Mechanisms Underlying Host Microbiome Interactions In Pathophysiology Of Human Diseases

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Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases

Jun Sun,Pradeep K. Dudeja
Mechanisms Underlying Host Microbiome Interactions in Pathophysiology of Human Diseases Book PDF

Author : Jun Sun,Pradeep K. Dudeja
Publisher : Springer
Page : 381 pages
File Size : 50,7 Mb
Release : 2018-01-26
Category : Medical
ISBN : 9781493975341

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Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases by Jun Sun,Pradeep K. Dudeja Pdf

Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.

Microbiome in Human Health and Disease

Pallaval Veera Bramhachari
Microbiome in Human Health and Disease Book PDF

Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
Page : 306 pages
File Size : 44,8 Mb
Release : 2021-10-18
Category : Medical
ISBN : 9789811631566

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Microbiome in Human Health and Disease by Pallaval Veera Bramhachari Pdf

The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.

Gut Microbiota in Neurologic and Visceral Diseases

Tahira Farooqui,Akhlaq A. Farooqui
Gut Microbiota in Neurologic and Visceral Diseases Book PDF

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Page : 388 pages
File Size : 54,6 Mb
Release : 2021-03-11
Category : Medical
ISBN : 9780128210406

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Gut Microbiota in Neurologic and Visceral Diseases by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Gut Microbiota in Neurologic and Visceral Diseases presents readers with comprehensive information on the involvement of microbiota in the pathogenesis of neurological disorders. Chapters cover the effect of microbiota on the development of visceral (obesity, type 2 diabetes, heart disease) and neurological disorders (Alzheimer’s disease, Parkinson’s, depression, anxiety, and autism). Sections focus on the molecular mechanisms and signal transduction processes associated with the links among microbiota-related visceral and neurological disorders. It is hoped that this discussion will not only integrate and consolidate knowledge in this field but will also jumpstart more studies on the involvement of microbiota in the pathogenesis of neurological disorders. Reviews the relationship between gut microbiome, diseases and disorders Discusses the relationship between diet, microbiota and inflammation Includes neurodegenerative, neuropsychiatric and cardiovascular disorders Covers diabetes, obesity and metabolic disorders Identifies molecular mechanisms and signal transduction processes Encompasses dietary fiber, fat, prebiotics and probiotics

Environmental Chemicals, the Human Microbiome, and Health Risk

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Environmental Chemicals the Human Microbiome and Health Risk Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Publisher : National Academies Press
Page : 123 pages
File Size : 44,7 Mb
Release : 2018-03-01
Category : Science
ISBN : 9780309468695

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Environmental Chemicals, the Human Microbiome, and Health Risk by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome Pdf

A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

The Gut Microbiome in Health and Disease

Dirk Haller
The Gut Microbiome in Health and Disease Book PDF

Author : Dirk Haller
Publisher : Springer
Page : 356 pages
File Size : 55,5 Mb
Release : 2018-07-27
Category : Medical
ISBN : 9783319905457

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The Gut Microbiome in Health and Disease by Dirk Haller Pdf

The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

Inflammation, Infection, and Microbiome in Cancers

Jun Sun
Inflammation Infection and Microbiome in Cancers Book PDF

Author : Jun Sun
Publisher : Springer Nature
Page : 513 pages
File Size : 44,6 Mb
Release : 2021-04-20
Category : Medical
ISBN : 9783030679514

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Inflammation, Infection, and Microbiome in Cancers by Jun Sun Pdf

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

Molecular Food Microbiology

Dongyou Liu
Molecular Food Microbiology Book PDF

Author : Dongyou Liu
Publisher : CRC Press
Page : 704 pages
File Size : 40,5 Mb
Release : 2021-04-12
Category : Science
ISBN : 9781351120364

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Molecular Food Microbiology by Dongyou Liu Pdf

