Obesity And Lipotoxicity

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Obesity and Lipotoxicity

Ayse Basak Engin,Atilla Engin
Obesity and Lipotoxicity Book PDF

Author : Ayse Basak Engin,Atilla Engin
Publisher : Springer
Page : 624 pages
File Size : 54,9 Mb
Release : 2017-06-05
Category : Science
ISBN : 9783319483825

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Obesity and Lipotoxicity by Ayse Basak Engin,Atilla Engin Pdf

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

Fatty Acid and Lipotoxicity in Obesity and Diabetes

Gregory R. Bock,Jamie A. Goode
Fatty Acid and Lipotoxicity in Obesity and Diabetes Book PDF

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 222 pages
File Size : 41,7 Mb
Release : 2008-03-11
Category : Medical
ISBN : 0470985569

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Fatty Acid and Lipotoxicity in Obesity and Diabetes by Gregory R. Bock,Jamie A. Goode Pdf

The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Obesity

Amelia Marti del Moral,Concepcion M. Aguilera
Obesity Book PDF

Author : Amelia Marti del Moral,Concepcion M. Aguilera
Publisher : Academic Press
Page : 304 pages
File Size : 50,5 Mb
Release : 2018-08-10
Category : Medical
ISBN : 9780128125052

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Obesity by Amelia Marti del Moral,Concepcion M. Aguilera Pdf

Obesity: Oxidative Stress and Dietary Antioxidants cover the science of oxidative stress in obesity and associated conditions, including metabolic syndrome, bariatric surgery, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are not described in isolation, but in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is but a single component. The book is designed for nutritionists, dietitians, food scientists, physicians and clinical workers, health care workers and research scientists. Covers the basic processes of oxidative stress, from molecular biology, to whole organs Highlights antioxidants in foods, including plants and other components of diet Provides the framework for further, in-depth analysis or studies via well-designed clinical trials or via the analysis of pathways, mechanisms and componentsa

Fat Detection

Jean-Pierre Montmayeur,Johannes le Coutre
Fat Detection Book PDF

Author : Jean-Pierre Montmayeur,Johannes le Coutre
Publisher : CRC Press
Page : 643 pages
File Size : 47,8 Mb
Release : 2009-09-14
Category : Science
ISBN : 1420067761

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Fat Detection by Jean-Pierre Montmayeur,Johannes le Coutre Pdf

Presents the State-of-the-Art in Fat Taste Transduction A bite of cheese, a few potato chips, a delectable piece of bacon – a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the sensory appeal of foods rich in fat. This well-researched text uses a multidisciplinary approach to shed new light on critical concerns related to dietary fat and obesity. Outlines Compelling Evidence for an Oral Fat Detection System Reflecting 15 years of psychophysical, behavioral, electrophysiological, and molecular studies, this book makes a well-supported case for an oral fat detection system. It explains how gustatory, textural, and olfactory information contribute to fat detection using carefully designed behavioral paradigms. The book also provides a detailed account of the brain regions that process the signals elicited by a fat stimulus, including flavor, aroma, and texture. This readily accessible work also discusses: The importance of dietary fats for living organisms Factors contributing to fat preference, including palatability Brain mechanisms associated with appetitive and hedonic experiences connected with food consumption Potential therapeutic targets for fat intake control Genetic components of human fat preference Neurological disorders and essential fatty acids Providing a comprehensive review of the literature from the leading scientists in the field, this volume delivers a holistic view of how the palatability and orosensory properties of dietary fat impact food intake and ultimately health. Fat Detection represents a new frontier in the study of food perception, food intake, and related health consequences.

Nutrition in the Prevention and Treatment of Abdominal Obesity

Ronald Ross Watson
Nutrition in the Prevention and Treatment of Abdominal Obesity Book PDF

Author : Ronald Ross Watson
Publisher : Elsevier
Page : 560 pages
File Size : 45,9 Mb
Release : 2014-02-26
Category : Medical
ISBN : 9780124079342

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Nutrition in the Prevention and Treatment of Abdominal Obesity by Ronald Ross Watson Pdf

Nutrition in the Prevention and Treatment of Abdominal Obesity focuses on the important roles that exercise, dietary changes, and foods play in promoting as well as reducing visceral fat. Nutritionists, dieticians, and healthcare providers seeking to address the abdominal obesity epidemic will use this comprehensive resource as a tool in their long-term goal of preventing chronic diseases, especially heart, vascular, and diabetic diseases. Experts from a broad range of disciplines are involved in dealing with the consequences of excessive abdominal fat: cardiology, diabetes research, studies of lipids, endocrinology and metabolism, nutrition, obesity, and exercise physiology. They have contributed chapters that define a range of dietary approaches to reducing risk and associated chronic diseases. They begin by defining visceral obesity and its major outcomes; they also discuss the importance and the challenges of dietary approaches to reduce abdominal obesity, as compared to clinical approaches, with major costs and risks. Offers detailed, well-documented reviews outlining the various dietary approaches to visceral obesity with their benefits and failures Includes chapters on types of foods, exercise, and supplements in reducing obesity and its chronic clinical companions, especially diabetes and cardiovascular disease Helps nutritionists, dieticians, and healthcare providers approach patients in making decision about nutritional therapies and clinical treatments for abdominal obesity, from an evidence-based perspective

Overweight and the Metabolic Syndrome:

George A. Bray,Louisiana State University,Donna Ryan
Overweight and the Metabolic Syndrome Book PDF

Author : George A. Bray,Louisiana State University,Donna Ryan
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 47,9 Mb
Release : 2007-02-16
Category : Medical
ISBN : 9780387321646

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Overweight and the Metabolic Syndrome: by George A. Bray,Louisiana State University,Donna Ryan Pdf

This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The volume covers evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.

