Mechanisms Of Adiponectin Action

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Mechanisms of Adiponectin Action

Tania Fiaschi
Mechanisms of Adiponectin Action Book PDF

Author : Tania Fiaschi
Publisher : MDPI
Page : 222 pages
File Size : 55,6 Mb
Release : 2019-07-26
Category : Medical
ISBN : 9783039212453

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Mechanisms of Adiponectin Action by Tania Fiaschi Pdf

The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.

Mechanisms of Adiponectin Action

Tania Fiaschi
Mechanisms of Adiponectin Action Book PDF

Author : Tania Fiaschi
Publisher : Unknown
Page : 222 pages
File Size : 40,9 Mb
Release : 2019
Category : Social sciences (General)
ISBN : 303921246X

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Mechanisms of Adiponectin Action by Tania Fiaschi Pdf

The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.

Mechanisms of Insulin Action

Alan R. Saltiel,Jeffrey E. Pessin
Mechanisms of Insulin Action Book PDF

Author : Alan R. Saltiel,Jeffrey E. Pessin
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 50,6 Mb
Release : 2007-10-05
Category : Medical
ISBN : 9780387722047

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Mechanisms of Insulin Action by Alan R. Saltiel,Jeffrey E. Pessin Pdf

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Polycystic Ovary Syndrome

Andrea Dunaif,R. Jeffrey Chang,Stephen Franks,Richard S. Legro
Polycystic Ovary Syndrome Book PDF

Author : Andrea Dunaif,R. Jeffrey Chang,Stephen Franks,Richard S. Legro
Publisher : Springer Science & Business Media
Page : 350 pages
File Size : 54,7 Mb
Release : 2008-01-12
Category : Medical
ISBN : 9781597451086

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Polycystic Ovary Syndrome by Andrea Dunaif,R. Jeffrey Chang,Stephen Franks,Richard S. Legro Pdf

This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.

Obesity and Lipotoxicity

Ayse Basak Engin,Atilla Engin
Obesity and Lipotoxicity Book PDF

Author : Ayse Basak Engin,Atilla Engin
Publisher : Springer
Page : 624 pages
File Size : 42,8 Mb
Release : 2017-06-05
Category : Science
ISBN : 9783319483825

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Obesity and Lipotoxicity by Ayse Basak Engin,Atilla Engin Pdf

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

Mitochondria in Obesity and Type 2 Diabetes

Beatrice Morio,Luc Penicaud,Michel Rigoulet
Mitochondria in Obesity and Type 2 Diabetes Book PDF

Author : Beatrice Morio,Luc Penicaud,Michel Rigoulet
Publisher : Academic Press
Page : 460 pages
File Size : 47,8 Mb
Release : 2019-04-26
Category : Science
ISBN : 9780128117521

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Mitochondria in Obesity and Type 2 Diabetes by Beatrice Morio,Luc Penicaud,Michel Rigoulet Pdf

Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Translational Research in Coronary Artery Disease

Wilbert S. Aronow,John Arthur McClung
Translational Research in Coronary Artery Disease Book PDF

Author : Wilbert S. Aronow,John Arthur McClung
Publisher : Academic Press
Page : 244 pages
File Size : 41,9 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780128026052

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Translational Research in Coronary Artery Disease by Wilbert S. Aronow,John Arthur McClung Pdf

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Epicardial Adipose Tissue

Gianluca Iacobellis
Epicardial Adipose Tissue Book PDF

Author : Gianluca Iacobellis
Publisher : Springer Nature
Page : 191 pages
File Size : 40,6 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9783030405700

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Epicardial Adipose Tissue by Gianluca Iacobellis Pdf

This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.

Hyperandrogenism in Women

R. Pasquali,D. Pignatelli
Hyperandrogenism in Women Book PDF

Author : R. Pasquali,D. Pignatelli
Publisher : Karger Medical and Scientific Publishers
Page : 201 pages
File Size : 50,6 Mb
Release : 2019-09-09
Category : Medical
ISBN : 9783318064711

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Hyperandrogenism in Women by R. Pasquali,D. Pignatelli Pdf

Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions.