The elucidation of DNA double helix in 1953 and the publication of DNA cloning protocol in 1973 have put wings under the sail of molecular biology, which has since quietly revolutionized many fields of biological science, including food microbiology. Exploiting the power and versatility of molecular technologies, molecular food microbiology extends and greatly improves on phenotypically based food microbiology, leading to the development of better diagnostics for foodborne infections and intoxications, and contributing to the design of more effective therapeutics and prophylaxes against foodborne diseases. Forming part of the Food Microbiology series, Molecular Food Microbiology provides a state of art coverage on molecular techniques applicable to food microbiology. While the introductory chapter contains an overview on the principles of current DNA, RNA and protein techniques and discusses their utility in helping solve practical problems that food microbiology is facing now and in the future, the remaining chapters present detailed moleuclar analyses of selective foodborne viruses, bacteria, fungi and parasites. Key Features: Contains a state of art overview on moleuclar techniques applicable to food microbiology research and development Presents in-depth molecular analysis of selective foodborne viruses, bacteria, fungi and parasites Highlights the utility of molecular tecniques for accurate diagnosis and effective control of foodborne diseases Includes expert contributions from international scientists involved in molecular food microbiology research Represents a highly informative textbook for students majoring in food, medical, and veterinary microbiology Offers a contemporary reference for scholars and educators wishing to keep abreast with the latest developments in molecular food microbiology With contributions from international scientists involved in molecular food microbiology research, this book constitutes an informative textbook for undergraduates and postgraduates majoring in food, medical, and veterinary microbiology; represents an indispensable guide for food, medical, and veterinary scientists engaged in molecular food microbiology research and development; and offers a contemporary update for scholars and educators trying to keep in touch with the latest developments in molecular food microbiology.

Microbiome and the Eye

Anat Galor,Jun Sun
Microbiome and the Eye Book PDF

Author : Anat Galor,Jun Sun
Publisher : Elsevier
Page : 242 pages
File Size : 40,7 Mb
Release : 2023-06-20
Category : Science
ISBN : 9780323985376

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Microbiome and the Eye by Anat Galor,Jun Sun Pdf

Microbiome and the Eye: What’s the connection? highlights how alterations in the gut and eye microbiomes can lead to systemic immune alterations with subsequent effects on the eye. The book is divided into two sections, one highlighting how alterations in the gut microbiome impact various components of health outside the gut, with a focus on the immune system and inflammatory mediators, and the second focusing on studies on a variety of ocular diseases, including ocular surface diseases/dry eye, keratitis, uveitis, glaucoma, and retinopathy to gut dysbiosis. With its translational approach, the book is suitable for both researchers and clinicians. The book will help readers understand the mechanisms in which gut and eye microbiome composition may influence health in multiple compartments, with a focus on eye diseases. Helps researchers understand the clinical eye diseases that have been linked to gut microbiome abnormalities Helps clinicians understand the mechanisms in which gut microbiome composition may influence health in multiple compartments Provides a foundation for future studies that consider gut microbiome manipulations as a treatment for specific eye diseases

The Microbiota in Gastrointestinal Pathophysiology

Martin H. Floch,Yehuda Ringel,W. Allen Walker
The Microbiota in Gastrointestinal Pathophysiology Book PDF

Author : Martin H. Floch,Yehuda Ringel,W. Allen Walker
Publisher : Academic Press
Page : 442 pages
File Size : 42,8 Mb
Release : 2016-11-16
Category : Medical
ISBN : 9780128040621

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The Microbiota in Gastrointestinal Pathophysiology by Martin H. Floch,Yehuda Ringel,W. Allen Walker Pdf

The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects Explores the gut microbiota as a therapeutic target Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field Serves as a ‘one-stop’ shop for a topic that’s currently spread across a number of various journals

Applied Microbiome Statistics

Yinglin Xia,Jun Sun
Applied Microbiome Statistics Book PDF

Author : Yinglin Xia,Jun Sun
Publisher : CRC Press
Page : 457 pages
File Size : 41,5 Mb
Release : 2024-07-22
Category : Mathematics
ISBN : 9781040045664

