Measuring Clinical Outcome In Asthma

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Measuring Clinical Outcome in Asthma

Author : Mike Pearson (FRCP.)
Publisher : Royal College of Physicians
Page : 112 pages
File Size : 52,7 Mb
Release : 2000
Category : Asthma
ISBN : 9781860160974

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Measuring Clinical Outcome in Asthma by Mike Pearson (FRCP.) Pdf

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Author : Agency for Health Care Research and Quality (U.S.)
Publisher : Government Printing Office
Page : 204 pages
File Size : 44,7 Mb
Release : 2013-02-21
Category : Medical
ISBN : 9781587634239

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Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by Agency for Health Care Research and Quality (U.S.) Pdf

This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Registries for Evaluating Patient Outcomes

Author : Agency for Healthcare Research and Quality/AHRQ
Publisher : Government Printing Office
Page : 396 pages
File Size : 46,6 Mb
Release : 2014-04-01
Category : Medical
ISBN : 9781587634338

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Registries for Evaluating Patient Outcomes by Agency for Healthcare Research and Quality/AHRQ Pdf

This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Outcomes in Clinical Trials

Author : Martin Kolb,Claus F. Vogelmeier
Publisher : European Respiratory Society
Page : 208 pages
File Size : 45,7 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9781849840453

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Outcomes in Clinical Trials by Martin Kolb,Claus F. Vogelmeier Pdf

The traditional end-points for clinical studies of lung diseases were based on functional parameters. Their value as surrogate markers for disease activity and progression has been increasingly questioned by scientists, carers, regulatory agencies and funding bodies. Novel tools and methods with regard to biomarkers and patient-reported outcomes have made these parameters emerge from their status as interesting secondary end-points and become potential primary outcomes for clinical trials. Nevertheless, their relevance and validity still needs to be proven. This issue of the European Respiratory Monograph describes the current status regarding end-points in all relevant areas of pulmonary medicine.

Severe Asthma

Author : Kian Fan Chung,Elliot Israel,Peter G. Gibson
Publisher : European Respiratory Society
Page : 360 pages
File Size : 48,9 Mb
Release : 2019-06-01
Category : Medical
ISBN : 9781849841047

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Severe Asthma by Kian Fan Chung,Elliot Israel,Peter G. Gibson Pdf

Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Expert Panel Report 2

Author : National Asthma Education and Prevention Program (National Heart, Lung, and Blood Institute). Second Expert Panel on the Management of Asthma
Publisher : Unknown
Page : 164 pages
File Size : 49,8 Mb
Release : 1998
Category : Asthma
ISBN : MINN:31951D01915740L

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Expert Panel Report 2 by National Asthma Education and Prevention Program (National Heart, Lung, and Blood Institute). Second Expert Panel on the Management of Asthma Pdf

Expert Panel Report

Author : Anonim
Publisher : Unknown
Page : 148 pages
File Size : 40,6 Mb
Release : 2003
Category : Asthma
ISBN : UCLA:L0087576492

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Expert Panel Report by Anonim Pdf

Individual Quality of Life

Author : Charles Richard Boddington Joyce,Hannah M. McGee,Ciaran A. O'Boyle
Publisher : Taylor & Francis
Page : 248 pages
File Size : 51,6 Mb
Release : 1999
Category : Health
ISBN : 9789057024245

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Individual Quality of Life by Charles Richard Boddington Joyce,Hannah M. McGee,Ciaran A. O'Boyle Pdf

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Improving Healthcare Quality in Europe Characteristics, Effectiveness and Implementation of Different Strategies

Author : OECD,World Health Organization
Publisher : OECD Publishing
Page : 128 pages
File Size : 41,7 Mb
Release : 2019-10-17
Category : Electronic
ISBN : 9789264805903

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Improving Healthcare Quality in Europe Characteristics, Effectiveness and Implementation of Different Strategies by OECD,World Health Organization Pdf

This volume, developed by the Observatory together with OECD, provides an overall conceptual framework for understanding and applying strategies aimed at improving quality of care. Crucially, it summarizes available evidence on different quality strategies and provides recommendations for their implementation. This book is intended to help policy-makers to understand concepts of quality and to support them to evaluate single strategies and combinations of strategies.

The National Children's Study Research Plan

Author : National Research Council,Institute of Medicine,Board on Population Health and Public Health Practice,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on National Statistics,Panel to Review the National Children's Study Research Plan
Publisher : National Academies Press
Page : 166 pages
File Size : 55,9 Mb
Release : 2008-08-16
Category : Social Science
ISBN : 9780309120562

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The National Children's Study Research Plan by National Research Council,Institute of Medicine,Board on Population Health and Public Health Practice,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on National Statistics,Panel to Review the National Children's Study Research Plan Pdf

The National Children's Study (NCS) is planned to be the largest long-term study of environmental and genetic effects on children's health ever conducted in the United States. It proposes to examine the effects of environmental influences on the health and development of approximately 100,000 children across the United States, following them from before birth until age 21. By archiving all of the data collected, the NCS is intended to provide a valuable resource for analyses conducted many years into the future. This book evaluates the research plan for the NCS, by assessing the scientific rigor of the study and the extent to which it is being carried out with methods, measures, and collection of data and specimens to maximize the scientific yield of the study. The book concludes that if the NCS is conducted as proposed, the database derived from the study should be valuable for investigating hypotheses described in the research plan as well as additional hypotheses that will evolve. Nevertheless, there are important weaknesses and shortcomings in the research plan that diminish the study's expected value below what it might be.