The ASMBS Textbook of Bariatric Surgery

Ninh T. Nguyen,Stacy A. Brethauer,John M. Morton,Jaime Ponce,Raul J. Rosenthal
The ASMBS Textbook of Bariatric Surgery Book PDF

Author : Ninh T. Nguyen,Stacy A. Brethauer,John M. Morton,Jaime Ponce,Raul J. Rosenthal
Publisher : Springer Nature
Page : 654 pages
File Size : 46,7 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9783030270216

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The ASMBS Textbook of Bariatric Surgery by Ninh T. Nguyen,Stacy A. Brethauer,John M. Morton,Jaime Ponce,Raul J. Rosenthal Pdf

​The fully updated 2nd edition of this textbook continues to serve as a comprehensive guide for information dealing with the ever-evolving field of bariatric surgery. The chapters are written by experts in the field and include the most up-to-date information, including new sections on quality in bariatric surgery, endoscopic surgery, and management of bariatric complications. This new edition continues to cover the basic considerations for bariatric surgery, the currently accepted procedures, outcomes of bariatric surgery including long-term weight loss, improvement and resolution of comorbidities, and improvement in quality of life. Other special emphasis is given to the topics of metabolic surgery and surgery for patients with lower BMI. In addition, new endoscopic bariatric procedures including the gastric balloons, endoscopic revisional procedures, and newer pharmacotherapy for obesity are reviewed. The ASMBS Textbook of Bariatric Surgery Second Edition will continue to be a leading source of scientific information for surgeons, physicians, residents, students, and integrated health members today and for years to come.

Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals

Bashar Saad,Hilal Zaid,Siba Shanak,Sleman Kadan
Anti diabetes and Anti obesity Medicinal Plants and Phytochemicals Book PDF

Author : Bashar Saad,Hilal Zaid,Siba Shanak,Sleman Kadan
Publisher : Springer
Page : 257 pages
File Size : 49,8 Mb
Release : 2017-05-11
Category : Technology & Engineering
ISBN : 9783319541020

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Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals by Bashar Saad,Hilal Zaid,Siba Shanak,Sleman Kadan Pdf

This work presents a systematic review of traditional herbal medicine and their active compounds, as well as their mechanism of action in the prevention and treatment of diabetes and obesity. The side effects and safety of herbal-derived anti-diabetic and anti-obesity phytochemicals are detailed in depth, and the text has a strong focus on current and future trends in anti-diabetic medicinal plants. This unique and comprehensive text is the only current book on the market focusing exclusively on medicinal plants used to combat obesity and diabetes. An introductory chapter focuses on diabetes and obesity and introduces the major causes and main treatments of this increasing epidemic in modern society. Readers are then introduced to medicinal plants, including details on their therapeutic aspects, plus side effects and safety. Following chapters focus on anti-diabetic and anti-obesity medicinal plants, as well as phytogenic natural products in the treatment of each. The text closes by focusing on present and future trends and challenges in these medicinal plants. Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals: Safety, Efficacy, and Action Mechanisms is a much-needed and truly original work, finally presenting in one place all the necessary information on medicinal plants used in conjunction with obesity and diabetes prevention.

Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

Helmut Sies
Oxidative Stress and Inflammatory Mechanisms in Obesity Diabetes and the Metabolic Syndrome Book PDF

Author : Helmut Sies
Publisher : CRC Press
Page : 344 pages
File Size : 52,8 Mb
Release : 2007-07-27
Category : Medical
ISBN : 142004379X

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Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome by Helmut Sies Pdf

