Environmental Chemicals The Human Microbiome And Health Risk

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Environmental Chemicals, the Human Microbiome, and Health Risk

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Environmental Chemicals the Human Microbiome and Health Risk Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Publisher : National Academies Press
Page : 123 pages
File Size : 48,5 Mb
Release : 2018-01-29
Category : Science
ISBN : 9780309468725

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Environmental Chemicals, the Human Microbiome, and Health Risk by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome Pdf

A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

Environmental Chemicals, the Human Microbiome, and Health Risk

National Academies of Sciences, Engineering, and Medicine (U.S.). Board on Life Sciences,National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Advancing Understanding of the Implications of Environmental-chemical Interactions with the Human Microbiome,National Academies of Sciences, Engineering, and Medicine (U.S.). Board on Environmental Studies and Toxicology,National Academies of Sciences, Engineering, and Medicine (U.S.). Division on Earth and Life Studies
Environmental Chemicals the Human Microbiome and Health Risk Book PDF

Author : National Academies of Sciences, Engineering, and Medicine (U.S.). Board on Life Sciences,National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Advancing Understanding of the Implications of Environmental-chemical Interactions with the Human Microbiome,National Academies of Sciences, Engineering, and Medicine (U.S.). Board on Environmental Studies and Toxicology,National Academies of Sciences, Engineering, and Medicine (U.S.). Division on Earth and Life Studies
Publisher : Unknown
Page : 109 pages
File Size : 52,8 Mb
Release : 2018
Category : Nature
ISBN : 0309468701

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Environmental Chemicals, the Human Microbiome, and Health Risk by National Academies of Sciences, Engineering, and Medicine (U.S.). Board on Life Sciences,National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Advancing Understanding of the Implications of Environmental-chemical Interactions with the Human Microbiome,National Academies of Sciences, Engineering, and Medicine (U.S.). Board on Environmental Studies and Toxicology,National Academies of Sciences, Engineering, and Medicine (U.S.). Division on Earth and Life Studies Pdf

"A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemical-microbiome interactions"--Publisher's description.

Microbiomes of the Built Environment

National Academies of Sciences, Engineering, and Medicine,National Academy of Engineering,Division on Engineering and Physical Sciences,Health and Medicine Division,Division on Earth and Life Studies,Board on Infrastructure and the Constructed Environment,Board on Environmental Studies and Toxicology,Board on Life Sciences,Committee on Microbiomes of the Built Environment: From Research to Application
Microbiomes of the Built Environment Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Engineering,Division on Engineering and Physical Sciences,Health and Medicine Division,Division on Earth and Life Studies,Board on Infrastructure and the Constructed Environment,Board on Environmental Studies and Toxicology,Board on Life Sciences,Committee on Microbiomes of the Built Environment: From Research to Application
Publisher : National Academies Press
Page : 318 pages
File Size : 41,6 Mb
Release : 2017-10-06
Category : Science
ISBN : 9780309449830

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Microbiomes of the Built Environment by National Academies of Sciences, Engineering, and Medicine,National Academy of Engineering,Division on Engineering and Physical Sciences,Health and Medicine Division,Division on Earth and Life Studies,Board on Infrastructure and the Constructed Environment,Board on Environmental Studies and Toxicology,Board on Life Sciences,Committee on Microbiomes of the Built Environment: From Research to Application Pdf

People's desire to understand the environments in which they live is a natural one. People spend most of their time in spaces and structures designed, built, and managed by humans, and it is estimated that people in developed countries now spend 90 percent of their lives indoors. As people move from homes to workplaces, traveling in cars and on transit systems, microorganisms are continually with and around them. The human-associated microbes that are shed, along with the human behaviors that affect their transport and removal, make significant contributions to the diversity of the indoor microbiome. The characteristics of "healthy" indoor environments cannot yet be defined, nor do microbial, clinical, and building researchers yet understand how to modify features of indoor environmentsâ€"such as building ventilation systems and the chemistry of building materialsâ€"in ways that would have predictable impacts on microbial communities to promote health and prevent disease. The factors that affect the environments within buildings, the ways in which building characteristics influence the composition and function of indoor microbial communities, and the ways in which these microbial communities relate to human health and well-being are extraordinarily complex and can be explored only as a dynamic, interconnected ecosystem by engaging the fields of microbial biology and ecology, chemistry, building science, and human physiology. This report reviews what is known about the intersection of these disciplines, and how new tools may facilitate advances in understanding the ecosystem of built environments, indoor microbiomes, and effects on human health and well-being. It offers a research agenda to generate the information needed so that stakeholders with an interest in understanding the impacts of built environments will be able to make more informed decisions.

