Mechanisms Of Drug Interactions

Author : Patrick F. D'Arcy,James C. McElnay,Peter G. Welling
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642610158

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Mechanisms of Drug Interactions by Patrick F. D'Arcy,James C. McElnay,Peter G. Welling Pdf

Over the years a number of excellent books have classified and detailed drug drug interactions into their respective categories, e.g. interactions at plasma protein binding sites; those altering intestinal absorption or bioavailability; those involving hepatic metabolising enzymes; those involving competition or antagonism for receptor sites, and drug interactions modifying excretory mechanisms. Such books have presented extensive tables of interactions and their management. Although of considerable value to clinicians, such publica tions have not, however, been so expressive about the individual mechanisms that underlie these interactions. It is within this sphere of "mechanisms" that this present volume specialises. It deals with mechanisms of in vitro and in vivo, drug-drug, drug food and drug-herbals interactions and those that cause drugs to interfere with diagnostic laboratory tests. We believe that an explanation of the mechanisms of such interactions will enable practitioners to understand more fully the nature of the interactions and thus enable them to manage better their clinical outcome. If mechanisms of interactions are better understood, then it may be pos sible for the researcher to develop meaningful animal/biochemical/tissue cul ture or physicochemical models to which new molecules could be exposed during their development stages. The present position, which largely relies on patients experiencing adverse interactions before they can be established or documented, can hardly be regarded as satisfactory. This present volume is classified into two major parts; firstly, pharmacoki netic drug interactions and, secondly, pharmacodynamic drug interactions.

Author : A. John Camm
Publisher : Unknown
Page : 3198 pages
File Size : 45,7 Mb
Release : 2019
Category : Cardiology
ISBN : 0198824874

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The ESC Textbook of Cardiovascular Medicine by A. John Camm Pdf

Author : Gerard Marshall Raj,Ramasamy Raveendran
Publisher : Springer Nature
Page : 410 pages
File Size : 54,8 Mb
Release : 2019-11-16
Category : Medical
ISBN : 9789813297791

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Introduction to Basics of Pharmacology and Toxicology by Gerard Marshall Raj,Ramasamy Raveendran Pdf

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Author : Stephen C. Piscitelli,Keith A. Rodvold,Manjunath P. Pai
Publisher : Springer Science & Business Media
Page : 692 pages
File Size : 50,5 Mb
Release : 2011-09-08
Category : Medical
ISBN : 1617792136

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Drug Interactions in Infectious Diseases by Stephen C. Piscitelli,Keith A. Rodvold,Manjunath P. Pai Pdf

The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The third edition features five new chapters that cover material not addressed in previous editions. These new chapters describe interactions with a number of drug classes such as non-HIV antiviral, antimalarial, antiparasitic, antihelmintic, macrolide, azalide and ketolide agents. A novel chapter on probe cocktail studies has been included to highlight an important research tool for drug development. These chapters address material that cannot be retrieved easily in the medical literature. The highly acclaimed food-drug interactions as well as the study design and analysis chapters remain definitive references. The newly written drug-cytokine interaction highlights the need for our improved understanding of the complex interrelationship of acute infection, inflammation, and the risk of drug interactions. Informative tables on specific drug-drug interactions are provided throughout the chapters as a quick clinical resource. The Third Edition of Drug Interactions in Infectious Diseases is a distillation of relevant drug interactions associated with antimicrobials, infection, and inflammation. This concise review of the mechanisms and strategies to manage drug interactions should be valuable to all health care practitioners. Features • Definitive reference source of up-to-date information on antimicrobial drug interactions • Informative tables on the degree of interaction for specific antimicrobial agents • In-depth discussion of mechanisms and potential mechanistic pathways of interaction • New chapters on non-HIV antiviral, antimalarial, antiparasitic, and macrolide, azalide and ketolide agents • New chapter on probe-cocktail studies as a research tool to study drug-drug interactions • Inclusion of new antimicrobial agents and their associated drug interactions • First rate chapters on study design and analysis, and drug-food interactions • A fresh perspective on drug-cytokine interactions • Authoritative chapter on regulatory considerations of drug interactions during drug development

Author : H.Gerhard Vogel,Jochen Maas,Alexander Gebauer
Publisher : Springer Science & Business Media
Page : 576 pages
File Size : 50,8 Mb
Release : 2010-12-15
Category : Medical
ISBN : 9783540898900

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Drug Discovery and Evaluation: Methods in Clinical Pharmacology by H.Gerhard Vogel,Jochen Maas,Alexander Gebauer Pdf

Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Author : Ivan H. Stockley
Publisher : Unknown
Page : 82 pages
File Size : 52,5 Mb
Release : 1973
Category : Electronic
ISBN : OCLC:174643509

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Drug Interactions and Their Mechanisms by Ivan H. Stockley Pdf

Author : Ashraf Mozayani,Lionel Raymon
Publisher : Springer Science & Business Media
Page : 662 pages
File Size : 53,5 Mb
Release : 2003-10-15
Category : Medical
ISBN : 9781592596546

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Handbook of Drug Interactions by Ashraf Mozayani,Lionel Raymon Pdf

A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents. Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.