Characterized by obesity, insulin resistance, dyslipidemia, and hypertension, metabolic syndrome is associated with the risks of type 2 diabetes mellitus and cardiovascular disease. Obesity, which increases the incidence of atherosclerotic cardiovascular disease and subsequently leads to increased stress and inflammation, appears to play a central role in the progression of the syndrome. Evidence of inflammatory processes in accumulated fat appears to be an early initiator of metabolic syndrome. Likewise, the more active angiotensin system in obesity may contribute to even greater oxidative stress that serves as a key signaling event in vascular remodeling. These factors strengthen obesity's association with oxidative stress. Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome is designed to encourage the development of evidence-based nutritional and pharmacological therapies that can attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome. The book offers a deep understanding of the molecular mechanisms that underlie the process. Edited by leading authorities on oxidative stress, the book's chapters report on cutting-edge research that explores intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and type 2 diabetes. It also brings together research on the molecular mechanisms inherent in the progression of metabolic stress, includes phenotypic perspectives, and discusses dietary factors, including the role of micronutrients. The chapter authors, each a leading expert in his or her field, discuss different components of metabolic stress and obesity and their associations with oxidative stress and inflammation. The book fills a unique role as a base of knowledge for researchers seeking to develop nutritional and or pharmacological therapies, as well as clinicians seeking a better understanding of this increasingly common disease process.

Obesity and Gynecology

Tahir A. Mahmood,Sabaratnam Arulkumaran,Frank A. Chervenak
Obesity and Gynecology Book PDF

Author : Tahir A. Mahmood,Sabaratnam Arulkumaran,Frank A. Chervenak
Publisher : Elsevier
Page : 353 pages
File Size : 41,8 Mb
Release : 2020-06-11
Category : Medical
ISBN : 9780128179208

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Obesity and Gynecology by Tahir A. Mahmood,Sabaratnam Arulkumaran,Frank A. Chervenak Pdf

Obesity and Gynecology, Second Edition, presents updated chapters on a variety of topics, ranging from adolescent obesity, contraception, assisted reproduction and sexual dysfunction, to bariatric surgery and improving semen parameters. The prevalence of obesity in men and women continues to dramatically increase around the world. Obesity presents specific challenges in relation to male and female infertility and general gynecology. Patients who are obese require specific considerations and knowledge. Presents an essential reference on the significant risks of obesity related to contraception, male and female infertility, and general gynecology Builds foundational knowledge, showing how obesity relates to general gynecology, including menstrual disorders, breasts cancer, menopause and sexual dysfunction Assembles critically evaluated chapters that focus on obesity and gynecology to meet the practical needs of gynecologists, endocrinologists and general practitioners

Obesity and Metabolism

Márta Korbonits
Obesity and Metabolism Book PDF

Author : Márta Korbonits
Publisher : Karger Medical and Scientific Publishers
Page : 305 pages
File Size : 42,6 Mb
Release : 2008-01-01
Category : Medical
ISBN : 9783805584296

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Obesity and Metabolism by Márta Korbonits Pdf

It has become increasingly difficult to keep up with the growing body of literature on the genetics, metabolic phenotype and treatment of obesity. This volume brings together an array of chapters from many of the foremost authorities and researchers in this area. Key advances in the genetics of obesity are summarized and the effects of obesity in pregnancy, childhood and old age explored. By scrutinizing the hormones and enzymes most recently implicated in the development, maintenance and consequences of obesity, the biochemical and physiological background of the abnormal metabolism of obesity is mapped out. Furthermore, a practical update on clinical approach and treatment of obesity is offered. Finally, the social aspects of obesity and the view of the obese body in art throughout the centuries are reflected. A valuable overview of causes, metabolic disturbances and treatment options, this volume will appeal to those with an interest in clinical as well as pathophysiological and genetic aspects of obesity. Furthermore, it will provide useful reading for scientists and students who would like to broaden and update their knowledge in this area.

Drosophila Models for Human Diseases

Masamitsu Yamaguchi
Drosophila Models for Human Diseases Book PDF

Author : Masamitsu Yamaguchi
Publisher : Springer
Page : 308 pages
File Size : 43,5 Mb
Release : 2018-06-27
Category : Medical
ISBN : 9789811305290

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Drosophila Models for Human Diseases by Masamitsu Yamaguchi Pdf

Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.