Metabolomics

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The Handbook of Metabonomics and Metabolomics

John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
The Handbook of Metabonomics and Metabolomics Book PDF

Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
Publisher : Elsevier
Page : 573 pages
File Size : 53,7 Mb
Release : 2011-08-11
Category : Science
ISBN : 9780080468006

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The Handbook of Metabonomics and Metabolomics by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes Pdf

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies* aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification* covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Microbial Metabolomics

David J. Beale,Konstantinos A. Kouremenos,Enzo A. Palombo
Microbial Metabolomics Book PDF

Author : David J. Beale,Konstantinos A. Kouremenos,Enzo A. Palombo
Publisher : Springer
Page : 321 pages
File Size : 53,5 Mb
Release : 2016-12-05
Category : Science
ISBN : 9783319463261

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Microbial Metabolomics by David J. Beale,Konstantinos A. Kouremenos,Enzo A. Palombo Pdf

This book brings together contributions from global experts who have helped to facilitate the exciting and rapid advances that are taking place in microbial metabolomics. The main application of this field is in clinical and veterinary microbiology, but there is a great potential to apply metabolomics to help to better understand complex biological systems that are dominated by multiple-species microbial populations exposed to changing growth and nutritional conditions. In particular, environmental (e.g., water, soil), food (e.g., microbial spoilage, food pathogens), and agricultural and industrial applications are seen as developing areas for microbial metabolomics. As such, the book includes contributions with clinical, environmental, and industrial perspectives.

Computational Methods and Data Analysis for Metabolomics

Shuzhao Li
Computational Methods and Data Analysis for Metabolomics Book PDF

Author : Shuzhao Li
Publisher : Humana
Page : 491 pages
File Size : 42,5 Mb
Release : 2021-02-01
Category : Science
ISBN : 1071602411

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Computational Methods and Data Analysis for Metabolomics by Shuzhao Li Pdf

This book provides a comprehensive guide to scientists, engineers, and students that employ metabolomics in their work, with an emphasis on the understanding and interpretation of the data. Chapters guide readers through common tools for data processing, using database resources, major techniques in data analysis, and integration with other data types and specific scientific domains. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, practical guidance of methods and techniques, useful web supplements, and connect the steps from experimental metabolomics to scientific discoveries. Authoritative and cutting-edge, Computational Methods and Data Analysis for Metabolomics to ensure successful results in the further study of this vital field.

Metabolomics: From Fundamentals to Clinical Applications

Alessandra Sussulini
Metabolomics From Fundamentals to Clinical Applications Book PDF

Author : Alessandra Sussulini
Publisher : Springer
Page : 350 pages
File Size : 44,5 Mb
Release : 2017-01-28
Category : Science
ISBN : 9783319476568

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Metabolomics: From Fundamentals to Clinical Applications by Alessandra Sussulini Pdf

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Metabolomics in Food and Nutrition

Bart C Weimer,Carolyn Slupsky
Metabolomics in Food and Nutrition Book PDF

Author : Bart C Weimer,Carolyn Slupsky
Publisher : Elsevier
Page : 264 pages
File Size : 42,9 Mb
Release : 2013-10-31
Category : Technology & Engineering
ISBN : 9780857098818

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Metabolomics in Food and Nutrition by Bart C Weimer,Carolyn Slupsky Pdf

Metabolomics enables valuable information about the biochemical composition of foods to be rapidly obtained. Since the biochemical profile of food largely determines key food properties such as flavour and shelf life, the information gained using metabolomics-based methods will enable greater control of food quality and also help to determine the relationship between diet and health. Metabolomics in food and nutrition provides an overview of their current and potential use in the food industry. Part one reviews equipment, methods and data interpretation in metabolomics including the use of nuclear magnetic resonance (NMR), statistical methods in metabolomics, and metabolic reconstruction databases and their application to metabolomics research. Part two explores applications of metabolomics in humans, plants and food. Chapters discuss metabolomics in nutrition, human samples for health assessments, and current methods for the analysis of human milk oligosaccharides (HMOs) and their novel applications. Further chapters highlight metabolomic analysis of plants and crops, metabolomics for the safety assessment of genetically modified (GM) crops, and applications of metabolomics in food science including food composition and quality, sensory and nutritional attributes. With its distinguished editors and team of expert contributors, Metabolomics in food and nutrition is a technical resource for industrial researchers in the food and nutrition sectors interested in the potential of metabolomics methods and academics and postgraduate students working in the area. Provides an overview of the current and potential future use of metabolomics in the food industry Chapters focus on key applications and review the analytical methods used and the bioinformatics techniques involved in processing the results Discusses metabolomics in nutrition, human samples for health assessments, and current methods for the analysis of human milk oligosaccharides (HMOs) and their novel applications