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Applied Microbiome Statistics by Yinglin Xia,Jun Sun Pdf

This unique book officially defines microbiome statistics as a specific new field of statistics and addresses the statistical analysis of correlation, association, interaction, and composition in microbiome research. It also defines the study of the microbiome as a hypothesis-driven experimental science and describes two microbiome research themes and six unique characteristics of microbiome data, as well as investigating challenges for statistical analysis of microbiome data using the standard statistical methods. This book is useful for researchers of biostatistics, ecology, and data analysts. Presents a thorough overview of statistical methods in microbiome statistics of parametric and nonparametric correlation, association, interaction, and composition adopted from classical statistics and ecology and specifically designed for microbiome research. Performs step-by-step statistical analysis of correlation, association, interaction, and composition in microbiome data. Discusses the issues of statistical analysis of microbiome data: high dimensionality, compositionality, sparsity, overdispersion, zero-inflation, and heterogeneity. Investigates statistical methods on multiple comparisons and multiple hypothesis testing and applications to microbiome data. Introduces a series of exploratory tools to visualize composition and correlation of microbial taxa by barplot, heatmap, and correlation plot. Employs the Kruskal–Wallis rank-sum test to perform model selection for further multi-omics data integration. Offers R code and the datasets from the authors’ real microbiome research and publicly available data for the analysis used. Remarks on the advantages and disadvantages of each of the methods used.

Statistical Analysis of Microbiome Data with R

Yinglin Xia,Jun Sun,Ding-Geng Chen
Statistical Analysis of Microbiome Data with R Book PDF

Author : Yinglin Xia,Jun Sun,Ding-Geng Chen
Publisher : Springer
Page : 505 pages
File Size : 44,8 Mb
Release : 2018-10-06
Category : Computers
ISBN : 9789811315343

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Statistical Analysis of Microbiome Data with R by Yinglin Xia,Jun Sun,Ding-Geng Chen Pdf

This unique book addresses the statistical modelling and analysis of microbiome data using cutting-edge R software. It includes real-world data from the authors’ research and from the public domain, and discusses the implementation of R for data analysis step by step. The data and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter, so that these new methods can be readily applied in their own research. The book also discusses recent developments in statistical modelling and data analysis in microbiome research, as well as the latest advances in next-generation sequencing and big data in methodological development and applications. This timely book will greatly benefit all readers involved in microbiome, ecology and microarray data analyses, as well as other fields of research.

Mycotoxin Exposure and Related Diseases

Susana Viegas,Ricardo Assunção
Mycotoxin Exposure and Related Diseases Book PDF

Author : Susana Viegas,Ricardo Assunção
Publisher : MDPI
Page : 222 pages
File Size : 44,7 Mb
Release : 2020-05-12
Category : Medical
ISBN : 9783039287048

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Mycotoxin Exposure and Related Diseases by Susana Viegas,Ricardo Assunção Pdf

Mycotoxins are considered the most frequently occurring natural contaminants in human and animal diets. Considering their potential toxic and carcinogenic effects, mycotoxin exposure assessment has particular importance in the context of health risk assessment. The magnitude of a given exposure allows the derivation of the associated risk and the potential for the establishment of a disease. Although food ingestion is considered a major route of human exposure to mycotoxins, other contexts may also result in exposure, such as specific occupational environments where exposure to organic dust also occurs due to the handling of organic materials. Animals could be exposed to mycotoxins through consumption of contaminated feed, subsequently entering in the food chain and thus constituting a source of exposure to humans. Human biomonitoring is considered a new frontier for the establishment of the human internal exposure to mycotoxins. Although several studies have summarized the potential outcomes associated with mycotoxin exposure, major gaps in data remain in recognizing the mycotoxins that are the cause of diseases. This book contributes provides research that supports the anticipation of potential consequences of the exposure of humans and animals to mycotoxins, future risk assessments, and the establishment of preventive measures.