Health Risk Assessment of Environmental Chemicals

Masami Ishido
Health Risk Assessment of Environmental Chemicals Book PDF

Author : Masami Ishido
Publisher : Springer Nature
Page : 303 pages
File Size : 49,7 Mb
Release : 2023-09-20
Category : Medical
ISBN : 9789819915606

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Health Risk Assessment of Environmental Chemicals by Masami Ishido Pdf

This book presents the frontier research of toxicology and health risk assessment of chemicals. First, it provides an overview of the current methods of evaluating safety amounts of chemicals and provides a new aspect of the principle of toxicology. Secondly, it shows recent research where the new method of health risk evaluation is adopted, followed by an integrated health risk assessment of chemicals. Finally, it describes the epigenetic inheritance of chemical impact on health throughout several generations. Estimating the safety amount of chemicals surrounding our lives is not sufficient for health risk evaluation, particularly for carcinogenic compounds, endocrine disruptors, and nano materials. The author’s group has found a family of chemicals linked to ADHD through animal screening and identified its chemical nature using chemoinformatics methods. Based on these new developments, this book proposes to utilize the biomarker common to those chemicals for health risk assessment, independent of exposure routes and physiological dimensions. The book appeals to researchers and students in the field of toxicology, health risk assessment, pharmacology, and public health.

Human Biomonitoring for Environmental Chemicals

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants
Human Biomonitoring for Environmental Chemicals Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants
Publisher : National Academies Press
Page : 320 pages
File Size : 50,9 Mb
Release : 2006-11-30
Category : Science
ISBN : 0309102723

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Human Biomonitoring for Environmental Chemicals by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants Pdf

Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

The Human Microbiome, Diet, and Health

Food Forum,Food and Nutrition Board,Institute of Medicine
The Human Microbiome Diet and Health Book PDF

Author : Food Forum,Food and Nutrition Board,Institute of Medicine
Publisher : National Academies Press
Page : 197 pages
File Size : 51,8 Mb
Release : 2013-02-27
Category : Medical
ISBN : 9780309265867

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The Human Microbiome, Diet, and Health by Food Forum,Food and Nutrition Board,Institute of Medicine Pdf

The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

Environmental Chemicals, the Human Microbiome, and Health Risk

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Environmental Chemicals the Human Microbiome and Health Risk Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome
Publisher : National Academies Press
Page : 123 pages
File Size : 43,5 Mb
Release : 2018-03-01
Category : Science
ISBN : 9780309468695

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Environmental Chemicals, the Human Microbiome, and Health Risk by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome Pdf

A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

Exposure Science in the 21st Century

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century
Exposure Science in the 21st Century Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century
Publisher : National Academies Press
Page : 210 pages
File Size : 52,9 Mb
Release : 2012-10-28
Category : Nature
ISBN : 9780309264686

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Exposure Science in the 21st Century by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century Pdf

From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day-many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies-including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics-have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.

Human Microbes - The Power Within

Vasu D. Appanna
Human Microbes The Power Within Book PDF

Author : Vasu D. Appanna
Publisher : Springer
Page : 175 pages
File Size : 54,8 Mb
Release : 2018-02-05
Category : Medical
ISBN : 9789811076848

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Human Microbes - The Power Within by Vasu D. Appanna Pdf

This book offers a unique perspective on the invisible organ, a body part that has been visualized only recently. It guides the readers into the world of the microbial constituents that make humans the way they are. The vitamins they produce, the smell they generate, the signals they create, and the molecular guards they elaborate are some of the benefits they bestow on humans. After introducing the notion as to why microbes are an integral component in the development of humans, the book examines the genesis of the microbiome and describes how the resident bacteria work in partnership with the skin, digestive tract, sexual organs, mouth and lungs to execute vital physiological functions. It then discusses the diseases that are triggered by the disruption of the harmonious relationships amongst these diverse systems and provides microbial cures to ailments such as obesity and digestive complications. Finally, the book focuses on the future when the workings of the human microbes will be fully unravelled. Societal changes in health education, the establishment of the microbiome bank, the fight against hunger, space travel, designer traits and enhanced security are explained. Each chapter is accompanied by captivating illustrations and ends with a visual summary. Dr. Appanna has been researching for over 30 years on various aspects of microbial and human cellular systems. He is a professor of biochemistry and has also served as Department Chair and Dean of the Faculty at Laurentian University, Sudbury, Canada. The book is aimed at readers enrolled in medical, chiropractic, nursing, pharmacy, and health science programs. Practicing health-care professionals and continuing education learners will also find the content beneficial.

Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease

Mark Lyte,John F. Cryan
Microbial Endocrinology The Microbiota Gut Brain Axis in Health and Disease Book PDF

Author : Mark Lyte,John F. Cryan
Publisher : Springer
Page : 436 pages
File Size : 51,5 Mb
Release : 2014-07-05
Category : Science
ISBN : 9781493908974

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Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease by Mark Lyte,John F. Cryan Pdf

The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.​

The Lung Microbiome

Michael J. Cox,Markus J. Ege,Erika von Mutius
The Lung Microbiome Book PDF

Author : Michael J. Cox,Markus J. Ege,Erika von Mutius
Publisher : European Respiratory Society
Page : 261 pages
File Size : 40,9 Mb
Release : 2019-03-01
Category : Medical
ISBN : 9781849841023

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The Lung Microbiome by Michael J. Cox,Markus J. Ege,Erika von Mutius Pdf

Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.

Integrative Environmental Medicine

Aly Cohen,Frederick S. vom Saal
Integrative Environmental Medicine Book PDF

Author : Aly Cohen,Frederick S. vom Saal
Publisher : Oxford University Press
Page : 400 pages
File Size : 43,8 Mb
Release : 2017-02-10
Category : Medical
ISBN : 9780190490935

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Integrative Environmental Medicine by Aly Cohen,Frederick S. vom Saal Pdf

At no other time in human existence have there been so many environmental changes. Over 87,000 chemicals are now commercially available in the U.S., almost all of which have not been tested for safety, particularly in young children and the growing fetus. The number and quantity of chemicals has continued to increase since World War II--and so too has the incidence of many chronic health problems, such as Type 2 Diabetes, obesity, thyroid disease, asthma, allergy, autoimmune disease, autism, ADHD, and several cancers. Many studies have revealed that exposure to chemicals and radiation in our everyday environment may increase risk for these conditions. Integrative Environmental Medicine examines the history and changing landscape of our environment in the U.S. and shares up-to-date research and information on ways to reduce exposures and reduce health risks. This text explores the unique properties of many chemicals and their ability to deceive the human body's normal workings, affecting everything from thyroid and autoimmune disease risk, to cancer development, to developmental issues in children, and even the development of diabetes and weight gain through gut bacteria manipulation. We discuss topics of improving regulations and appropriate testing for chemicals, remediation of environmental catastrophes, and designing healthier products for the future. Finally, we discuss best practices for clinicians to ascertain exposure history and teach patients how to avoid harmful exposures and help their bodies eliminate contaminates through better dietary and lifestyle practices. Throughout this book, we share vetted, practical resources and tools--including websites, phone apps, physician and patient hand-outs--to help healthcare practitioners facilitate healthier choices for themselves and their patients. This text is unique in that it offers tangible, practical information that can easily be integrated into the daily work flow of patient clinical care.

Skin Microbiome Handbook

Nava Dayan
Skin Microbiome Handbook Book PDF

Author : Nava Dayan
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 43,6 Mb
Release : 2020-09-01
Category : Medical
ISBN : 9781119592235

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Skin Microbiome Handbook by Nava Dayan Pdf

The book provides a comprehensive detailed summary of current status on skin microbiome research in health and disease as well as key regulatory and legal aspects. In the past decade, interest and technology have greatly advanced to unravel the nature and effect of skin microbiome on our health. Diseases such as atopic dermatitis and acne are at the forefront of this research, but also other conditions such as skin cancer are under investigation. In addition, mapping of the skin microbiome has gone from basic to more detailed with attempts to correlate it to various ages, ethnicities and genders. In parallel to mapping it, a great deal of research is dedicated to understanding its functionality and communication (and hence effect) on human cells. The Skin Microbiome Handbook is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome and oral-skin interaction; skin microbiome observational research; skin microbiome in disequilibrium and disease; skin's innate immunity; testing and study design; regulatory and legal aspects for skin microbiome related products. The 18 chapters of the book are written by carefully selected leaders in the academia and industry exhibiting extensive experience and understanding in the areas of interest.

The Exposome

Gary W Miller
The Exposome Book PDF

Author : Gary W Miller
Publisher : Elsevier
Page : 118 pages
File Size : 54,5 Mb
Release : 2013-11-16
Category : Science
ISBN : 9780124172180

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The Exposome by Gary W Miller Pdf

The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Inorganic Arsenic
Critical Aspects of EPA s IRIS Assessment of Inorganic Arsenic Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Inorganic Arsenic
Publisher : National Academies Press
Page : 128 pages
File Size : 40,7 Mb
Release : 2013-11-20
Category : Nature
ISBN : 9780309297097

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Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Inorganic Arsenic Pdf

The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.