Clinical Metabolomics

Martin Giera
Clinical Metabolomics Book PDF

Author : Martin Giera
Publisher : Humana
Page : 389 pages
File Size : 44,8 Mb
Release : 2019-06-04
Category : Science
ISBN : 1493985302

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Clinical Metabolomics by Martin Giera Pdf

This detailed volume presents a comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. The methodologies explored here form the core of several very promising initiatives evolving around personalized health care and precision medicine, which can be seen as complimentary to the field of clinical chemistry and aid the aforementioned field with novel disease markers and diagnostic patterns. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical Metabolomics: Methods and Protocols aims to serve as the basis for successful communication between scientists from several fields, including chemists, biologist, bioinformaticians, and clinicians, ultimately leading to effective study design and completion.

NMR-Based Metabolomics

G. A. Nagana Gowda,Daniel Raftery
NMR Based Metabolomics Book PDF

Author : G. A. Nagana Gowda,Daniel Raftery
Publisher : Humana
Page : 489 pages
File Size : 49,8 Mb
Release : 2020-08-29
Category : Science
ISBN : 1493996924

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NMR-Based Metabolomics by G. A. Nagana Gowda,Daniel Raftery Pdf

This book provides broad coverage of nuclear magnetic resonance (NMR) spectroscopy-based methods and applications for the analysis of metabolites in a wide range of biological samples, from biofluids, cells, animal models, human, to plants and foods. The applications range from mechanistic understanding, biomarker discovery, environmental studies, and drug discovery to nutrition, while NMR methods include global, targeted, and isotope tracer-based techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, NMR-Based Metabolomics: Methods and Protocols serves as a wealth of information for beginners as well as advanced practitioners and also as stepping stones for further advances in the field of metabolomics.

Metabolomics

Paul L. Wood
Metabolomics Book PDF

Author : Paul L. Wood
Publisher : Humana
Page : 0 pages
File Size : 40,9 Mb
Release : 2020-11-01
Category : Medical
ISBN : 1071608630

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Metabolomics by Paul L. Wood Pdf

This volume discusses the latest analytical approaches used to sample defined molecular populations of metabolites via functional group derivatization, specialized chromatographic methods, and ionization techniques. Chapters cover key methods for sample introductions to the ion source, including direct flow, gas chromatography, liquid chromatography, and capillary electrophoresis. Chapters also explore non-targeted and targeted analyses, as well as the emerging field of metallomics. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Metabolomics is a valuable resource for students, researchers, practicing physicians and veterinarians, and administrators involved in the funding of research.

Metabolomics Data Processing and Data Analysis-Current Best Practices

Justin Van Der Hooft,Kati Hanhineva
Metabolomics Data Processing and Data Analysis Current Best Practices Book PDF

Author : Justin Van Der Hooft,Kati Hanhineva
Publisher : Mdpi AG
Page : 276 pages
File Size : 53,7 Mb
Release : 2021-09-10
Category : Computers
ISBN : 3036511946

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Metabolomics Data Processing and Data Analysis-Current Best Practices by Justin Van Der Hooft,Kati Hanhineva Pdf

Metabolomics data analysis strategies are central to transforming raw metabolomics data files into meaningful biochemical interpretations that answer biological questions or generate novel hypotheses. This book contains a variety of papers from a Special Issue around the theme "Best Practices in Metabolomics Data Analysis". Reviews and strategies for the whole metabolomics pipeline are included, whereas key areas such as metabolite annotation and identification, compound and spectral databases and repositories, and statistical analysis are highlighted in various papers. Altogether, this book contains valuable information for researchers just starting in their metabolomics career as well as those that are more experienced and look for additional knowledge and best practice to complement key parts of their metabolomics workflows.