Clinical Asthma

Author : Jonathan A. Bernstein,Mark L. Levy
Publisher : CRC Press
Page : 340 pages
File Size : 41,9 Mb
Release : 2014-02-06
Category : Medical
ISBN : 9781466585614

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Clinical Asthma by Jonathan A. Bernstein,Mark L. Levy Pdf

Enormous progress in asthma research has been made in the past 50 years, including a greater understanding of its complex pathogenesis and new and more effective therapies. Consequently, the scientific literature has grown vast and can be difficult to integrate. With contributions from a distinguished panel of world-renowned authors, Clinical Asthma: Theory and Practice presents a comprehensive study of both the common and the more challenging problems faced by all health care personnel who treat patients with asthma. The book is divided into seven sections, starting with the basics of asthma and ending with a discussion on the approach to asthma worldwide and in the primary care setting. Reflecting a strong clinical emphasis, each chapter begins with a patient case study supported by essential background information on the basic science and clinical decision-making process. This is followed by a discussion of clinical evaluation and management. The multidisciplinary coverage explores a range of topics including genetics, inflammation, immunology, and the identification of different endotypes. Using a bench-to-bedside approach, the book links basic science to the clinical management of asthma and explores options for improvement. The carefully selected authorship from experts worldwide presents a truly global outlook.

Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Food and Nutrition Board,Committee on the Development of Guiding Principles for the Inclusion of Chronic Disease Endpoints in Future Dietary Reference Intakes
Publisher : National Academies Press
Page : 335 pages
File Size : 49,5 Mb
Release : 2017-12-21
Category : Medical
ISBN : 9780309462563

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Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Food and Nutrition Board,Committee on the Development of Guiding Principles for the Inclusion of Chronic Disease Endpoints in Future Dietary Reference Intakes Pdf

Since 1938 and 1941, nutrient intake recommendations have been issued to the public in Canada and the United States, respectively. Currently defined as the Dietary Reference Intakes (DRIs), these values are a set of standards established by consensus committees under the National Academies of Sciences, Engineering, and Medicine and used for planning and assessing diets of apparently healthy individuals and groups. In 2015, a multidisciplinary working group sponsored by the Canadian and U.S. government DRI steering committees convened to identify key scientific challenges encountered in the use of chronic disease endpoints to establish DRI values. Their report, Options for Basing Dietary Reference Intakes (DRIs) on Chronic Disease: Report from a Joint US-/Canadian-Sponsored Working Group, outlined and proposed ways to address conceptual and methodological challenges related to the work of future DRI Committees. This report assesses the options presented in the previous report and determines guiding principles for including chronic disease endpoints for food substances that will be used by future National Academies committees in establishing DRIs.

Fundamentals of Clinical Data Science

Author : Pieter Kubben,Michel Dumontier,Andre Dekker
Publisher : Springer
Page : 219 pages
File Size : 51,6 Mb
Release : 2018-12-21
Category : Medical
ISBN : 9783319997131

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Fundamentals of Clinical Data Science by Pieter Kubben,Michel Dumontier,Andre Dekker Pdf

This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.

Clearing the Air

Author : Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee on the Assessment of Asthma and Indoor Air
Publisher : National Academies Press
Page : 457 pages
File Size : 51,9 Mb
Release : 2000-05-24
Category : Science
ISBN : 9780309064965

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Clearing the Air by Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee on the Assessment of Asthma and Indoor Air Pdf

Since about 1980, asthma prevalence and asthma-related hospitalizations and deaths have increased substantially, especially among children. Of particular concern is the high mortality rate among African Americans with asthma. Recent studies have suggested that indoor exposuresâ€"to dust mites, cockroaches, mold, pet dander, tobacco smoke, and other biological and chemical pollutantsâ€"may influence the disease course of asthma. To ensure an appropriate response, public health and education officials have sought a science-based assessment of asthma and its relationship to indoor air exposures. Clearing the Air meets this need. This book examines how indoor pollutants contribute to asthmaâ€"its causation, prevalence, triggering, and severity. The committee discusses asthma among the general population and in sensitive subpopulations including children, low-income individuals, and urban residents. Based on the most current findings, the book also evaluates the scientific basis for mitigating the effects of indoor air pollutants implicated in asthma. The committee identifies priorities for public health policy, public education outreach, preventive intervention, and further research.

Quality of Life as Perceived by 30 Year Old Army Veterans

Author : Sandra Reitz Wilson,John Clemans Flanagan,Julius E. Uhlaner
Publisher : Unknown
Page : 44 pages
File Size : 53,5 Mb
Release : 1975
Category : Psychology, Military
ISBN : MINN:31951D03425858B

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Quality of Life as Perceived by 30 Year Old Army Veterans by Sandra Reitz Wilson,John Clemans Flanagan,Julius E. Uhlaner Pdf

An intensive investigation of the impact Army service has had on the quality of life for a representative sample of young Americans is analyzed in terms of possible improvement in Army personnel procedures. A total of 166 men (of a potential 200) and 49 women (of a potential 50) were interviewed. The information from these interviews; a review of interviewee lives before, during, and after Army service to about the age of 30; and Project talent (a 1960 national survey of high school students) information have been analyzed. Background and purpose of the study, a definition of the information required, a description of the sample group, procedures for collecting the data and the results of its analysis, and the impact of Army service on present quality of life are discussed. A summary indicates that, for the group as a whole, Army service had a positive effect on their subsequent quality of life. Results imply that the Army could improve in its career guidance and training programs and thus have an opportunity to make a significant improvement in the life planning activities of many of the nation's young people. One table and five figures supplement the discussion.