Mechanisms Of Cerebral Hypoxia And Stroke

Author : G. Somjen
Publisher : Springer Science & Business Media
Page : 474 pages
File Size : 50,6 Mb
Release : 2013-03-13
Category : Science
ISBN : 9781468455625

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Mechanisms of Cerebral Hypoxia and Stroke by G. Somjen Pdf

The articles and short communications in this volume are based on papers pre sented to the Symposium on Cerebral Hypoxia and Stroke held in Budapest in August of 1987. Besides participants at the meeting, three scientists who were invited but could not attend have also contributed chapters to this volume. A synopsis of the general discussion at the conference and a review chapter conclude this volume. To the readers of this book it will not be news that stroke is a worldwide problem. Efforts to cope with this often devastating condition are worldwide also, as attested by the international membership of the conference. It has been said of oxygen deficiency that it not only stops the machine, it also wrecks the machinery. The paramount question in stroke research is this: why can't the brain be restarted after a hypoxic episode in much the same manner as a motor car can when its gas tank is refilled after it stalled because it ran out of fuel? Participants at the Symposium had been requested in advance of the meeting to especially consider a series of specific questions in relation to this general problem. Among these specific questions were: the mechanism of synaptic blockade in hypoxic brain tissue; the transition from reversible to irreversible arrest of function; the nature of postischemic (delayed) cell death; the possible basic differences in the consequences of hypoxia and ischemia; and actual and potential approaches to the prevention and treatment of cell damage in hypoxia and stroke.

Author : G. Somjen
Publisher : Unknown
Page : 488 pages
File Size : 49,8 Mb
Release : 1988-11-01
Category : Electronic
ISBN : 146845563X

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Mechanisms of Cerebral Hypoxia and Stroke by G. Somjen Pdf

Author : Gabriel G. Haddad,Shan Ping Yu
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 40,7 Mb
Release : 2009-01-06
Category : Medical
ISBN : 9781603275798

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Brain Hypoxia and Ischemia by Gabriel G. Haddad,Shan Ping Yu Pdf

Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.

Author : Eetu Hämäläinen
Publisher : Nova Publishers
Page : 332 pages
File Size : 54,6 Mb
Release : 2008
Category : Medical
ISBN : 1604561408

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New Trends in Brain Hypoxia Ischemia Research by Eetu Hämäläinen Pdf

This book presents recent and significant research from around the world dedicated to brain hypoxia-ischemia which is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain edema; coma; and other conditions.

Author : Océane M. Roux
Publisher : Nova Publishers
Page : 314 pages
File Size : 50,6 Mb
Release : 2008
Category : Cerebral anoxia
ISBN : 1604561394

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Brain Hypoxia-Ischemia Research Progress by Océane M. Roux Pdf

Brain hypoxia-ischemia is a disorder characterised by a reduction in oxygen supply (hypoxia) combined with reduced blood flow (ischemia) to the brain. This condition may result from a localised obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ischemic attack, transient; brain infarction; brain oedema; coma; and other conditions. This book presents the latest research in this field from around the world.

Author : Chung Y. Hsu
Publisher : Karger Medical and Scientific Publishers
Page : 176 pages
File Size : 43,5 Mb
Release : 1998
Category : Medical
ISBN : 9783805565608

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Ischemic Stroke by Chung Y. Hsu Pdf

'... Provides an admirable review of current knowledge regarding experimental stroke research, and outlines the problems and some solutions in the clinical application of such knowledge.'

Author : Marilyn J. Cipolla
Publisher : Biota Publishing
Page : 82 pages
File Size : 54,8 Mb
Release : 2016-07-28
Category : Medical
ISBN : 9781615047239

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The Cerebral Circulation by Marilyn J. Cipolla Pdf

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Author : R. Gilberto González,Joshua A. Hirsch,Michael H. Lev,Pamela W. Schaefer,Lee H. Schwamm
Publisher : Springer Science & Business Media
Page : 299 pages
File Size : 53,8 Mb
Release : 2010-10-05
Category : Medical
ISBN : 9783642127519

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Acute Ischemic Stroke by R. Gilberto González,Joshua A. Hirsch,Michael H. Lev,Pamela W. Schaefer,Lee H. Schwamm Pdf

This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.

