Measles Virus Nucleoprotein

Author : Sonia Longhi
Publisher : Nova Publishers
Page : 180 pages
File Size : 54,7 Mb
Release : 2007
Category : Measles virus
ISBN : 1600216293

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Measles Virus Nucleoprotein by Sonia Longhi Pdf

Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.

Author : Volker ter Meulen,Martin F. Bach
Publisher : Springer Science & Business Media
Page : 204 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642786211

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Measles Virus by Volker ter Meulen,Martin F. Bach Pdf

Measles, also called the greatest killer of children in history, still annually affects about 50 million individuals and causes close to a million deaths primarily in developing countries. Before the advent of measles vaccine some 30 years ago, these figures were roughly three times higher. Attenuated measles virus (MV) strains, all quite closely related to the original Edmonston isolate, have a very good record as a safe and highly efficacious vaccine and have brought down the measles toll in industrialized countries to almost negligible levels. However, recent outbreaks in the USA and Europe have again brought the measles problem to public attention. Sadly enough, these outbreaks were more instrumental in inducing activities to drastically reduce and hopefully finally eradicate measles than were the ten thousand times higher number of victims in developing countries. To reach this goal, as detailed in this volume, apparently it is not enough to of the existing vaccine as was the rigorously enforce use case with smallpox eradication: the intricacies of measles disease phenomena, in particular the generalized immune suppression which favors secondary infections, require more basic knowledge of the virus-host interactions and probably the development of new vaccines for special applications such as first immunizations of very young infants in developing countries.

Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Page : 532 pages
File Size : 41,6 Mb
Release : 2012-02-07
Category : Science
ISBN : 9780470618318

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Flexible Viruses by Vladimir Uversky,Sonia Longhi Pdf

This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Author : David W. Kingsbury
Publisher : Springer Science & Business Media
Page : 608 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461537908

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The Paramyxoviruses by David W. Kingsbury Pdf

What justifies the size of this compendium of reviews on the paramyxoviruses? As intracellular parasites that reproduce with almost complete indifference to nuclear activities, paramyxoviruses have not been providing insights about genes that regulate cellular activities and development, topics that account for much of the excitement in modem biology. For contributions of virus research to those topics, we must look to the retroviruses, which have the propensity to steal developmentally important genes and subvert them to malignant pur poses, and to the nuclear DNA viruses, whose gene expression depends heavily upon cellular transcription machinery, making them exceptionally useful tools for identifying and characterizing components of that machinery. From this perspective, it may appear that purely lytic viruses like the paramyxoviruses are sitting on the sidelines of contemporary biology. But there is plenty of action on the sidelines. Paramyxoviruses remain unconquered, devastating agents of disease. Human deaths attributable to paramyxoviruses worldwide, especially in children, are numbered in the mil lions annually. There are many pathogenic paramyxoviruses and too few effec tive vaccines, and those vaccines (against measles and mumps) are affordable only by relatively affluent nations. Moreover, the paramyxoviruses are intrin sically interesting organisms, presenting the challenge of understanding the self-replication of RNA and many other challenges peculiar to the structures and functions of their proteins, not only as individual entities, but also as they act in concert during virus reproduction and interact with vital functions of the cells they infect and often (but not always) destroy.

Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Page : 642 pages
File Size : 49,9 Mb
Release : 2016-10-24
Category : Medical
ISBN : 9780128031032

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Mesenchymal Stromal Cells as Tumor Stromal Modulators by Marcela Bolontrade,Mariana García Pdf

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Author : Diane E. Griffin,Michael B. A. Oldstone
Publisher : Springer Science & Business Media
Page : 201 pages
File Size : 50,6 Mb
Release : 2008-10-30
Category : Medical
ISBN : 9783540705239

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Measles by Diane E. Griffin,Michael B. A. Oldstone Pdf

Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some communities continue to result in nearly 40 million cases and over 300,000 deaths per year from measles.

Author : C. Candler
Publisher : Unknown
Page : 456 pages
File Size : 44,5 Mb
Release : 1889
Category : Measles
ISBN : HARVARD:HC53BT

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The Prevention of Measles by C. Candler Pdf

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 42,9 Mb
Release : 2024-05-18
Category : Electronic
ISBN : 9789814464451

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Negative Strand RNA Virus by Anonim Pdf

Author : Snežana Jovanović-Ćupić,Muhammad Abubakar,Ayse Emel Onal,Muhammad Kashif Saleemi,Ana Božović,Milena Krajnovic
Publisher : BoD – Books on Demand
Page : 172 pages
File Size : 40,9 Mb
Release : 2020-06-17
Category : Science
ISBN : 9781789856330

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Viruses and Viral Infections in Developing Countries by Snežana Jovanović-Ćupić,Muhammad Abubakar,Ayse Emel Onal,Muhammad Kashif Saleemi,Ana Božović,Milena Krajnovic Pdf

This book contains information on various virus families, with the focus on viruses causing prevalent infections in parts of developing countries in Africa and Asia. Viral proteins play an important role in their replication and infection potential, and are the main candidates for antiviral therapy and vaccines. While some antiviral vaccines are available for quite some time (e.g. MMR), there are regions in the world still struggling with some infections. This is especially the problem in regions where the morbidity rate from viral infections among young children is high. This situation requires urgent measures to put infections under control.

Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Page : 792 pages
File Size : 45,8 Mb
Release : 2011-01-31
Category : Science
ISBN : 9780470602607

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Instrumental Analysis of Intrinsically Disordered Proteins by Vladimir Uversky,Sonia Longhi Pdf

Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Author : Mauricio G. Mateu
Publisher : Springer Science & Business Media
Page : 728 pages
File Size : 49,7 Mb
Release : 2013-06-04
Category : Medical
ISBN : 9789400765528

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Structure and Physics of Viruses by Mauricio G. Mateu Pdf

This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.

Author : Institute of Medicine,Board on Global Health,Forum on Emerging Infections
Publisher : National Academies Press
Page : 233 pages
File Size : 43,7 Mb
Release : 2002-08-18
Category : Medical
ISBN : 9780309084147

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Considerations for Viral Disease Eradication by Institute of Medicine,Board on Global Health,Forum on Emerging Infections Pdf

Since smallpox eradication, the science of eradication has changed and with it, our definitions of what diseases are possible to eradicate. However, eradication must not beget complacency. As has been learned from past control or eradication attempts with a variety of viral diseases, from yellow fever to influenza, accidental or intentional reintroduction is a real threat-one that could strike anywhere and for which we need to be fully prepared. The criteria for assessing eradicability of polio, measles, and other viral infections have been debated extensively. With the elimination and eradication of several viral diseases on the horizon, issues surrounding the cessation of immunization activities become exceedingly important. In an effort to better understand the dynamics of disease eradication and post-immunization policies, the Institute of Medicine Forum on Emerging Infections hosted a two-day workshop (February 1-2, 2001) on The Consequences of Viral Disease Eradication. This book explores the principles underlying the biological challenges, medical interventions, the continuing research agenda, and operational considerations for post-immunization strategies for vaccine-preventable viral diseases, and highlights important efforts that may facilitate wise decision making.

Author : Monika Fuxreiter,Peter Tompa
Publisher : Springer Science & Business Media
Page : 190 pages
File Size : 55,6 Mb
Release : 2012-03-07
Category : Medical
ISBN : 9781461406594

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Fuzziness by Monika Fuxreiter,Peter Tompa Pdf

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Author : Alan D.T. Barrett,Lawrence R. Stanberry
Publisher : Academic Press
Page : 1488 pages
File Size : 51,5 Mb
Release : 2009-03-05
Category : Science
ISBN : 0080919022

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Vaccines for Biodefense and Emerging and Neglected Diseases by Alan D.T. Barrett,Lawrence R. Stanberry Pdf

The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. * Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats * Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace * Each chapter will include a map of the world showing where that particular disease is naturally found

Author : Sandra W. Roush,Sandra W Roush Mph,Lynne McIntyre,Lynne McIntyre Mals,Linda M. Baldy,Linda M Baldy Mph,Centers for Disease Control and Prevention
Publisher : CreateSpace
Page : 472 pages
File Size : 53,7 Mb
Release : 2013-11
Category : Medical
ISBN : 1493733796

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Manual for the Surveillance of Vaccine-Preventable Diseases, 2013 by Sandra W. Roush,Sandra W Roush Mph,Lynne McIntyre,Lynne McIntyre Mals,Linda M. Baldy,Linda M Baldy Mph,Centers for Disease Control and Prevention Pdf

The Manual for the Surveillance of Vaccine-Preventable Diseases, updated through 2013, provides current guidelines for those directly involved in surveillance of vaccine-preventable diseases, especially personnel at the local health departments. For each of the vaccine-preventable diseases, this manual includes a chapter describing the importance of rapid case identification; the importance of surveillance; disease reduction goals; case definitions (including clinical description and case classifications); epidemiologically important data to be collected during case investigation; activities for enhancing surveillance; activities for case investigation; and activities for outbreak control. Other chapters include information on surveillance indicators; surveillance data analyses; reporting adverse events following vaccination; and enhancing surveillance. In addition, the manual includes a section reserved for insertion of state-specific guidance for VPD surveillance and extensive appendices. This manual was first developed in 1996 to provide general guidance to state and local health department personnel who are involved in surveillance activities for vaccine-preventable diseases. This manual answers commonly asked questions regarding the surveillance and reporting of vaccine-preventable diseases and provides information on enhancing existing surveillance systems.