Metabolic Cardiomyopathy

H. Böhles,A. C. Sewell
Metabolic Cardiomyopathy Book PDF

Author : H. Böhles,A. C. Sewell
Publisher : CRC Press
Page : 188 pages
File Size : 54,9 Mb
Release : 2004
Category : Cardiomyopathy
ISBN : 3887631048

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Metabolic Cardiomyopathy by H. Böhles,A. C. Sewell Pdf

During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.

Innovative Medicine

Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Innovative Medicine Book PDF

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 51,9 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Mechanisms of Adiponectin Action

Tania Fiaschi
Mechanisms of Adiponectin Action Book PDF

Author : Tania Fiaschi
Publisher : MDPI
Page : 222 pages
File Size : 47,9 Mb
Release : 2019-07-26
Category : Medical
ISBN : 9783039212453

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Mechanisms of Adiponectin Action by Tania Fiaschi Pdf

The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.

Obesity-induced inflammation and insulin resistance

Tsuguhito Ota
Obesity induced inflammation and insulin resistance Book PDF

Author : Tsuguhito Ota
Publisher : Frontiers Media SA
Page : 121 pages
File Size : 55,6 Mb
Release : 2015-03-26
Category : Diseases of the endocrine glands. Clinical endocrinology
ISBN : 9782889194285

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Obesity-induced inflammation and insulin resistance by Tsuguhito Ota Pdf

Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the innate immune system with subsequent recruitment of immune cells such as macrophages and T cells, which contributes to the development of insulin resistance. In particular, a significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). ATMs are a prominent source of proinflammatory cytokines, such as TNF-a and IL-6, that can block insulin action in adipose tissue, skeletal muscle, and liver autocrine/paracrine signaling and cause systemic insulin resistance via endocrine signaling, providing a potential link between inflammation and insulin resistance. All articles in this topic highlight the interconnection between obesity, inflammation, and insulin resistance in all its diversity to the mechanisms of obesity-induced inflammation and role of immune system in the pathogenesis of insulin resistance and diabetes.

Obesity and Diabetes

Christos S. Mantzoros
Obesity and Diabetes Book PDF

Author : Christos S. Mantzoros
Publisher : Springer Science & Business Media
Page : 553 pages
File Size : 54,5 Mb
Release : 2007-11-16
Category : Medical
ISBN : 9781592599851

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Obesity and Diabetes by Christos S. Mantzoros Pdf

International experts from world-renowned medical schools comprehensively review for practicing clinicians and scientists alike the latest understanding of the epidemiology, causation, and consequences of diabetes and obesity. The authors discuss in detail their diagnosis, clinical manifestations, complications, and best practices for diagnosis and treatment. They also review the history and epidemiology of these conditions, explain their genetics and pathophysiology, and illuminate their known mechanisms and interactions. State-of-the-art survey-chapters critique current approaches (lifestyle and pharmacological) to the treatment of these conditions.

Obesity

Robert H. Eckel
Obesity Book PDF

Author : Robert H. Eckel
Publisher : Lippincott Williams & Wilkins
Page : 624 pages
File Size : 50,6 Mb
Release : 2003
Category : Medical
ISBN : 0781728444

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Obesity by Robert H. Eckel Pdf

Written by an international group of leading experts on obesity and related disorders, this volume is the first to address the clinical aspects of obesity. The contributors review the latest clinically relevant findings on the etiology and pathophysiology of obesity, examine the full spectrum of comorbid conditions and complications, and discuss the role of drugs, behavioral interventions, exercise, and surgery in treatment of obesity. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Male Infertility

Sijo J. Parekattil,Sandro C. Esteves,Ashok Agarwal
Male Infertility Book PDF

Author : Sijo J. Parekattil,Sandro C. Esteves,Ashok Agarwal
Publisher : Springer Nature
Page : 895 pages
File Size : 54,6 Mb
Release : 2020-01-24
Category : Health & Fitness
ISBN : 9783030323004

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Male Infertility by Sijo J. Parekattil,Sandro C. Esteves,Ashok Agarwal Pdf

A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book’s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.

Cellular and Biochemical Mechanisms of Obesity

Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Cellular and Biochemical Mechanisms of Obesity Book PDF

Author : Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 420 pages
File Size : 42,9 Mb
Release : 2021-12-15
Category : Medical
ISBN : 9783030847630

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Cellular and Biochemical Mechanisms of Obesity by Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla Pdf

Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood. Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.

Pathophysiology of Obesity-Induced Health Complications

Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Pathophysiology of Obesity Induced Health Complications Book PDF

Author : Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla
Publisher : Springer Nature
Page : 348 pages
File Size : 48,6 Mb
Release : 2020-01-17
Category : Medical
ISBN : 9783030353582

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Pathophysiology of Obesity-Induced Health Complications by Paramjit S. Tappia,Bram Ramjiawan,Naranjan S. Dhalla Pdf

​According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The first section serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.