancer by Roger J. A. Grand Pdf

Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed. Individual chapters have been written by an international group of experts in their own field of research.

Author : Leonard J. Rosenthal
Publisher : Karger Medical and Scientific Publishers
Page : 171 pages
File Size : 54,5 Mb
Release : 2001-01-01
Category : Medical
ISBN : 9783805572477

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Mechanisms of DNA Tumor Virus Transformation by Leonard J. Rosenthal Pdf

Approximately 15% of human cancer incidence can be attributed to virus infection, i.e. viruses represent the second most important risk factor (after tobacco consumption) for cancer development in humans. Today, five virus types are known to be involved in causing human cancer: papillomaviruses, retroviruses, herpesviruses, hepadnaviruses, and flaviviruses. This volume provides a comprehensive review of a number of DNA tumor viruses. Leading experts in the field of tumor virology discuss up-to-date information, focusing on the transforming genes of DNA tumor viruses, the mechanisms of transformation and the in vitro methodology used for their identification and characterization. In vitro studies have revealed several common mechanisms of viral transformation. Presented in a clear and concise manner, this book will be of value to students as well as researchers in the fields of general biology, molecular biology, cell biology and microbiology.

Author : Werner H. Kirsten
Publisher : Unknown
Page : 192 pages
File Size : 49,9 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 3642874037

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Malignant Transformation by Viruses by Werner H. Kirsten Pdf

Author : Anonim
Publisher : Unknown
Page : 177 pages
File Size : 51,5 Mb
Release : 1966
Category : Electronic
ISBN : OCLC:779504199

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Malignant Transformation by Viruses by Anonim Pdf

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 42,9 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Albert Kaplan
Publisher : Elsevier
Page : 186 pages
File Size : 47,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323160537

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Viral Transformation and Endogenous Viruses by Albert Kaplan Pdf

Viral Transformation and Endogenous Viruses is a collection of papers presented at the symposium on ""Viral Transformation and Endogenous Viruses"" held at Vanderbilt University on April 1-2, 1974. Contributors discuss the viral function(s) responsible for the transformation of the cells that are infected with oncogenic viruses, emphasizing the type of changes that characterize transformed cells and the regulatory mechanisms that are altered after malignant transformations. This volume is organized into 10 chapters and begins with an overview of DNA-containing tumor viruses, particularly Simian Virus 40 (SV40) and its mutants with DNA deletions, insertions, and duplications. The integration and transcription of adenovirus DNA is considered, along with the characteristics of temperature-sensitive mutants of these viruses. The reader is then introduced to the chemistry and biology of RNA-containing tumor viruses, which are useful reagents to study neoplastic transformation both in vivo and in vitro. A major aspect of these viruses concerns the analysis of their genome at the chemical and genetic levels. The last part of the book is devoted to biochemical and genetic analyses of endogenous viruses isolated from avian cells. This book is a valuable resource for scientists and investigators in fields such as pathology, molecular virology, molecular biology, microbiology, oncology, and biochemistry.

Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 40,7 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641

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Human Herpesviruses by Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi Pdf

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : Blossom Damania,James Pipas
Publisher : Springer Science & Business Media
Page : 805 pages
File Size : 47,8 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387689456

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DNA Tumor Viruses by Blossom Damania,James Pipas Pdf

This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.

Author : Jan Ponten
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709182581

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Spontaneous and Virus Induced Transformation in Cell Culture by Jan Ponten Pdf

A. Definitions of Transformation in vitro When normal tissues or organs are explanted to conditions favoring the growth of cells as individual units ("cell culture"), the original cell population undergoes a large variety of modifications. Only a minority of the cells will thrive and multiply and within a rather short period of time, the complex composition of the original explant is replaced by a much simplified one of only a few recogniz ably different cell types. With most organs fibroblast-like cells survive longest and outgrow other types. This is then a stable state of affairs for many gener ations. This treatise will not discuss whether this simplification and stabilization represents selection of certain pre-existing cell types or a modification of cells into only a few recognizably different categories; for an excellent review see HARRIS. (1964). Table 1. Terminology Employed to Describe Transformations in vitro Type of transformation Essential features Irregular growth Lack of contact inhibition of cell membrane movement ("ruffled membranes") between juxtaposed cells Unrestrained growth Deficient inhibition of the cell cycle (mitosis) in a crowded culture Infinite growth Capacity of cells to undergo an infinite number of di visions (formation of established cell lines) Cells may depart from this typical behavior in numerous ways involving for instance cellular morphology, immunology, chromosomes or metabolism. Such changes have, sometimes rather vaguely, been called "transformations". This is unprecise and the term "transformation" will here be used exclusively to indicate disturbances in cell growth related to neoplasia.

Author : Alecsandru Ioan Baba,Cornel Cătoi
Publisher : Unknown
Page : 787 pages
File Size : 55,5 Mb
Release : 2007
Category : Electronic books
ISBN : 9732714573

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Comparative Oncology by Alecsandru Ioan Baba,Cornel Cătoi Pdf

Author : Rolf Knippers,Arnold J. Levine
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642745782

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Transforming Proteins of DNA Tumor Viruses by Rolf Knippers,Arnold J. Levine Pdf

It is surprising, and even disappointing, that there have been very few meetings and published volumes resulting from these meetings that focus attention upon all of the groups of DNA tumor viruses. Historically, separate meetings were held each year for the adenovirus-SV40-polyoma researchers, the herpes viruses, hepatitis B virus and the papillomaviruses. It was as if these four virus groups were four fields of study developing independently with a literature and culture of their own. When a virologist crossed the field from the adenovirus group to the herpesvirus or papillomaviruses, he or she was lost to their former group because of the structure of separate meetings and remote literature. This, of course, has resulted from historical accident and is being rectified by the rapid progress made in our understanding of how these viruses contribute to the causation of cancer in animals and humans. It was pre cisely because of these factors that it was time to hold a meeting and publish its proceedings on the subject of transforming proteins of DNA tumor viruses. For the first time, DNA tumor viruses were defined as all of the virus groups that can contribute to cancer in animals with the exception, unfortunately, of the . poxviruses. The purpose of the meeting was to bring together scientists who rarely attend meetings together but actually work on the same problems with different viruses.

Author : Frederick Becker
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 40,9 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9781468427332

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Cancer a Comprehensive Treatise 2 by Frederick Becker Pdf

The impact of basic research on oncology has been particularly impressive in the recent search for the cause of malignancy. Equally impressive is our appreciation of the cause of tumors based on observation. Even in the earliest era of the study of infectious diseases, it was proposed that tumorous growth in animals and birds resulted from "minute" infectious particles. Experiments then supported the hypothesis, that the etiologic agent in many animal tumors was viral. The development of molecular biology, supported by technical advances and conceptual understanding of macromolecular action, led to an explosive increase in studies of animal oncogenic viruses. For a decade, new findings emerged from research laboratories revealing the enormous variety of such agents, the complex ity of their interactions with cells, and the tantalizingly possible mechanisms by which they might cause malignant transformation of the cell. Repeatedly, clues emerged which suggested the intervention of viral agents in human tumors. A breathless excitement pervaded both the scientific and public communities as highly publicized findings rapidly followed one another. The excitement was no less scientific than it was practical, for implicit in the concept of the viral oncogen is the possibility of specific virostatic or virotoxic agents or of immunization.

Author : Anonim
Publisher : Unknown
Page : 1254 pages
File Size : 50,5 Mb
Release : 1984
Category : Oncogenic viruses
ISBN : UOM:39015013229722

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RNA Tumor Viruses: Supplements and appendixes by Anonim Pdf