Matrix Metalloproteinases

Author : Anonim
Publisher : Elsevier
Page : 375 pages
File Size : 50,7 Mb
Release : 1998-03-27
Category : Science
ISBN : 9780080535982

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Matrix Metalloproteinases by Anonim Pdf

The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions. Provides state-of-the-art information on a field with broad implications to many areas of biology Includes detailed coverage of the structure and regulation of all major matrix metalloproteinases Chapters focus on a timely and expanding field Topics have direct relevance to understanding human disease pathology of cancer, arthritis, and vascular disease Discusses latest strategies used in the development of new therapeutics to inhibit metalloproteinase activity

Author : Francesco Travascio
Publisher : BoD – Books on Demand
Page : 202 pages
File Size : 46,9 Mb
Release : 2017-12-20
Category : Medical
ISBN : 9789535137177

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The Role of Matrix Metalloproteinase in Human Body Pathologies by Francesco Travascio Pdf

Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body.

Author : Satya Prakash Gupta
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 45,7 Mb
Release : 2012-04-05
Category : Medical
ISBN : 9783034803649

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Matrix Metalloproteinase Inhibitors by Satya Prakash Gupta Pdf

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.

Author : Constance E Brinckerhoff
Publisher : World Scientific
Page : 296 pages
File Size : 52,6 Mb
Release : 2017-05-05
Category : Science
ISBN : 9789813207561

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Matrix Metalloproteinases In Health And Disease: Sculpting The Human Body by Constance E Brinckerhoff Pdf

The biochemistry and cell biology of Matrix Metalloproteinases (MMPs) are not necessarily straightforward, but basic information on the history of these enzymes, their various functions that extend far beyond the cleaving of the extracellular matrix, and the complex mechanisms that control their expression are valuable to both scientists and clinicians. This volume summarizes the salient features and functions of MMPs and applies this information in a practical manner in order to understand how they contribute to normal physiology and pathology of selected diseases. Chapters by noted clinicians Jean-Michel Dayer, MD in rheumatology, Jian Cao, MD in oncology, and Peter Libby, MD in cardiology, represent important practical and clinically-oriented contributions.

Author : Ian M. Clark
Publisher : Humana Press
Page : 0 pages
File Size : 48,7 Mb
Release : 2010-03-04
Category : Science
ISBN : 1603272984

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Matrix Metalloproteinase Protocols by Ian M. Clark Pdf

Since the discovery of a collagen-degrading protease in the tadpole tail in 1962, matrix metalloproteinase research has led to the discovery of more than twenty distinct vertebrate MMPs, along with a variety of homologues from diverse organisms such as the sea urchin, plants, insects, and nematode worms. Fully updating and adding to the popular first edition, Matrix Metalloproteinase Protocols, Second Edition includes a series of state-of-the-art techniques provided by eminent experts in the field. Beginning with a brief overview of the MMP arena, from how these enzymes fit into the larger degradome to what occurs when their expression and function in the mouse is modulated, the volume continues with sections on the expression and purification of MMPs and TIMPs, the detection of MMPs and TIMPs at both the protein and mRNA level, and our ability to assay MMP and TIMP activities in a wide variety of circumstances. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Matrix Metalloproteinase Protocols, Second Edition is an ideal source for many of the essential laboratory techniques for both novice and seasoned researchers alike collected in one convenient volume.

Author : Ian M. Clark
Publisher : Springer Science & Business Media
Page : 547 pages
File Size : 49,5 Mb
Release : 2008-02-05
Category : Science
ISBN : 9781592590469

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Matrix Metalloproteinase Protocols by Ian M. Clark Pdf

Research in the matrix metalloproteinase field began with the demonstration by Gross and Lapière, in 1962, that resorbing tadpole tail expressed an enzyme that could degrade collagen gels. These humble beginnings have led us to the elucidation of around twenty distinct vertebrate MMPs, along with a variety of homologs from such diverse organisms as sea urchin, plants, nematode worm, and bacteria. This, coupled with four known specific inhibitors of MMPs, the TIMPs, gives a complex picture. Part I of Matrix Metalloproteinase Protocols provides the reader with a selective overview of the MMP arena, and a chance to come to grips with where the field has been, where it is, and where it is going. I hope that this complements all of the methodology that comes later. Part II presents the reader with a diverse set of methods for the expression and purification of MMPs and TIMPs, bringing together the long and often hard-earned experience of a number of researchers. Part III allows the reader to detect MMPs and TIMPs at both the protein and mRNA level, whereas Part IV gives the ability to assay MMP and TIMP activities in a wide variety of circumstances.

Author : J. F. Woessner,Jacob Frederick Woessner,Hideaki Nagase,The Kennedy Institute of Rheumatology Hideaki Nagase
Publisher : Oxford University Press on Demand
Page : 223 pages
File Size : 54,8 Mb
Release : 2000
Category : Medical
ISBN : 0198502680

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Matrix Metalloproteinases and TIMPs by J. F. Woessner,Jacob Frederick Woessner,Hideaki Nagase,The Kennedy Institute of Rheumatology Hideaki Nagase Pdf

The matrix metalloproteinases (MMPs) are a large family of enzymes that breakdown different components of the extracellular matrix. Their catalytic activity is dependent a metal ion, usually zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this, is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the 4 known classes of TIMP. Matrix metalloproteinases will therefore be an invaluable source of data for all researchers interested in MMPs and TIMPs.