Metabolomics

Jens Nielsen,Michael C. Jewett
Metabolomics Book PDF

Author : Jens Nielsen,Michael C. Jewett
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 40,8 Mb
Release : 2007-09-19
Category : Science
ISBN : 9783540747192

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Metabolomics by Jens Nielsen,Michael C. Jewett Pdf

Giving a fresh, substantial and in-depth overview of the topic, this book brings together the latest results in the field of metabolomics. It comprehensively presents the current state of the metabolomics field by underscoring experimental methods, analysis techniques, standardization practices, and advances in specific model systems. As a result, it helps to significantly broaden our perspective on the principles and strategies underpinning this emerging field.

Metabolomics

Ron Wehrens,International Agency for Research on Can
Metabolomics Book PDF

Author : Ron Wehrens,International Agency for Research on Can
Publisher : CRC Press
Page : 313 pages
File Size : 42,8 Mb
Release : 2019-08-19
Category : Mathematics
ISBN : 9781315353487

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Metabolomics by Ron Wehrens,International Agency for Research on Can Pdf

Metabolomics is the scientific study of the chemical processes in a living system, environment and nutrition. It is a relatively new omics science, but the potential applications are wide, including medicine, personalized medicine and intervention studies, food and nutrition, plants, agriculture and environmental science. The topics presented and discussed in this book are based on the European Molecular Biology Organization (EMBO) practical courses in metabolomics bioinformatics taught to those working in the field, from masters to postgraduate students, PhDs, postdoctoral and early PIs. The book covers the basics and fundamentals of data acquisition and analytical technologies, but the primary focus is data handling and data analysis. The mentioning and usage of a particular data analysis tool has been avoided; rather, the focus is on the concepts and principles of data processing and analysis. The material has been class-tested and includes lots of examples, computing and exercises. Key Features: Provides an overview of qualitative /quantitative methods in metabolomics Offers an introduction to the key concepts of metabolomics, including experimental design and technology Covers data handling, processing, analysis, data standards and sharing Contains lots of examples to illustrate the topics Includes contributions from some of the leading researchers in the field of metabolomics with extensive teaching experiences

Proteomic and Metabolomic Approaches to Biomarker Discovery

Haleem J. Issaq,Timothy D. Veenstra
Proteomic and Metabolomic Approaches to Biomarker Discovery Book PDF

Author : Haleem J. Issaq,Timothy D. Veenstra
Publisher : Academic Press
Page : 504 pages
File Size : 50,5 Mb
Release : 2019-10-24
Category : Science
ISBN : 9780128197882

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Proteomic and Metabolomic Approaches to Biomarker Discovery by Haleem J. Issaq,Timothy D. Veenstra Pdf

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

NMR Metabolomics in Cancer Research

Miroslava Čuperlović-Culf
NMR Metabolomics in Cancer Research Book PDF

Author : Miroslava Čuperlović-Culf
Publisher : Elsevier
Page : 446 pages
File Size : 51,8 Mb
Release : 2012-12-17
Category : Medical
ISBN : 9781908818263

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NMR Metabolomics in Cancer Research by Miroslava Čuperlović-Culf Pdf

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Metabolomics

Wolfram Weckwerth
Metabolomics Book PDF

Author : Wolfram Weckwerth
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 52,6 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781597452441

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Metabolomics by Wolfram Weckwerth Pdf

Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic analysis. Leading researchers in the field present protocols for the application of complementary analytical methods, such as gas chromatography-mass spectrometry (GC-MS). Metabolomics: Methods and Protocols contains forward-looking protocols, which provide the essential groundwork for future efforts in elucidating the structure of the unknowns detected in metabolomic studies.

Cancer Metabolomics

Shen Hu
Cancer Metabolomics Book PDF

Author : Shen Hu
Publisher : Springer Nature
Page : 317 pages
File Size : 49,9 Mb
Release : 2021-04-01
Category : Medical
ISBN : 9783030516529

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Cancer Metabolomics by Shen Hu Pdf

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.