Mechanisms In Fibre Carcinogenesis

Author : Robert C. Brown,John A. Hoskins,Neil F. Johnson
Publisher : Springer Science & Business Media
Page : 564 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468413632

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Mechanisms in Fibre Carcinogenesis by Robert C. Brown,John A. Hoskins,Neil F. Johnson Pdf

The Editors are sorry that the production of this volume was delayed by the ill health of one of them and we hope that this does not detract from the value of the con tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.

Author : A. B. Kane
Publisher : Unknown
Page : 164 pages
File Size : 47,6 Mb
Release : 1996
Category : Cancer
ISBN : UCSD:31822018659532

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Mechanisms of Fibre Carcinogenesis by A. B. Kane Pdf

The result of a meeting held at IARC early in 1996, this volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposure and interactions with other carcinogens. The relevance of mechanistic data from in vitro and in vivo assays to the evaluation of fibre carcinogenicity are also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.

Author : A. B. Kane
Publisher : International Agency for Research on Cancer (I A R C)
Page : 166 pages
File Size : 40,6 Mb
Release : 1996
Category : Cancer
ISBN : 9283221400

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Mechanisms of Fibre Carcinogenesis by A. B. Kane Pdf

The result of a meeting held at IARC early in 1996, this volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposure and interactions with other carcinogens. The relevance of mechanistic data fromin vitroandin vivoassays to the evaluation of fibre carcinogenicity are also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.

Author : Yin-Tak Woo,David Y. Lai,Joseph C. Arcos
Publisher : Academic Press
Page : 898 pages
File Size : 48,9 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483216027

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Natural, Metal, Fiber, and Macromolecular Carcinogens by Yin-Tak Woo,David Y. Lai,Joseph C. Arcos Pdf

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered. The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.

Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400925267

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Mechanisms of Carcinogenesis by Elizabeth K. Weisburger Pdf

but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

Author : Patricia A. Buffler
Publisher : IARC Scientific Publications
Page : 464 pages
File Size : 49,8 Mb
Release : 2004
Category : Medical
ISBN : UCSD:31822032522062

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Mechanisms of Carcinogenesis by Patricia A. Buffler Pdf

During the last two decades, molecular epidemiology has become an important discipline in cancer research. It has evolved towards the development, validation and application of markers of susceptibility and, more recently, markers of mechanisms of cancer development. This volume on mechanisms of carcinogenesis covers from an interdisciplinary perspective, the contribution of molecular epidemiology to the understanding of mechanisms of carcinogenesis, and represents a further contribution to the development of molecular epidemiology as a major cancer research domain.

Author : Giorgio Bronzetti,Hikoya Hayatsu,Silvio De Flora,Michael D. Waters,Delbert M. Shankel
Publisher : Springer
Page : 0 pages
File Size : 55,6 Mb
Release : 2012-11-02
Category : Medical
ISBN : 1461362997

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Antimutagenesis and Anticarcinogenesis Mechanisms III by Giorgio Bronzetti,Hikoya Hayatsu,Silvio De Flora,Michael D. Waters,Delbert M. Shankel Pdf

Lifestyle, in any part of the world, is associated with the occurrence of major chronic diseases, including coronary heart disease, hypertension, and stroke; many distinct types of cancer; and adult onset diabetes (11,22,70,75). One important element of lifestyle is tobacco use, which appreciably increases the risk of a number of chronic diseases (21). Other lifestyle factors relate to nutritional traditions, alcohol use, and exercise (11,30,58,60,70,71). The underlying evidence is, in part, based on the evidence of specific diseases in relation to dietary habits in a given geographic region, as well as changes in such disease occurrences in migrant populations from a low risk to a high risk area, and vice versa (25,42). Populations that customarily consume fruits and vegetables and also whole grain cereal products generally have a lower risk of cardiovascular diseases and specific types of cancer than populations with a lower intake of such foods, everything else being equal (63). In the last few years, research has provided mechanistic explanations as to the reasons for the protective effects of specific foods. This paper will emphasize the mechanisms whereby cancer risks are reduced by dietary modification.

Author : J H Duffus
Publisher : Woodhead Publishing
Page : 296 pages
File Size : 44,7 Mb
Release : 2014-01-31
Category : Technology & Engineering
ISBN : 9781782424413

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Carcinogenicity of Inorganic Substances by J H Duffus Pdf

Focuses on the state of scientific knowledge about the carcinogenicity of metals, their compounds and other inorganic substances. It provides a valuable guide for chemists involved in risk assessment, health and safety and toxicology.

Author : Lewis L. Smith,Francesco De Matteis
Publisher : CRC Press
Page : 235 pages
File Size : 49,6 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000006001

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Molecular and Cellular Mechanisms of Toxicity by Lewis L. Smith,Francesco De Matteis Pdf

First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 44,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Joseph C. Arcos
Publisher : Unknown
Page : 869 pages
File Size : 49,8 Mb
Release : 1968
Category : Carcinogenesis
ISBN : 012059353X

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Chemical Induction of Cancer by Joseph C. Arcos Pdf

Author : Harri Vainio
Publisher : Unknown
Page : 644 pages
File Size : 55,5 Mb
Release : 1992
Category : Medical
ISBN : UCSD:31822008176695

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Mechanisms of Carcinogenesis in Risk Identification by Harri Vainio Pdf

This comprehensive, authoritative volume includes a consensus document drawn up by a working group of international experts in various fields of carcinogenesis. It describes the multistage and multifactorial nature of carcinogenesis, the different mechanisms of action of carcinogens, epidemiological and laboratory means for their identification, and proposed principles and procedures for their possible use in the prediction and evaluation of carcinogenic risks to humans. Other chapters cover critical molecular targets in chemical carcinogenesis; mechanisms of carcinogenicity; animal carcinogenicity tests and their interpretations; biological markers in exposed humans; and data analysis and modelling. This work will be a valuable reference for cancer researchers and toxicologists.

Author : Anonim
Publisher : Unknown
Page : 342 pages
File Size : 47,9 Mb
Release : 1993
Category : Environmental health
ISBN : IND:30000143548901

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Environmental Health Perspectives by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 314 pages
File Size : 55,5 Mb
Release : 1994
Category : Air
ISBN : IND:30000143548711

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Biopersistence of Respirable Synthetic Fibers and Minerals by Anonim Pdf

Author : Leon P. Bignold
Publisher : Academic Press
Page : 468 pages
File Size : 48,5 Mb
Release : 2015-08-19
Category : Medical
ISBN : 9780128017531

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Principles of Tumors by Leon P. Bignold Pdf

Principles of Tumors covers all of the fundamental aspects of tumors, including their definitions, incidences, causation, pathogenesis, treatments, and prevention. The book provides a unique approach, integrating a wide range of basic bioscience findings with clinico-pathological observations and phenomena encountered in their treatment. As tumors are studied in fairly separate, broad areas, such as basic biological sciences, pathology, oncology, and epidemiology, this book brings together these perspectives, providing an all-inclusive text that benefits all researchers, while also providing an avenue for translational research. Integrates both cell mechanisms and tumor physiopathology Brings together research and perspectives from basic biological sciences, pathology, oncology, and epidemiology, providing an all-inclusive text Provides a concise tumor reference for the tumor researcher and oncologist Includes appendices for foundational material Brings out the cell detail of tumors