Statistical Data Analysis of Microbiomes and Metabolomics

Yinglin Xia,Jun Sun
Statistical Data Analysis of Microbiomes and Metabolomics Book PDF

Author : Yinglin Xia,Jun Sun
Publisher : American Chemical Society
Page : 229 pages
File Size : 42,9 Mb
Release : 2022-02-03
Category : Science
ISBN : 9780841299160

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Statistical Data Analysis of Microbiomes and Metabolomics by Yinglin Xia,Jun Sun Pdf

Compared with other research fields, both microbiome and metabolomics data are complicated and have some unique characteristics, respectively. Thus, choosing an appropriate statistical test or method is a very important step in the analysis of microbiome and metabolomics data. However, this is still a difficult task for those biomedical researchers without a statistical background and for those biostatisticians who do not have research experiences in these fields. Graduate students studying microbiome and metabolomics; statisticians, working on microbiome and metabolomics projects, either for their own research, or for their collaborative research for experimental design, grant application, and data analysis; and researchers who investigate biomedical and biochemical projects with the microbiome, metabolome, and multi-omics data analysis will benefit from reading this work.

Nutritional Science and Technology

Tejpal Dhewa,Anil Kumar Puniya,Anil Panghal
Nutritional Science and Technology Book PDF

Author : Tejpal Dhewa,Anil Kumar Puniya,Anil Panghal
Publisher : John Wiley & Sons
Page : 437 pages
File Size : 55,7 Mb
Release : 2023-10-03
Category : Science
ISBN : 9781119808961

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Nutritional Science and Technology by Tejpal Dhewa,Anil Kumar Puniya,Anil Panghal Pdf

NUTRITIONAL SCIENCE AND TECHNOLOGY Food science is a rapidly changing and complicated subject. This new series addresses the current state-of-the-art concepts and technologies associated with the industry and will cover new ideas and emerging novel technologies and processes. The book Nutritional Science and Technology: Concept to Application in the series, “Bioprocessing in Food Science,” is an excellent resource for any scientist, engineer, student, or other industry professional interested in this topic. It covers a wide range of topics, including human nutrition, technological processes, the health benefits of fermented foods, and food safety concerns. The content contributors and editors are experts in the field, and their primary goal is to provide extensive knowledge about recent technologies in nutritional science and technology to students, researchers, and industry professionals. Manufacturers are looking for new possibilities to occupy a growing share of the rapidly changing food market, and this book will enable them to make informed decisions about adopting appropriate processing technology, implementation, economics, and constraints of different technologies. The book also provides insights on advances in nutritional science and technology for healthy and safe nutrition, with maximum illustrations of how to ensure public health safety and adequate nutrition. Overall, this book is a comprehensive overview of this study area and a valuable resource for anyone interested in this field.

Human Microbiota in Health and Disease

Bryan Tungland
Human Microbiota in Health and Disease Book PDF

Author : Bryan Tungland
Publisher : Academic Press
Page : 680 pages
File Size : 52,7 Mb
Release : 2018-05-25
Category : Science
ISBN : 9780128146507

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Human Microbiota in Health and Disease by Bryan Tungland Pdf

Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion on all the aspects associated with the early colonization of gut microbiota, its development and maintenance, and its symbiotic relationship with the host in promoting health. Chapters illustrate the complex mechanisms and metabolic signaling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, all while mediating inflammatory processes involved in the etiology of many chronic disease conditions. With today's common use of pharmaceutical medicine in treating symptoms and frequent overuse of antibiotics in chronic disease within mainstream medical practice, our understanding of the etiological mechanisms of dysbiosis-induced chronic disease and natural approaches to prevention and potential cures for these diseases is of vital importance to overall human health. Details the complex relationship between human microbiota in the gut, oral cavity and skin as well as their colonization, development and impact of factors that influence the relationship Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification and pro- and prebiotics in preventing chronic disease