Author : John Parry Griffin,Patrick Francis D'Arcy
Publisher : Butterworth-Heinemann
Page : 444 pages
File Size : 45,6 Mb
Release : 1984
Category : Drug antagonism
ISBN : UOM:39015007123493

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A Manual of Adverse Drug Interactions by John Parry Griffin,Patrick Francis D'Arcy Pdf

Author : Markus Müller
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 54,7 Mb
Release : 2011-02-04
Category : Medical
ISBN : 9783709101445

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Clinical Pharmacology: Current Topics and Case Studies by Markus Müller Pdf

Today we witness an eventful time in which the powerful new forces of genomics, information technology and economics are rapidly changing the science and art of medicine. This will require more specialization than ever before. However, there is also an increasing demand for an integrated approach, which is provided by the discipline of Clinical Pharmacology (CP). CP pursues a scientific goal by studying drug action in patients and volunteers, a clinical goal by administering appropriate drug therapy and a regulatory goal by assessing the risk/benefit ratio of drug candidates in drug development and reimbursement. This introduction to current topics of CP covers traditional topics of clinical drug research and trial methodology but also provides insight in current topics like genomics, imaging technology and issues in drug reimbursement. A number of concrete case studies in clinical drug research and development help to give a better understanding of the general principles of CP.

Author : Ivan H. Stockley
Publisher : Unknown
Page : 1018 pages
File Size : 50,8 Mb
Release : 1996
Category : Drug interactions
ISBN : UOM:39015040153960

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Drug Interactions by Ivan H. Stockley Pdf

This is a source book of adverse drug reactions covering their clinical importance, mechanisms and management. This fourth edition has been revised from an extensive database. Major interaction mechanisms are followed by alphabetically-arranged material covering all the drug groups. As with prior editions, there is a series of monographs with a consistent plan devised to offer quick and easy reading. Both British and American drug names have been used throughout the book and bibliogrpahies are provided for those who wish to use the book as a reference source.

Author : A. David Rodrigues
Publisher : CRC Press
Page : 769 pages
File Size : 55,5 Mb
Release : 2019-01-03
Category : Medical
ISBN : 9780849375941

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Drug-Drug Interactions by A. David Rodrigues Pdf

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes

Author : Honghui Zhou,Bernd Meibohm
Publisher : John Wiley & Sons
Page : 378 pages
File Size : 44,8 Mb
Release : 2013-05-10
Category : Medical
ISBN : 9781118630211

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Drug-Drug Interactions for Therapeutic Biologics by Honghui Zhou,Bernd Meibohm Pdf

Strategize, plan, and execute comprehensive drug-druginteraction assessments for therapeutic biologics Offering both theory and practical guidance, this book fullyexplores drug-drug interaction assessments for therapeuticbiologics during the drug development process. It draws togetherand analyzes all the latest findings and practices in order topresent our current understanding of the topic and point the way tonew research. Case studies and examples, coupled with expertadvice, enable readers to better understand the complex mechanismsof biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics featurescontributions from leading international experts in all areas oftherapeutic biologics drug development and drug-drug interactions.The authors' contributions reflect a thorough review and analysisof the literature as well as their own firsthand laboratoryexperience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small moleculesand other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment andprediction Risk-based strategies for evaluating biologic drug-druginteractions Strategies to minimize drug-drug interaction risk and mitigatetoxic interactions Key regulations governing drug-drug interaction assessments fortherapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics isrecommended for pharmaceutical and biotechnology scientists,clinical pharmacologists, medicinal chemists, and toxicologists. Byenabling these readers to understand how therapeutic biologics mayinteract with other drugs, the book will help them develop safer,more effective therapeutic biologics.

Author : Wen Xie
Publisher : Academic Press
Page : 294 pages
File Size : 48,5 Mb
Release : 2016-09-12
Category : Medical
ISBN : 9780128029633

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Drug Metabolism in Diseases by Wen Xie Pdf

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Author : Howard Rogers,Roy G. Spector
Publisher : Elsevier
Page : 420 pages
File Size : 55,9 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483195513

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An Introduction to Mechanisms in Pharmacology and Therapeutics by Howard Rogers,Roy G. Spector Pdf

An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, but it is not meant to replace existing pharmacology textbooks. It also attempts to show the connection between cell biology and the practice of clinical medicine. This book is organized into 13 chapters that discuss drug-receptor interactions and the influence of drugs on the nervous, respiratory, circulatory, and alimentary systems. They also explain the concepts of pharmacogenetics, intracellular control mechanisms, chemotherapy, and the different types of drugs. This book will be of interest to preclinical and clinical medical students and those preparing for Bachelor of Science degree in Pharmacology and others interested in understanding how drugs work.

Author : Binghe Wang
Publisher : John Wiley & Sons
Page : 261 pages
File Size : 52,8 Mb
Release : 2008-03-05
Category : Medical
ISBN : 9780470187913

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Drug-Drug Interactions in Pharmaceutical Development by Binghe Wang Pdf

Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.