Author : P.L. Lutz,Göran E. Nilsson,H.M. Prentice
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 40,8 Mb
Release : 2003-02-28
Category : Medical
ISBN : 1402011652

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The Brain Without Oxygen by P.L. Lutz,Göran E. Nilsson,H.M. Prentice Pdf

It is well known and researched, that deprivation of oxygen to the brain can quickly result in irreversible damage and death. What is less well known, is that some vertebrate species are exceptionally tolerant of brain hypoxia. The Brain Without Oxygen: Causes of failure - Physiological and molecular mechanisms for survival, Third edition, discusses the mechanisms of brain hypoxia tolerance in these exceptional vertebrates, which include diving marine mammals, high altitude dwellers and the hibernating mammal. Special attention is given to the extraordinary adaptations that allow a few turtle and fish species to tolerate months of brain anoxia. This third, fully updated edition addresses the potential of these animal models as targets for human clinical intervention. Perhaps the most interesting of these, are those involved in the suppression of metabolic activities to new set points well below their normoxic minima or maintenance levels. This volume will be valuable reading for researchers in physiology, medicine and general biological sciences, and of great importance to pharmaceutical companies researching novel models for stroke and brain ischemia.

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 42,5 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : Michael Brainin,Wolf-Dieter Heiss,Susanne Tabernig
Publisher : Cambridge University Press
Page : 425 pages
File Size : 55,6 Mb
Release : 2014-09-11
Category : Medical
ISBN : 9781107047495

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Textbook of Stroke Medicine by Michael Brainin,Wolf-Dieter Heiss,Susanne Tabernig Pdf

Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.

Author : S. Andrew Josephson,W. David Freeman,David J. Likosky
Publisher : Cambridge University Press
Page : 128 pages
File Size : 45,8 Mb
Release : 2011-09-29
Category : Medical
ISBN : 9781139501828

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Neurohospitalist Medicine by S. Andrew Josephson,W. David Freeman,David J. Likosky Pdf

Over the past decade, the hospitalist model has become a dominant system for the delivery of inpatient care. Forces such as national mandates to improve safety and quality, and intense pressure to safely reduce length of hospital stays, are now exerting pressure on neurologists. To meet these challenges, a new neurohospitalist model is emerging. This is the first authoritative text to detail the advances and strategies for treating neurologic disease in a hospital setting. It includes chapters on specific acute neurologic diseases including stroke, epilepsy, neuromuscular disease and traumatic brain injury and also addresses common reasons for neurologic consultation in the hospital including encephalopathy, electrolyte disturbances and neurologic complications of pregnancy. Ethical and structural issues commonly encountered in neurologic inpatients are also addressed. This will be a key resource for any clinician or trainee caring for neurologic patients in the hospital including practising neurologists, internists and trainees across multiple subspecialities.

Author : Michel T. Torbey,Magdy H. Selim
Publisher : Cambridge University Press
Page : 395 pages
File Size : 41,5 Mb
Release : 2013-07-18
Category : Medical
ISBN : 9781107634725

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The Stroke Book by Michel T. Torbey,Magdy H. Selim Pdf

An essential companion for busy professionals seeking to navigate stroke-related clinical situations successfully and make quick informed treatment decisions.

Author : Basil F. Matta,David K. Menon,Martin Smith
Publisher : Cambridge University Press
Page : 128 pages
File Size : 48,7 Mb
Release : 2011-10-13
Category : Medical
ISBN : 9781139499859

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Core Topics in Neuroanaesthesia and Neurointensive Care by Basil F. Matta,David K. Menon,Martin Smith Pdf

Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.

Author : David R. Dantzker
Publisher : Philadelphia : Saunders
Page : 888 pages
File Size : 49,5 Mb
Release : 1991
Category : Medical
ISBN : UOM:39015019841470

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Cardiopulmonary Critical Care by David R. Dantzker Pdf

Explores the spectrum of topics important to the treatment of critically ill patients with cardiac and respiratory failure, including in-depth discussions on pathophysiologic principles, approaches to therapy and individual disorders. Ethical and legal aspects are also considered.