Author : Anonim
Publisher : Academic Press
Page : 446 pages
File Size : 43,8 Mb
Release : 2017-06-26
Category : Science
ISBN : 9780128128312

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Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy by Anonim Pdf

Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy, Volume, Volume 148, the latest volume in the Progress in Molecular Biology and Translational Science series covers a variety of timely topics, with chapters focusing on The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs, Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target, Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy, Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia, and Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology. This volume is the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease. It focuses on the role of MMPs in other systems, target tissues, and pathological disorders and the potential benefits of MMP inhibitors in various disorders. Serves as the second part of a thematic on matrix metalloproteinases and tissue remodeling in health and disease Focuses on cardiovascular remodeling Contains contributions from leading authorities on the topics Publishes cutting-edge reviews in molecular biology

Author : Satya Prakash Gupta
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 51,6 Mb
Release : 2012-04-05
Category : Medical
ISBN : 9783034803649

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Matrix Metalloproteinase Inhibitors by Satya Prakash Gupta Pdf

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.

Author : Katherine Conant,Paul E Gottschall
Publisher : World Scientific
Page : 348 pages
File Size : 43,7 Mb
Release : 2005-07-26
Category : Medical
ISBN : 9781783260287

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Matrix Metalloproteinases in the Central Nervous System by Katherine Conant,Paul E Gottschall Pdf

This book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and chemokines, and cell surface receptors. Studies implicating MMPs in neuronal process outgrowth and cell migration in CNS development are covered. The book also touches on studies suggesting that, in certain situations, dysregulated MMP activity and/or production may be critical to blood–brain barrier breakdown and neuronal damage. Contents:A Brief OverviewRegulation of MMP ExpressionMMP FunctionMMPs and TIMPs in DevelopmentMMPs and TIMPs in Disease Readership: Academics, researchers and graduate students in biochemistry and neuroscience, neurologists, immunologists, pharmaceutical specialists and those interested in vascular diseases. Key Features:Several pharmacologic inhibitors of matrix metalloproteinases are presently available and many are being tested in clinical trials. An understanding of the role of proteinases in the normal and diseased brain is critical if these drugs are to be used wiselyContributions from leaders in the field of metalloproteinase biology including Sarah McFarlane, Dylan Edwards, Wee Yong, John Sandy, Diane Jaworski, Iain Campbell, Gary Rosenberg, Jasti Rao, Jeanine D'Armiento, Dieter Zimmerman, and Paul GottschallKeywords:Matrix Metalloproteinases;Central Nervous System;Neurons;Astrocytes;Blood–Brain Barrier

Author : Vincent Lagente,Elisabeth Boichot
Publisher : Springer Science & Business Media
Page : 177 pages
File Size : 55,9 Mb
Release : 2008-11-07
Category : Medical
ISBN : 9783764385859

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Matrix Metalloproteinases in Tissue Remodelling and Inflammation by Vincent Lagente,Elisabeth Boichot Pdf

This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship between activation of inflammatory cells and tissue remodelling and advise new therapeutics possibilities to the treatment of inflammatory disease. The volume has an international authorship and is written by leading experts in the field.

Author : M. Nelson,W. Hillen,R.A. Greenwald
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 48,6 Mb
Release : 2001-10-01
Category : Science
ISBN : 3764362820

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Tetracyclines in Biology, Chemistry and Medicine by M. Nelson,W. Hillen,R.A. Greenwald Pdf

The tetracyclines have an illustrious history as therapeutic agents which dates back over half a century. Initially discovered as an antibiotic in 1947, the four ringed molecule has captured the fancy of chemists and biologists over the ensuing decades. Of further interest, as described in the chapter by George Armelagos, tetracyclines were already part of earlier cultures, 1500-1700 years ago, as revealed in traces of drug found in Sudanese Nubian mummies. The diversity of chapters which this book presents to the reader should illus trate the many disciplines which have examined and seen benefits from these fascinating natural molecules. From antibacterial to anti-inflammatory to anti autoimmunity to gene regulation, tetracyclines have been modified and redesigned for various novel properties. Some have called this molecule a biol ogist's dream because of its versatility, but others have seen it as a chemist's nightmare because of the synthetic chemistry challenges and "chameleon-like" properties (see the chapter by S. Schneider).

Author : Neil J. Clendeninn,Krzysztof Appelt
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 51,8 Mb
Release : 2000-09-17
Category : Medical
ISBN : 9781592590117

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Matrix Metalloproteinase Inhibitors in Cancer Therapy by Neil J. Clendeninn,Krzysztof Appelt Pdf

Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.

Author : Irit Sagi,Jean Gaffney
Publisher : Unknown
Page : 128 pages
File Size : 44,9 Mb
Release : 2015
Category : SCIENCE
ISBN : 1118772288

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Matrix Metalloproteinase Biology by Irit Sagi,Jean Gaffney Pdf

Author : Anonim
Publisher : Academic Press
Page : 320 pages
File Size : 53,8 Mb
Release : 2017-04-14
Category : Science
ISBN : 9780128116388

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Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling by Anonim Pdf

Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Cardiovascular Remodeling is the latest volume in the Progress in Molecular Biology and Translational Science series. This volume is the first part of a thematic and contains up-to-date information on the biology and function of matrix metalloproteinases, and how their effects on tissue remodeling are altered in diseases of the cardiovascular, pulmonary, and musculoskeletal systems and other tissues and organs, as well as cancer. Contributors include prominent scientists and highly-recognized experts with major accomplishments in the research field of matrix metalloproteinases. Focuses on matrix metalloproteinases and their role in tissue remodeling under physiological and pathological conditions Contains up-to-date information on matrix metalloproteinases that is clearly presented in a concise fashion with helpful illustrations and supporting references Includes comprehensive reviews written by prominent scientists and highly-recognized experts in the field of matrix metalloproteinases and tissue remodeling